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    Methods for deploying a positioning anchor with a stent-graft
    1.
    发明授权
    Methods for deploying a positioning anchor with a stent-graft 有权
    用支架移植物部署定位锚的方法

    公开(公告)号：US09113999B2

    公开(公告)日：2015-08-25

    申请号：US11876458

    申请日：2007-10-22

    申请人： Charles S. Taylor ,  Christopher Zarins ,  Robert A. Geshlider ,  Dwight P. Morejohn ,  Peter Johansson ,  Susan W. Vican ,  James T. McKinley

    发明人： Charles S. Taylor ,  Christopher Zarins ,  Robert A. Geshlider ,  Dwight P. Morejohn ,  Peter Johansson ,  Susan W. Vican ,  James T. McKinley

    IPC分类号： A61F2/06 ,  A61F2/82 ,  A61F2/07

    CPC分类号： A61F2/958 ,  A61F2/07 ,  A61F2002/061 ,  A61F2002/065 ,  A61F2002/077 ,  A61F2230/0069 ,  A61F2240/002 ,  A61F2250/0003

    摘要： A positioning anchor is provided for a stent-graft for implantation to treat a damaged body lumen. The positioning anchor is generally tubular surrounding a primary fluid conduit. Arms extend laterally from the generally tubular structure of the anchor surrounding lateral fluid conduits. The form of these arms is preferably custom configured to match a particular patient's luminal geometry. The anchor thus fits within the luminal geometry to remain in a desired fixed position for implantation of the anchor and any stent-graft coupled to the anchor. The anchor is most preferably formed with two walls having a void therebetween which can be filled with fixation media to further secure the anchor at the desired implantation site. A lumen shaper balloon and delivery catheter are also disclosed for proper delivery, expansion and inflation of the positioning anchor and stent-graft elements according to this invention.

    摘要翻译： 提供了用于植入用于治疗受损体腔的支架移植物的定位锚。 定位锚通常围绕初级流体导管管状。 臂从围绕侧向流体管道的锚固体的大致管状结构横向延伸。 优选地，这些臂的形式被定制以匹配特定患者的管腔几何形状。 因此，锚固件适合于内腔几何形状以保持在期望的固定位置，用于植入锚固件和联接到锚固件的任何支架 - 移植物。 锚固件最优选地形成有两个壁，其间具有空隙，其中可以填充固定介质以进一步将锚固件固定在期望的植入部位。 还公开了管腔整形气囊和输送导管，用于根据本发明的定位锚和支架移植物元件的适当递送，膨胀和膨胀。

    Methods and devices to curb appetite and/or to reduce food intake
    2.
    发明授权
    Methods and devices to curb appetite and/or to reduce food intake 失效
    抑制食欲和/或减少食物摄入的方法和装置

    公开(公告)号：US08585771B2

    公开(公告)日：2013-11-19

    申请号：US11807107

    申请日：2007-05-25

    申请人： Kenneth F. Binmoeller ,  Matthew Yurek ,  Zhenyong Keck ,  James T. McKinley

    发明人： Kenneth F. Binmoeller ,  Matthew Yurek ,  Zhenyong Keck ,  James T. McKinley

    IPC分类号： A61F2/04

    CPC分类号： A61F5/0076 ,  A61F2002/044 ,  A61F2002/045 ,  A61F2210/0014 ,  A61N1/36007

    摘要： The present invention relates to devices and methods of operating the devices that contribute to curbing appetite and/or reducing food intake. In some embodiments, the methods and devices of the present invention include as intestinal/duodenal insert comprising an elongated member with at least one flow reduction element that can cause the stimulation of one or more biological signals of satiety. Some embodiments of the inserted device are anchored at the duodenal site by an anchoring member residing in the stomach, other embodiments of the device are stabilized at a targeted site by appropriate dimensions of length as well as one or more angled portions of the device that correspond to angled portions of the targeted site in the dodenum. Embodiments of the device exert effects by virtue of physical presence, as well as by more active forms of intervention, including release of bioactive materials and electrical stimulation of neurons.

