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公开(公告)号：US08593629B2
公开(公告)日：2013-11-26
申请号：US13029915
申请日：2011-02-17
IPC分类号： G01J3/44
CPC分类号： B82Y20/00 , G01N21/658 , G01N21/7703
摘要： An apparatus for performing surface enhanced Raman spectroscopy includes an optical waveguide, a plurality of flexible nano-structures, wherein the plurality of nano-structures have respective free ends positioned within an evanescent field to be generated by light propagated through the optical waveguide, wherein the plurality of nano-structures are movable from a first position and a second position, wherein in the first position, the free ends of the plurality of nano-structures are substantially spaced from each other and in the second position, the free ends of a plurality of the nano-structures are substantially in contact with each other.
摘要翻译： 用于进行表面增强拉曼光谱的装置包括光波导，多个柔性纳米结构，其中所述多个纳米结构具有位于由通过光波导传播的光产生的消逝场内的各自自由端，其中， 多个纳米结构可以从第一位置和第二位置移动，其中在第一位置，多个纳米结构的自由端基本上彼此间隔开，并且在第二位置，多个纳米结构的自由端 的纳米结构基本上彼此接触。
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公开(公告)号：US20120212732A1
公开(公告)日：2012-08-23
申请号：US13029915
申请日：2011-02-17
CPC分类号： B82Y20/00 , G01N21/658 , G01N21/7703
摘要： An apparatus for performing surface enhanced Raman spectroscopy includes an optical waveguide, a plurality of flexible nano-structures, wherein the plurality of nano-structures have respective free ends positioned within an evanescent field to be generated by light propagated through the optical waveguide, wherein the plurality of nano-structures are movable from a first position and a second position, wherein in the first position, the free ends of the plurality of nano-structures are substantially spaced from each other and in the second position, the free ends of a plurality of the nano-structures are substantially in contact with each other.
摘要翻译： 用于进行表面增强拉曼光谱的装置包括光波导，多个柔性纳米结构，其中所述多个纳米结构具有位于由通过光波导传播的光产生的消逝场内的各自自由端，其中， 多个纳米结构可以从第一位置和第二位置移动，其中在第一位置，多个纳米结构的自由端基本上彼此间隔开，并且在第二位置，多个纳米结构的自由端 的纳米结构基本上彼此接触。
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公开(公告)号：US08138756B2
公开(公告)日：2012-03-20
申请号：US12429876
申请日：2009-04-24
申请人： Paul E. Barclay , Raymond G. Beausoleil , Kai-Mei Camilla Fu , Charles M. Santori , Marco Fiorentino
发明人： Paul E. Barclay , Raymond G. Beausoleil , Kai-Mei Camilla Fu , Charles M. Santori , Marco Fiorentino
IPC分类号： G01R33/02
CPC分类号： G01R33/032 , B29D11/00663 , G01R33/323 , Y10S977/96
摘要： A magnetometer includes a tapered microfiber having a curved portion, an excitation laser in optical communication with the tapered microfiber, and a nanocrystal attached to the curved portion of the tapered microfiber. Laser light emitted from the excitation laser interacts with the nanocrystal to create an emitted photon flux which is monitored to detect a magnetic field passing through the nanocrystal.
摘要翻译： 磁力计包括具有弯曲部分的锥形超细纤维，与锥形超细纤维光学连通的激发激光，以及附着到锥形超细纤维的弯曲部分的纳米晶体。 从激发激光发射的激光与纳米晶体相互作用以产生发射的光子通量，该光子通量被监测以检测通过纳米晶体的磁场。
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公开(公告)号：US20100271016A1
公开(公告)日：2010-10-28
申请号：US12429876
申请日：2009-04-24
申请人： Paul E. Barclay , Raymond G. Beausoleil , Kai-Mei Camilla Fu , Charles M. Santori , Marco Fiorentino
发明人： Paul E. Barclay , Raymond G. Beausoleil , Kai-Mei Camilla Fu , Charles M. Santori , Marco Fiorentino
CPC分类号： G01R33/032 , B29D11/00663 , G01R33/323 , Y10S977/96
摘要： A magnetometer includes a tapered microfiber having a curved portion, an excitation laser in optical communication with the tapered microfiber, and a nanocrystal attached to the curved portion of the tapered microfiber. Laser light emitted from the excitation laser interacts with the nanocrystal to create an emitted photon flux which is monitored to detect a magnetic field passing through the nanocrystal.
