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公开(公告)号：US20100084787A1
公开(公告)日：2010-04-08
申请号：US12633369
申请日：2009-12-08
Applicant: Chris Brough , Ryan Nielson , Gershon Yaniv
Inventor： Chris Brough , Ryan Nielson , Gershon Yaniv
IPC: B29C39/10
CPC classification number: E01B3/46 , B29C45/14073 , B29C45/14549 , B29C45/14778 , B29C45/14819 , E01B3/10
Abstract: A composite load bearing member is provided comprising an elongated inner structural member and a thick polymeric composite outer member. An apparatus for producing the composite load bearing member is provided including devices for suspending the inner structural member within a mold cavity prior to and during injection of the polymeric composite outer member. A method of using the apparatus to produce the composite load bearing member is provided.
Abstract translation: 提供一种复合承载构件，其包括细长的内部结构构件和厚的聚合物复合材料外部构件。 提供了一种用于生产复合载荷构件的装置，其包括用于在聚合物复合材料外部构件注射之前和期间将内部结构构件悬挂在模具腔内的装置。 提供了一种使用该装置来生产复合载荷件的方法。
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2.发明申请PHARMACEUTICAL FORMULATIONS OF ACETYL-11-KETO-B-BOSWELLIC ACID, DIINDOLYLMETHANE, AND CURCUMIN FOR PHARMACEUTICAL APPLICATIONS 审中-公开乙酰基-11-酮酸B-BOSWELLIC酸，DIINDOLYLMETHANE和CURCUMIN用于药物应用的药物制剂公开(公告)号：US20140039031A1
公开(公告)日：2014-02-06
申请号：US14001098
申请日：2012-02-23
Applicant: Chris Brough , Robert O. Williams, III , James W. McGinity , Dave A. Miller , Justin Hughey , Ryan Bennett
Inventor： Chris Brough , Robert O. Williams, III , James W. McGinity , Dave A. Miller , Justin Hughey , Ryan Bennett
IPC: A61K31/404 , A61K31/12 , A61K31/19
CPC classification number: A61K31/19 , A61K31/05 , A61K31/12 , A61K31/404
Abstract: The present disclosure is directed to compositions and methods for formulating a pharmaceutical dosage form by forming a composition comprising acetyl-11-keto-β-boswellic acid, diindolylmethane, or curcumin with one or more pharmaceutically acceptable excipients for enhanced solubility to increase bioavailability and improve therapeutic efficacy. The composition can be processed by thermo-kinetic compounding along with conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
Abstract translation: 本公开涉及通过形成包含乙酰基-11-酮基-β-乳糖酸，二吲哚基甲烷或姜黄素与一种或多种药学上可接受的赋形剂的组合物来配制药物剂型的组合物和方法，以提高溶解度以提高生物利用度并提高 治疗功效。 组合物可以通过热动力学混合以及本领域已知的常规方法如热熔体挤出，熔融造粒，压塑，压片，胶囊填充，薄膜包衣或注射成型加工。
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公开(公告)号：US20080179418A1
公开(公告)日：2008-07-31
申请号：US11669262
申请日：2007-01-31
Applicant: Chris Brough , Ryan Nielson , Gershon Yaniv
Inventor： Chris Brough , Ryan Nielson , Gershon Yaniv
IPC: E01B31/24
CPC classification number: E01B3/46 , B29C45/14073 , B29C45/14549 , B29C45/14778 , B29C45/14819 , E01B3/10
Abstract: A composite load bearing member is provided comprising an elongated inner structural member and a thick polymeric composite outer member. An apparatus for producing the composite load bearing member is provided including devices for suspending the inner structural member within a mold cavity prior to and during injection of the polymeric composite outer member. A method of using the apparatus to produce the composite load bearing member is provided.
