公开(公告)号：US06181811B2

公开(公告)日：2001-01-30

申请号：US09006457

申请日：1998-01-13

申请人： Chih-Chau L. Kuan ,  Shih-Jong J. Lee ,  Seho Oh ,  Larry A. Nelson ,  Dayle G. Ellison ,  Florence W. Patten

发明人： Chih-Chau L. Kuan ,  Shih-Jong J. Lee ,  Seho Oh ,  Larry A. Nelson ,  Dayle G. Ellison ,  Florence W. Patten

IPC分类号： G06K900

CPC分类号： G06K9/00127

摘要： A method and apparatus for optimizing biological and cytological specimen screening and diagnosis. A slide review process is recommended for cytological specimen screening to identify abnormal sub-populations for further review and also diagnosis by a human expert. An automated screener processes a cytological specimen. Using a slide score generated by the automated screener, a slide review process using a slide score classification is determined. The recommendation of slide review processes improves overall performance of the screening process as measured by sensitivity to abnormal specimens, and at the same time reduces the work load of a human reviewer. The system also effectively and smoothly integrates the process of initial screening of the specimen with the process of further review of the specimen and final diagnosis of the specimen.

摘要翻译： 用于优化生物学和细胞学标本筛选和诊断的方法和装置。 推荐用于细胞学标本筛选的幻灯片审查过程，以识别异常亚群以供进一步审查，并由人类专家进行诊断。 自动筛选器处理细胞学标本。 使用由自动筛选器生成的幻灯片得分，确定使用幻灯片分数分类的幻灯片审阅过程。 幻灯片审查过程的推荐通过对异常标本的敏感度测量，提高了筛选过程的整体性能，同时降低了人类审阅者的工作量。 该系统还将样品初始筛选过程与样品进一步检查和样品的最终诊断过程进行了有效平滑的整合。

公开(公告)号：US5787208A

公开(公告)日：1998-07-28

申请号：US472389

申请日：1995-06-07

申请人： Seho Oh ,  Shih-Jong J. Lee ,  Michael J. Seo ,  Chih-Chau L. Kuan ,  Florence W. Patten

发明人： Seho Oh ,  Shih-Jong J. Lee ,  Michael J. Seo ,  Chih-Chau L. Kuan ,  Florence W. Patten

IPC分类号： G06K9/00 ,  G06T5/30 ,  G06K9/40

CPC分类号： G06T5/30 ,  G06K9/00127 ,  G06T5/003 ,  G06T2207/10056 ,  G06T2207/20192

摘要： Image enhancement for a digital image, such as an image of a biological specimen mounted on a microscope slide or a cytological specimen is herein described. A digital representation of the image is dilated to produce a dilated image and eroded to provide an eroded image. The dilated image, eroded image and the digital representation of the image are then processed to produce an enhanced image.

摘要翻译： 这里描述了数字图像的图像增强，例如安装在显微镜载玻片或细胞学标本上的生物样本的图像。 图像的数字表示被扩大以产生扩张的图像并被侵蚀以提供侵蚀的图像。 然后处理扩张图像，侵蚀图像和图像的数字表示以产生增强图像。

公开(公告)号：US07494809B2

公开(公告)日：2009-02-24

申请号：US11353353

申请日：2006-02-14

申请人： Alan C. Nelson ,  Florence W. Patten

发明人： Alan C. Nelson ,  Florence W. Patten

IPC分类号： C12N5/06 ,  C12M3/00

CPC分类号： C12M47/04 ,  C12M47/02

摘要： A method for automated cell enrichment preparation where biological cells are injected into a first subchamber and flowed through the first subchamber, through a large pore filter and into a second subchamber so that the large pore filter retains particles large particles in the first subchamber, while the biological cells pass through the first filter into the second subchamber and are retained by a small pore filter. After clearing, the biological cells are stained. A solvent exchange leaves the biological cells in solvent and they are released into a concentration module where a portion of the solvent is removed to form an enriched concentrated cell suspension.

摘要翻译： 一种用于自动细胞富集制备的方法，其中将生物细胞注入第一子室并流过第一子室，通过大孔过滤器并进入第二子室，使得大孔过滤器在第一子室中保留颗粒大颗粒，而 生物细胞通过第一过滤器进入第二子室并由小孔过滤器保留。 清除后，生物细胞染色。 溶剂交换将溶剂中的生物细胞离开，并将其释放到浓缩模块中，其中去除一部分溶剂以形成富集的浓缩细胞悬液。