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1.发明申请公开(公告)号：US20040248169A1
公开(公告)日：2004-12-09
申请号：US10812737
申请日：2004-03-30
申请人： ChondroGene Limited
发明人： Choong-Chin Liew
IPC分类号： C12Q001/68
CPC分类号： C12Q1/6883 , C12Q1/6809 , C12Q2600/158
摘要： The present invention is directed to detection and measurement of gene transcripts and their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-specific genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.
摘要翻译： 本发明涉及血液中基因转录物及其等价核酸产物的检测和测量。 具体提供的是使用基因特异性和/或组织特异性引物检测，诊断和监测疾病的一滴血液进行的分析。 本发明还描述了通过该方法描绘疾病特异性基因的序列和/或表达水平的定量，可以立即进行准确的疾病诊断/预后测试或评估特定治疗方案的效果。
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2.发明申请公开(公告)号：US20040241729A1
公开(公告)日：2004-12-02
申请号：US10813097
申请日：2004-03-30
申请人： ChondroGene Limited
发明人： Choong-Chin Liew
IPC分类号： C12Q001/68 , G01N033/53 , G01N033/569
CPC分类号： C12Q1/6809 , C12Q1/6883 , C12Q2600/158
摘要： The present invention is directed to detection and measurement of gene transcripts and their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-specific genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.
摘要翻译： 本发明涉及血液中基因转录物及其等价核酸产物的检测和测量。 具体提供的是使用基因特异性和/或组织特异性引物检测，诊断和监测疾病的一滴血液进行的分析。 本发明还描述了通过该方法描绘疾病特异性基因的序列和/或表达水平的定量，可以立即进行准确的疾病诊断/预后测试或评估特定治疗方案的效果。
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3.发明申请Method for the detection of hyperlipidemia related gene transcripts in blood 审中-公开检测血液中高脂血症相关基因转录物的方法公开(公告)号：US20040248170A1
公开(公告)日：2004-12-09
申请号：US10812777
申请日：2004-03-30
申请人： ChondroGene Limited
发明人： Choong-Chin Liew
IPC分类号： C12Q001/68
CPC分类号： C12Q1/6809 , C12Q1/6883 , C12Q2600/158
摘要： The present invention is directed to detection and measurement of gene transcripts and their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-specific genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.
摘要翻译： 本发明涉及血液中基因转录物及其等价核酸产物的检测和测量。 具体提供的是使用基因特异性和/或组织特异性引物检测，诊断和监测疾病的一滴血液进行的分析。 本发明还描述了通过该方法描绘疾病特异性基因的序列和/或表达水平的定量，可以立即进行准确的疾病诊断/预后测试或评估特定治疗方案的效果。
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4.发明申请Method for the detection of schizophrenia related gene transcripts in blood 审中-公开血液中精神分裂症相关基因转录物检测方法公开(公告)号：US20040241727A1
公开(公告)日：2004-12-02
申请号：US10812731
申请日：2004-03-30
申请人： ChondroGene Limited
发明人： Choong-Chin Liew
IPC分类号： C12Q001/68
CPC分类号： C12Q1/6809 , C12Q1/6883 , C12Q2600/158
摘要： The present invention is directed to detection and measurement of gene transcripts and their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-specific genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.
摘要翻译： 本发明涉及血液中基因转录物及其等价核酸产物的检测和测量。 具体提供的是使用基因特异性和/或组织特异性引物检测，诊断和监测疾病的一滴血液进行的分析。 本发明还描述了通过该方法描绘疾病特异性基因的序列和/或表达水平的定量，可以立即进行准确的疾病诊断/预后测试或评估特定治疗方案的效果。
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5.发明申请Method for the detection of type II diabetes related gene transcripts in blood 审中-公开检测血液中II型糖尿病相关基因转录物的方法公开(公告)号：US20040265869A1
公开(公告)日：2004-12-30
申请号：US10812716
申请日：2004-03-30
申请人： ChondroGene Limited
发明人： Choong-Chin Liew
IPC分类号： C12Q001/68
CPC分类号： C12Q1/6809 , C12Q1/6883 , C12Q2600/158
摘要： The present invention is directed to detection and measurement of gene transcripts and their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-specific genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.
