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公开(公告)号：US07183286B2
公开(公告)日：2007-02-27
申请号：US10796657
申请日：2004-03-09
申请人： Christine C. Dykstra , Maurice Daniel Givens , David A. Stringfellow , Kenny Brock , David W. Boykin , Arvid Kumar , W. David Wilson , Richard R. Tidwell , Chad F. Stephens
发明人： Christine C. Dykstra , Maurice Daniel Givens , David A. Stringfellow , Kenny Brock , David W. Boykin , Arvid Kumar , W. David Wilson , Richard R. Tidwell , Chad F. Stephens
IPC分类号： A61K31/506 , A61K31/4184 , C07D401/14 , C07D235/04
CPC分类号： C07D207/08 , A61K31/341 , A61K31/381 , A61K31/401 , A61K31/4178 , A61K31/4184 , A61K31/426 , C07D207/09 , C07D277/28 , C07D307/14 , C07D307/52 , C07D307/54 , C07D333/20 , C07D405/04 , C07D405/10 , C07D405/14
摘要： The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)–(VI) as recited throughout the application.
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公开(公告)号：US07410999B2
公开(公告)日：2008-08-12
申请号：US11601889
申请日：2006-11-20
申请人： Christine C. Dykstra , Maurice Daniel Givens , David A. Stringfellow , Kenny Brock , David Boykin , Arvid Kumar , W. David Wilson , Richard R. Tidwell , Chad F. Stephens
发明人： Christine C. Dykstra , Maurice Daniel Givens , David A. Stringfellow , Kenny Brock , David Boykin , Arvid Kumar , W. David Wilson , Richard R. Tidwell , Chad F. Stephens
IPC分类号： A61K31/341 , A61K31/381 , A61K31/40 , A61K31/4178 , A61K31/426 , C07D233/20 , C07D207/337 , C07D277/30 , C07D333/24 , C07D307/54 , C07C257/10 , C07C257/18
CPC分类号： C07D405/14 , A61K31/341 , A61K31/381 , A61K31/401 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/506 , C07D207/08 , C07D207/09 , C07D277/28 , C07D307/14 , C07D333/20 , C07D405/04 , C07D405/10
摘要： The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.
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3.发明授权Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection 失效用于治疗牛病毒性腹泻病毒（BVDV）感染和丙型肝炎病毒（HCV）感染的化合物，方法和组合物公开(公告)号：US07410989B2
公开(公告)日：2008-08-12
申请号：US11602031
申请日：2006-11-20
申请人： Christine C. Dykstra , Maurice Daniel Givens , David A. Stringfellow , Kenny Brock , David Boykin , Arvid Kumar , W. David Wilson , Richard R. Tidwell , Chad F. Stephens
发明人： Christine C. Dykstra , Maurice Daniel Givens , David A. Stringfellow , Kenny Brock , David Boykin , Arvid Kumar , W. David Wilson , Richard R. Tidwell , Chad F. Stephens
IPC分类号： A61K31/4184 , C07D235/06 , C07D403/14 , C07C257/10 , C07C257/18
CPC分类号： C07D405/14 , A61K31/341 , A61K31/381 , A61K31/401 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/506 , C07D207/08 , C07D207/09 , C07D277/28 , C07D307/14 , C07D333/20 , C07D405/04 , C07D405/10
摘要： The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.
摘要翻译： 本发明涉及可用于治疗黄病毒科病毒家族的新化合物和方法。 本发明的化合物将具有根据本申请所述的式（I） - （VI）的结构。
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公开(公告)号：US07163955B2
公开(公告)日：2007-01-16
申请号：US11262427
申请日：2005-10-28
申请人： Christine C. Dykstra , Maurice Daniel Givens , David A. Stringfellow , Kenny Brock , David Boykin , Arvid Kumar , W. David Wilson , Richard R. Tidwell , Chad F. Stephens
发明人： Christine C. Dykstra , Maurice Daniel Givens , David A. Stringfellow , Kenny Brock , David Boykin , Arvid Kumar , W. David Wilson , Richard R. Tidwell , Chad F. Stephens
IPC分类号： A61K31/4178 , C07D233/06
CPC分类号： C07D405/14 , A61K31/341 , A61K31/381 , A61K31/401 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/506 , C07D207/08 , C07D207/09 , C07D277/28 , C07D307/14 , C07D333/20 , C07D405/04 , C07D405/10
摘要： The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)–(VI) as recited throughout the application.
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5.发明授权Methods of combatting infectious diseases using dicationic bis-benzimidazoles 失效使用双极化双苯并咪唑来防治传染病的方法公开(公告)号：US06294565B1
公开(公告)日：2001-09-25
申请号：US09544643
申请日：2000-04-06
IPC分类号： A61K31415
CPC分类号： A61K31/427 , A61K31/4184 , A61K31/422 , A61K31/4439 , A61K31/497 , A61K31/506
摘要： The present invention provides methods for treating Crytococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.
