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    N-OXIDES OF DIARYLUREA DERIVATIVES AND THEIR USE AS Chk1 INHIBITORS FOR THE TREATMENT OF CANCER
    3.
    发明申请
    N-OXIDES OF DIARYLUREA DERIVATIVES AND THEIR USE AS Chk1 INHIBITORS FOR THE TREATMENT OF CANCER 审中-公开
    二恶嗪衍生物的N-氧化物及其作为治疗癌症的Chk1抑制剂的用途

    公开(公告)号：US20090270416A1

    公开(公告)日：2009-10-29

    申请号：US12304345

    申请日：2007-06-08

    申请人： Robert George Boyle ,  Stuart Travers

    发明人： Robert George Boyle ,  Stuart Travers

    IPC分类号： A61K31/4965 ,  C07D241/02 ,  C07D401/04

    CPC分类号： C07D401/12 ,  C07D213/75 ,  C07D241/20

    摘要： The invention provides a Chk-1 kinase inhibiting compound of the formula (I) or a salt, solvate or tautomer thereof, wherein: G is CH2, O, NH, NHCO or CONH; A is a group (CH2)n where n is 1 to 4 provided that when G is O or NH, n is at least 2; X1 is nitrogen or CH; X2 is nitrogen or a group CR5; X3 is nitrogen or a group CR5; X4 is nitrogen or CH; provided that no more than two of X2, X3 and X4 are nitrogen; and R1; R2; R3; R4; R5 and R6 are as defined in the claims.

    摘要翻译： 本发明提供抑制式（I）的Chk-1激酶抑制化合物或其盐，溶剂合物或互变异构体，其中：G为CH 2，O，NH，NHCO或CONH; A是基团（CH 2）n，其中n为1至4，条件是当G为O或NH时，n为至少2; X1是氮或CH; X2是氮或基团CR5; X3是氮或基团CR5; X4是氮或CH; 条件是X2，X3和X4中不超过2个为氮; 和R1; R2; R3; R4; R5和R6如权利要求中所定义。