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21 条记录 (耗时 0.036 秒)

    15-O-Desmethylmacbecin Derivatives and Their Use in the Treatment of Cancer or B-Cell Malignancies
    3.
    发明申请
    15-O-Desmethylmacbecin Derivatives and Their Use in the Treatment of Cancer or B-Cell Malignancies 审中-公开
    15-O-去甲基衍生物及其在治疗癌症或B细胞恶性肿瘤中的应用

    公开(公告)号：US20090209507A1

    公开(公告)日：2009-08-20

    申请号：US12294253

    申请日：2007-03-30

    申请人： Sabine Gaisser ,  Christine Martin ,  Ming Zhang ,  Barrie Wilkinson ,  Nigel Coates ,  Mohammed Nur-E-Alam ,  William Vousden

    发明人： Sabine Gaisser ,  Christine Martin ,  Ming Zhang ,  Barrie Wilkinson ,  Nigel Coates ,  Mohammed Nur-E-Alam ,  William Vousden

    IPC分类号： A61K31/395 ,  C07D225/06 ,  A61P35/00 ,  C12P17/10 ,  C12N5/10

    CPC分类号： C07D225/06

    摘要： The present invention relates to 15-O-desmethylmacbecin analogues according to the formula (IA) or (IB) herein, or a pharmaceutically acceptable salt thereof: wherein: R1 and R2 either both represent H or together they represent a bond (i.e. C4 to C5 is a double bond); and R3 represents H or CONH2 that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.

    摘要翻译： 本发明涉及根据本文的式（IA）或（IB）的15-O-去甲基蒿酸类似物或其药学上可接受的盐：其中：R 1和R 2都表示H或一起表示一个键（即C 4至 C5是双键）; 并且R 3表示可用的H或CONH 2，例如。 在治疗癌症，B细胞恶性肿瘤，疟疾，真菌感染，中枢神经系统疾病和神经变性疾病，依赖于血管生成的疾病，自身免疫疾病和/或作为癌症的预防性预处理。 本发明还提供了这些化合物的制备方法及其在医药中的用途，特别是用于治疗和/或预防癌症或B细胞恶性肿瘤的方法。

    18 ,21-Didesoxymacbecin Derivatives for the Treatment of Cancer
    5.
    发明申请
    18 ,21-Didesoxymacbecin Derivatives for the Treatment of Cancer 审中-公开
    18，21-Didesoxymacbecin衍生物治疗癌症

    公开(公告)号：US20090253667A1

    公开(公告)日：2009-10-08

    申请号：US12296542

    申请日：2007-05-09

    申请人： Christine Martin ,  Ming Zhang ,  Nigel Coates ,  William Vousden ,  Steven Moss ,  Sabine Gaisser

    发明人： Christine Martin ,  Ming Zhang ,  Nigel Coates ,  William Vousden ,  Steven Moss ,  Sabine Gaisser

    IPC分类号： A61K31/395 ,  C12P17/10 ,  C12N1/00 ,  C07D225/06

    CPC分类号： C07D225/06

    摘要： The present invention relates to 18,21-didesoxymacbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pre-treatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.

    摘要翻译： 本发明涉及有用的18,21-二氧杂氧化锍类似物。 在治疗癌症，B细胞恶性肿瘤，疟疾，真菌感染，中枢神经系统疾病和神经变性疾病，依赖于血管生成的疾病，自身免疫性疾病和/或作为癌症的预防性预处理。 本发明还提供了这些化合物的制备方法及其在医药中的用途，特别是用于治疗和/或预防癌症或B细胞恶性肿瘤的方法。

    Production of polyketides and other natural products
    8.
    发明授权
    Production of polyketides and other natural products 有权
    生产聚酮化合物等天然产物

    公开(公告)号：US07300942B2

    公开(公告)日：2007-11-27

    申请号：US10497135

    申请日：2003-07-16

    申请人： Matthew Alan Gregory ,  Sabine Gaisser ,  Hrvoje Petkovic ,  Steven Moss

    发明人： Matthew Alan Gregory ,  Sabine Gaisser ,  Hrvoje Petkovic ,  Steven Moss

    IPC分类号： C07D498/18 ,  A61P31/00

    CPC分类号： C07D498/18 ,  C07D405/12 ,  C07D471/18 ,  C07D487/18 ,  C07D493/18 ,  C07K14/36 ,  C12N15/52 ,  C12N15/70 ,  C12N15/76 ,  C12P17/188

    摘要： The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their,preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).

    摘要翻译： 本发明涉及聚酮化合物和其它天然产物的生产以及化合物和单个新化合物的文库。 一个重要的领域是产生这些化合物的新型FKBP-配体类似物和宿主细胞的分离和潜在的使用。 本发明特别涉及有效转化产生FKBP类似物的菌株和重组细胞的方法，其中克隆的基因或基因盒被表达以产生新的化合物，例如聚酮化合物（特别是雷帕霉素）FKBP-配体类似物， ，制备和其中使用的手段（例如核酸，载体，基因盒和遗传修饰的菌株）。

    PRODUCTION OF POLYKETIDES AND OTHER NATURAL PRODUCTS
    10.
    发明申请
    PRODUCTION OF POLYKETIDES AND OTHER NATURAL PRODUCTS 有权
    生产多晶硅及其他天然产品

    公开(公告)号：US20080021211A1

    公开(公告)日：2008-01-24

    申请号：US11778264

    申请日：2007-07-16

    申请人： Matthew Gregory ,  Sabine Gaisser ,  Hrvoje Petkovic ,  Steven Moss

    发明人： Matthew Gregory ,  Sabine Gaisser ,  Hrvoje Petkovic ,  Steven Moss

    IPC分类号： C07D273/00

    CPC分类号： C07D498/18 ,  C07D405/12 ,  C07D471/18 ,  C07D487/18 ,  C07D493/18 ,  C07K14/36 ,  C12N15/52 ,  C12N15/70 ,  C12N15/76 ,  C12P17/188

    摘要： The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).

    摘要翻译： 本发明涉及聚酮化合物和其它天然产物的生产以及化合物和单个新化合物的文库。 一个重要的领域是产生这些化合物的新型FKBP-配体类似物和宿主细胞的分离和潜在的使用。 本发明特别涉及有效转化产生FKBP类似物的菌株和重组细胞的方法，其中克隆的基因或基因盒被表达以产生新的化合物，例如聚酮化合物（特别是雷帕霉素）FKBP-配体类似物， 制备和其中使用的手段（例如核酸，载体，基因盒和遗传修饰的菌株）。