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1.发明申请VIRUS-LIKE PARTICLES COMPRISING COMPOSITE CAPSID AMINO ACID SEQUENCES FOR ENHANCED CROSS REACTIVITY 有权包含复合CAPSID氨基酸序列的病毒样颗粒增强交叉反应性公开(公告)号：US20150023995A1
公开(公告)日：2015-01-22
申请号：US14341375
申请日：2014-07-25
IPC分类号： C07K14/005 , A61K39/12 , A61K47/36 , C12N7/00
CPC分类号： C07K14/005 , A61K39/12 , A61K47/36 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55572 , A61K2039/55583 , A61K2039/70 , C12N7/00 , C12N2770/16022 , C12N2770/16023 , C12N2770/16034 , Y02A50/467
摘要： The present invention provides polypeptides having a composite amino acid sequence derived from a consensus sequence representing the capsid proteins of two or more circulating strains of a non-enveloped virus. In particular, the invention provides virus-like particles comprising at least one composite polypeptide. Such virus-like particles have antigenic epitopes of two or more circulating strains of a non-enveloped virus and produce an increase in antisera cross-reactivity to one or more circulating strains of the non-enveloped virus. Methods of making composite virus-like particles and vaccine formulations comprising composite virus-like particles are also disclosed.
摘要翻译： 本发明提供具有衍生自代表非包膜病毒的两个或更多个循环株的衣壳蛋白的共有序列的复合氨基酸序列的多肽。 特别地，本发明提供包含至少一种复合多肽的病毒样颗粒。 这种病毒样颗粒具有两个或更多个非包膜病毒的循环株的抗原表位，并且对一个或多个非包膜病毒的循环株产生抗血清交叉反应性的增加。 还公开了制备复合病毒样颗粒和包含复合病毒样颗粒的疫苗制剂的方法。
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2.发明申请VIRUS-LIKE PARTICLES COMPRISING COMPOSITE CAPSID AMINO ACID SEQUENCES FOR ENHANCED CROSS REACTIVITY 有权包含复合CAPSID氨基酸序列的病毒样颗粒增强交叉反应性公开(公告)号：US20110195113A1
公开(公告)日：2011-08-11
申请号：US13023363
申请日：2011-02-08
IPC分类号： A61K39/125 , C07K14/00 , C07H21/04 , A61K39/12 , A61K9/127 , A61P37/04 , A61P31/14 , C12N15/63 , C12N5/10 , C12N1/00 , C12P21/00 , C12P21/02
CPC分类号： C07K14/005 , A61K39/12 , A61K47/36 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55572 , A61K2039/55583 , A61K2039/70 , C12N7/00 , C12N2770/16022 , C12N2770/16023 , C12N2770/16034 , Y02A50/467
摘要： The present invention provides polypeptides having a composite amino acid sequence derived from a consensus sequence representing the capsid proteins of two or more circulating strains of a non-enveloped virus. In particular, the invention provides virus-like particles comprising at least one composite polypeptide. Such virus-like particles have antigenic epitopes of two or more circulating strains of a non-enveloped virus and produce an increase in antisera cross-reactivity to one or more circulating strains of the non-enveloped virus. Methods of making composite virus-like particles and vaccine formulations comprising composite virus-like particles are also disclosed.
摘要翻译： 本发明提供具有衍生自代表非包膜病毒的两个或更多个循环株的衣壳蛋白的共有序列的复合氨基酸序列的多肽。 特别地，本发明提供包含至少一种复合多肽的病毒样颗粒。 这种病毒样颗粒具有两个或更多个非包膜病毒的循环株的抗原表位，并且对一个或多个非包膜病毒的循环株产生抗血清交叉反应性的增加。 还公开了制备复合病毒样颗粒和包含复合病毒样颗粒的疫苗制剂的方法。
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公开(公告)号：US20120156243A1
公开(公告)日：2012-06-21
申请号：US12816495
申请日：2010-06-16
IPC分类号： A61K39/125 , A61P31/14
CPC分类号： A61K39/12 , A61K39/125 , A61K39/39 , A61K2039/5258 , A61K2039/54 , A61K2039/543 , A61K2039/55572 , A61K2039/70 , C07K16/10 , C12N7/00 , C12N2770/16023 , C12N2770/16034
摘要： The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to a process for the production of both monovalent and multivalent VLPs, the VLPs comprising capsid proteins from one or more Norovirus genogroups.
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公开(公告)号：US20100266636A1
公开(公告)日：2010-10-21
申请号：US12765641
申请日：2010-04-22
IPC分类号： A61K39/125 , A61P31/14
CPC分类号： A61K39/12 , A61K39/125 , A61K2039/5258 , A61K2039/543 , A61K2039/55572 , A61K2039/57 , C12N2770/16034
摘要： The present invention relates to vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to methods of conferring protective immunity to Norovirus infections in a human subject.
摘要翻译： 本发明涉及包含诺如病毒抗原和佐剂，特别是单价VLP和多价VLP的混合物的混合物的疫苗组合物，以及赋予人受试者诺如病毒感染的保护性免疫的方法。
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