公开(公告)号：US20080233585A1

公开(公告)日：2008-09-25

申请号：US12047358

申请日：2008-03-13

申请人： Christopher Burgess ,  Susan Myerow ,  Arunthathi Thiagalingam ,  Peter Maimonis ,  Gary Molino ,  Lawrence Burgart ,  Lisa Allyn Boardman ,  Stephen Thibodeau ,  Marcia Lewis

发明人： Christopher Burgess ,  Susan Myerow ,  Arunthathi Thiagalingam ,  Peter Maimonis ,  Gary Molino ,  Lawrence Burgart ,  Lisa Allyn Boardman ,  Stephen Thibodeau ,  Marcia Lewis

IPC分类号： C12Q1/68 ,  C07K16/18 ,  G01N33/53

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/136

摘要： The present invention relates to novel marker sequences that are differentially expressed in cancer cells or tissue of a subject with cancerous conditions. The present invention also relates to assays for diagnosis, prognosis, staging, monitoring, therapeutic treatment, and marker sequence related agents including probes, primers, antibodies, and therapeutic compositions.

摘要翻译： 本发明涉及在具有癌症病症的受试者的癌细胞或组织中差异表达的新型标记序列。 本发明还涉及用于诊断，预后，分期，监测，治疗性治疗和包括探针，引物，抗体和治疗组合物的标记序列相关试剂的测定。

公开(公告)号：US20060188889A1

公开(公告)日：2006-08-24

申请号：US10700439

申请日：2003-11-04

申请人： Christopher Burgess ,  Susan Myerow ,  Arunthathi Thiagalingam ,  Peter Maimonis ,  Gary Molino ,  Lawrence Burgart ,  Lisa Boardman ,  Stephen Thibodeau ,  Marcia Lewis

发明人： Christopher Burgess ,  Susan Myerow ,  Arunthathi Thiagalingam ,  Peter Maimonis ,  Gary Molino ,  Lawrence Burgart ,  Lisa Boardman ,  Stephen Thibodeau ,  Marcia Lewis

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/136

摘要： The present invention relates to novel marker sequences that are differentially expressed in cancer cells or tissue of a subject with cancerous conditions. The present invention also relates to assays for diagnosis, prognosis, staging, monitoring, therapeutic treatment, and marker sequence related agents including probes, primers, antibodies, and therapeutic compositions.

摘要翻译： 本发明涉及在具有癌症病症的受试者的癌细胞或组织中差异表达的新型标记序列。 本发明还涉及用于诊断，预后，分期，监测，治疗性治疗和包括探针，引物，抗体和治疗组合物的标记序列相关试剂的测定。

公开(公告)号：US20060134653A1

公开(公告)日：2006-06-22

申请号：US11105233

申请日：2005-04-13

申请人： Christopher Burgess ,  Theodore Catino ,  Gary Molino ,  Susan Myerow ,  Arunthathi Thiagalingam ,  Marcia Lewis ,  Stephen Thibodeau ,  Lisa Boardman ,  Lawrence Burgart

发明人： Christopher Burgess ,  Theodore Catino ,  Gary Molino ,  Susan Myerow ,  Arunthathi Thiagalingam ,  Marcia Lewis ,  Stephen Thibodeau ,  Lisa Boardman ,  Lawrence Burgart

IPC分类号： C12Q1/68

CPC分类号： G01N33/574 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156 ,  G01N33/57419 ,  G01N2500/00 ,  G01N2800/52

摘要： The present invention relates to nucleic acid sequences which are overexpressed in colorectal tumors which display a high level of microsatellite instability (MSI-H) vs. tumors displaying a low level of microsatellite instability (MSS), and can thus be used to identify MSI-H in a patient, and be used further to facilitate patient prognosis, monitor disease progression/regression, identify appropriate treatment regimes, and evaluate the efficacy of treatment.

摘要翻译： 本发明涉及在显示高水平的微卫星不稳定性（MSI-H）与显示低水平微卫星不稳定性（MSS）的肿瘤的结直肠肿瘤中过表达的核酸序列，因此可用于鉴定MSI- H，并进一步用于促进患者预后，监测疾病进展/消退，确定适当的治疗方案，并评估治疗的疗效。

公开(公告)号：US20060179496A1

公开(公告)日：2006-08-10

申请号：US11190172

申请日：2005-07-26

申请人： Christopher Burgess ,  Jon Astle ,  Eddie Carroll ,  Theodore Catino ,  Poornima Dwivedi ,  Gary Molino ,  Arunthathi Thiagalingam ,  Marcia Lewis ,  Stephen Thibodeau ,  Lawrence Burgart ,  Lisa Boardman

发明人： Christopher Burgess ,  Jon Astle ,  Eddie Carroll ,  Theodore Catino ,  Poornima Dwivedi ,  Gary Molino ,  Arunthathi Thiagalingam ,  Marcia Lewis ,  Stephen Thibodeau ,  Lawrence Burgart ,  Lisa Boardman

IPC分类号： A01K67/027 ,  C07K14/82 ,  C12Q1/68 ,  C07H21/04 ,  C12P21/06

CPC分类号： G01N33/6893 ,  A01K2217/05 ,  A61K38/00 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/574 ,  G01N33/57419 ,  G01N2500/00

摘要： This invention relates to novel nucleic acid sequences which are differentially expressed in cancer cells. The invention also relates to proteins and peptides encoded by the sequences, to diagnostic assays and therapeutic agents based on the sequences and proteins, and to probes, antisense constructs, and antibodies derived from the sequences and proteins or peptides. The subject nucleic acids have been found to be differentially expressed by tumor cells, particularly in colon cancer tissue.

摘要翻译： 本发明涉及在癌细胞中差异表达的新型核酸序列。 本发明还涉及由序列编码的蛋白质和肽，基于序列和蛋白质的诊断测定和治疗剂，以及衍生自序列和蛋白质或肽的探针，反义构建体和抗体。 已经发现目标核酸被肿瘤细胞差异表达，特别是在结肠癌组织中。

公开(公告)号：US20050266493A1

公开(公告)日：2005-12-01

申请号：US11186284

申请日：2005-07-21

申请人： Allison Berger ,  Tracy Guillemette ,  Robert Schlegel ,  John Monahan ,  Shubhangi Kamatkar ,  Stephen Thibodeau ,  Lawrence Burgart

发明人： Allison Berger ,  Tracy Guillemette ,  Robert Schlegel ,  John Monahan ,  Shubhangi Kamatkar ,  Stephen Thibodeau ,  Lawrence Burgart

IPC分类号： C07K14/47 ,  C12Q1/68 ,  C07H21/04 ,  C07K14/82

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/158

摘要： The invention relates to newly discovered nucleic acid molecules and proteins associated with colon cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human colon cancers are provided.

摘要翻译： 本发明涉及新发现的与结肠癌相关的核酸分子和蛋白质。 提供了用于检测，表征，预防和治疗人类结肠癌的组合物，试剂盒和方法。