摘要翻译： 磁力计包括具有弯曲部分的锥形超细纤维，与锥形超细纤维光学连通的激发激光，以及附着到锥形超细纤维的弯曲部分的纳米晶体。 从激发激光发射的激光与纳米晶体相互作用以产生发射的光子通量，该光子通量被监测以检测通过纳米晶体的磁场。
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5.发明授权Optically integrated biosensor based on optically detected magnetic resonance 失效基于光学检测的磁共振的光学集成生物传感器公开(公告)号：US08193808B2
公开(公告)日：2012-06-05
申请号：US12558408
申请日：2009-09-11
IPC分类号： G01V3/00
CPC分类号： G01R33/323 , G01N24/088 , G01R33/302
摘要： An optically integrated magnetic biosensor includes an optically detected magnetic resonance (ODMR) center and a fluidics layer configured to contain a solution comprising analytes, the fluidics layer being disposed over the ODMR center. A light source which generates incident light excites electrons within the ODMR center from a ground state to an excited state and a radio frequency (RF) antenna generates an RF field incident with frequencies which correspond to ground state transitions in the ODMR center. The ODMR center produces emitted light when illuminated by the incident light. The characteristics of the emitted light are influenced by the RF field and magnetic nanoparticles attached to the analytes. A method for detecting analytes using optically detected magnetic resonance is also provided.
摘要翻译： 光学集成的磁性生物传感器包括光学检测的磁共振（ODMR）中心和被配置为容纳包含分析物的溶液的流体层，流体层设置在ODMR中心上。 产生入射光的光源激发ODMR中心内的电子从基态到激发态，射频（RF）天线产生与ODMR中心的基态状态转换相对应的频率入射的RF场。 当由入射光照亮时，ODMR中心产生发射光。 发射光的特性受到附着在分析物上的RF场和磁性纳米粒子的影响。 还提供了使用光学检测的磁共振来检测分析物的方法。
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6.发明申请OPTICALLY INTEGRATED BIOSENSOR BASED ON OPTICALLY DETECTED MAGNETIC RESONANCE 失效基于光学检测的磁共振的光学集成生物传感器公开(公告)号：US20110062957A1
公开(公告)日：2011-03-17
申请号：US12558408
申请日：2009-09-11
IPC分类号： G01R33/44
CPC分类号： G01R33/323 , G01N24/088 , G01R33/302
摘要： An optically integrated magnetic biosensor includes an optically detected magnetic resonance (ODMR) center and a fluidics layer configured to contain a solution comprising analytes, the fluidics layer being disposed over the ODMR center. A light source which generates incident light excites electrons within the ODMR center from a ground state to an excited state and a radio frequency (RF) antenna generates an RF field incident with frequencies which correspond to ground state transitions in the ODMR center. The ODMR center produces emitted light when illuminated by the incident light. The characteristics of the emitted light are influenced by the RF field and magnetic nanoparticles attached to the analytes. A method for detecting analytes using optically detected magnetic resonance is also provided.
摘要翻译： 光学集成的磁性生物传感器包括光学检测的磁共振（ODMR）中心和被配置为容纳包含分析物的溶液的流体层，流体层设置在ODMR中心上。 产生入射光的光源激发ODMR中心内的电子从基态到激发态，射频（RF）天线产生与ODMR中心的基态状态转换相对应的频率入射的RF场。 当由入射光照亮时，ODMR中心产生发射光。 发射光的特性受到附着在分析物上的RF场和磁性纳米粒子的影响。 还提供了使用光学检测的磁共振来检测分析物的方法。
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公开(公告)号：US20130188172A1
公开(公告)日：2013-07-25
申请号：US13877319
申请日：2010-10-11
申请人： Kai-Mei Camilla Fu , Paul Edward Barclay , David A. Fattal , Jingjing Li , Raymond G. Beausoleil
发明人： Kai-Mei Camilla Fu , Paul Edward Barclay , David A. Fattal , Jingjing Li , Raymond G. Beausoleil
IPC分类号： G01N21/03
CPC分类号： G01N21/0303 , B01L3/502715 , B01L2200/0668 , B01L2300/0816 , B01L2300/168 , G01N2015/1415
摘要： In one embodiment, an optical system includes a microfluidic chip assembly. The microfluidic chip assembly includes a first structure that provides a first wall of a fluid channel. A second structure provides a second wall of the fluid channel. The second structure includes a diffraction grating configured to provide, in the presence of incident light of a wavelength band of interest on a first surface of the second structure, a plurality of regions of high intensity light within the fluid channel.
