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公开(公告)号：US5599986A
公开(公告)日：1997-02-04
申请号：US513501
申请日：1995-08-31
IPC分类号： A61K31/135 , A61P43/00 , C07C20060101 , C07C17/16 , C07C25/24 , C07C29/147 , C07C29/149 , C07C33/48 , C07C69/65 , C07C209/62 , C07C211/29 , C07C231/08 , C07C231/24 , C07C233/13 , C07C233/90 , C07C233/00
CPC分类号： C07C17/16 , C07C211/29 , C07C233/13 , C07C25/24 , C07C29/147 , C07C33/483 , C07C69/65
摘要： The present invention relates to a novel process for preparing alkali metal salts of diformylamide and a novel crystalline form of sodium diformylamide.
摘要翻译： 本发明涉及一种制备二酰胺的碱金属盐的新方法和二甲酰胺钠的新结晶形式。
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2.发明授权Process for the preparation of (E)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane, novel processes for preparing an intermediate thereof, and novel intermediates thereof 失效制备（E）-1-氨基-2-（氟代亚甲基）-4-（对氟苯基）丁烷的方法，制备其中间体的新方法及其新型中间体
公开(公告)号：US5488188A
公开(公告)日：1996-01-30
申请号：US315041
申请日：1994-09-29
IPC分类号： C07C17/16 , C07C25/24 , C07C29/147 , C07C33/48 , C07C69/65 , C07C211/29 , C07C233/13 , C07C25/13 , C07C19/08 , C07C21/18
CPC分类号： C07C25/24 , C07C17/16 , C07C211/29 , C07C233/13 , C07C29/147 , C07C33/483 , C07C69/65
摘要： The present invention relates to a novel process for preparing (E)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane, also known in the art as (E)-(p-fluorophenethyl)-3-fluoroallylamine, novel intermediates thereof, a novel process for the preparing (E)-2-(fluoromethylene)-4-(p-fluorophenyl)butan-1-ol, and a novel process for preparing alkali metal salts of diformylamide.
摘要翻译： 本发明涉及一种制备（E）-1-氨基-2-（氟亚甲基）-4-（对氟苯基）丁烷的新方法，本领域也称为（E） - （对氟苯乙基）-3 - 氟烯丙胺，其新型中间体，制备（E）-2-（氟亚甲基）-4-（对氟苯基）丁-1-醇的新方法，以及制备二酰胺的碱金属盐的新方法。
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3.发明授权Process for the preparation of (epsilon)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane and novel intermediate thereof 失效（ε）-1-氨基-2-（氟代亚甲基）-4-（对氟苯基）丁烷及其新型中间体的制备方法
公开(公告)号：US5679854A
公开(公告)日：1997-10-21
申请号：US519273
申请日：1995-08-25
申请人： Jonathan C. Evans , Christian T. Goralski , Daniel R. Henton , Cynthia L. Rand , Paul C. Vosejpka
发明人： Jonathan C. Evans , Christian T. Goralski , Daniel R. Henton , Cynthia L. Rand , Paul C. Vosejpka
IPC分类号： C07C17/16 , C07C25/24 , C07C29/147 , C07C33/48 , C07C69/65 , C07C211/29 , C07C233/13 , C07C209/50 , C07C209/62 , C07C233/31
CPC分类号： C07C25/24 , C07C17/16 , C07C211/29 , C07C233/13 , C07C29/147 , C07C33/483 , C07C69/65
摘要： The present invention relates to a novel process for preparing (E)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane, also known in the art as (E)-(p-fluorophenethyl)-3-fluoroallylamine, novel intermediates thereof, a novel process for the preparing (E)-2-(fluoromethylene)-4-(p-fluorophenyl)butan-1-ol, and a novel process for preparing alkali metal salts of diformylamide.
