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    1-(ARYLTHIO, ARYLSULFINYL AND ARYLSULFONYL)-1,1-DIHALOMETHANESULFONAMIDES
    5.
    发明授权
    1-(ARYLTHIO, ARYLSULFINYL AND ARYLSULFONYL)-1,1-DIHALOMETHANESULFONAMIDES 失效
    1-（ARYLTHIO，ARYLSULFINYL和ARYLSULFONYL）-1,1-二缩水甘油醚

    公开(公告)号：US3946007A

    公开(公告)日：1976-03-23

    申请号：US554953

    申请日：1975-03-03

    申请人： Christian T. Goralski ,  Thomas C. Klingler

    发明人： Christian T. Goralski ,  Thomas C. Klingler

    IPC分类号： C07D211/10 ,  C07D295/26 ,  C07D295/22

    CPC分类号： C07D295/26 ,  C07D211/10

    摘要： The compounds of the formula ##SPC1##In which R is lower alkyl, lower alkoxy or halo, x is an integer from 0 to 2, n is an integer from 0 to 3, Y is halo and R.sub.1 and R.sub.2 independently are hydrogen, lower alkyl, phenyl or substituted phenyl, or, together with the nitrogen atom, form a heterocyclic ring also containing up to one oxygen atom in the heterocycle. The compounds in which x is 0 are prepared by adding chlorine or bromine to a 1-arylthiomethanesulfonamide in the presence of pyridine to form the 1-arylthio-1, 1-dihalomethanesulfonamide. The compounds in which x is 1 or 2 is prepared by adding sodium hypochlorite or sodium hypobromite to a 1-(arylsulfinyl)methane-sulfonamide or a 1-(arylsulfonyl)methanesulfonamide to form the 1-(arylsulfinyl)-1,1-dihalomethanesulfonamide or 1-(arylsulfonyl)-1,1-dihalomethanesulfonamide, respectively. The compounds are useful as antimicrobial agents.

    摘要翻译： 式中R为低级烷基，低级烷氧基或卤素的化合物，x为0至2的整数，n为0至3的整数，Y为卤素，R 1和R 2各为氢，低级烷基，苯基 或取代的苯基，或者与氮原子一起形成在该杂环中也含有至多一个氧原子的杂环。 在吡啶存在下，通过在1-芳基硫代甲磺酰胺中加入氯或溴来制备x为0的化合物，形成1-芳硫基-1,1-二卤代甲磺酰胺。 通过向1-（芳基亚磺酰基）甲磺酰胺或1-（芳基磺酰基）甲磺酰胺中加入次氯酸钠或次溴酸钠，形成1-（芳基亚磺酰基）-1,1-二卤代甲磺酰胺制备x为1或2的化合物 或1-（芳基磺酰基）-1,1-二卤代甲磺酰胺。 这些化合物可用作抗微生物剂。

    N-(5,7-dibromo-1,3-benzoxathiol-2-ylidene)-N-methylmethanaminium bromide, N-(5,7-diiodo-1,3-benzoxathiol-2-ylidene)-N-methylmethanaminium iodide and their preparation
    8.
    发明授权
    N-(5,7-dibromo-1,3-benzoxathiol-2-ylidene)-N-methylmethanaminium bromide, N-(5,7-diiodo-1,3-benzoxathiol-2-ylidene)-N-methylmethanaminium iodide and their preparation 失效
    N-（5,7-二溴-1,3-苯并恶唑-2-亚基）-N-甲基甲基溴化铵，N-（5,7-二碘-1,3-苯并恶唑-2-亚基）-N-甲基甲胺碘化物和 他们的准备

    公开(公告)号：US4087445A

    公开(公告)日：1978-05-02

    申请号：US780889

    申请日：1977-03-24

    申请人： Charles E. Reineke ,  Christian T. Goralski

    发明人： Charles E. Reineke ,  Christian T. Goralski

    IPC分类号： C07D327/04 ,  A61K31/40

    CPC分类号： C07D327/04 ,  C07C323/00

    摘要： N-(5,7-Dibromo-1,3-benzoxathiol-2-ylidene)-N-methylmethanaminium bromide and the analogous diodo iodide, new compounds, are prepared by the thermal rearrangement of O-(2,4,6-tribromophenyl)-N,N-dimethylthiocarbamate and O-(2,4,6-triiodophenyl)-N,N-dimethylthiocarbamate. The first-named compound has antimicrobial utility. Both compounds are useful as starting materials for the preparation of bis-(3,5-dibromo-2-hydroxyphenyl)disulfide and 2,4-diiodo-6-mercaptophenol, respectively, by hydrolysis of the two first-named compounds with methanolic sodium hydroxide. Both the disulfide and the mercaptophenol compounds have antimicrobial utility.

    摘要翻译： 通过O-（2,4,6-三溴苯基）的热重排制备N-（5,7-二溴-1,3-苯并恶唑-2-亚基）-N-甲基甲铵溴化物和类似的二碘碘化物，新化合物 ）-N，N-二甲基硫代氨基甲酸酯和O-（2,4,6-三碘苯基）-N，N-二甲基硫代氨基甲酸酯。 第一个命名的化合物具有抗菌效用。 两种化合物分别可用作制备双 - （3,5-二溴-2-羟基苯基）二硫化物和2,4-二碘-6-巯基苯酚的起始原料，通过两种首先命名的化合物与甲醇钠的水解 氢氧化物。 二硫化物和巯基苯酚化合物都具有抗菌效用。