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公开(公告)号：US20100331297A1
公开(公告)日：2010-12-30
申请号：US12741992
申请日：2008-11-07
IPC分类号： A61K31/52 , C12P21/06 , C12N5/02 , A61K31/519 , C07D473/00 , C07D487/02 , A61P25/16 , A61P25/28 , A61P3/10
CPC分类号： A61K31/519 , C07D487/04
摘要： Compounds and compositions are provided for treatment or amelioration of one or more disorders characterized by defects in protein trafficking. A method of treating a disorder characterized by impaired protein trafficking includes administering to a subject or contacting a cell with a compound of Formula I: [formula here] or pharmaceutically acceptable salts or derivatives thereof.
摘要翻译： 提供化合物和组合物用于治疗或改善以蛋白质运输缺陷为特征的一种或多种病症。 治疗以蛋白质运输受损为特征的疾病的方法包括向受试者施用或使细胞与式I化合物或其药学上可接受的盐或衍生物接触。
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公开(公告)号：US6046000A
公开(公告)日：2000-04-04
申请号：US966269
申请日：1997-11-07
CPC分类号： C12Q1/6897 , C12N15/1034 , C12N15/1051 , C12N15/81
摘要： The invention involves a method of identifying nucleic acid sequences encoding signal peptide-containing proteins. The method features chimeric constructs containing a KRE9 gene that lacks a signal sequence. Yeast containing chimeric KRE9 plasmid constructs that encode signal sequences are selected based on their ability to grow on media in which sucrose is the sole carbon source.
摘要翻译： 本发明涉及鉴定编码含有信号肽的蛋白质的核酸序列的方法。 该方法具有含有缺少信号序列的KRE9基因的嵌合构建体。 基于它们在其中蔗糖是唯一碳源的培养基上生长的能力来选择含有编码信号序列的嵌合KRE9质粒构建体的酵母。
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公开(公告)号：US06953672B2
公开(公告)日：2005-10-11
申请号：US10225323
申请日：2002-08-21
CPC分类号： C07K14/4738
摘要： Disclosed is a yeast cell whose genetic complement includes an inactive allele of the yeast CDC7 gene, a first nucleic acid that encodes a mammalian Cdc7 protein, and a second nucleic acid that encodes a mammalian Dbf4 protein. The yeast cell is dependent on the mammalian Cdc7 and Dbf4 proteins for viability. The yeast cell can be used to identify potential anti-proliferative agents by virtue of their inhibition of the mammalian Cdc7 and Dbf4 proteins. In some embodiments, a control yeast cell which does not depend on Cdc7 for viability is used in a secondary screen.
摘要翻译： 公开了酵母细胞，其遗传补体包括酵母CDC7基因的无活性等位基因，编码哺乳动物Cdc7蛋白的第一核酸和编码哺乳动物Dbf4蛋白的第二核酸。 酵母细胞依赖于哺乳动物Cdc7和Dbf4蛋白的活力。 酵母细胞可以通过抑制哺乳动物Cdc7和Dbf4蛋白来鉴定潜在的抗增殖剂。 在一些实施方案中，在二次屏幕中使用不依赖Cdc7作为存活力的对照酵母细胞。
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公开(公告)号：US20100273776A1
公开(公告)日：2010-10-28
申请号：US12294893
申请日：2007-03-29
申请人： Susan L. Lindquist , Tiago Outeiro , Richard Labaudinière , James Fleming , Christine Ellen Bulawa , Charlotte Weigel , Feng Liang , Sandeep Gupta , Amy Ripka
发明人： Susan L. Lindquist , Tiago Outeiro , Richard Labaudinière , James Fleming , Christine Ellen Bulawa , Charlotte Weigel , Feng Liang , Sandeep Gupta , Amy Ripka
IPC分类号： A61K31/519 , A61K31/4045 , A61K31/416 , A61K31/454 , A61K31/445 , A61K31/435 , A61K31/55 , C07D487/04 , C07D209/14 , C07D231/56 , C07D471/04 , A61P43/00 , A61P25/16 , A61P25/28 , C12N5/07
CPC分类号： A61K31/4178 , A61K31/27 , A61K31/445 , A61K31/473 , A61K31/55 , A61K45/06 , A61K2300/00
摘要： Compounds and compositions are provided for treatment or amelioration of one or more symptoms of α-synuclein toxicity, α-synuclein mediated diseases or diseases in which α-synuclein fibrils are a symptom or cause of the disease.
摘要翻译： 提供化合物和组合物用于治疗或改善α-突触核蛋白毒性，α-突触核蛋白介导的疾病或其中α-突触核蛋白原纤维是疾病的症状或原因的疾病的一种或多种症状。
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5.发明授权Aspergillus fumigatus acetyl coenzyme-A carboxylase genes and polypeptides and uses thereof 失效烟曲霉乙酰辅酶A羧化酶基因和多肽及其用途公开(公告)号：US06514726B1
公开(公告)日：2003-02-04
申请号：US09475252
申请日：1999-12-30
IPC分类号： C12N1509
CPC分类号： C12N9/93 , A61K38/00 , C07K2319/00 , C12Q1/18 , G01N2333/38
摘要： Disclosed are Aspergillus fumigatus coenzyme-A carboxylase genes and polypeptides and their use in identifying antifungal agents, for example.
摘要翻译： 公开了烟曲霉辅酶A羧化酶基因和多肽及其在鉴定抗真菌剂中的用途。
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