Abstract translation: 提供一种复合承载构件，其包括细长的内部结构构件和厚的聚合物复合材料外部构件。 提供了一种用于生产复合载荷构件的装置，其包括用于在聚合物复合材料外部构件注射之前和期间将内部结构构件悬挂在模具腔内的装置。 提供了一种使用该装置来生产复合载荷件的方法。
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Patent Agency Ranking
4.发明授权Multiple speed process for preserving heat sensitive portions of a thermokinetically melt blended batch 有权用于保存热动力学熔融混合批料的热敏部分的多速加工方法公开(公告)号：US09545361B1
公开(公告)日：2017-01-17
申请号：US13190176
申请日：2011-07-25
Applicant: Chris Brough
Inventor： Chris Brough
IPC: A61J3/02
CPC classification number: B01F7/04 , A61J3/02 , A61J3/04 , A61J3/07 , A61J3/10 , B01F7/00141 , B01F7/0025 , B01F15/06 , B01F2015/062 , B01F2215/0032
Abstract: The present disclosure is directed to compositions and methods for making a pharmaceutical composition by thermokinetic compounding, wherein the compositions include one or more thermolabile components, for example one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients. The methods comprise thermokinetic processing of the thermolabile components into a composite by blending certain thermolabile components in a thermokinetic mixer using multiple speeds during a single, rotationally continuous operation. The composite can be further processed into pharmaceutical compositions by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
Abstract translation: 本公开涉及通过热动力学复合制备药物组合物的组合物和方法，其中所述组合物包括一种或多种不溶性组分，例如一种或多种与一种或多种药学上可接受的赋形剂的活性药物成分（API）。 该方法包括通过在单次旋转连续操作期间使用多种速度在热动力学混合器中混合某些热不稳定组分将热不稳定组分热复合加工成复合物。 复合材料可以通过本领域已知的常规方法进一步加工成药物组合物，例如热熔融挤出，熔融造粒，压塑，压片，胶囊填充，薄膜包衣或注塑成型。
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公开(公告)号：US20090053315A1
公开(公告)日：2009-02-26
申请号：US12196154
申请日：2008-08-21
Applicant: Chris Brough , James W. McGinity , Dave A. Miller , James C. DiNunzio , Robert O. Williams
Inventor： Chris Brough , James W. McGinity , Dave A. Miller , James C. DiNunzio , Robert O. Williams
IPC: A61K9/14 , A61K38/02 , A61K31/7088
CPC classification number: A61K31/573 , A61J3/00 , A61J3/07 , A61J3/10 , A61K9/146 , A61K9/1694 , A61K9/2077 , A61K31/343 , A61K31/496 , A61K47/32 , A61K47/38
Abstract: Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
Abstract translation: 用于制备药物剂型的组合物和方法包括制备药物组合物，其包含一种或多种活性药物成分（API）与一种或多种药学上可接受的赋形剂，通过热动力学复合制成复合材料。 将包含一种或多种API的复合材料与一种或多种赋形剂预处理的组合物和方法包括热动力学复合，其包括将所述API与所述赋形剂的热机械加工成复合材料，其中所述复合材料可以通过本领域已知的常规方法进一步加工， 热熔挤出，熔融造粒，压缩成型，片剂压缩，胶囊填充，薄膜包衣或注塑成型。
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公开(公告)号：US08486423B2
公开(公告)日：2013-07-16
申请号：US12196154
申请日：2008-08-21
Applicant: Chris Brough , James W. McGinity , Dave A. Miller , James DiNunzio , Robert O. Williams
Inventor： Chris Brough , James W. McGinity , Dave A. Miller , James DiNunzio , Robert O. Williams
CPC classification number: A61K31/573 , A61J3/00 , A61J3/07 , A61J3/10 , A61K9/146 , A61K9/1694 , A61K9/2077 , A61K31/343 , A61K31/496 , A61K47/32 , A61K47/38
Abstract: Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
Abstract translation: 用于制备药物剂型的组合物和方法包括制备药物组合物，其包含一种或多种活性药物成分（API）与一种或多种药学上可接受的赋形剂，通过热动力学复合制成复合材料。 将包含一种或多种API的复合材料与一种或多种赋形剂预处理的组合物和方法包括热动力学复合，其包括将所述API与所述赋形剂的热机械加工成复合材料，其中所述复合材料可以通过本领域已知的常规方法进一步加工， 热熔挤出，熔融造粒，压缩成型，片剂压缩，胶囊填充，薄膜包衣或注塑成型。
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7.发明申请公开(公告)号：US20170232409A1
公开(公告)日：2017-08-17
申请号：US15402556
申请日：2017-01-10
Applicant: Chris Brough
Inventor： Chris Brough
CPC classification number: B01F7/04 , A61J3/00 , A61J3/02 , A61J3/04 , A61J3/07 , A61J3/10 , A61K9/1629 , B01F7/001 , B01F7/00125 , B01F7/00141 , B01F7/0025 , B01F7/00708 , B01F15/00175 , B01F15/00181 , B01F15/00201 , B01F15/00253 , B01F15/00259 , B01F15/00389 , B01F15/06 , B01F2015/062 , B01F2215/0032 , B01F2215/0481
Abstract: The present disclosure is directed to compositions and methods for making a pharmaceutical composition by thermokinetic compounding, wherein the compositions include one or more thermolabile components, for example one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients. The methods comprise thermokinetic processing of the thermolabile components into a composite by blending certain thermolabile components in a thermokinetic mixer using multiple speeds during a single, rotationally continuous operation. The composite can be further processed into pharmaceutical compositions by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
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公开(公告)号：US07950591B2
公开(公告)日：2011-05-31
申请号：US12633369
申请日：2009-12-08
Applicant: Chris Brough , Ryan Nielson , Gershon Yaniv
Inventor： Chris Brough , Ryan Nielson , Gershon Yaniv
IPC: E01B9/14
CPC classification number: E01B3/46 , B29C45/14073 , B29C45/14549 , B29C45/14778 , B29C45/14819 , E01B3/10
Abstract: A composite load bearing member is provided comprising an elongated inner structural member and a thick polymeric composite outer member. An apparatus for producing the composite load bearing member is provided including devices for suspending the inner structural member within a mold cavity prior to and during injection of the polymeric composite outer member. A method of using the apparatus to produce the composite load bearing member is provided.
Abstract translation: 提供一种复合承载构件，其包括细长的内部结构构件和厚的聚合物复合材料外部构件。 提供了一种用于生产复合载荷构件的装置，其包括用于在聚合物复合材料外部构件注射之前和期间将内部结构构件悬挂在模具腔内的装置。 提供了一种使用该装置来生产复合载荷件的方法。
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