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1.发明授权Anti-CD70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders 有权抗CD70抗体 - 药物偶联物及其用于治疗癌症和免疫疾病的用途公开(公告)号：US08535678B2
公开(公告)日：2013-09-17
申请号：US13485536
申请日：2012-05-31
IPC分类号： A61K39/395
CPC分类号： A61K47/48561 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, immunosuppressive, or other therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译： 公开了与细胞毒性，免疫抑制或其它治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体 - 和抗体衍生物 - 药物共轭物的药物组合物和试剂盒。 还公开了用于治疗表达CD70的癌症和免疫学疾病的方法，包括向受试者施用所公开的药物组合物。
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公开(公告)号：US20120251559A1
公开(公告)日：2012-10-04
申请号：US13491475
申请日：2012-06-07
IPC分类号： A61K39/395 , A61P35/02 , A61P35/00
CPC分类号： A61K47/48561 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of a CD70-expressing cancer, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译： 公开了与细胞毒性治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体 - 和抗体衍生物 - 药物偶联物的药物组合物和试剂盒。 还公开了用于治疗表达CD70的癌症的方法，包括向受试者施用所公开的药物组合物。
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3.发明申请ANTI-CD70 ANTIBODY-DRUG CONJUGATES AND THEIR USE FOR THE TREATMENT OF CANCER AND IMMUNE DISORDERS 审中-公开抗CD70抗体药物治疗及其用于治疗癌症和免疫缺陷病毒的用途公开(公告)号：US20100183636A1
公开(公告)日：2010-07-22
申请号：US12467182
申请日：2009-05-15
IPC分类号： A61K39/395 , A61P37/06 , A61P29/00 , A61P17/06 , A61P31/06
CPC分类号： A61K47/6803 , A61K47/65 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, immunosuppressive, or other therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译： 公开了与细胞毒性，免疫抑制或其它治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体 - 和抗体衍生物 - 药物共轭物的药物组合物和试剂盒。 还公开了用于治疗表达CD70的癌症和免疫学疾病的方法，包括向受试者施用所公开的药物组合物。
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4.发明申请公开(公告)号：US20100158910A1
公开(公告)日：2010-06-24
申请号：US12635607
申请日：2009-12-10
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： A61K47/48561 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing a cancer, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译： 公开了与细胞毒性，治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体 - 和抗体衍生物 - 药物偶联物的药物组合物和试剂盒。 还公开了用于治疗表达癌症的CD70的方法，包括向受试者施用所公开的药物组合物。
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5.发明授权公开(公告)号：US09345785B2
公开(公告)日：2016-05-24
申请号：US12635607
申请日：2009-12-10
IPC分类号： A61K39/395 , A61K47/48 , A61K49/00 , C07K16/28
CPC分类号： A61K47/48561 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing a cancer, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译： 公开了与细胞毒性，治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体 - 和抗体衍生物 - 药物偶联物的药物组合物和试剂盒。 还公开了用于治疗表达癌症的CD70的方法，包括向受试者施用所公开的药物组合物。
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6.发明申请Anti-CD70 Antibody-Drug Conjugates and Their Use for the Treatment of Cancer and Immune Disorders 有权抗CD70抗体 - 药物偶联物及其用于治疗癌症和免疫疾病的用途公开(公告)号：US20120288512A1
公开(公告)日：2012-11-15
申请号：US13485536
申请日：2012-05-31
CPC分类号： A61K47/48561 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, immunosuppressive, or other therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译： 公开了与细胞毒性，免疫抑制或其它治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体 - 和抗体衍生物 - 药物共轭物的药物组合物和试剂盒。 还公开了用于治疗表达CD70的癌症和免疫学疾病的方法，包括向受试者施用所公开的药物组合物。
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7.发明申请公开(公告)号：US20100150925A1
公开(公告)日：2010-06-17
申请号：US12635571
申请日：2009-12-10
IPC分类号： A61K39/395 , A61P35/00 , A61P35/02
CPC分类号： A61K47/6803 , A61K47/65 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of a CD70-expressing cancer, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译： 公开了与细胞毒性治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体和抗体衍生物 - 药物偶联物的药物组合物和试剂盒。 还公开了用于治疗表达CD70的癌症的方法，包括向受试者施用所公开的药物组合物。
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8.发明授权公开(公告)号：US08609104B2
公开(公告)日：2013-12-17
申请号：US13491475
申请日：2012-06-07
IPC分类号： A61K39/395
CPC分类号： A61K47/48561 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of a CD70-expressing cancer, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译： 公开了与细胞毒性治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体和抗体衍生物 - 药物偶联物的药物组合物和试剂盒。 还公开了用于治疗表达CD70的癌症的方法，包括向受试者施用所公开的药物组合物。
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9.发明授权Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders 有权抗cd70抗体 - 药物偶联物及其用于治疗癌症和免疫疾病的用途公开(公告)号：US07662387B2
公开(公告)日：2010-02-16
申请号：US10546304
申请日：2004-02-20
IPC分类号： A61K39/00
CPC分类号： A61K47/48561 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, immunosuppressive, or other therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译： 公开了与细胞毒性，免疫抑制或其它治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体 - 和抗体衍生物 - 药物共轭物的药物组合物和试剂盒。 还公开了用于治疗表达CD70的癌症和免疫学疾病的方法，包括向受试者施用所公开的药物组合物。
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公开(公告)号：US07795411B2
公开(公告)日：2010-09-14
申请号：US11669811
申请日：2007-01-31
申请人： Nathalie Scholler , Barbara Garvik
发明人： Nathalie Scholler , Barbara Garvik
CPC分类号： C12N15/81 , C07K16/00 , C07K16/005 , C07K16/3069 , C07K2317/622 , C07K2317/92 , C07K2319/02 , C07K2319/05 , C12N9/93 , C12P21/02
摘要： The present invention provides compositions and methods for generating in vivo biotinylated, secreted recombinant polypeptides comprising recombinantly co-expressing in a yeast cell (a) a secreted recombinant polypeptide comprising a biotin accepting site; and (b) a biotin ligase fused to the golgi localization domain so that the biotin ligase is localized to the golgi of the yeast cell where it acts on the biotin-accepting site of the secreted polypeptide as it transits the secretory system.
摘要翻译： 本发明提供用于产生体内生物素化的分泌的重组多肽的组合物和方法，包括在酵母细胞中重组共表达（a）包含生物素受体位点的分泌重组多肽; 并且（b）与高尔基体定位结构域融合的生物素连接酶，使得生物素连接酶定位于酵母细胞的高尔基体，当其在转运分泌系统时，其作用于分泌多肽的生物素受体位点。
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