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372 条记录 (耗时 0.037 秒)

    15-O-Desmethylmacbecin Derivatives and Their Use in the Treatment of Cancer or B-Cell Malignancies
    3.
    发明申请
    15-O-Desmethylmacbecin Derivatives and Their Use in the Treatment of Cancer or B-Cell Malignancies 审中-公开
    15-O-去甲基衍生物及其在治疗癌症或B细胞恶性肿瘤中的应用

    公开(公告)号：US20090209507A1

    公开(公告)日：2009-08-20

    申请号：US12294253

    申请日：2007-03-30

    申请人： Sabine Gaisser ,  Christine Martin ,  Ming Zhang ,  Barrie Wilkinson ,  Nigel Coates ,  Mohammed Nur-E-Alam ,  William Vousden

    发明人： Sabine Gaisser ,  Christine Martin ,  Ming Zhang ,  Barrie Wilkinson ,  Nigel Coates ,  Mohammed Nur-E-Alam ,  William Vousden

    IPC分类号： A61K31/395 ,  C07D225/06 ,  A61P35/00 ,  C12P17/10 ,  C12N5/10

    CPC分类号： C07D225/06

    摘要： The present invention relates to 15-O-desmethylmacbecin analogues according to the formula (IA) or (IB) herein, or a pharmaceutically acceptable salt thereof: wherein: R1 and R2 either both represent H or together they represent a bond (i.e. C4 to C5 is a double bond); and R3 represents H or CONH2 that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.

    摘要翻译： 本发明涉及根据本文的式（IA）或（IB）的15-O-去甲基蒿酸类似物或其药学上可接受的盐：其中：R 1和R 2都表示H或一起表示一个键（即C 4至 C5是双键）; 并且R 3表示可用的H或CONH 2，例如。 在治疗癌症，B细胞恶性肿瘤，疟疾，真菌感染，中枢神经系统疾病和神经变性疾病，依赖于血管生成的疾病，自身免疫疾病和/或作为癌症的预防性预处理。 本发明还提供了这些化合物的制备方法及其在医药中的用途，特别是用于治疗和/或预防癌症或B细胞恶性肿瘤的方法。

    18 ,21-Didesoxymacbecin Derivatives for the Treatment of Cancer
    7.
    发明申请
    18 ,21-Didesoxymacbecin Derivatives for the Treatment of Cancer 审中-公开
    18，21-Didesoxymacbecin衍生物治疗癌症

    公开(公告)号：US20090253667A1

    公开(公告)日：2009-10-08

    申请号：US12296542

    申请日：2007-05-09

    申请人： Christine Martin ,  Ming Zhang ,  Nigel Coates ,  William Vousden ,  Steven Moss ,  Sabine Gaisser

    发明人： Christine Martin ,  Ming Zhang ,  Nigel Coates ,  William Vousden ,  Steven Moss ,  Sabine Gaisser

    IPC分类号： A61K31/395 ,  C12P17/10 ,  C12N1/00 ,  C07D225/06

    CPC分类号： C07D225/06

    摘要： The present invention relates to 18,21-didesoxymacbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pre-treatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.

    摘要翻译： 本发明涉及有用的18,21-二氧杂氧化锍类似物。 在治疗癌症，B细胞恶性肿瘤，疟疾，真菌感染，中枢神经系统疾病和神经变性疾病，依赖于血管生成的疾病，自身免疫性疾病和/或作为癌症的预防性预处理。 本发明还提供了这些化合物的制备方法及其在医药中的用途，特别是用于治疗和/或预防癌症或B细胞恶性肿瘤的方法。

    C21-Deoxy Ansamycin Derivatives as Antitumor Agents
    8.
    发明申请
    C21-Deoxy Ansamycin Derivatives as Antitumor Agents 审中-公开
    C21-Deoxy Ansamycin衍生物作为抗肿瘤剂

