公开(公告)号：US20080039923A1

公开(公告)日：2008-02-14

申请号：US11876458

申请日：2007-10-22

申请人： Charles Taylor ,  Christopher Zarins ,  Robert Geshlider ,  Dwight Morejohn ,  Peter Johansson ,  Sue Vican ,  James McKinley

发明人： Charles Taylor ,  Christopher Zarins ,  Robert Geshlider ,  Dwight Morejohn ,  Peter Johansson ,  Sue Vican ,  James McKinley

IPC分类号： A61F2/84 ,  A61F2/06 ,  A61M25/00 ,  A61M29/00 ,  B29C45/14

CPC分类号： A61F2/958 ,  A61F2/07 ,  A61F2002/061 ,  A61F2002/065 ,  A61F2002/077 ,  A61F2230/0069 ,  A61F2240/002 ,  A61F2250/0003

摘要： A positioning anchor is provided for a stent-graft for implantation to treat a damaged body lumen. The positioning anchor is generally tubular surrounding a primary fluid conduit. Arms extend laterally from the generally tubular structure of the anchor surrounding lateral fluid conduits. The form of these arms is preferably custom configured to match a particular patient's luminal geometry. The anchor thus fits within the luminal geometry to remain in a desired fixed position for implantation of the anchor and any stent-graft coupled to the anchor. The anchor is most preferably formed with two walls having a void therebetween which can be filled with fixation media to further secure the anchor at the desired implantation site. A lumen shaper balloon and delivery catheter are also disclosed for proper delivery, expansion and inflation of the positioning anchor and stent-graft elements according to this invention.

摘要翻译： 提供了用于植入用于治疗受损体腔的支架移植物的定位锚。 定位锚通常围绕初级流体导管管状。 臂从围绕侧向流体管道的锚固体的大致管状结构横向延伸。 优选地，这些臂的形式被定制以匹配特定患者的管腔几何形状。 因此，锚固件适合于内腔几何形状以保持在期望的固定位置，用于植入锚固件和联接到锚固件的任何支架 - 移植物。 锚固件最优选地形成有两个壁，其间具有空隙，其中可以填充固定介质以进一步将锚定件固定在期望的植入部位。 还公开了管腔整形气囊和输送导管，用于根据本发明的定位锚和支架移植物元件的适当递送，膨胀和膨胀。

公开(公告)号：US09113999B2

公开(公告)日：2015-08-25

申请号：US11876458

申请日：2007-10-22

申请人： Charles S. Taylor ,  Christopher Zarins ,  Robert A. Geshlider ,  Dwight P. Morejohn ,  Peter Johansson ,  Susan W. Vican ,  James T. McKinley

发明人： Charles S. Taylor ,  Christopher Zarins ,  Robert A. Geshlider ,  Dwight P. Morejohn ,  Peter Johansson ,  Susan W. Vican ,  James T. McKinley

IPC分类号： A61F2/06 ,  A61F2/82 ,  A61F2/07

CPC分类号： A61F2/958 ,  A61F2/07 ,  A61F2002/061 ,  A61F2002/065 ,  A61F2002/077 ,  A61F2230/0069 ,  A61F2240/002 ,  A61F2250/0003

摘要： A positioning anchor is provided for a stent-graft for implantation to treat a damaged body lumen. The positioning anchor is generally tubular surrounding a primary fluid conduit. Arms extend laterally from the generally tubular structure of the anchor surrounding lateral fluid conduits. The form of these arms is preferably custom configured to match a particular patient's luminal geometry. The anchor thus fits within the luminal geometry to remain in a desired fixed position for implantation of the anchor and any stent-graft coupled to the anchor. The anchor is most preferably formed with two walls having a void therebetween which can be filled with fixation media to further secure the anchor at the desired implantation site. A lumen shaper balloon and delivery catheter are also disclosed for proper delivery, expansion and inflation of the positioning anchor and stent-graft elements according to this invention.

摘要翻译： 提供了用于植入用于治疗受损体腔的支架移植物的定位锚。 定位锚通常围绕初级流体导管管状。 臂从围绕侧向流体管道的锚固体的大致管状结构横向延伸。 优选地，这些臂的形式被定制以匹配特定患者的管腔几何形状。 因此，锚固件适合于内腔几何形状以保持在期望的固定位置，用于植入锚固件和联接到锚固件的任何支架 - 移植物。 锚固件最优选地形成有两个壁，其间具有空隙，其中可以填充固定介质以进一步将锚固件固定在期望的植入部位。 还公开了管腔整形气囊和输送导管，用于根据本发明的定位锚和支架移植物元件的适当递送，膨胀和膨胀。

公开(公告)号：US20070238169A1

公开(公告)日：2007-10-11

申请号：US11732911

申请日：2007-04-05

申请人： Oscar Abilez ,  Peyman Benharash ,  Christopher Zarins

发明人： Oscar Abilez ,  Peyman Benharash ,  Christopher Zarins

IPC分类号： C12M3/00 ,  C12N5/06 ,  C12N5/08

CPC分类号： C12N5/0657 ,  C12M25/14 ,  C12M29/18 ,  C12M35/02 ,  C12M47/04 ,  C12N2501/165

摘要： Methods and apparatus are provided for culturing cells under conditions for determining cellular differentiation and for separating cells from culture media based on differentiation. The apparatus comprises a bioreactor, media reservoir, a magnetic cell separator, an inlet port for adding magnetic particles to the bioreactor, and a circulating pump, wherein the bioreactor, media reservoir, magnetic cell separator and inlet port are on a single fluid circuit. The present method and apparatus provides a method for separating cells from culture without removing the cells from culture, so that un-selected cells may be returned to the bioreactor for further culture. The method employs magnetic labeling in culture, where the magnetic label specifically identifies cells to be distinguished, either by separation or retention in the culture. The method and apparatus are further designed to comprise means for electromechanical stimulation of hum embryonic stem cells for preparation of electrically responsive tissue.

摘要翻译： 提供了用于在确定细胞分化的条件下培养细胞并基于分化从培养基中分离细胞的方法和装置。 该装置包括生物反应器，介质储存器，磁性细胞分离器，用于向生物反应器中添加磁性颗粒的入口端口和循环泵，其中生物反应器，介质容器，磁性细胞分离器和入口位于单个流体回路上。 本方法和装置提供了从培养物中分离细胞而不从培养物中除去细胞的方法，使得未选择的细胞可以返回到生物反应器进行进一步培养。 该方法在培养中使用磁性标记，其中磁性标记通过在培养物中分离或保留来特异性鉴定待鉴别的细胞。 所述方法和装置还被设计成包括用于机电刺激脐带胚干细胞用于制备电响应性组织的装置。