摘要翻译： 本发明涉及一种制备（E）-1-氨基-2-（氟亚甲基）-4-（对氟苯基）丁烷的新方法，本领域也称为（E） - （对氟苯乙基）-3 - 氟烯丙胺，其新型中间体，制备（E）-2-（氟亚甲基）-4-（对氟苯基）丁-1-醇的新方法，以及制备二酰胺的碱金属盐的新方法。
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4.发明授权New organoboron reagents for the preparation unsubstituted propargylic alcohols 失效用于制备未经取代的炔丙醇的新的有机硼试剂
公开(公告)号：US5110966A
公开(公告)日：1992-05-05
申请号：US717970
申请日：1991-06-20
IPC分类号： C07C29/00 , C07C33/044 , C07F7/02 , C07F7/08
CPC分类号： C07F7/082
摘要： The novel organoboron reagent of the present invention is useful in the preparation of unsubstituted propargylic alcohols. This compound reacts with aldehydes and ketones cleanly to afford propargylic alcohols in excellent yields. Unsubstituted propargylic alcohols are important synthetic intermediates in the synthesis of a number of natural products. In addition, the novel organoboron reagent of the present invention also demonstrates diastereomeric selectivity when reacted with enatiomerically pure aldehydes.
摘要翻译： 本发明的新型有机硼试剂可用于制备未取代的炔丙醇。 该化合物干燥地与醛和酮反应，以优异的产率得到炔丙醇。 未取代的炔丙醇是合成多种天然产物的重要合成中间体。 此外，本发明的新型有机硼试剂在与对映体纯醛反应时也表现出非对映异构体选择性。
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5.发明授权
公开(公告)号：US5157167A
公开(公告)日：1992-10-20
申请号：US829131
申请日：1992-01-31
IPC分类号： C07F7/08
CPC分类号： C07F7/082
摘要： The novel organoboron reagent of the present invention is useful in the preparation of unsubstituted propargylic alcohols. This compound reacts with aldehydes and ketones cleanly to afford propargylic alcohols in excellent yields Unsubstituted propargylic alcohols are important synthetic intermediates in the synthesis of a number of natural products. In addition, the novel organoboron reagent of the present invention also demonstrates diastereomeric selectivity when reacted with enatiomerically pure aldehydes.
摘要翻译： 本发明的新型有机硼试剂可用于制备未取代的炔丙醇。 该化合物与醛和酮清洁地反应，以优异的产率提供炔丙醇。未取代的炔丙醇是合成多种天然产物的重要合成中间体。 此外，本发明的新型有机硼试剂在与对映体纯醛反应时也表现出非对映异构体选择性。
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公开(公告)号：US10302619B2
公开(公告)日：2019-05-28
申请号：US15731024
申请日：2017-04-07
申请人： Jonathan C. Evans , Theodore W. Selby , Marta Manning , Derrick D. Hilliker , Michael A. Habitz
发明人： Jonathan C. Evans , Theodore W. Selby , Marta Manning , Derrick D. Hilliker , Michael A. Habitz
IPC分类号： G01N33/28 , C10M117/02 , C10M121/04 , C10M113/06 , C10M105/32 , C10M105/00
摘要： Grease wear test device includes a body in a form of a collar having an outer surface, a first side and an opposing second side, which are open to form a hollow, open channel through the body, which has a center axis, into which opposing vee blocks can be inserted; and perpendicular to the center axis, a pair of opposing holes through and open to the outer surface of the body and the cylindrical inside wall, through which a cylindrical test journal (falex pin) can be inserted for contact in general with opposing vee-shaped channels of the inserted, opposing vee blocks, and for rotation during testing. The device can be used to modify a falex pin and vee block device, to receive and contain a small sample of grease or another organic paste product for testing such as a modified version of an ASTM D2670 test method for measuring wear properties of fluid lubricants (falex pin and vee block method).
