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![PYRIDO [2, 3-D] PYRIMIDIN-7-ONE COMPOUNDS AS INHIBITORS OF P13K-ALPHA FOR THE TREATMENT OF CANCER](/abs-image/US/2010/06/17/US20100150827A1/abs.jpg.150x150.jpg)
1.发明申请PYRIDO [2, 3-D] PYRIMIDIN-7-ONE COMPOUNDS AS INHIBITORS OF P13K-ALPHA FOR THE TREATMENT OF CANCER 审中-公开PYRIDO [2，3-D] PYRIMIDIN-7-ONE化合物作为P13K-ALPHA的抑制剂治疗癌症公开(公告)号：US20100150827A1
公开(公告)日：2010-06-17
申请号：US12595226
申请日：2008-04-11
申请人： Chris A. Buhr , William Bajjalieh , Anagha Abhijit Joshi , Katherine Lara , Sunghoon Ma , Charles K. Marlowe , Longcheng Wang , Bryan K.S. Yeung
发明人： Chris A. Buhr , William Bajjalieh , Anagha Abhijit Joshi , Katherine Lara , Sunghoon Ma , Charles K. Marlowe , Longcheng Wang , Bryan K.S. Yeung
IPC分类号： A61K31/519 , C07D471/04 , A61K51/00 , A61K39/395 , A61P35/00 , A61P35/02
CPC分类号： C07D471/04 , A61K31/519
摘要： The invention is directed to a Compound of Formula I, II, or III. The invention provides compounds that inhibit, regulate, and/or modulate PI3K that are useful in the treatment of hyperproliferatives diseases, such as cancer.
摘要翻译： 本发明涉及式I，II或III的化合物。 本发明提供抑制，调节和/或调节PI3K的化合物，其可用于治疗过度增殖性疾病如癌症。
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公开(公告)号：US20090270430A1
公开(公告)日：2009-10-29
申请号：US11988848
申请日：2006-10-09
申请人： Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Morrison Mac , John M. Nuss , Longcheng Wang , Yong Wang , Bryan K.S. Yeung
发明人： Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Morrison Mac , John M. Nuss , Longcheng Wang , Yong Wang , Bryan K.S. Yeung
IPC分类号： A61K31/519 , C07D471/04 , A61P35/00
CPC分类号： C07D471/04 , A61K9/0095 , A61K9/02 , A61K9/08 , A61K9/10 , A61K9/2018 , A61K9/4858
摘要： The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐或溶剂合物，以及制备和使用该化合物的方法。
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公开(公告)号：US20090062274A1
公开(公告)日：2009-03-05
申请号：US11988859
申请日：2006-10-09
申请人： Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Longcheng Wang , Bryan K.S. Yeung
发明人： Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Longcheng Wang , Bryan K.S. Yeung
IPC分类号： A61K31/5377 , C07D471/04 , A61K31/519
CPC分类号： C07D471/04
摘要： The invention is directed to Compounds of Formula I and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐或溶剂合物，以及制备和使用该化合物的方法。
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公开(公告)号：US20110237608A1
公开(公告)日：2011-09-29
申请号：US13152045
申请日：2011-06-02
申请人： Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Morrison Mac , John M. Nuss , Longcheng Wang , Yong Wang , Bryan K.S. Yeung
发明人： Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Morrison Mac , John M. Nuss , Longcheng Wang , Yong Wang , Bryan K.S. Yeung
IPC分类号： A61K31/519 , C07D471/04 , A61P35/00 , A61P35/02
CPC分类号： C07D471/04 , A61K9/0095 , A61K9/02 , A61K9/08 , A61K9/10 , A61K9/2018 , A61K9/4858
摘要： The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐或溶剂合物，以及制备和使用该化合物的方法。
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![Substituted pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors of phospatidylinositol 3-kinase alpha](/abs-image/US/2011/10/25/US08044062B2/abs.jpg.150x150.jpg)
5.发明授权Substituted pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors of phospatidylinositol 3-kinase alpha 有权取代的吡啶并[2,3-d]嘧啶-7（8H） - 酮磷酸肌醇3-激酶α抑制剂公开(公告)号：US08044062B2
公开(公告)日：2011-10-25
申请号：US11988848
申请日：2006-10-09
申请人： Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Morrison Mac , John M. Nuss , Longcheng Wang , Yong Wang , Bryan K. S. Yeung
发明人： Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Morrison Mac , John M. Nuss , Longcheng Wang , Yong Wang , Bryan K. S. Yeung
IPC分类号： C07D471/04 , A61K31/519 , A61P35/00
CPC分类号： C07D471/04 , A61K9/0095 , A61K9/02 , A61K9/08 , A61K9/10 , A61K9/2018 , A61K9/4858
摘要： The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐或溶剂合物，以及制备和使用该化合物的方法。
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公开(公告)号：US08247408B2
公开(公告)日：2012-08-21
申请号：US11988859
申请日：2006-10-09
申请人： Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Longcheng Wang , Bryan K. S. Yeung
发明人： Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Longcheng Wang , Bryan K. S. Yeung
IPC分类号： C07D471/04 , C07D471/14 , C07D413/14 , A61K31/519 , A61K31/5355 , A61P35/00 , A61P29/00 , A61P3/10