    摘要翻译： 本发明涉及操作有助于抑制食欲和/或减少食物摄取的装置的装置和方法。 在一些实施方案中，本发明的方法和装置包括肠/十二指肠插入物，其包含具有至少一个流动减少元件的细长构件，其可以引起一种或多种饱腹感的生物学信号的刺激。 插入的装置的一些实施例通过驻留在胃中的锚固构件锚定在十二指肠部位，装置的其它实施例通过适当的长度尺寸以及对应的装置的一个或多个成角度的部分而被稳定在目标部位 到达目标地点的角部分。 该装置的实施方案由于物理存在以及通过更积极的干预形式（包括释放生物活性物质和电刺激神经元）而发挥作用。

    Conformationally-Stabilized Intraluminal Device for Medical Applications
    4.
    发明申请
    Conformationally-Stabilized Intraluminal Device for Medical Applications 有权
    用于医疗应用的构象稳定的管腔内装置

    公开(公告)号：US20090187206A1

    公开(公告)日：2009-07-23

    申请号：US12174337

    申请日：2008-07-16

    申请人： Kenneth F. Binmoeller ,  James T. McKinley ,  Matthew Yurek ,  Fiona M. Sander

    发明人： Kenneth F. Binmoeller ,  James T. McKinley ,  Matthew Yurek ,  Fiona M. Sander

    IPC分类号： A61M29/00

    CPC分类号： A61F5/0036 ,  A61F5/0013 ,  A61F5/003 ,  A61F5/0076 ,  A61F2002/044 ,  A61F2002/045 ,  A61F2210/0014 ,  A61F2210/0019 ,  A61F2210/009

    摘要： The invention relates to devices that are stabilized at an intraluminal residence site in the gastrointestinal tract by their conformation, including dimensions of length and curvature. The device as a whole corresponds to the conformation of the residence site; more particularly, the curved or angled portions correspond to the curved or angled portions of the residence site and do not conform to an immediately proximal or distal site. In some embodiments, the conformationally stabilized device may effect a change in the residence site shape that contributes to stability of the device. Some embodiments are directed toward curbing appetite and/or reducing food intake, other embodiments may be directed toward other therapeutic ends. Some embodiments of the device are designed to reside wholly in the duodenum; others reside principally within the duodenum but extend proximally into the gastric antrum, while other embodiments are designed to reside elsewhere within the gastrointestinal tract.

    摘要翻译： 本发明涉及通过其构象（包括长度和曲率的尺寸）稳定在胃肠道内腔内停留部位的装置。 整个装置对应于居住地点的构造; 更具体地，弯曲或成角度的部分对应于居住部位的弯曲或成角度部分，并且不符合直接近端或远端部位。 在一些实施例中，构象稳定的装置可以影响驻留位置形状的变化，这有助于装置的稳定性。 一些实施例旨在限制食欲和/或减少食物摄取，其他实施方案可以针对其他治疗目的。 设备的一些实施例被设计为完全驻留在十二指肠中; 其他的主要存在于十二指肠内，但是向近端延伸到胃窦内，而其它实施例被设计为驻留在胃肠道内的其他地方。

    Spinal surgery guidance platform
    6.
    发明授权
    Spinal surgery guidance platform 失效
    脊柱手术指导平台

    公开(公告)号：US06221082B1

    公开(公告)日：2001-04-24

    申请号：US09326739

    申请日：1999-06-04

    申请人： James F. Marino ,  Corbett W. Stone ,  Dan K. Ahlgren ,  Troy K. Christopher ,  James T. McKinley

    发明人： James F. Marino ,  Corbett W. Stone ,  Dan K. Ahlgren ,  Troy K. Christopher ,  James T. McKinley

    IPC分类号： A61B1900

    CPC分类号： A61B17/1757 ,  A61B17/3421 ,  A61B90/11 ,  A61B90/39 ,  A61B2017/00261

    摘要： A spinal surgery system having a base, a cross member suspended from the base, and a pair of cannula guides suspended from the cross member, wherein the cannula guides are adapted to hold cannulae received therein such that the canulae remain co-planar with one another as the cannula guides are moved to various positions in the patient's intervertebral plane. By first suspending a pair of radiopaque markers in the cannual guides, and then viewing the image of the radiopaque markers, the cannulae guides can be aligned so that when the radiopaque markers have been removed and replaced with cannulae, the cannulae can be positioned along various paths which are disposed in the patient's intervertebral plane such that surgical tools can be advanced in preferred paths toward the patient's intervertebral space.

