公开(公告)号：US07282368B2

公开(公告)日：2007-10-16

申请号：US10375251

申请日：2003-02-27

申请人： Cheng Hock Toh ,  Liliana Tejidor ,  Mike Neisheim ,  Gregory Jones

发明人： Cheng Hock Toh ,  Liliana Tejidor ,  Mike Neisheim ,  Gregory Jones

IPC分类号： G01N33/92 ,  G01N33/68

CPC分类号： G01N33/92

摘要： A method for diagnosing and monitoring subjects for hemostatic dysfunction, severe infection and systematic inflammatory response syndrome is provided whereby lipoproteins are examined for abnormalities, particularly for prothrominase enhancement, through quantitative and qualitative analysis.

摘要翻译： 提供了用于诊断和监测止血功能障碍，严重感染和系统性炎症反应综合征的受试者的方法，通过定量和定性分析来检查脂蛋白异常，特别是促血清素增加的异常。

公开(公告)号：US07211438B2

公开(公告)日：2007-05-01

申请号：US10884293

申请日：2004-07-02

申请人： Cheng Hock Toh ,  Colin Downey ,  Timothy J. Fischer

发明人： Cheng Hock Toh ,  Colin Downey ,  Timothy J. Fischer

IPC分类号： G01N33/86

CPC分类号： G01N33/86 ,  G01N33/4905

摘要： Methods for predicting the presence of haemostatic dysfunction in a patient from a time-dependent measurement profile include performing a time-dependent measurement on an unknown sample and measuring a respective property over time so as to derive a time-dependent measurement profile. The slope of the time-dependent measurement profile is computed prior to clot formation. A biphasic waveform is detected in the time-dependent measurement profile based on the computed slope. The presence of haemostatic dysfunction in the patient is predicted based on the detected biphasic waveform.

摘要翻译： 从时间依赖性测量轮廓预测患者中止血功能障碍的存在的方法包括对未知样本执行时间依赖性测量并随时间测量相应的属性，以便导出时间依赖性测量分布。 在凝块形成之前计算时间依赖性测量曲线的斜率。 基于计算的斜率，在时间依赖的测量轮廓中检测到双相波形。 基于检测到的双相波形预测患者中止血功能障碍的存在。

公开(公告)号：US06898532B1

公开(公告)日：2005-05-24

申请号：US10377228

申请日：2003-02-28

申请人： Cheng Hock Toh ,  Colin Downey ,  Timothy J. Fischer

发明人： Cheng Hock Toh ,  Colin Downey ,  Timothy J. Fischer

IPC分类号： G01N33/49 ,  G01N33/86 ,  G06F19/00 ,  G01N21/00

CPC分类号： G01N33/86 ,  G01N33/4905 ,  G06F19/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/50 ,  Y02A90/26

摘要： A method is disclosed for predicting the presence of haemostatic dysfunction. At least one time-dependent measurement on an unknown sample is performed and a respective property of the sample is measured over time so as to derive a time-dependent measurement profile. One or more predictor variables, including initial slope, are defined which sufficiently define the data of the time-dependent measurement profile. A model is then derived that represents the relationship between the abnormality and the set of predictor variables. Subsequently, the model is utilized to predict haemostatic dysfunction, such as septicemia or disseminated intravascular coagulation (DIC).

摘要翻译： 公开了一种用于预测止血功能障碍的存在的方法。 对未知样品进行至少一次时间依赖性测量，并随时间测量样品的相应性质，从而导出时间依赖性测量分布。 定义一个或多个预测变量，包括初始斜率，其充分地定义时间依赖性测量分布的数据。 然后导出代表异常和预测变量集之间的关系的模型。 随后，该模型用于预测止血功能障碍，例如败血病或弥散性血管内凝血（DIC）。

公开(公告)号：US06429017B1

公开(公告)日：2002-08-06

申请号：US09372954

申请日：1999-08-12

申请人： Cheng Hock Toh ,  Colin Downey ,  Timothy J. Fischer

发明人： Cheng Hock Toh ,  Colin Downey ,  Timothy J. Fischer

IPC分类号： G01N3386

CPC分类号： G01N33/4905 ,  G01N30/96 ,  G01N33/86

摘要： A method which may be used to determine haemostatic dysfunction in a patient is carried out by (a) adding a reagent to a test sample, wherein the test sample includes at least a component of a blood sample from a patient; and then (b) measuring the formation of a precipitate due to the reaction of the test sample and the reagent, over time so as to derive a time-dependent measurement profile, the reagent forming a precipitate in the test sample without causing substantial fibrin polymerization.

摘要翻译： 可以用于确定患者止血功能障碍的方法是通过（a）向试验样品中加入试剂，其中所述测试样品至少包括来自患者的血样的成分; 然后（b）随着时间的推移测量由于测试样品和试剂的反应而产生的沉淀物的形成，从而导出时间依赖性测量曲线，试剂在测试样品中形成沉淀物而不引起显着的纤维蛋白聚合 。