摘要翻译： 本发明涉及血液中基因转录物及其等价核酸产物的检测和测量。 具体提供的是使用基因特异性和/或组织特异性引物检测，诊断和监测疾病的一滴血液进行的分析。 本发明还描述了通过该方法描绘疾病特异性基因的序列和/或表达水平的定量，可以立即进行准确的疾病诊断/预后测试或评估特定治疗方案的效果。
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公开(公告)号：US20040209275A1
公开(公告)日：2004-10-21
申请号：US10661242
申请日：2003-09-12
申请人： Chondrogene Limited
IPC分类号： C12Q001/68 , C07H021/04
CPC分类号： C12Q1/6883 , C07K14/47 , C12Q2600/158
摘要： The invention relates to the identification and selection of sequences which demonstrate particular advantage in identifying individuals having osteoarthritis (OA). The invention also provides a selection of sequences particularly useful in diagnosing the degree of advancement of osteoarthritis of an individual and in the identification of novel therapeutic targets for OA. The invention further provides for the use of these sequences as a tool to diagnose disease progression and to monitor the efficacy of therapeutic regimens.
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7.发明申请公开(公告)号：US20040265868A1
公开(公告)日：2004-12-30
申请号：US10812702
申请日：2004-03-30
申请人： ChondroGene Limited
发明人： Choong-Chin Liew
IPC分类号： C12Q001/68
CPC分类号： C12Q1/6809 , C12Q1/6883 , C12Q2600/158
摘要： The present invention is directed to detection and measurement of gene transcripts and their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-specific genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.
摘要翻译： 本发明涉及血液中基因转录物及其等价核酸产物的检测和测量。 具体提供的是使用基因特异性和/或组织特异性引物检测，诊断和监测疾病的一滴血液进行的分析。 本发明还描述了通过该方法描绘疾病特异性基因的序列和/或表达水平的定量，可以立即进行准确的疾病诊断/预后测试或评估特定治疗方案的效果。
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8.发明申请公开(公告)号：US20040241728A1
公开(公告)日：2004-12-02
申请号：US10812764
申请日：2004-03-30
申请人： ChondroGene Limited
发明人： Choong-Chin Liew
IPC分类号： C12Q001/68
CPC分类号： C12Q1/6809 , C12Q1/6883 , C12Q2600/112 , C12Q2600/158
摘要： The present invention is directed to detection and measurement of gene transcripts and their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-specific genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.
摘要翻译： 本发明涉及血液中基因转录物及其等价核酸产物的检测和测量。 具体提供的是使用基因特异性和/或组织特异性引物检测，诊断和监测疾病的一滴血液进行的分析。 本发明还描述了通过该方法描绘疾病特异性基因的序列和/或表达水平的定量，可以立即进行准确的疾病诊断/预后测试或评估特定治疗方案的效果。
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9.发明申请公开(公告)号：US20040241726A1
公开(公告)日：2004-12-02
申请号：US10812707
申请日：2004-03-30
申请人： ChondroGene Limited
发明人： Choong-Chin Liew
IPC分类号： C12Q001/68 , G01N033/53
CPC分类号： C12Q1/6809 , C12Q1/6883 , C12Q2600/158
摘要： The present invention is directed to detection and measurement of gene transcripts and their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-specific genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.
摘要翻译： 本发明涉及血液中基因转录物及其等价核酸产物的检测和测量。 具体提供的是使用基因特异性和/或组织特异性引物检测，诊断和监测疾病的一滴血液进行的分析。 本发明还描述了通过该方法描绘疾病特异性基因的序列和/或表达水平的定量，可以立即进行准确的疾病诊断/预后测试或评估特定治疗方案的效果。
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10.发明申请Beta-2 microglobulin (B2M) and B2M related gene products for the regulation of osteoarthritis pathogenesis and chondrocyte proliferation 审中-公开β-2微球蛋白（B2M）和B2M相关基因产物用于调节骨关节炎发病机制和软骨细胞增殖公开(公告)号：US20040127445A1
公开(公告)日：2004-07-01
申请号：US10649959
申请日：2003-08-26
申请人： Chondrogene Limited
IPC分类号： C12Q001/68 , G01N033/53 , A61K048/00 , A61K038/17
CPC分类号： C07K14/47
摘要： The invention relates to the discovery of the role of beta-2 microglobulin (B2M) in the pathogenesis of osteoarthritis (OA) and the ability of B2M to inhibit chondrocyte proliferation. The invention further relates to the identification of genes regulated by B2M (the nullB2M related genesnull).
摘要翻译： 本发明涉及β-2微球蛋白（B2M）在骨关节炎（OA）发病机理中的作用及B2M抑制软骨细胞增殖的能力的发现。 本发明还涉及由B2M（“B2M相关基因”）调控的基因的鉴定。
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