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1.发明授权公开(公告)号：US09353186B2
公开(公告)日：2016-05-31
申请号：US14123517
申请日：2012-05-31
申请人： Christoph Freiberg , Christiane Otto , Lars Linden , Axel Harrenga , Mark Trautwein , Simone Greven , Andreas Wilmen
发明人： Christoph Freiberg , Christiane Otto , Lars Linden , Axel Harrenga , Mark Trautwein , Simone Greven , Andreas Wilmen
IPC分类号： C07K16/28 , A61K39/395 , A61K45/06 , A61K39/00
CPC分类号： C07K16/2869 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/3015 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The neutralizing prolactin receptor antibody Mat3, and antigen binding fragments, pharmaceutical compositions containing them and their use in the treatment or prevention of benign disorders and indications mediated by the prolactin receptor such as endometriosis, adenomyosis, non-hormonal female contraception, benign breast disease and mastalgia, lactation inhibition, benign prostate hyperplasia, fibroids, hyper- and normoprolactinemic hair loss, and cotreatment in combined hormone therapy to inhibit mammary epithelial cell proliferation and for the treatment and prevention of antiestrogen-resistant breast cancer. The antibody blocks prolactin receptor-mediated signalling.
摘要翻译： 中和催乳素受体抗体Mat3和抗原结合片段，含有它们的药物组合物及其用于治疗或预防由催乳素受体介导的良性疾病和适应症的用途，例如子宫内膜异位症，子宫腺肌症，非激素雌性避孕，良性乳腺疾病和 乳腺，泌乳抑制，良性前列腺增生，肌瘤，高血压和正常泌乳素脱发，以及联合激素治疗中的联合抑制乳腺上皮细胞增殖和治疗和预防抗雌激素抵抗性乳腺癌。 该抗体阻断催乳素受体介导的信号传导。
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2.发明申请公开(公告)号：US20140141003A1
公开(公告)日：2014-05-22
申请号：US14123517
申请日：2012-05-31
申请人： Christoph Freiberg , Christiane Otto , Lars Linden , Axel Harrenga , Mark Trautwein , Simone Greven , Andreas Wilmen
发明人： Christoph Freiberg , Christiane Otto , Lars Linden , Axel Harrenga , Mark Trautwein , Simone Greven , Andreas Wilmen
IPC分类号： C07K16/28 , A61K45/06 , A61K39/395
CPC分类号： C07K16/2869 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/3015 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The neutralizing prolactin receptor antibody Mat3, and antigen binding fragments, pharmaceutical compositions containing them and their use in the treatment or prevention of benign disorders and indications mediated by the prolactin receptor such as endometriosis, adenomyosis, non-hormonal female contraception, benign breast disease and mastalgia, lactation inhibition, benign prostate hyperplasia, fibroids, hyper- and normoprolactinemic hair loss, and cotreatment in combined hormone therapy to inhibit mammary epithelial cell proliferation and for the treatment and prevention of antiestrogen-resistant breast cancer. The antibody blocks prolactin receptor-mediated signalling.
摘要翻译： 中和催乳素受体抗体Mat3和抗原结合片段，含有它们的药物组合物及其用于治疗或预防由催乳素受体介导的良性疾病和适应症的用途，例如子宫内膜异位症，子宫腺肌症，非激素雌性避孕，良性乳腺疾病和 乳腺，泌乳抑制，良性前列腺增生，肌瘤，高血压和正常泌乳素脱发，以及联合激素治疗中的联合抑制乳腺上皮细胞增殖和治疗和预防抗雌激素抵抗性乳腺癌。 该抗体阻断催乳素受体介导的信号传导。
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公开(公告)号：US20140187491A1
公开(公告)日：2014-07-03
申请号：US14130493
申请日：2012-06-29
申请人： Andreas Wilmen , Ulrich Haupts , Christoph Freiberg , Mark Trautwein , Lars Linden , Kirsten Leineweber , Hanna Tinel
发明人： Andreas Wilmen , Ulrich Haupts , Christoph Freiberg , Mark Trautwein , Lars Linden , Kirsten Leineweber , Hanna Tinel
CPC分类号： C07K14/64 , A61K38/00 , C07K16/18 , C07K2319/31 , C07K2319/75
摘要： The present invention provides Relaxin fusion polypeptides A-L-B with a non-wild type array of the Relaxin A-chain and Relaxin B-chain, wherein the A- and B-chains are connected by a linker peptide. The invention further provides Relaxin fusion polypeptides with extended half-life. Furthermore, the invention provides nucleic acid sequences encoding the foregoing fusion polypeptides, vectors containing the same, pharmaceutical compositions and medical use of such fusion polypeptides.
