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15 条记录 (耗时 0.063 秒)

    Substituted diamino-1,3,5-triazine derivatives
    5.
    发明授权
    Substituted diamino-1,3,5-triazine derivatives 失效
    取代的二氨基-1,3,5-三嗪衍生物

    公开(公告)号：US06380194B1

    公开(公告)日：2002-04-30

    申请号：US08938602

    申请日：1997-09-26

    申请人： Paul A. J. Janssen ,  Jan Heeres ,  Henri E. L. Moereels ,  Michael Joseph Kukla ,  Donald W. Ludovici

    发明人： Paul A. J. Janssen ,  Jan Heeres ,  Henri E. L. Moereels ,  Michael Joseph Kukla ,  Donald W. Ludovici

    IPC分类号： C07D25150

    CPC分类号： C07D403/06 ,  C07D251/18 ,  C07D251/48 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12

    摘要： This invention concerns the compounds of formula the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein R1 and R2 are each independently selected from hydrogen; hydroxy; amino; optionally substituted C1-6alkyl; C1-6alkyloxy; C1-6alkylcarbonyl; C1-6alkyloxycarbonyl; Ar1; mono- or di(C1-6alkyl)amino; mono- or di(C1-6alkyl)-aminocarbonyl; dihydro-2(3H)-furanone; or R1and R2 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C1-6alkyl)amino-C1-4alkylidene; R3 is hydrogen, Ar1, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxycarbonyl, C1-6alkyl substituted with C1-6alkyloxycarbonyl; and R4, R5, R6, R7 and R8 are each independently selected from hydrogen, halo, C1-6alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy; L is optionally substituted C1-10alkyl; C3-10alkenyl; C3-10alkynyl; C3-7cycloalkyl; Ar1is optionally substituted phenyl; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection. It further relates to new compounds being a subgroup of the compounds of formula (I), their preparation and compositions comprising them.

    摘要翻译： 本发明涉及配制药学上可接受的酸加成盐及其立体化学异构形式的化合物，其中R 1和R 2各自独立地选自氢; 羟基; 氨基; 任选取代的C 1-6烷基; C 1-6烷氧基; C 1-6烷基羰基; C 1-6烷氧基羰基; Ar1; 单或二（C 1-6烷基）氨基; 单或二（C 1-6烷基） - 氨基羰基; 二氢-2（3H） - 呋喃酮; 或R 1和R 2一起可以形成吡咯烷基，哌啶基，吗啉基，叠氮基或单或二（C 1-6烷基）氨基-C 1-4亚烷基; R3是氢，Ar1，C1-6烷基羰基，C1-6烷基，C1-6烷氧基羰基，被C1-6烷氧基羰基取代的C1-6烷基; 并且R 4，R 5，R 6，R 7和R 8各自独立地选自氢，卤素，C 1-6烷基，C 1-6烷氧基，氰基，氨基羰基，硝基，氨基，三卤甲基或三卤代甲氧基。 L是任选取代的C 1-10烷基; C3-10烯基; C3-10炔基; C 3-7环烷基; 任选取代的苯基; 用于制造用于治疗患有HIV（人类免疫缺陷病毒）感染的受试者的药物。 它还涉及作为式（I）化合物的亚组的新化合物，其制备方法和包含它们的组合物。

    Substituted diamino-1,3,5-triazine derivatives
    10.
    发明授权
    Substituted diamino-1,3,5-triazine derivatives 失效

    公开(公告)号：US07449575B2

    公开(公告)日：2008-11-11

    申请号：US11203325

    申请日：2005-08-12

    申请人： Paul A. J. Janssen ,  Jan Heeres ,  Henri E. L. Moereels ,  Michael Joseph Kukla ,  Donald W. Ludovici

    发明人： Paul A. J. Janssen ,  Jan Heeres ,  Henri E. L. Moereels ,  Michael Joseph Kukla ,  Donald W. Ludovici

    IPC分类号： C07D251/48 ,  C07D403/04

    CPC分类号： C07D403/06 ,  C07D251/18 ,  C07D251/48 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12

    摘要： This invention concerns the compounds of formula the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein R1 and R2 are each independently selected from hydrogen; hydroxy; amino; optionally substituted C1-6alkyl; C1-6alkyloxy; C1-6alkylcarbonyl; C1-6alkyloxycarbonyl; Ar1; mono- or di(C1-6alkyl)amino; mono- or di(C1-6alkyl)-aminocarbonyl; dihydro-2(3H)-furanone; or R1 and R2 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C1-6alkyl)amino-C1-4alkylidene; R3 is hydrogen, Ar1, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxy-carbonyl, C1-6alkyl substituted with C1-6alkyloxycarbonyl; and R4, R5, R6, R7 and R8 are each independently selected from hydrogen, halo, C1-6alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy; L is optionally substituted C1-10alkyl; C3-10alkenyl; C3-10alkynyl; C3-7cycloalkyl; Ar1 is optionally substituted phenyl; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection. It further relates to new compounds being a subgroup of the compounds of formula (I), their preparation and compositions comprising them.