摘要翻译： 本发明提供了在需要这种治疗的受试者中治疗新型隐球菌和白色假丝酵母的方法。 所述方法包括以有效治疗病症的量给予受试者双阳离子双苯并咪唑。
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6.发明授权
公开(公告)号：US6017941A
公开(公告)日：2000-01-25
申请号：US145368
申请日：1998-09-01
IPC分类号： C07D401/14 , A61K31/415 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/445 , A61K31/497 , A61K31/505 , A61K31/506 , A61P31/04 , C07D403/14 , C07D405/14
CPC分类号： A61K31/427 , A61K31/4184 , A61K31/422 , A61K31/4439 , A61K31/497 , A61K31/506
摘要： The present invention provides methods for treating Cryptococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.
摘要翻译： 本发明提供了在需要这种治疗的受试者中治疗新型隐球菌和白色念珠菌的方法。 所述方法包括以有效治疗病症的量给予受试者双阳离子双苯并咪唑。
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公开(公告)号：US5939440A
公开(公告)日：1999-08-17
申请号：US130496
申请日：1998-08-07
IPC分类号： C07D401/14 , A61K31/415 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/445 , A61K31/497 , A61K31/505 , A61K31/506 , A61P31/04 , C07D403/14 , C07D405/14 , C07D235/06
CPC分类号： A61K31/427 , A61K31/4184 , A61K31/422 , A61K31/4439 , A61K31/497 , A61K31/506
摘要： The present invention provides methods for treating Cryptococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.
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公开(公告)号：US5817686A
公开(公告)日：1998-10-06
申请号：US865427
申请日：1997-05-29
IPC分类号： C07D401/14 , A61K31/415 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/445 , A61K31/497 , A61K31/505 , A61K31/506 , A61P31/04 , C07D403/14 , C07D405/14
CPC分类号： A61K31/427 , A61K31/4184 , A61K31/422 , A61K31/4439 , A61K31/497 , A61K31/506
摘要： The present invention provides methods for treating Cryptococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.
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9.发明授权Methods of combatting infectious diseases using dicationic bis-benzimidazoles 有权使用双极化双苯并咪唑来防治传染病的方法
公开(公告)号：US6046226A
公开(公告)日：2000-04-04
申请号：US352391
申请日：1999-07-13
IPC分类号： C07D401/14 , A61K31/415 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/445 , A61K31/497 , A61K31/505 , A61K31/506 , A61P31/04 , C07D403/14 , C07D405/14
CPC分类号： A61K31/427 , A61K31/4184 , A61K31/422 , A61K31/4439 , A61K31/497 , A61K31/506
摘要： The present invention provides methods for treating Cryptococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.
摘要翻译： 本发明提供了在需要这种治疗的受试者中治疗新型隐球菌和白色念珠菌的方法。 所述方法包括以有效治疗病症的量给予受试者双阳离子双苯并咪唑。
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10.发明授权Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans, and kits useful therefor 失效使用双阳离子芳基呋喃荧光检测核酸和细胞骨架元件的方法，以及可用于其的试剂盒
公开(公告)号：US5723288A
公开(公告)日：1998-03-03
申请号：US238766
申请日：1994-05-06
申请人： Christine C. Dykstra , Richard R. Tidwell , David W. Boykin , W. David Wilson , Jaroslaw Spychala , Bijan P. Das , Arvind Kumar
发明人： Christine C. Dykstra , Richard R. Tidwell , David W. Boykin , W. David Wilson , Jaroslaw Spychala , Bijan P. Das , Arvind Kumar
IPC分类号： G01N33/50 , A61K31/505 , A61K31/506 , C07D307/52 , C07D307/54 , C07D307/58 , C07D403/10 , C07D403/14 , C07D405/14 , C09B23/01 , C12Q1/68 , G01N21/78 , G01N33/52 , G01N33/58
CPC分类号： G01N33/52 , A61K31/505 , A61K31/506 , C07D307/54 , C07D403/10 , C07D403/14 , C07D405/14 , C09B23/0075 , Y10S435/808 , Y10S435/81
摘要： Disclosed is a method of fluorescent detection of a nucleic acid. The method comprises contacting to the nucleic acid a bis-dicationic aryl furan compound, such as 2,5-bis�4-(4,5,6,7-tetrahydro-1H-1,3-diazepin-2-yl) phenyl! furan; 2,5-bis{�4-(N-isopropyl) amidino! phenyl}furan; and physiologically acceptable salts thereof, and exposing the nucleic acid to light at a frequency to induce fluorescence of the compound. A method for fluorescent detection of cytoskeleton elements, and novel bis-dicationic aryl furan compounds are also disclosed.
摘要翻译： 公开了一种荧光检测核酸的方法。 该方法包括使双酸性芳基呋喃化合物如2,5-双[4-（4,5,6,7-四氢-1H-1,3-二氮杂-2-基）苯基 ]呋喃 2,5-双{[4-（N-异丙基）脒基]苯基}呋喃; 和其生理上可接受的盐，并且以一定的频率使核酸暴露以诱导化合物的荧光。 还公开了细胞骨架元件的荧光检测方法，以及新型的双 - 二盐酸芳基呋喃化合物。
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