-
公开(公告)号:US09833476B2
公开(公告)日:2017-12-05
申请号:US14342060
申请日:2012-08-31
申请人: Tong Zhang , Charles L. Sentman
发明人: Tong Zhang , Charles L. Sentman
IPC分类号: C07K14/70 , A61K35/17 , C07K14/705 , C12N5/0783 , A61K38/00
CPC分类号: A61K35/17 , A61K38/00 , C07K14/70503 , C07K14/70521 , C07K14/70575 , C07K14/70578 , C07K14/70596 , C07K2319/00 , C07K2319/03 , C12N5/0636 , C12N2800/22
摘要: The invention is directed to T cells and other cells that express chimeric NK-p30 receptors (“chimeric NKp30 T cells”), methods of making and using chimeric NKp30 T cells, and methods of using these chimeric NKp30 T cells, isolated populations thereof, and compositions comprising the same. In another aspect, said chimeric NKp30 T cells are further designed to express a functional non-TCR receptor. The disclosure also pertains to methods of making said chimeric NKp30 T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said chimeric NKp30 T cells, populations thereof, or compositions comprising the same.
-
公开(公告)号:US08252914B2
公开(公告)日:2012-08-28
申请号:US13155909
申请日:2011-06-08
申请人: Tong Zhang , Charles L. Sentman
发明人: Tong Zhang , Charles L. Sentman
CPC分类号: C07K14/705 , A61K35/17 , A61K38/10 , A61K45/06 , C07K14/715
摘要: The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a protein associated therewith, fused to an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif. Methods for using the chimeric receptors are further provided.
摘要翻译: 本发明涉及用于减少或消除肿瘤的嵌合免疫受体分子。 嵌合受体是与含有基于免疫受体酪氨酸的活化基序的免疫信号受体融合的C型凝集素样天然杀伤细胞受体或与其相关的蛋白质。 还提供了使用嵌合受体的方法。
-
公开(公告)号:US20100029749A1
公开(公告)日:2010-02-04
申请号:US11575878
申请日:2005-08-31
申请人: Tong Zhang , Charles L. Sentman
发明人: Tong Zhang , Charles L. Sentman
IPC分类号: A61K31/7088 , C07H21/04 , A61P35/00 , C12N15/74
CPC分类号: C07K14/705 , A61K35/17 , A61K38/10 , A61K45/06 , C07K14/715
摘要: The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a protein associated therewith, fused to an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif. Methods for using the chimeric receptors are further provided.
摘要翻译: 本发明涉及用于减少或消除肿瘤的嵌合免疫受体分子。 嵌合受体是与含有基于免疫受体酪氨酸的活化基序的免疫信号受体融合的C型凝集素样天然杀伤细胞受体或与其相关的蛋白质。 还提供了使用嵌合受体的方法。
-
公开(公告)号:US20090202501A1
公开(公告)日:2009-08-13
申请号:US12407440
申请日:2009-03-19
申请人: Tong Zhang , Charles L. Sentman
发明人: Tong Zhang , Charles L. Sentman
CPC分类号: C07K14/705 , A61K35/17 , A61K38/10 , A61K45/06 , C07K14/715
摘要: The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a protein associated therewith, fused to an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif. Methods for using the chimeric receptors are further provided.
摘要翻译: 本发明涉及用于减少或消除肿瘤的嵌合免疫受体分子。 嵌合受体是与含有基于免疫受体酪氨酸的活化基序的免疫信号受体融合的C型凝集素样天然杀伤细胞受体或与其相关的蛋白质。 还提供了使用嵌合受体的方法。
-
公开(公告)号:US20150110760A1
公开(公告)日:2015-04-23
申请号:US14342060
申请日:2012-08-31
申请人: Tong Zhang , Charles L. Sentman
发明人: Tong Zhang , Charles L. Sentman
IPC分类号: A61K35/17 , C12N5/0783 , C07K14/705
CPC分类号: A61K35/17 , A61K38/00 , C07K14/70503 , C07K14/70521 , C07K14/70575 , C07K14/70578 , C07K14/70596 , C07K2319/00 , C07K2319/03 , C12N5/0636 , C12N2800/22
摘要: The invention is directed to T cells and other cells that express chimeric NK-p30 receptors (“chimeric NKp30 T cells”), methods of making and using chimeric NKp30 T cells, and methods of using these chimeric NKp30 T cells, isolated populations thereof, and compositions comprising the same. In another aspect, said chimeric NKp30 T cells are further designed to express a functional non-TCR receptor. The disclosure also pertains to methods of making said chimeric NKp30 T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said chimeric NKp30 T cells, populations thereof, or compositions comprising the same.
摘要翻译: 本发明涉及表达嵌合NK-p30受体(“嵌合NKp30T细胞”)的T细胞和其他细胞,制备和使用嵌合NKp30 T细胞的方法,以及使用这些嵌合NKp30T细胞,其分离群体的方法, 和包含它们的组合物。 在另一方面,进一步设计所述嵌合NKp30T细胞以表达功能性非TCR受体。 本公开还涉及制备所述嵌合NKp30T细胞的方法,以及使用所述嵌合NKp30T细胞,其群体或包含其的组合物来减少或改善或预防或治疗疾病和病症的方法。
-
公开(公告)号:US20120294857A1
公开(公告)日:2012-11-22
申请号:US13521532
申请日:2011-01-07
申请人: Charles L. Sentman , Tong Zhang
发明人: Charles L. Sentman , Tong Zhang
IPC分类号: C07K19/00 , C12N15/62 , A61P31/00 , C12N1/21 , C12N5/10 , A61P35/00 , A61K39/395 , C12N15/63
CPC分类号: C07K16/2809 , C07K14/70503 , C07K14/7056 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/33
摘要: The present invention embraces a bi-specific fusion protein composed of an effector cell-specific antibody-variable region fragment operably linked to at least a portion of a natural killer cell receptor. Methods for using the fusion protein in the treatment of cancer and pathogenic infections are also provided.