    公开(公告)号：US20100210597A1

    公开(公告)日：2010-08-19

    申请号：US12526605

    申请日：2008-03-03

    申请人： Steven Moss ,  Christine Martin ,  Ming Zhang

    发明人： Steven Moss ,  Christine Martin ,  Ming Zhang

    IPC分类号： A61K31/675 ,  C07D225/06 ,  A61K31/33 ,  A61P35/00 ,  A61P31/00 ,  A61P25/00 ,  A61P37/06 ,  A61P9/00

    CPC分类号： C07D225/06

    摘要： According to the invention there are provided derivatives of a C21-deoxy ansamycin or salt thereof which contain a 1-hydroxyphenyl moiety bearing at position 3 an aminocarboxy substituent, in which position 5 and the aminocarboxy substituent at position 3 are connected by an aliphatic chain of varying length characterised in that the 1-hydroxy position of the phenyl ring is derivatised by an aminoalkyleneaminocarbonyl group, which alkylene group (which may optionally be substituted by alkyl groups) has a chain length of 2 or 3 carbon atoms, a phosphoric acid, or a phosphoric acid ester (such as an alkyl ester) group, or a salt thereof, and which derivatising group increases the water solubility and/or the bioavailability of the parent molecule. Such compounds are useful in therapy eg in the treatment of cancer and B-cell malignancies.

    摘要翻译： 根据本发明，提供了一种C21-脱氧安莎霉素或其盐的衍生物，其含有在位置3具有氨基羧基取代基的1-羟基苯基部分，其中位置5和位置3上的氨基羧基取代基通过脂族链连接 变化的长度，其特征在于苯环的1-羟基位置被氨基亚烷基氨基羰基衍生，该亚烷基（其可以任选被烷基取代）具有2或3个碳原子的链长，磷酸或 磷酸酯（例如烷基酯）或其盐，并且该衍生基增加了母体分子的水溶性和/或生物利用度。 这样的化合物可用于治疗，例如治疗癌症和B细胞恶性肿瘤。

    Pet coat
    9.
    外观设计
    Pet coat 有权

    公开(公告)号：USD1048588S1

    公开(公告)日：2024-10-22

    申请号：US29834457

    申请日：2022-04-12

    申请人： Ming Zhang

    设计人： Ming Zhang

    摘要： FIG. 1 is a front perspective view of a pet coat showing my new design.
    FIG. 2 is a front view of a pet coat.
    FIG. 3 is a rear view of a pet coat.
    FIG. 4 is a left side view of a pet coat.
    FIG. 5 is a right side view of a pet coat.
    FIG. 6 is a top view of a pet coat; and,
    FIG. 7 is a bottom view of a pet coat.
    The broken lines depict stitching lines and form part of the claimed design.

    House structure with expandable function
    10.
    发明授权
    House structure with expandable function 有权

    公开(公告)号：US11512486B2

    公开(公告)日：2022-11-29

    申请号：US16904591

    申请日：2020-06-18

    申请人： Chuan Yu ,  Ming Zhang ,  Dechong Zeng ,  Jiangshan Li

    发明人： Chuan Yu ,  Ming Zhang ,  Dechong Zeng ,  Jiangshan Li

    IPC分类号： E04H1/00 ,  E04H14/00 ,  G01C21/20 ,  G01S19/42 ,  G05D1/02

    摘要： The invention discloses a house structure with expandable function, comprising a house body (20), wherein an elevator shaft (21) is provided in the house body (20), and a carrying elevator (22) is provided in the elevator shaft (21); a multifunctional balcony (23) is further provided on both sides of the elevator shaft (21), and the multifunctional balcony (23) and the elevator shaft (21) are connected via a landing door (24); the car of the carrying elevator (22) is provided with a car front door, a car left door and a car right door, respectively; a multifunctional cabin (1) can be detachably connected to an automatic carrying system (35) capable of autonomous driving. The house structure provided by the invention can take into account the owner's demand for various aspects of the house, and improves the functionality of the house.