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    INDUSTRIAL PRODUCTION OF ORGANIC COMPOUNDS USING RECOMBINANT ORGANISMS EXPRESSING METHYL HALIDE TRANSFERASE
    1.
    发明申请
    INDUSTRIAL PRODUCTION OF ORGANIC COMPOUNDS USING RECOMBINANT ORGANISMS EXPRESSING METHYL HALIDE TRANSFERASE 审中-公开
    使用表达甲基卤化物转移酶的重组体进行工业化生产有机化合物

    公开(公告)号：US20110151534A1

    公开(公告)日：2011-06-23

    申请号：US12745538

    申请日：2008-11-26

    申请人： Christopher A. Voigt ,  Daniel V. Santi ,  Travis S. Bayer

    发明人： Christopher A. Voigt ,  Daniel V. Santi ,  Travis S. Bayer

    IPC分类号： C12P1/02 ,  C12N1/13 ,  C12N1/15 ,  C12N1/21 ,  C12N1/19

    CPC分类号： C12N9/10 ,  C12P5/00 ,  Y02E50/16

    摘要： The invention relates to a process for production of organic compounds using genetically engineered organisms expressing a S-adenosylmethionine (SAM)-dependent methyl halide transferase and, optionally modified at loci that affect flux through SAM metabolic pathways or affect intracellular halide levels. In one approach the organism, halides (chlorine, bromine and/or iodine); and a carbon source are incubated in a cultivation medium under conditions in which methyl halide is produced. The methyl halide may be collected and converted into non-halogenated organic molecules.

    摘要翻译： 本发明涉及使用表达S-腺苷甲硫氨酸（SAM） - 依赖性甲基卤转移酶的遗传工程生物生产有机化合物的方法，并且任选地在通过SAM代谢途径影响通过或影响细胞内卤化物水平的位点处修饰。 在一种方法中，生物体，卤化物（氯，溴和/或碘）; 并将碳源在培养基中在产生甲基卤的条件下培养。 甲基卤可以被收集并转化成非卤化的有机分子。

    CONTROLLED DRUG RELEASE FROM DENDRIMERS
    2.
    发明申请
    CONTROLLED DRUG RELEASE FROM DENDRIMERS 有权
    控制药物从DENDRIMERS发布

    公开(公告)号：US20130123461A1

    公开(公告)日：2013-05-16

    申请号：US13696301

    申请日：2011-05-05

    申请人： Gary Ashley ,  Daniel V. Santi

    发明人： Gary Ashley ,  Daniel V. Santi

    IPC分类号： A61K47/48

    CPC分类号： A61K47/48315 ,  A61K38/2242 ,  A61K38/26 ,  A61K38/50 ,  A61K47/60 ,  A61K47/641 ,  A61K47/645 ,  C08G83/003 ,  C08G83/004

    摘要： The invention relates to compositions that comprise dendrimers useful in medical and veterinary applications that provide controlled release of drugs, such as peptides, nucleic acids and small molecules. The drugs are covalently coupled to the dendrimer through a linkage that releases the drug or a prodrug through controlled beta elimination.

    摘要翻译： 本发明涉及包含用于医学和兽医学应用中的树枝状大分子的组合物，其提供药物（例如肽，核酸和小分子）的受控释放。 这些药物通过通过对照β消除释放药物或前药的连接共价偶联到树状聚合物上。

    Modified peptide and peptide libraries with protease resistance, derivatives thereof and methods of producing and screening such
    6.
    发明授权
    Modified peptide and peptide libraries with protease resistance, derivatives thereof and methods of producing and screening such 失效
    具有蛋白酶抗性的修饰肽和肽文库，其衍生物以及生产和筛选方法

    公开(公告)号：US6075121A

    公开(公告)日：2000-06-13

    申请号：US438436

    申请日：1995-05-10

    申请人： Reyna J. Simon ,  Paul A. Bartlett ,  Daniel V. Santi

    发明人： Reyna J. Simon ,  Paul A. Bartlett ,  Daniel V. Santi

    IPC分类号： A61K38/00 ,  A61K47/48 ,  B01J19/00 ,  C07H21/00 ,  C07K1/04 ,  C07K5/02 ,  C07K7/02 ,  C07K14/00 ,  C40B40/10 ,  C40B60/14

    CPC分类号： C07H21/00 ,  A61K47/48238 ,  B01J19/0046 ,  C07K1/045 ,  C07K1/047 ,  C07K14/001 ,  C07K5/0207 ,  C07K7/02 ,  A61K38/00 ,  B01J2219/00283 ,  B01J2219/00286 ,  B01J2219/00308 ,  B01J2219/00416 ,  B01J2219/00418 ,  B01J2219/00423 ,  B01J2219/00466 ,  B01J2219/00493 ,  B01J2219/005 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00691 ,  B01J2219/00725 ,  C07B2200/11 ,  C40B40/10 ,  C40B60/14

    摘要： Peptoids are provided which are polymers comprised of monomer units wherein the monomer units include at least some substitute amino acids and may include conventional amino acids. The peptoids can be synthesized in large numbers so as to provide libraries of peptoids which can be screened in order to isolate peptoids of desired biological activity. Although the peptoids may include amino acids, they preferably include only substituted amino acids and are designed in a manner so as to have a particular biological activity. Certain peptoids are designed to mimic as closely as possible the activity of known proteins. Other peptoids are designed so as to have greater or lesser activity than known proteins and may be designed so as to block known receptor sites and/or elicit a desired immunogenic response and thereby act as vaccines. In that the peptoids are comprised of substitute amino acids they can be designed to have structures which natural proteins cannot conform to. A range of different amino acid substitutes are disclosed, as are their methods of synthesis and methods of using such amino acid substitutes in the synthesis of peptoids and peptoid libraries. Methods of screening the libraries in order to obtain desired peptoids of a particular biological activity are also disclosed. The peptoids are preferably linked to a pharmaceutically active drug forming a conjugate with increased binding affinity to a particular biological receptor site.

