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1.Substituted pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors of phospatidylinositol 3-kinase alpha 有权
标题翻译: 取代的吡啶并[2,3-d]嘧啶-7(8H) - 酮磷酸肌醇3-激酶α抑制剂公开(公告)号:US08044062B2
公开(公告)日:2011-10-25
申请号:US11988848
申请日:2006-10-09
申请人: Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Morrison Mac , John M. Nuss , Longcheng Wang , Yong Wang , Bryan K. S. Yeung
发明人: Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Morrison Mac , John M. Nuss , Longcheng Wang , Yong Wang , Bryan K. S. Yeung
IPC分类号: C07D471/04 , A61K31/519 , A61P35/00
CPC分类号: C07D471/04 , A61K9/0095 , A61K9/02 , A61K9/08 , A61K9/10 , A61K9/2018 , A61K9/4858
摘要: The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.
摘要翻译: 本发明涉及式I化合物及其药学上可接受的盐或溶剂合物,以及制备和使用该化合物的方法。
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公开(公告)号:US20110237608A1
公开(公告)日:2011-09-29
申请号:US13152045
申请日:2011-06-02
申请人: Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Morrison Mac , John M. Nuss , Longcheng Wang , Yong Wang , Bryan K.S. Yeung
发明人: Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Morrison Mac , John M. Nuss , Longcheng Wang , Yong Wang , Bryan K.S. Yeung
IPC分类号: A61K31/519 , C07D471/04 , A61P35/00 , A61P35/02
CPC分类号: C07D471/04 , A61K9/0095 , A61K9/02 , A61K9/08 , A61K9/10 , A61K9/2018 , A61K9/4858
摘要: The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.
摘要翻译: 本发明涉及式I化合物及其药学上可接受的盐或溶剂合物,以及制备和使用该化合物的方法。
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公开(公告)号:US20090270430A1
公开(公告)日:2009-10-29
申请号:US11988848
申请日:2006-10-09
申请人: Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Morrison Mac , John M. Nuss , Longcheng Wang , Yong Wang , Bryan K.S. Yeung
发明人: Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Morrison Mac , John M. Nuss , Longcheng Wang , Yong Wang , Bryan K.S. Yeung
IPC分类号: A61K31/519 , C07D471/04 , A61P35/00
CPC分类号: C07D471/04 , A61K9/0095 , A61K9/02 , A61K9/08 , A61K9/10 , A61K9/2018 , A61K9/4858
摘要: The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.
摘要翻译: 本发明涉及式I化合物及其药学上可接受的盐或溶剂合物,以及制备和使用该化合物的方法。
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公开(公告)号:US20090203577A1
公开(公告)日:2009-08-13
申请号:US12096961
申请日:2006-12-12
申请人: Tae-Gon Baik , Chris A. Buhr , Brett B. Busch , Diva Sze-Ming Chan , Brenton T. Flatt , Xiao-Hui Gu , Vasu Jammalamadaka , Richard George Khoury , Katherine Lara , Sunghoon Ma , Richard Martin , Raju Mohan , John M. Nuss , Jason Jevious Parks , Jason H. Wu , Bryan K. S. Yeung , Wei Xu , Tie-Lin Wang , Longcheng Wang
发明人: Tae-Gon Baik , Chris A. Buhr , Brett B. Busch , Diva Sze-Ming Chan , Brenton T. Flatt , Xiao-Hui Gu , Vasu Jammalamadaka , Richard George Khoury , Katherine Lara , Sunghoon Ma , Richard Martin , Raju Mohan , John M. Nuss , Jason Jevious Parks , Jason H. Wu , Bryan K. S. Yeung , Wei Xu , Tie-Lin Wang , Longcheng Wang
IPC分类号: A61K31/55 , C07D487/04 , A61P3/00 , A61K38/22 , A61K38/28
CPC分类号: C07D487/04
摘要: The present invention relates to compounds of formula I, which exhibit affinity for the farnesoid X receptor.
摘要翻译: 本发明涉及对法呢酯X受体表现出亲和性的式I化合物。
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5.
公开(公告)号:US08247408B2
公开(公告)日:2012-08-21
申请号:US11988859
申请日:2006-10-09
申请人: Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Longcheng Wang , Bryan K. S. Yeung
发明人: Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Longcheng Wang , Bryan K. S. Yeung
IPC分类号: C07D471/04 , C07D471/14 , C07D413/14 , A61K31/519 , A61K31/5355 , A61P35/00 , A61P29/00 , A61P3/10
CPC分类号: C07D471/04
摘要: The invention is directed to Compounds of Formula I and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.
摘要翻译: 本发明涉及式I化合物及其药学上可接受的盐或溶剂合物,以及制备和使用该化合物的方法。
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公开(公告)号:US20090062274A1
公开(公告)日:2009-03-05
申请号:US11988859
申请日:2006-10-09
申请人: Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Longcheng Wang , Bryan K.S. Yeung
发明人: Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Longcheng Wang , Bryan K.S. Yeung
IPC分类号: A61K31/5377 , C07D471/04 , A61K31/519
CPC分类号: C07D471/04
摘要: The invention is directed to Compounds of Formula I and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.