CPC分类号： C07D471/04
摘要： The invention is directed to Compounds of Formula I and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐或溶剂合物，以及制备和使用该化合物的方法。
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公开(公告)号：US08012956B2
公开(公告)日：2011-09-06
申请号：US12290159
申请日：2008-10-27
申请人： Kenneth D. Rice , Naing Aay , Neel Kumar Anand , Arlyn Arcalas , Tae-Gon Baik , Charles M. Blazey , Owen Joseph Bowles , Chris A. Buhr , Joerg Bussenius , Simona Costanzo , Jeffrey Kimo Curtis , Steven Charles Defina , Larisa Dubenko , Abigail R. Kennedy , Angie Inyoung Kim , Katherine Lara , Sunghoon Ma , Jean-Claire Limun Manalo , Csaba J. Peto , Tsze H. Tsang , Longcheng Wang
发明人： Kenneth D. Rice , Naing Aay , Neel Kumar Anand , Arlyn Arcalas , Tae-Gon Baik , Charles M. Blazey , Owen Joseph Bowles , Chris A. Buhr , Joerg Bussenius , Simona Costanzo , Jeffrey Kimo Curtis , Steven Charles Defina , Larisa Dubenko , Abigail R. Kennedy , Angie Inyoung Kim , Katherine Lara , Sunghoon Ma , Jean-Claire Limun Manalo , Csaba J. Peto , Tsze H. Tsang , Longcheng Wang
IPC分类号： A61K31/46 , A61K31/5377 , A61K31/496 , A61K31/497 , C07D451/04
CPC分类号： C07D451/02
摘要： A compound according to Formula I or II: wherein R1, R1b, R2, L1, and L2 and L2b are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译： 根据式I或II的化合物：其中R1，R1b，R2，L1和L2和L2b如说明书中所定义，其药物组合物及其使用方法。
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公开(公告)号：US20090203577A1
公开(公告)日：2009-08-13
申请号：US12096961
申请日：2006-12-12
申请人： Tae-Gon Baik , Chris A. Buhr , Brett B. Busch , Diva Sze-Ming Chan , Brenton T. Flatt , Xiao-Hui Gu , Vasu Jammalamadaka , Richard George Khoury , Katherine Lara , Sunghoon Ma , Richard Martin , Raju Mohan , John M. Nuss , Jason Jevious Parks , Jason H. Wu , Bryan K. S. Yeung , Wei Xu , Tie-Lin Wang , Longcheng Wang
发明人： Tae-Gon Baik , Chris A. Buhr , Brett B. Busch , Diva Sze-Ming Chan , Brenton T. Flatt , Xiao-Hui Gu , Vasu Jammalamadaka , Richard George Khoury , Katherine Lara , Sunghoon Ma , Richard Martin , Raju Mohan , John M. Nuss , Jason Jevious Parks , Jason H. Wu , Bryan K. S. Yeung , Wei Xu , Tie-Lin Wang , Longcheng Wang
IPC分类号： A61K31/55 , C07D487/04 , A61P3/00 , A61K38/22 , A61K38/28
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of formula I, which exhibit affinity for the farnesoid X receptor.
摘要翻译： 本发明涉及对法呢酯X受体表现出亲和性的式I化合物。
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公开(公告)号：US20090163471A1
公开(公告)日：2009-06-25
申请号：US12290159
申请日：2008-10-27
申请人： Kenneth D. Rice , Naing Aay , Neel Kumar Anand , Arlyn Arcalas , Tae-Gon Baik , Charles M. Blazey , Owen Joseph Bowles , Chris A. Buhr , Joerg Bussenius , Simona Costanzo , Jeffrey Kimo Curtis , Steven Charles Defina , Larisa Dubenko , Abigail R. Kennedy , Angie Inyoung Kim , Katherine Lara , Sunghoon Ma , Jean-Claire Limun Manalo , Csaba J. Peto , Tsze H. Tsang , Longcheng Wang
发明人： Kenneth D. Rice , Naing Aay , Neel Kumar Anand , Arlyn Arcalas , Tae-Gon Baik , Charles M. Blazey , Owen Joseph Bowles , Chris A. Buhr , Joerg Bussenius , Simona Costanzo , Jeffrey Kimo Curtis , Steven Charles Defina , Larisa Dubenko , Abigail R. Kennedy , Angie Inyoung Kim , Katherine Lara , Sunghoon Ma , Jean-Claire Limun Manalo , Csaba J. Peto , Tsze H. Tsang , Longcheng Wang
IPC分类号： A61K31/46 , C07D451/04 , A61K31/5377 , A61K31/496 , A61K31/497
CPC分类号： C07D451/02
摘要： A compound according to Formula I or II: wherein R1, R1b, R2, L1, and L2 and L2b are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译： 根据式I或II的化合物：其中R1，R1b，R2，L1和L2和L2b如说明书中所定义，其药物组合物及其使用方法。
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公开(公告)号：US08710038B2
公开(公告)日：2014-04-29
申请号：US11575411
申请日：2005-09-15
申请人： Tae-Gon Baik , Chris A. Buhr , Sunghoon Ma , John M. Nuss , Zerom Tesfai , Longcheng Wang , Bryan K. S. Yeung
发明人： Tae-Gon Baik , Chris A. Buhr , Sunghoon Ma , John M. Nuss , Zerom Tesfai , Longcheng Wang , Bryan K. S. Yeung
IPC分类号： C07D403/00 , A01N43/00 , A61K31/33
CPC分类号： C07D403/04 , C07D231/12 , C07D401/04 , C07D405/04 , C07D409/04
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 本发明的化合物抑制，调节和/或调节激酶。 使用化合物及其药物组合物治疗激酶依赖性疾病和病症的方法也是本发明的一个方面。
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