摘要翻译: 本发明包括由与天然杀伤细胞受体的至少一部分可操作地连接的效应细胞特异性抗体可变区片段组成的双特异性融合蛋白。 还提供了使用融合蛋白治疗癌症和致病性感染的方法。
-
公开(公告)号:US07994298B2
公开(公告)日:2011-08-09
申请号:US11575878
申请日:2005-08-31
申请人: Tong Zhang , Charles L. Sentman
发明人: Tong Zhang , Charles L. Sentman
CPC分类号: C07K14/705 , A61K35/17 , A61K38/10 , A61K45/06 , C07K14/715
摘要: The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a protein associated therewith, fused to an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif. Methods for using the chimeric receptors are further provided.
摘要翻译: 本发明涉及用于减少或消除肿瘤的嵌合免疫受体分子。 嵌合受体是与含有基于免疫受体酪氨酸的活化基序的免疫信号受体融合的C型凝集素样天然杀伤细胞受体或与其相关的蛋白质。 还提供了使用嵌合受体的方法。
-
公开(公告)号:US09239967B2
公开(公告)日:2016-01-19
申请号:US14234099
申请日:2011-07-29
申请人: Ke-Yan Liu , Xin-Yun Sun , Tong Zhang , Lei Wang , Min Wang
发明人: Ke-Yan Liu , Xin-Yun Sun , Tong Zhang , Lei Wang , Min Wang
CPC分类号: G06K9/6218 , G06F17/30247 , G06K9/6219
摘要: Methods, systems, and computer readable media with executable instructions, and/or logic are provided for incremental image clustering. An example method for incremental image clustering can include identifying, via a computing device, a number of candidate nodes from among evaluated leaf image cluster (LIC) nodes on an image cluster tree (ICT) based on a similarity between a feature of a new image and an average feature of each of the evaluated LIC nodes. The evaluated nodes include at least one node along each path from a root node to either a leaf node or a node having a similarity exceeding a first threshold. A most-similar node can be determined, via the computing device, from among the number of candidate nodes. The new image can be inserted to a node associated with the determined most-similar node, via the computing device.
摘要翻译: 提供了具有可执行指令和/或逻辑的方法,系统和计算机可读介质用于增量图像聚类。 用于增量图像聚类的示例性方法可以包括基于新图像的特征之间的相似性,经由计算设备识别来自图像簇树(ICT)上的评估叶图像簇(LIC)节点中的候选节点的数量 以及每个评估的LIC节点的平均特征。 评估的节点包括沿着从根节点到叶节点或具有超过第一阈值的相似度的节点的每个路径的至少一个节点。 可以通过计算设备从候选节点的数量中确定最相似的节点。 可以通过计算设备将新图像插入到与所确定的最相似的节点相关联的节点。
-
公开(公告)号:US09025864B2
公开(公告)日:2015-05-05
申请号:US13700820
申请日:2010-08-02
申请人: Tong Zhang , Wei Zhang , Daniel R Tretter
发明人: Tong Zhang , Wei Zhang , Daniel R Tretter
CPC分类号: G06K9/6256 , G06K9/00677
摘要: The disclosure relates to a system and a method for generating clothing feature data representative of at least one clothing feature of a piece of clothing being worn by the person in a set of images, and training a discriminative clothing classifier using the clothing feature data to provide a personal clothing model that corresponds to the piece of clothing. The personal clothing model can be used to identify additional images in which the person appears.
摘要翻译: 本公开涉及一种用于生成表示人在一组图像中穿着的服装的至少一个服装特征的服装特征数据的系统和方法,并且使用服装特征数据来训练鉴别服装分类器以提供 一件与服装相对应的个人服装模特。 个人服装模型可以用于识别该人出现的其他图像。
-
公开(公告)号:US08861873B2
公开(公告)日:2014-10-14
申请号:US13642352
申请日:2010-08-02
申请人: Tong Zhang , Wei Zhang , Daniel Tretter
发明人: Tong Zhang , Wei Zhang , Daniel Tretter
CPC分类号: G06K9/6218 , G06K9/00677
摘要: The disclosure is related to a system and method for learning robust clothing clustering based on a cluster ensemble technique applied to the clothing features of images to improve clustering of images. Different types of clothing features that are complementary to each other are computed to provide extensive description of the clothing in the images. Multiple partitions are computed based on the clothing features to generate a cluster ensemble set. A consensus function is applied to the multiple partitions to generate a final clothing consensus clustering that encompasses the information contained in the multiple partitions. A system and method are disclosed for clustering images based on the clothing of one or more persons in the images.
摘要翻译: 本公开涉及用于基于应用于图像的服装特征的群集合成技术来学习鲁棒服装聚类的系统和方法,以改善图像的聚类。 计算出彼此互补的不同类型的服装功能,以便对图像中的服装进行广泛的描述。 基于服装特征计算多个分区以生成群集集合集。 将共同功能应用于多个分区以生成包含多个分区中包含的信息的最终服装共识聚类。 公开了一种基于图像中的一个或多个人的衣服对图像进行聚类的系统和方法。
-
-
-
-
-
-
-
-
-