摘要翻译： 本发明提供松弛蛋白融合多肽A-L-B与松弛蛋白A链和松弛蛋白B链的非野生型阵列，其中所述A和B链通过连接肽连接。 本发明进一步提供具有延长的半衰期的松弛素融合多肽。 此外，本发明提供了编码前述融合多肽的核酸序列，含有该融合多肽的载体，药物组合物和这种融合多肽的医学应用。
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公开(公告)号：US09382305B2
公开(公告)日：2016-07-05
申请号：US14130493
申请日：2012-06-29
申请人： Andreas Wilmen , Ulrich Haupts , Christoph Freiberg , Mark Trautwein , Lars Linden , Kirsten Leineweber , Hanna Tinel
发明人： Andreas Wilmen , Ulrich Haupts , Christoph Freiberg , Mark Trautwein , Lars Linden , Kirsten Leineweber , Hanna Tinel
CPC分类号： C07K14/64 , A61K38/00 , C07K16/18 , C07K2319/31 , C07K2319/75
摘要： The present invention provides Relaxin fusion polypeptides A-L-B with a non-wild type array of the Relaxin A-chain and Relaxin B-chain, wherein the A- and B-chains are connected by a linker peptide. The invention further provides Relaxin fusion polypeptides with extended half-life. Furthermore, the invention provides nucleic acid sequences encoding the foregoing fusion polypeptides, vectors containing the same, pharmaceutical compositions and medical use of such fusion polypeptides.
摘要翻译： 本发明提供松弛蛋白融合多肽A-L-B与松弛蛋白A链和松弛蛋白B链的非野生型阵列，其中所述A和B链通过连接肽连接。 本发明进一步提供具有延长的半衰期的松弛素融合多肽。 此外，本发明提供了编码前述融合多肽的核酸序列，含有该融合多肽的载体，药物组合物和这种融合多肽的医学应用。
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公开(公告)号：US20140050743A1
公开(公告)日：2014-02-20
申请号：US13980431
申请日：2012-01-17
申请人： Frank Dittmer , Anja Buchmüller , Christoph Gerdes , Adrian Tersteegen , Mark Jean Gnoth , Lars Linden , Axel Harrenga , Joanna Grudzinska-Goebel , Mario Jeske , Martina Schäfer , Jörg Birkenfeld , Holger Paulsen , Ricarda Finnern , Anke Mayer-Bartschmid , Andrea Eicker , Simone Greven , Susanne Steinig
发明人： Frank Dittmer , Anja Buchmüller , Christoph Gerdes , Adrian Tersteegen , Mark Jean Gnoth , Lars Linden , Axel Harrenga , Joanna Grudzinska-Goebel , Mario Jeske , Martina Schäfer , Jörg Birkenfeld , Holger Paulsen , Ricarda Finnern , Anke Mayer-Bartschmid , Andrea Eicker , Simone Greven , Susanne Steinig
IPC分类号： C07K16/44
CPC分类号： C07K16/44 , A61K2039/505 , A61K2300/00 , C07K2317/55 , C07K2317/76
摘要： The present invention relates to the identification and use of antigen-binding regions, antibodies, antigen-binding antibody fragments and antibody mimetics, neutralizing the anti-coagulant effect of an anticoagulant in vitro and/or in vivo. Antibodies and functional fragments of the invention and antibody mimetics can be used to specifically reverse the pharmacological effect of an anticoagulant e.g. a FXa inhibitor for therapeutic (antidote) and/or diagnostic purposes. The invention also provides nucleic acid sequences encoding foregoing molecules, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
摘要翻译： 本发明涉及抗原结合区，抗体，抗原结合抗体片段和抗体模拟物的鉴定和用途，其中和抗凝血剂在体外和/或体内的抗凝血作用。 本发明的抗体和功能片段和抗体模拟物可用于特异性地逆转抗凝血剂的药理学作用。 用于治疗（解毒剂）和/或诊断目的的FXa抑制剂。 本发明还提供了编码前述分子的核酸序列，含有该分子的载体，药物组合物和具有使用说明书的试剂盒。
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公开(公告)号：US20120321619A1
公开(公告)日：2012-12-20
申请号：US13514789
申请日：2010-12-08
