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    CC CHEMOKINE RECEPTOR 5 DNA, NEW ANIMAL MODELS AND THERAPEUTIC AGENTS FOR HIV INFECTION
    1.
    发明申请
    CC CHEMOKINE RECEPTOR 5 DNA, NEW ANIMAL MODELS AND THERAPEUTIC AGENTS FOR HIV INFECTION 审中-公开
    CC CHEMOKINE RECEPTOR 5 DNA，新动物模型和艾滋病毒感染治疗剂

    公开(公告)号：US20110117101A1

    公开(公告)日：2011-05-19

    申请号：US13012482

    申请日：2011-01-24

    申请人： Christophe Combadiere ,  Philip M. Murphy ,  Edward A. Berger

    发明人： Christophe Combadiere ,  Philip M. Murphy ,  Edward A. Berger

    IPC分类号： A61K39/395 ,  A61P31/18 ,  C12N5/071

    CPC分类号： C07K14/7158 ,  A01K2217/05 ,  A61K38/00

    摘要： The susceptibility of human macrophages to human immunodeficiency virus (HIV) infection depends on cell surface expression of the human CD4 molecule and CC cytokine receptor 5. CCR5 is a member of the 7-transmembrane segment superfamily of G-protein-coupled cell surface molecules. CCR5 plays an essential role in the membrane fusion step of infection by some HIV isolates. The establishment of stable, nonhuman cell lines and transgenic mammals having cells that coexpress human CD4 and CCR5 provides valuable tools for the continuing research of HIV infection. In addition, antibodies which bind to CCR5, CCR5 variants, and CCR5-binding agents, capable of blocking membrane fusion between HIV and target cells represent potential anti-HIV therapeutics for macrophage-tropic strains of HIV.

    摘要翻译： 人类巨噬细胞对人类免疫缺陷病毒（HIV）感染的易感性取决于人CD4分子和CC细胞因子受体5的细胞表面表达。CCR5是G蛋白偶联细胞表面分子的7-跨膜段超家族的成员。 CCR5在一些HIV分离物感染的膜融合步骤中起着重要作用。 建立稳定的非人细胞系和具有共表达人CD4和CCR5的细胞的转基因哺乳动物为继续研究艾滋病毒感染提供了宝贵的工具。 此外，结合CCR5，CCR5变体和CCR5结合剂的能够阻断HIV和靶细胞之间的膜融合的抗体代表了HIV巨噬细胞趋化株的潜在的抗HIV治疗剂。

    CC chemokine receptor 5 DNA, new animal models and therapeutic agents for HIV infection
    4.
    发明授权
    CC chemokine receptor 5 DNA, new animal models and therapeutic agents for HIV infection 有权
    CC趋化因子受体5 DNA，新型动物模型和HIV感染治疗剂

    公开(公告)号：US08198042B2

    公开(公告)日：2012-06-12

    申请号：US10846185

    申请日：2004-05-14

    申请人： Christophe Combadiere ,  Philip M. Murphy

    发明人： Christophe Combadiere ,  Philip M. Murphy

    IPC分类号： C12N15/12 ,  C07K14/705

    CPC分类号： C07K14/7158 ,  A01K2217/05 ,  A61K38/00

    摘要： The susceptibility of human macrophages to human immunodeficiency virus (HIV) infection depends on cell surface expression of the human CD4 molecule and CC cytokine receptor 5. CCR5 is a member of the 7-transmembrane segment superfamily of G-protein-coupled cell surface molecules. CCR5 plays an essential role in the membrane fusion step of infection by some HIV isolates. The establishment of stable, nonhuman cell lines and transgenic mammals having cells that coexpress human CD4 and CCR5 provides valuable tools for the continuing research of HIV infection. In addition, antibodies which bind to CCR5, CCR5 variants, and CCR5-binding agents, capable of blocking membrane fusion between HIV and target cells represent potential anti-HIV therapeutics for macrophage-tropic strains of HIV.

    摘要翻译： 人类巨噬细胞对人类免疫缺陷病毒（HIV）感染的易感性取决于人CD4分子和CC细胞因子受体5的细胞表面表达。CCR5是G蛋白偶联细胞表面分子的7-跨膜段超家族的成员。 CCR5在一些HIV分离物感染的膜融合步骤中起着重要作用。 建立稳定的非人细胞系和具有共表达人CD4和CCR5的细胞的转基因哺乳动物为继续研究艾滋病毒感染提供了宝贵的工具。 此外，结合CCR5，CCR5变体和CCR5结合剂的能够阻断HIV和靶细胞之间的膜融合的抗体代表了HIV巨噬细胞趋化株的潜在的抗HIV治疗剂。

    CC chemokine receptor 5 DNA, new animal models and therapeutic agents for HIV infection
    5.
    发明授权
    CC chemokine receptor 5 DNA, new animal models and therapeutic agents for HIV infection 有权
    CC趋化因子受体5 DNA，新型动物模型和HIV感染治疗剂

