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公开(公告)号：US20120251559A1
公开(公告)日：2012-10-04
申请号：US13491475
申请日：2012-06-07
IPC分类号： A61K39/395 , A61P35/02 , A61P35/00
CPC分类号： A61K47/48561 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of a CD70-expressing cancer, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译： 公开了与细胞毒性治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体 - 和抗体衍生物 - 药物偶联物的药物组合物和试剂盒。 还公开了用于治疗表达CD70的癌症的方法，包括向受试者施用所公开的药物组合物。
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2.发明申请ANTI-CD70 ANTIBODY-DRUG CONJUGATES AND THEIR USE FOR THE TREATMENT OF CANCER AND IMMUNE DISORDERS 审中-公开抗CD70抗体药物治疗及其用于治疗癌症和免疫缺陷病毒的用途公开(公告)号：US20100183636A1
公开(公告)日：2010-07-22
申请号：US12467182
申请日：2009-05-15
IPC分类号： A61K39/395 , A61P37/06 , A61P29/00 , A61P17/06 , A61P31/06
CPC分类号： A61K47/6803 , A61K47/65 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, immunosuppressive, or other therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译： 公开了与细胞毒性，免疫抑制或其它治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体 - 和抗体衍生物 - 药物共轭物的药物组合物和试剂盒。 还公开了用于治疗表达CD70的癌症和免疫学疾病的方法，包括向受试者施用所公开的药物组合物。
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3.发明申请公开(公告)号：US20100158910A1
公开(公告)日：2010-06-24
申请号：US12635607
申请日：2009-12-10
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： A61K47/48561 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing a cancer, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译： 公开了与细胞毒性，治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体 - 和抗体衍生物 - 药物偶联物的药物组合物和试剂盒。 还公开了用于治疗表达癌症的CD70的方法，包括向受试者施用所公开的药物组合物。
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4.发明授权公开(公告)号：US09345785B2
公开(公告)日：2016-05-24
申请号：US12635607
申请日：2009-12-10
IPC分类号： A61K39/395 , A61K47/48 , A61K49/00 , C07K16/28
CPC分类号： A61K47/48561 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing a cancer, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译： 公开了与细胞毒性，治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体 - 和抗体衍生物 - 药物偶联物的药物组合物和试剂盒。 还公开了用于治疗表达癌症的CD70的方法，包括向受试者施用所公开的药物组合物。
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5.发明申请Anti-CD70 Antibody-Drug Conjugates and Their Use for the Treatment of Cancer and Immune Disorders 有权抗CD70抗体 - 药物偶联物及其用于治疗癌症和免疫疾病的用途公开(公告)号：US20120288512A1
公开(公告)日：2012-11-15
申请号：US13485536
申请日：2012-05-31
CPC分类号： A61K47/48561 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, immunosuppressive, or other therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译： 公开了与细胞毒性，免疫抑制或其它治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体 - 和抗体衍生物 - 药物共轭物的药物组合物和试剂盒。 还公开了用于治疗表达CD70的癌症和免疫学疾病的方法，包括向受试者施用所公开的药物组合物。
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6.发明申请公开(公告)号：US20100150925A1
公开(公告)日：2010-06-17
申请号：US12635571
申请日：2009-12-10
IPC分类号： A61K39/395 , A61P35/00 , A61P35/02
CPC分类号： A61K47/6803 , A61K47/65 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of a CD70-expressing cancer, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译： 公开了与细胞毒性治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体和抗体衍生物 - 药物偶联物的药物组合物和试剂盒。 还公开了用于治疗表达CD70的癌症的方法，包括向受试者施用所公开的药物组合物。
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7.发明授权公开(公告)号：US08609104B2
公开(公告)日：2013-12-17
申请号：US13491475
申请日：2012-06-07
IPC分类号： A61K39/395
CPC分类号： A61K47/48561 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of a CD70-expressing cancer, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译： 公开了与细胞毒性治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体和抗体衍生物 - 药物偶联物的药物组合物和试剂盒。 还公开了用于治疗表达CD70的癌症的方法，包括向受试者施用所公开的药物组合物。
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8.发明授权Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders 有权抗cd70抗体 - 药物偶联物及其用于治疗癌症和免疫疾病的用途公开(公告)号：US07662387B2
公开(公告)日：2010-02-16
申请号：US10546304
申请日：2004-02-20
IPC分类号： A61K39/00
CPC分类号： A61K47/48561 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, immunosuppressive, or other therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译： 公开了与细胞毒性，免疫抑制或其它治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体 - 和抗体衍生物 - 药物共轭物的药物组合物和试剂盒。 还公开了用于治疗表达CD70的癌症和免疫学疾病的方法，包括向受试者施用所公开的药物组合物。
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9.发明授权Anti-CD70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders 有权抗CD70抗体 - 药物偶联物及其用于治疗癌症和免疫疾病的用途公开(公告)号：US08535678B2
公开(公告)日：2013-09-17
申请号：US13485536
申请日：2012-05-31
IPC分类号： A61K39/395
CPC分类号： A61K47/48561 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, immunosuppressive, or other therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译： 公开了与细胞毒性，免疫抑制或其它治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体 - 和抗体衍生物 - 药物共轭物的药物组合物和试剂盒。 还公开了用于治疗表达CD70的癌症和免疫学疾病的方法，包括向受试者施用所公开的药物组合物。
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