摘要翻译： 在一个实施例中，光学系统包括微流体芯片组件。 微流体芯片组件包括提供流体通道的第一壁的第一结构。 第二结构提供了流体通道的第二壁。 第二结构包括衍射光栅，被配置成在存在感兴趣的波长带的入射光存在于第二结构的第一表面上时，在流体通道内提供高强度光的多个区域。
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公开(公告)号：US20130271759A1
公开(公告)日：2013-10-17
申请号：US13976346
申请日：2011-01-31
IPC分类号： G01N21/65
CPC分类号： G01N21/65 , G01J3/0208 , G01J3/18 , G01J3/32 , G01J3/36 , G01N21/658
摘要： An apparatus for performing spectroscopy includes a substrate, a photodetector positioned at a distance with respect to the substrate, and a plurality of sub-wavelength grating (SWG) filters positioned between the substrate and the photodetector, in which the SWG filters are to filter different ranges of predetermined wavelengths of light emitted from an excitation location prior to being emitted onto the photodetector.
摘要翻译： 用于进行光谱分析的装置包括：基板，相对于基板设置一定距离的光电检测器;以及定位在基板和光电检测器之间的多个亚波长光栅（SWG）滤光片，其中SWG滤光片将被滤除 在被发射到光电检测器之前从激发位置发射的预定波长的光的范围。
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公开(公告)号：US20100272386A1
公开(公告)日：2010-10-28
申请号：US12430061
申请日：2009-04-24
IPC分类号： G02B6/12
CPC分类号： G11C13/04 , G11C13/0004 , G11C13/0007 , G11C13/047 , G11C2213/77 , H01L27/24 , H01L45/04 , H01L45/145
摘要： Disclosed herein are optically and electrically actuatable devices. The optically and electrically actuatable device includes an insulating substrate, two electrodes, an active region, and a concentrator. At least one of the two electrodes is established on the insulating substrate, and another of the two electrodes is established a spaced distance vertically or laterally from the at least one of the two electrodes. The other of the two electrodes is an optical input electrode. The active region is established between or beneath the two electrodes. The concentrator is optically coupled to the optical input electrode for concentrating incident light such that a predetermined portion of the active region is optically actuatable.
摘要翻译： 本文公开了光学和电致动装置。 光和电致动装置包括绝缘基板，两个电极，有源区域和集中器。 在绝缘基板上建立两个电极中的至少一个，并且两个电极中的另一个电极与两个电极中的至少一个垂直或横向地建立间隔距离。 两个电极中的另一个是光输入电极。 在两个电极之间或之下建立有源区。 聚光器光学耦合到光学输入电极，用于聚集入射光，使得有源区域的预定部分是光学可致动的。
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公开(公告)号：US08121444B2
公开(公告)日：2012-02-21
申请号：US12430061
申请日：2009-04-24
IPC分类号： G02B6/12 , H01L27/14 , H01L31/0232
CPC分类号： G11C13/04 , G11C13/0004 , G11C13/0007 , G11C13/047 , G11C2213/77 , H01L27/24 , H01L45/04 , H01L45/145
摘要： Disclosed herein are optically and electrically actuatable devices. The optically and electrically actuatable device includes an insulating substrate, two electrodes, an active region, and a concentrator. At least one of the two electrodes is established on the insulating substrate, and another of the two electrodes is established a spaced distance vertically or laterally from the at least one of the two electrodes. The other of the two electrodes is an optical input electrode. The active region is established between or beneath the two electrodes. The concentrator is optically coupled to the optical input electrode for concentrating incident light such that a predetermined portion of the active region is optically actuatable.
摘要翻译： 本文公开了光学和电致动装置。 光和电致动装置包括绝缘基板，两个电极，有源区域和集中器。 在绝缘基板上建立两个电极中的至少一个，并且两个电极中的另一个电极与两个电极中的至少一个垂直或横向地建立间隔距离。 两个电极中的另一个是光输入电极。 在两个电极之间或之下建立有源区。 聚光器光学耦合到光学输入电极，用于聚集入射光，使得有源区域的预定部分是光学可致动的。
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