公开(公告)号：US20060178420A1

公开(公告)日：2006-08-10

申请号：US11391655

申请日：2006-03-02

Applicant: Chris Broka ,  Jeffrey Campbell

Inventor： Chris Broka ,  Jeffrey Campbell

IPC: C07D209/56 ,  A61K31/404

CPC classification number: C07D209/42 ,  C07D209/10 ,  C07D209/30 ,  C07D209/36

Abstract: This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a —CH2—, —O—, —S—, or —S(O)—; and the other substituents are as defined in the specification; or individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents

公开(公告)号：US20050176803A1

公开(公告)日：2005-08-11

申请号：US11065841

申请日：2005-02-25

Applicant: Chris Broka ,  Jeffrey Campbell

Inventor： Chris Broka ,  Jeffrey Campbell

IPC: A61K31/404 ,  A61P15/06 ,  A61P19/02 ,  A61P19/06 ,  A61P25/28 ,  A61P29/00 ,  A61P43/00 ,  C07D209/10 ,  C07D209/30 ,  C07D209/36 ,  C07D209/42 ,  C07D209/04

CPC classification number: C07D209/42 ,  C07D209/10 ,  C07D209/30 ,  C07D209/36

Abstract: This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a —CH2—, —O—, —S—, or —S(O)—; and the other substituents are as defined in the specification; or individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents

Abstract translation: 本发明涉及通常为抗炎和止痛化合物的化合物，其由式I表示：其中A为-CH 2 - ， - O - ， - S-或 - 所以）-; 而其它取代基如说明书中所定义; 或各异构体，异构体的混合物及其药学上可接受的盐。 本发明还涉及含有这些化合物的药物组合物及其用作治疗剂的方法

公开(公告)号：US20060084677A1

公开(公告)日：2006-04-20

申请号：US11291867

申请日：2005-11-30

Applicant: Chris Broka ,  Woongki Kim ,  David Smith ,  Kevin McLaren

Inventor： Chris Broka ,  Woongki Kim ,  David Smith ,  Kevin McLaren

IPC: A61K31/47 ,  C07D215/60

CPC classification number: C07D215/36

Abstract: This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a CH2, CH(OH), C(O), C═NOR4, NR5, O, S, S(O), or S(O)2, and the other substituents are as defined in the specification; or prodrugs, individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents

Abstract translation: 本发明涉及通常为抗炎和止痛化合物的化合物，其由式I表示：其中A是CH 2，CH（OH），C（O），C- NOR 4，NR 5，O，S，S（O）或S（O）2，其它取代基如所定义 在规范中; 或前药，各异构体，异构体的混合物及其药学上可接受的盐。 本发明还涉及含有这些化合物的药物组合物及其用作治疗剂的方法

公开(公告)号：US20070049609A1

公开(公告)日：2007-03-01

申请号：US11509921

申请日：2006-08-25

Applicant: Chris Broka ,  David Carter ,  Michael Dillon ,  Anthony Ford ,  Ronald Hawley ,  Alam Jahangir ,  Amy Moore ,  Daniel Parish

Inventor： Chris Broka ,  David Carter ,  Michael Dillon ,  Anthony Ford ,  Ronald Hawley ,  Alam Jahangir ,  Amy Moore ,  Daniel Parish

IPC: A61K31/513

CPC classification number: A61K31/506 ,  A61K31/505 ,  A61K31/513 ,  A61K31/538 ,  Y10S514/826

Abstract: Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Abstract translation: 用于治疗由P2X 3和/或P2X 3/3受体拮抗剂介导的呼吸道和胃肠道疾病的方法，所述方法包括向有需要的受试者施用有效量 的式（I）化合物或其药学上可接受的盐，其中D，X，Y，R 1，R 2，R 3， R 4，R 4，R 5，R 6，R 7和R 8， SUP>如本文所定义。

公开(公告)号：US20050209260A1

公开(公告)日：2005-09-22

申请号：US11071555

申请日：2005-03-03

Applicant: Chris Broka ,  David Carter ,  Michael Dillon ,  Ronald Hawley ,  Alam Jahangir ,  Clara Lin ,  Daniel Parish

Inventor： Chris Broka ,  David Carter ,  Michael Dillon ,  Ronald Hawley ,  Alam Jahangir ,  Clara Lin ,  Daniel Parish

IPC: A61K31/505 ,  A61K31/506 ,  C07D239/48 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D43/02

CPC classification number: C07D239/49 ,  A61K31/505 ,  A61K31/506 ,  C07D239/48 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Abstract translation: 用于治疗由P2X 3和/或P2X 3/3受体拮抗剂介导的疾病的化合物和方法，所述方法包括向有需要的受试者施用有效量的 式（I）化合物或其药学上可接受的盐，溶剂化物或前药，其中D，X，Y，R 1，R 2，R 2， R 4，R 4，R 5，R 6，R 7和R 9， 8“如本文所定义。