    摘要翻译： 提供了由单体单元组成的聚合物，其中单体单元包括至少一些替代氨基酸并且可以包括常规氨基酸。 可以大量合成拟肽，以便提供可以筛选的拟肽文库，以分离所需生物活性的拟肽。 虽然拟肽可以包括氨基酸，但它们优选仅包括取代的氨基酸，并且以具有特定生物活性的方式设计。 某些拟肽被设计为尽可能模拟已知蛋白质的活性。 其他拟肽被设计为具有比已知蛋白质更大或更小的活性，并且可以被设计成阻断已知的受体位点和/或引发所需的免疫原性应答并由此作为疫苗。 因为拟肽由替代氨基酸组成，它们可被设计成具有天然蛋白质不能符合的结构。 公开了一系列不同的氨基酸替代物，以及它们的合成方法以及在合成拟肽和拟肽文库中使用这种氨基酸替代物的方法。 还公开了为了获得特定生物活性所需的拟肽而筛选文库的方法。 拟肽优选与形成具有对特定生物受体位点的增加的结合亲和力的缀合物的药学活性药物连接。

    Method of obtaining a peptide with desired target property
    8.
    发明授权
    Method of obtaining a peptide with desired target property 失效
    获得具有所需靶特性的肽的方法

    公开(公告)号：US5438119A

    公开(公告)日：1995-08-01

    申请号：US981759

    申请日：1992-11-25

    申请人： William J. Rutter ,  Daniel V. Santi

    发明人： William J. Rutter ,  Daniel V. Santi

    IPC分类号： A61K38/02 ,  C07K1/04 ,  C07K1/14 ,  C07K1/36 ,  C07K5/00 ,  C07K7/00 ,  G01N33/68 ,  A61K38/00 ,  C07K17/00

    CPC分类号： C07K1/047 ,  C07K1/36 ,  G01N33/68

    摘要： A method to obtain selected individual peptides or families thereof which have a target property and optionally to determine the amino acid sequence of a selected peptide or peptides to permit synthesis in practical quantities is disclosed. In general outline, the method of the invention comprises synthesizing a mixture of randomly or deliberately generated peptides using standard synthesis techniques, but adjusting the individual concentrations of the components of a mixture of sequentially added amino acids according to the coupling constants for each amino acid/amino acid coupling. The subgroup of peptides having the target property can then be selected, and either each peptide isolated and sequenced, or analysis performed on the mixture to permit its composition to be reproduced. Also included in the invention is an efficient method to determine the relevant coupling constants.

    摘要翻译： 公开了获得具有目标特性并任选地确定所选择的肽或肽的氨基酸序列以允许实际合成的所选单独肽或其家族的方法。 总的来说，本发明的方法包括使用标准合成技术合成随机或故意产生的肽的混合物，但是根据每个氨基酸/偶联物的偶联常数调节相继添加的氨基酸的混合物的组分的个体浓度， 氨基酸偶联。 然后可以选择具有靶特性的肽亚组，并且分离和测序每个肽，或对混合物进行分析以允许其复制其组成。 本发明还包括确定相关耦合常数的有效方法。

    Peptide mixtures
    9.
    发明授权
    Peptide mixtures 失效
    肽混合物

    公开(公告)号：US5266684A

    公开(公告)日：1993-11-30

    申请号：US525899

    申请日：1990-05-18

    申请人： William J. Rutter ,  Daniel V. Santi

    发明人： William J. Rutter ,  Daniel V. Santi

    IPC分类号： A61K38/02 ,  C07K1/04 ,  C07K1/14 ,  C07K1/36 ,  C07K5/00 ,  C07K7/00 ,  G01N33/68 ,  C07K1/08

    CPC分类号： C07K1/047 ,  C07K1/36 ,  G01N33/68

    摘要： A method to obtain selected individual peptides or families thereof which have a target property and optionally to determine the amino acid sequence of a selected peptide or peptides to permit synthesis in practical quantities is disclosed. In general outline, the method of the invention comprises synthesizing a mixture of randomly or deliberately generated peptides using standard synthesis techniques, but adjusting the individual concentrations of the components of a mixture of sequentially added amino acids according to the coupling constants for each amino acid/amino acid coupling. The subgroup of peptides having the target property can then be selected, and either each peptide isolated and sequenced, or analysis performed on the mixture to permit its composition to be reproduced. Also included in the invention is an efficient method to determine the relevant coupling constants.

    摘要翻译： 公开了获得具有目标特性并任选地确定所选择的肽或肽的氨基酸序列以允许实际合成的所选单独肽或其家族的方法。 总的来说，本发明的方法包括使用标准合成技术合成随机或故意产生的肽的混合物，但是根据每个氨基酸/偶联物的偶联常数调节相继添加的氨基酸的混合物的组分的个体浓度， 氨基酸偶联。 然后可以选择具有靶特性的肽亚组，并且分离和测序每个肽，或对混合物进行分析以允许其复制其组成。 本发明还包括确定相关耦合常数的有效方法。