    摘要翻译： 脊柱手术系统，其具有基部，从基部悬挂的横向构件和从该横向构件悬挂的一对插管导向件，其中所述插管导向件适于容纳收纳在其中的插管，使得所述套管彼此保持共面 当套管引导件移动到患者的椎间平面内的各个位置时。 通过先将一对不透射线的标记悬挂在插入式导板中，然后观察不透射线标记的图像，可以对齐导管，使得当不透射线的标记物被移除并用插管替换时，套管可以沿着各种 设置在患者椎间平面中的路径，使得外科手术工具可以朝向患者的椎间空间的优选路径前进。

    Conformationally-stabilized intraluminal device for medical applications
    7.
    发明授权
    Conformationally-stabilized intraluminal device for medical applications 有权
    用于医疗应用的构象稳定的管腔内装置

    公开(公告)号：US09060835B2

    公开(公告)日：2015-06-23

    申请号：US12174337

    申请日：2008-07-16

    申请人： Kenneth F. Binmoeller ,  James T. McKinley ,  Matthew Yurek ,  Fiona M. Sander

    发明人： Kenneth F. Binmoeller ,  James T. McKinley ,  Matthew Yurek ,  Fiona M. Sander

    IPC分类号： A61F2/04 ,  A61F5/00

    CPC分类号： A61F5/0036 ,  A61F5/0013 ,  A61F5/003 ,  A61F5/0076 ,  A61F2002/044 ,  A61F2002/045 ,  A61F2210/0014 ,  A61F2210/0019 ,  A61F2210/009

    摘要： The invention relates to devices that are stabilized at an intraluminal residence site in the gastrointestinal tract by their conformation, including dimensions of length and curvature. The device as a whole corresponds to the conformation of the residence site; more particularly, the curved or angled portions correspond to the curved or angled portions of the residence site and do not conform to an immediately proximal or distal site. In some embodiments, the conformationally stabilized device may effect a change in the residence site shape that contributes to stability of the device. Some embodiments are directed toward curbing appetite and/or reducing food intake, other embodiments may be directed toward other therapeutic ends. Some embodiments of the device are designed to reside wholly in the duodenum; others reside principally within the duodenum but extend proximally into the gastric antrum, while other embodiments are designed to reside elsewhere within the gastrointestinal tract.

    摘要翻译： 本发明涉及通过其构象（包括长度和曲率的尺寸）稳定在胃肠道内腔内停留部位的装置。 整个装置对应于居住地点的构造; 更具体地，弯曲或成角度的部分对应于居住部位的弯曲或成角度部分，并且不符合直接近端或远端部位。 在一些实施例中，构象稳定的装置可以影响驻留位置形状的变化，这有助于装置的稳定性。 一些实施例旨在限制食欲和/或减少食物摄取，其他实施方案可以针对其他治疗目的。 设备的一些实施例被设计为完全驻留在十二指肠中; 其他的主要存在于十二指肠内，但是向近端延伸到胃窦内，而其它实施例被设计为驻留在胃肠道内的其他地方。

    METHODS AND DEVICES FOR DELIVERING OR DELAYING LIPIDS WITHIN A DUODENUM
    8.
    发明申请
    METHODS AND DEVICES FOR DELIVERING OR DELAYING LIPIDS WITHIN A DUODENUM 审中-公开
    用于在杜鹃中输送或延迟脂肪的方法和装置