申请人： Lars Linden , Yong-Jiang Cao , Gabriele Leder , Beatrix Stelte-ludwig , Axel Harrenga , Ricarda Finnern , Frank Dittmer , Anke Mayer-Bartschmid , Juergen Franz , Simone Greven , Jörg Willuda , Jan Tebbe
发明人： Lars Linden , Yong-Jiang Cao , Gabriele Leder , Beatrix Stelte-ludwig , Axel Harrenga , Ricarda Finnern , Frank Dittmer , Anke Mayer-Bartschmid , Juergen Franz , Simone Greven , Jörg Willuda , Jan Tebbe
IPC分类号： C07K16/30 , C12N15/85 , A61P35/04 , C12P21/08 , A61K39/395 , C12N1/21 , C12N15/13 , C12N5/10
CPC分类号： C07K16/30 , A61K39/39558 , A61K2039/505 , C07K16/28 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要： The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 29 kDa C4.4a polypeptide, which is over expressed in several tumors, e.g. lung, colorectal, pancreas, prostate, renal and breast cancer. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of C4.4a in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
摘要翻译： 本发明提供重组抗原结合区和抗体以及含有对多个肿瘤中过表达的膜锚定的29kDa C4,4a多肽具有特异性的此类抗原结合区的功能片段。 肺，结肠直肠，胰腺，前列腺，肾和乳腺癌。 因此，这些抗体可用于治疗这些和其他病症和病症。 本发明的抗体也可用于诊断领域，以及用于进一步研究C4.4a在与癌症相关疾病进展中的作用。 本发明还提供了编码前述抗体的核酸序列，含有该抗体的载体，药物组合物和具有使用说明书的试剂盒。
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公开(公告)号：US20140127240A1
公开(公告)日：2014-05-08
申请号：US14113070
申请日：2012-04-20
申请人： Hans-Georg Lerchen , Lars Linden , Sherif El Sheikh , Jörg Willuda , Charlotte C. Kopitz , Joachim Schuhmacher , Simone Greven , Christoph Mahlert , Beatrix Stelte-Ludwig , Sven Golfier , Rudolf Beier , Iring Heisler , Axel Harrenga , Karl-Heinz Thierauch , Sandra Bruder , Heike Petrul , Hannah Jörißen , Sandra Brokowski
发明人： Hans-Georg Lerchen , Lars Linden , Sherif El Sheikh , Jörg Willuda , Charlotte C. Kopitz , Joachim Schuhmacher , Simone Greven , Christoph Mahlert , Beatrix Stelte-Ludwig , Sven Golfier , Rudolf Beier , Iring Heisler , Axel Harrenga , Karl-Heinz Thierauch , Sandra Bruder , Heike Petrul , Hannah Jörißen , Sandra Brokowski
CPC分类号： A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/422 , A61K31/4245 , A61K31/5355 , A61K31/536 , A61K31/537 , A61K31/5377 , A61K39/3955 , A61K45/06 , A61K47/542 , A61K47/6803 , A61K47/6851 , A61K47/6859 , A61K47/6869 , A61K47/6889 , C07K5/0205 , C07K5/0207 , C07K5/06 , C07K5/06034 , C07K5/06052 , C07K5/0606 , C07K7/02 , C07K7/06 , C07K16/18 , C07K16/28 , C07K16/2812 , C07K16/2863 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/565 , C07K2317/76
摘要： The present patent application relates to novel binder-drug conjugates (ADCs) of N,N-dialkylauristatins directed against the target epidermal growth factor receptor (EGFR, gene ID 1956), effective metabolites of these ADCs, methods for producing these ADCs, use of these ADCs for treatment and or prevention of diseases as well as the use of these ADCs to produce pharmaceutical drugs for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic diseases such as cancer, for example. Such treatments may be administered as monotherapy or in combination with other pharmaceutical drugs or other therapeutic measures.