摘要翻译: 本发明涉及式I化合物及其药学上可接受的盐或溶剂合物,以及制备和使用该化合物的方法。
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公开(公告)号:US08012956B2
公开(公告)日:2011-09-06
申请号:US12290159
申请日:2008-10-27
申请人: Kenneth D. Rice , Naing Aay , Neel Kumar Anand , Arlyn Arcalas , Tae-Gon Baik , Charles M. Blazey , Owen Joseph Bowles , Chris A. Buhr , Joerg Bussenius , Simona Costanzo , Jeffrey Kimo Curtis , Steven Charles Defina , Larisa Dubenko , Abigail R. Kennedy , Angie Inyoung Kim , Katherine Lara , Sunghoon Ma , Jean-Claire Limun Manalo , Csaba J. Peto , Tsze H. Tsang , Longcheng Wang
发明人: Kenneth D. Rice , Naing Aay , Neel Kumar Anand , Arlyn Arcalas , Tae-Gon Baik , Charles M. Blazey , Owen Joseph Bowles , Chris A. Buhr , Joerg Bussenius , Simona Costanzo , Jeffrey Kimo Curtis , Steven Charles Defina , Larisa Dubenko , Abigail R. Kennedy , Angie Inyoung Kim , Katherine Lara , Sunghoon Ma , Jean-Claire Limun Manalo , Csaba J. Peto , Tsze H. Tsang , Longcheng Wang
IPC分类号: A61K31/46 , A61K31/5377 , A61K31/496 , A61K31/497 , C07D451/04
CPC分类号: C07D451/02
摘要: A compound according to Formula I or II: wherein R1, R1b, R2, L1, and L2 and L2b are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译: 根据式I或II的化合物:其中R1,R1b,R2,L1和L2和L2b如说明书中所定义,其药物组合物及其使用方法。
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公开(公告)号:US20090163471A1
公开(公告)日:2009-06-25
申请号:US12290159
申请日:2008-10-27
申请人: Kenneth D. Rice , Naing Aay , Neel Kumar Anand , Arlyn Arcalas , Tae-Gon Baik , Charles M. Blazey , Owen Joseph Bowles , Chris A. Buhr , Joerg Bussenius , Simona Costanzo , Jeffrey Kimo Curtis , Steven Charles Defina , Larisa Dubenko , Abigail R. Kennedy , Angie Inyoung Kim , Katherine Lara , Sunghoon Ma , Jean-Claire Limun Manalo , Csaba J. Peto , Tsze H. Tsang , Longcheng Wang
发明人: Kenneth D. Rice , Naing Aay , Neel Kumar Anand , Arlyn Arcalas , Tae-Gon Baik , Charles M. Blazey , Owen Joseph Bowles , Chris A. Buhr , Joerg Bussenius , Simona Costanzo , Jeffrey Kimo Curtis , Steven Charles Defina , Larisa Dubenko , Abigail R. Kennedy , Angie Inyoung Kim , Katherine Lara , Sunghoon Ma , Jean-Claire Limun Manalo , Csaba J. Peto , Tsze H. Tsang , Longcheng Wang
IPC分类号: A61K31/46 , C07D451/04 , A61K31/5377 , A61K31/496 , A61K31/497
CPC分类号: C07D451/02
摘要: A compound according to Formula I or II: wherein R1, R1b, R2, L1, and L2 and L2b are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译: 根据式I或II的化合物:其中R1,R1b,R2,L1和L2和L2b如说明书中所定义,其药物组合物及其使用方法。
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9.PYRIDO [2, 3-D] PYRIMIDIN-7-ONE COMPOUNDS AS INHIBITORS OF P13K-ALPHA FOR THE TREATMENT OF CANCER 审中-公开
标题翻译: PYRIDO [2,3-D] PYRIMIDIN-7-ONE化合物作为P13K-ALPHA的抑制剂治疗癌症公开(公告)号:US20100150827A1
公开(公告)日:2010-06-17
申请号:US12595226
申请日:2008-04-11
申请人: Chris A. Buhr , William Bajjalieh , Anagha Abhijit Joshi , Katherine Lara , Sunghoon Ma , Charles K. Marlowe , Longcheng Wang , Bryan K.S. Yeung
发明人: Chris A. Buhr , William Bajjalieh , Anagha Abhijit Joshi , Katherine Lara , Sunghoon Ma , Charles K. Marlowe , Longcheng Wang , Bryan K.S. Yeung
IPC分类号: A61K31/519 , C07D471/04 , A61K51/00 , A61K39/395 , A61P35/00 , A61P35/02
CPC分类号: C07D471/04 , A61K31/519
摘要: The invention is directed to a Compound of Formula I, II, or III. The invention provides compounds that inhibit, regulate, and/or modulate PI3K that are useful in the treatment of hyperproliferatives diseases, such as cancer.
摘要翻译: 本发明涉及式I,II或III的化合物。 本发明提供抑制,调节和/或调节PI3K的化合物,其可用于治疗过度增殖性疾病如癌症。
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