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公开(公告)号：US20180326385A1
公开(公告)日：2018-11-15
申请号：US15932658
申请日：2018-04-03
CPC分类号： B01J19/0013 , B01J19/02 , B01J2219/00011 , B01J2219/00132 , G01N31/00 , G01N2035/00099
摘要： An active pharmaceutical ingredients (API) or related substance (RS) can be tested for stability by placing the API or RS in an instrument containing a pressure-controllable atmosphere, controlling the pressure of the atmosphere in the instrument for a predetermined time, and evaluating the API or RS for stability. Testing can be carried out also at predetermined temperature(s) and/or under the influence of gaseous trigger(s) and so forth. For instance, an API sample can be placed in a bomb test instrument/reactor, oxygen as a gaseous trigger can be introduced to contact the API sample under constant and/or ramped temperature(s) and elevated pressure(s) for predetermined time(s), and the API sample can be evaluated for stability. An insert carousel may hold a sample of API(s) and/or RS(s) and/or aliquot(s) of sample(s) of API(s) and/or RS(s) for insertion into the bomb test instrument/reactor.
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公开(公告)号：US10823656B1
公开(公告)日：2020-11-03
申请号：US16350085
申请日：2018-09-21
申请人： Sarah R. Nuss-Warren , Douglas J. Wirsing , Derrick D. Hilliker , Theodore W. Selby , Jonathan C. Evans , Michael T. Kelly , Robert Culver , Fernando Moreira Mendes
发明人： Sarah R. Nuss-Warren , Douglas J. Wirsing , Derrick D. Hilliker , Theodore W. Selby , Jonathan C. Evans , Michael T. Kelly , Robert Culver , Fernando Moreira Mendes
摘要： Instrumentation embraces an at least partially automated rotational tapered bearing simulator viscometer having electronic control and/or monitoring that includes task unit electronics, which includes a task unit electronics interface. With or without such electronics, the instrumentation may include a particular component configuration and/or employ at least one particular material. Further feature(s) may be extant.
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公开(公告)号：US20170284994A1
公开(公告)日：2017-10-05
申请号：US15731004
申请日：2017-04-05
IPC分类号： G01N33/28 , C10M113/06 , C10M169/02 , C10M109/00 , C10M121/04
CPC分类号： G01N33/2805 , C10M109/00 , C10M113/06 , C10M121/04 , C10M169/02 , C10N2240/10 , G01N21/35 , G01N33/2888 , G01N2021/3595
摘要： Effects of Oxygen on grease or another organic paste product can be evaluated with a modified version of the ASTM D942 test methodology for oxidation stability of lubricating greases or other organic paste products by employment of an oxidation pressure vessel, in which at least one of (A) a very small sample of the grease or other organic paste product is deployed for testing within the oxidation pressure vessel such that the sample has an enhanced surface area to mass ratio, and (B) a temperature other than about 99° C. is employed during the testing. In general, the testing is carried out under oxidation pressure conditions. The sample may be evaluated with respect to Oxygen uptake. Additional technique(s) directed to oxidation and/or other properties of the sample may be carried out before to after any Oxygen uptake evaluation, for example, FTIR analysis and/or ATR-FTIR analysis.
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公开(公告)号：US09175906B2
公开(公告)日：2015-11-03
申请号：US10639361
申请日：2003-08-12
CPC分类号： A61K9/1688 , A61K6/0008 , A61K9/14 , A61K9/145 , A61K9/1694 , A61K9/19 , A61K9/5089 , A61K31/192 , A61K31/38 , A61K31/4412 , A61K31/496 , A61K31/55 , A61K31/573 , A61K31/58 , A61K38/13 , F26B5/065 , F26B17/284
摘要： The present invention is a method for preparing micron-sized or submicron-sized drug particles comprising contacting a solution comprising a poorly water soluble drug substance and at least one freezable organic solvent with a cold surface so as to freeze the solution; and removing the organic solvent. The resulting particles are also disclosed, as are several embodiments of an apparatus that can be used in performing the method of the present invention.
摘要翻译： 本发明是一种制备微米级或亚微米尺寸药物颗粒的方法，其包括将包含难溶于水的药物物质和至少一种可冷冻有机溶剂的溶液与冷表面接触以冷冻该溶液; 并除去有机溶剂。 还可以公开所得到的颗粒，以及可以用于执行本发明的方法的装置的几个实施方案。
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