    公开(公告)号：US20110137227A1

    公开(公告)日：2011-06-09

    申请号：US12999180

    申请日：2009-07-02

    申请人： James T. McKinley ,  Zhenyong Keck ,  Fiona M. Sander

    发明人： James T. McKinley ,  Zhenyong Keck ,  Fiona M. Sander

    IPC分类号： A61F2/04

    CPC分类号： A61F5/0079 ,  A61M27/002

    摘要： Devices are described that are adapted and configured for use within the duodenum of a mammal. One aspect of the device includes a spine having a proximal end and a distal end; an atraumatic feature positioned on at least one of the proximal end and the distal end of the spine; and a flow reduction element positioned along the spine and having a variable porosity along its length. In another aspect, there is a flow reduction device adapted and configured for use within the duodenum of a mammal having a spine having a length, a proximal end and a distal end; a first atraumatic feature positioned adjacent to the spine proximal end; a second atraumatic feature positioned adjacent to the spine distal end wherein the length of the spine is selected so that when the first atraumatic feature is in the stomach the second atraumatic feature is in the fourth portion of the duodenum; and a flow reduction element having a proximal end, a distal end, an interior portion, an exterior portion and a variable porosity between the proximal end and the distal end. Additionally or alternatively, some or all of the components of the device may be formed from or coated with a lipid-philic material. There is also provided a method for adjusting the passage of ingesta through the duodenum of a mammal. The method includes placing the distal end of a flow reduction device in the duodenum of a mammal; placing the proximal end of the flow reduction device in a stomach of the mammal; expanding within the duodenum of the mammal a variable porosity flow reduction element supported by the flow reduction device; and directing at least a portion of the flow of ingesta through the duodenum through the proximal end of the variable porosity flow reduction element and into an interior portion of the variable porosity flow reduction element.

    摘要翻译： 描述适于和配置用于哺乳动物十二指肠内的装置。 该装置的一个方面包括具有近端和远端的脊柱; 位于脊柱的近端和远端中的至少一个上的无创伤特征; 以及沿着脊柱定位的沿着其长度具有可变孔隙率的流动减少元件。 在另一方面，存在一种适于和构造用于具有脊柱的哺乳动物十二指肠内的流动减少装置，其具有长度，近端和远端; 邻近脊柱近端定位的第一无创伤特征; 第二无创伤特征位于脊柱远端附近，其中脊柱的长度被选择为使得当第一无创伤特征在胃中时，第二无创伤特征位于十二指肠的第四部分中; 以及流动减少元件，其具有近端，远端，内部部分，外部部分和近端和远端之间的可变孔隙率。 另外或替代地，装置的部分或全部组分可以由亲脂材料形成或涂覆有脂质材料。 还提供了一种用于调节通过哺乳动物十二指肠的食入通道的方法。 该方法包括将流量减少装置的远端放置在哺乳动物的十二指肠中; 将所述减流装置的近端放置在哺乳动物的胃中; 在哺乳动物的十二指肠内扩张由流量减小装置支撑的可变孔隙度流减少元件; 并且通过可变孔隙度流减少元件的近端引导摄食流的至少一部分通过十二指肠并进入可变孔隙度流减少元件的内部。

    Spinal surgery guidance platform
    10.
    发明授权
    Spinal surgery guidance platform 失效
    脊柱手术指导平台

    公开(公告)号：US06530930B1

    公开(公告)日：2003-03-11

    申请号：US09812026

    申请日：2001-03-19

    申请人： James F. Marino ,  Corbett W. Stone ,  Dan K. Ahlgren ,  Troy K. Christopher ,  James T. McKinley

    发明人： James F. Marino ,  Corbett W. Stone ,  Dan K. Ahlgren ,  Troy K. Christopher ,  James T. McKinley

    IPC分类号： A61B1900

    CPC分类号： A61B17/1757 ,  A61B17/3421 ,  A61B90/11 ,  A61B90/39 ,  A61B2017/00261

    摘要： A method of positioning a cannula along a path in a patient's intervertebral plane, comprising: suspending a cross member across a patient, the cross member having two cannula guides attached thereto, the cannula guides each being adjustably movable both along the length of the cross member and around a central longitudinally extending axis of the cross member; suspending radiopaque markers from the cannula guides; aligning the radiopoaque markers with the intervertebral plane as viewed in a radio-image, thereby aligning the cannula guides with the intervertebral plane; and advancing a cannula through the cannula guide.

    摘要翻译： 一种将插管沿患者椎间平面中的路径定位的方法，包括：将横梁悬挂在患者身上，所述横向构件具有两个插管导向件，所述插管导向件连接到所述插管导向件上，所述插管导向件可以沿所述横梁的长度可调节地移动 并围绕横向构件的中心纵向延伸的轴线; 从插管引导件悬挂不透射线的标记; 将放射性标记与在无线电图像中观察到的椎间平面对准，从而使套管引导件与椎间平面对齐; 并且使插管穿过套管引导件。