摘要翻译： 本专利申请涉及针对靶表皮生长因子受体（EGFR，基因ID 1956）的N，N-二烷基硫酸锡的新型粘合剂 - 药物共轭物（ADC），这些ADC的有效代谢物，制备这些ADC的方法， 这些ADC用于治疗和/或预防疾病，以及使用这些ADC来制备用于治疗和/或预防疾病，特别是过度增生和/或血管发生疾病例如癌症的药物。 这样的治疗可以作为单一疗法或与其它药物或其他治疗措施组合施用。
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公开(公告)号：US20130066055A1
公开(公告)日：2013-03-14
申请号：US13451950
申请日：2012-04-20
申请人： Hans-Georg Lerchen , Lars Linden , Sherif El Sheikh , Jörg Willuda , Charlotte Christine Kopitz , Joachim Schuhmacher , Simone Greven , Christoph Mahlert , Beatrix Stelte-Ludwig , Sven Golfier , Rudolf Beier , Iring Heisler , Axel Harrenga , Karl-Heinz Thierauch , Sandra Bruder , Heike Petrul , Hannah Jörissen , Sandra Borkowski
发明人： Hans-Georg Lerchen , Lars Linden , Sherif El Sheikh , Jörg Willuda , Charlotte Christine Kopitz , Joachim Schuhmacher , Simone Greven , Christoph Mahlert , Beatrix Stelte-Ludwig , Sven Golfier , Rudolf Beier , Iring Heisler , Axel Harrenga , Karl-Heinz Thierauch , Sandra Bruder , Heike Petrul , Hannah Jörissen , Sandra Borkowski
IPC分类号： C07K17/02
CPC分类号： A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/422 , A61K31/4245 , A61K31/5355 , A61K31/536 , A61K31/537 , A61K31/5377 , A61K39/3955 , A61K45/06 , A61K47/542 , A61K47/6803 , A61K47/6851 , A61K47/6859 , A61K47/6869 , A61K47/6889 , C07K5/0205 , C07K5/0207 , C07K5/06 , C07K5/06034 , C07K5/06052 , C07K5/0606 , C07K7/02 , C07K7/06 , C07K16/18 , C07K16/28 , C07K16/2812 , C07K16/2863 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/565 , C07K2317/76
摘要： The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target C4.4a, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures.
摘要翻译： 本申请涉及针对目标C4.4a的N，N-二烷基硫酸钠的新粘合剂 - 药物共轭物（ADC），这些ADC的活性代谢物，制备这些ADC的方法，使用这些ADC 治疗和/或预防疾病，以及使用这些ADC用于制备用于治疗和/或预防疾病的药物，更特别是过度增殖和/或血管生成疾病，例如癌症疾病。 这样的治疗可以作为单一疗法来实施，或者与其它药物组合或进一步的治疗措施。
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公开(公告)号：US20130291696A1
公开(公告)日：2013-11-07
申请号：US13884485
申请日：2011-11-10
申请人： Conny Gustavsson , Hasse Hultman , Lars Linden , Jim Frolander
发明人： Conny Gustavsson , Hasse Hultman , Lars Linden , Jim Frolander
摘要： The present invention relates to a saw blade for a sawing machine, said sawing machine (10) being arranged for cutting micro trenches by means of said saw blade (1), wherein said micro trenches are adapted for receiving at least one duct/cable; wherein said saw blade comprises mechanical coding means (2) selected from the group consisting of holes, depressions and protrusions arranged on said saw blade (1); and said holes, depressions and protrusions being coding elements for forming at least one code symbol (4) representing a unique identity (ID) for said saw blade.
摘要翻译： 本发明涉及一种用于锯床的锯片，所述锯床（10）用于通过所述锯片（1）切割微沟槽，其中所述微沟槽适用于容纳至少一个管道/电缆; 其中所述锯片包括从由所述锯片（1）上布置的孔，凹陷和突起组成的组中选择的机械编码装置（2）。 并且所述孔，凹陷和突起是用于形成代表所述锯片的唯一标识（ID）的至少一个代码符号（4）的编码元件。
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公开(公告)号：US20050130260A1
公开(公告)日：2005-06-16
申请号：US10736448
申请日：2003-12-15
申请人： Lars Linden , Stefan Prytulla , Thomas Ostermann , Monika Baehner , Tilmann Roos , Andreas Thess , Hans Kiefer , Wolfgang Vogt
发明人： Lars Linden , Stefan Prytulla , Thomas Ostermann , Monika Baehner , Tilmann Roos , Andreas Thess , Hans Kiefer , Wolfgang Vogt
IPC分类号： C07K1/113 , C07K14/705 , C07K14/72 , C12P21/06
CPC分类号： C07K14/723 , C07K1/1136 , C07K14/705
摘要： The present invention relates to a method for preparing a solution of a refolded, recombinantly expressed or chemically synthesized eukaryotic membrane protein in monodisperse form, to methods for preparing a crystalline form of a recombinantly expressed or chemically synthesized membrane protein, to a crystalline form of a recombinantly expressed, or chemically synthesized eukaryotic membrane protein, and to a crystalline form of a complex of a recombinantly expressed or chemically synthesized eukaryotic membrane protein and of an accessory agent.
摘要翻译： 本发明涉及一种制备重折叠，重组表达或化学合成的单分散形式的真核细胞蛋白质的溶液的方法，用于制备重组表达或化学合成的膜蛋白的结晶形式的方法， 重组表达或化学合成的真核膜蛋白，以及重组表达或化学合成的真核细胞蛋白质和辅助剂的复合物的结晶形式。
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