    公开(公告)号：US07374872B2

    公开(公告)日：2008-05-20

    申请号：US11594375

    申请日：2006-11-07

    申请人： Christophe Combadiere ,  Philip M. Murphy

    发明人： Christophe Combadiere ,  Philip M. Murphy

    IPC分类号： C12Q1/00

    CPC分类号： C07K14/7158 ,  A01K2217/05 ,  A61K38/00

    摘要： The susceptibility of human macrophages to human immunodeficiency virus (HIV) infection depends on cell surface expression of the human CD4 molecule and CC cytokine receptor 5. CCR5 is a member of the 7-transmembrane segment superfamily of G-protein-coupled cell surface molecules. CCR5 plays an essential role in the membrane fusion step of infection by some HIV isolates. The establishment of stable, nonhuman cell lines and transgenic mammals having cells that coexpress human CD4 and CCR5 provides valuable tools for the continuing research of HIV infection. In addition, antibodies which bind to CCR5, CCR5 variants, and CCR5-binding agents, capable of blocking membrane fusion between HIV and target cells represent potential anti-HIV therapeutics for macrophage-tropic strains of HIV.

    摘要翻译： 人类巨噬细胞对人类免疫缺陷病毒（HIV）感染的易感性取决于人CD4分子和CC细胞因子受体5的细胞表面表达。CCR5是G蛋白偶联细胞表面分子的7-跨膜段超家族的成员。 CCR5在一些HIV分离物感染的膜融合步骤中起着重要作用。 建立稳定的非人细胞系和具有共表达人CD4和CCR5的细胞的转基因哺乳动物为继续研究艾滋病毒感染提供了宝贵的工具。 此外，结合CCR5，CCR5变体和CCR5结合剂的能够阻断HIV和靶细胞之间的膜融合的抗体代表了HIV巨噬细胞趋化株的潜在的抗HIV治疗剂。

    Amino acid sequence for a functional human interleukin-8 receptor
    7.
    发明授权
    Amino acid sequence for a functional human interleukin-8 receptor 失效
    功能性人白细胞介素-8受体的氨基酸序列

    公开(公告)号：US5374506A

    公开(公告)日：1994-12-20

    申请号：US759568

    申请日：1991-09-13

    申请人： Philip M. Murphy

    发明人： Philip M. Murphy

    IPC分类号： A61K38/00 ,  C07K14/715 ,  C07K13/00

    CPC分类号： C07K14/715 ,  A61K38/00

    摘要： A cDNA clone from HL60 neutrophils, designated p2, which encodes a human interleukin-8 receptor. This IL-8 receptor can be expressed in oocytes or transfected host cells. This receptor has 77% amino acid identity with a second human neutrophil receptor isotype that also binds IL-8. It also exhibits 69% amino acid identity with a protein reported to be an N-formyl peptide receptor from rabbit neutrophils.

    摘要翻译： 来自HL60嗜中性粒细胞的cDNA克隆，命名为p2，其编码人白细胞介素-8受体。 该IL-8受体可以在卵母细胞或转染的宿主细胞中表达。 该受体与也能结合IL-8的第二人嗜中性粒细胞受体同种型具有77％的氨基酸同一性。 它还与来自兔嗜中性粒细胞的报道为N-甲酰基肽受体的蛋白质显示69％的氨基酸同一性。

    Cloning and expression of the human macrophage inflammatory protein-1.alpha . .alpha.) /rantes receptor
    9.
    发明授权
    Cloning and expression of the human macrophage inflammatory protein-1.alpha . .alpha.) /rantes receptor 失效
    克隆和表达人巨噬细胞炎症蛋白-1（MIP-1α）/兰特受体

    公开(公告)号：US5652133A

    公开(公告)日：1997-07-29

    申请号：US12988

    申请日：1993-01-28

    申请人： Philip M. Murphy

    发明人： Philip M. Murphy

    IPC分类号： C07K14/715 ,  C12N15/12 ,  C07K14/705

    CPC分类号： C07K14/715

    摘要： This invention provides for the cloning and expression of the human Macrophage Inflammatory Protein-1.alpha. (MIP-1.alpha.)/RANTES Receptor. This receptor binds two cytokines MIP-1.alpha. and RANTES which are pro-inflammatory cytokines. The receptor is useful for assaying the levels of these cytokines in biological specimens. These cytokines play key roles in the inflammatory processes afflicting man.

    摘要翻译： 本发明提供人巨噬细胞炎症蛋白-1（MIP-1α）/ RANTES受体的克隆和表达。 该受体结合作为促炎细胞因子的两种细胞因子MIP-1α和RANTES。 该受体可用于测定生物标本中这些细胞因子的水平。 这些细胞因子在患有炎症过程的人中起关键作用。