公开(公告)号：US08337379B2

公开(公告)日：2012-12-25

申请号：US11772692

申请日：2007-07-02

申请人： Christopher Fletcher ,  William Sweat ,  Jeremy Kolenbrander ,  Aditya Dalvi ,  John R. Linder

发明人： Christopher Fletcher ,  William Sweat ,  Jeremy Kolenbrander ,  Aditya Dalvi ,  John R. Linder

IPC分类号： B04B9/10 ,  B04B13/00 ,  A61M37/00

CPC分类号： B04B13/00 ,  B04B5/0442 ,  B04B15/00 ,  B04B2013/006 ,  G01N15/042 ,  G01N15/05 ,  G01N33/491 ,  G06T7/0012 ,  G06T7/12 ,  G06T7/181 ,  G06T2207/10016 ,  G06T2207/20068 ,  G06T2207/30024 ,  H04N7/18

摘要： A centrifuge for separating blood having a camera observing fluid flow, and a controller controlling the flow. The location of an interface is detected by image processing steps, which may comprise the steps of “spoiling” the image, “diffusing” the image, “edge detection”, “edge linking”, “region-based confirmation”, and “interface calculation”. “Spoiling” reduces the number of pixels to be examined preferentially on orthogonal axis oriented with respect to the expected location of the interface or phase boundary. “Diffusing” smoothes out small oscillations in the interface boundary, making the location of the interface more distinct. “Edge detection” computes the rate of change in pixel intensity, or. “Edge linking” connects adjacent maxima. “Region-based confirmation” creates a pseudo image of the regions that qualify as distinct. “Final edge calculation” uses the points where the shade changes in the pseudo image, averages the radial displacement of these points for the interface position.

摘要翻译： 一种离心机，用于分离具有观察流体流动的相机的血液，以及控制该流量的控制器。 通过图像处理步骤检测接口的位置，其可以包括破坏图像，扩散图像，边缘检测，边缘链接，基于区域的确认和接口计算的步骤。 扰乱减少了相对于接口或相位边界的预期位置定向的正交轴上优先检查的像素数。 扩散平滑了界面边界的小振荡，使界面的位置更加明显。 边缘检测计算像素强度的变化率，或。 边缘连接连接相邻的最大值。 基于区域的确认将创建符合不同区域的区域的伪图像。 最终边缘计算使用伪图像中阴影变化的点，对接口位置的这些点的径向位移进行平均。

公开(公告)号：US20080041772A1

公开(公告)日：2008-02-21

申请号：US11774073

申请日：2007-07-06

申请人： William Sweat ,  Jeremy Kolenbrander ,  John R. Lindner

发明人： William Sweat ,  Jeremy Kolenbrander ,  John R. Lindner

IPC分类号： B04B13/00

CPC分类号： G01N15/042 ,  B04B5/0442 ,  B04B13/00 ,  B04B2013/006 ,  G01N15/05 ,  G01N33/491 ,  G06T7/0012 ,  G06T7/12 ,  G06T7/181 ,  G06T2207/10016 ,  G06T2207/20068 ,  G06T2207/30024

摘要： A density centrifuge blood processing system comprising a separation chamber rotating about a central rotation axis, the separation chamber having an outflow passage, a light source in optical communication with the density centrifuge blood processing system, the light source providing an incident light beam for illuminating an observation region and a viewing region on the outflow passage, a first detector for the separation chamber to detect light from the observation region, a second detector for the outflow passage, a computational apparatus distinguishing one or more phase boundaries in the observation region and distinguishing fluid composition in the viewing region as a function of light intensity received from the viewing region, and a controller regulating speed of at least one pump or of said separation chamber in response to signals from the computational apparatus.

摘要翻译： 1.一种密度离心机血液处理系统，包括围绕中心旋转轴线旋转的分离室，所述分离室具有流出通道，与所述密度离心机血液处理系统光学连通的光源，所述光源提供入射光束以照射 观察区域和流出通道上的观察区域，用于检测来自观察区域的光的分离室的第一检测器，用于流出通道的第二检测器，区分观察区域中的一个或多个相位边界的识别流体 观察区域中的组成作为从观察区域接收的光强度的函数，以及控制器响应于来自计算设备的信号调节至少一个泵或所述分离室的速度。

公开(公告)号：US08066888B2

公开(公告)日：2011-11-29

申请号：US12238697

申请日：2008-09-26

申请人： William Sweat ,  Jeremy Kolenbrander ,  John R. Lindner ,  Jennifer Hinz

发明人： William Sweat ,  Jeremy Kolenbrander ,  John R. Lindner ,  Jennifer Hinz

IPC分类号： B01D21/32

CPC分类号： A61M1/3693 ,  A61M1/3696 ,  A61M2205/123 ,  A61M2205/3313

摘要： A blood cell collection system having means for detecting when a cell separation chamber has filled with white blood cells, and flushing the cells out of the cell separation chamber into a collect bag. A red-green sensor senses the optical characteristics of fluid leaving the cell separation chamber. A baseline value is calculated. The device calculates a ratio of the intensities of red light and green light and a peak-to-peak ratio of intensities. If either ratio exceeds thresholds computed from the baseline, the device flushes the cells into the collect bag. A camera detects white cells passing into the cell separation chamber and the device calculates the number of cells being collected. If the calculated number of collected cells exceeds a certain limit, the cell separation chamber is flushed. If the device is unable to establish a baseline, the donation can proceed, relying solely on the calculated number of collected cells.

摘要翻译： 一种血细胞收集系统，其具有用于检测细胞分离室何时已经填充有白细胞的装置，并且将细胞从细胞分离室冲洗成收集袋。 红绿色传感器检测离开细胞分离室的流体的光学特性。 计算基准值。 该装置计算红光和绿光的强度与强度的峰 - 峰比的比率。 如果任一比例超过从基线计算的阈值，则设备将细胞冲洗到收集袋中。 相机检测到进入细胞分离室的白细胞，并且该装置计算正在收集的细胞数量。 如果计算得到的细胞数超过一定限度，则细胞分离室被冲洗。 如果设备无法建立基线，捐赠可以继续进行，仅依赖于计算的收集细胞数。

公开(公告)号：US07072769B2

公开(公告)日：2006-07-04

申请号：US09797325

申请日：2001-03-01

申请人： Peter Fletcher-Haynes ,  William Sweat ,  Richard Judy ,  Scott Butzke ,  Kim Pemberton ,  Frank Corbin, III ,  Robert W. Langley ,  Steven Gage Urdahl ,  Christopher Fletcher

发明人： Peter Fletcher-Haynes ,  William Sweat ,  Richard Judy ,  Scott Butzke ,  Kim Pemberton ,  Frank Corbin, III ,  Robert W. Langley ,  Steven Gage Urdahl ,  Christopher Fletcher

IPC分类号： G01N33/48 ,  G01N33/50

CPC分类号： A61M1/0286 ,  A61M1/30 ,  A61M1/3496 ,  A61M1/3693 ,  A61M1/38 ,  A61M1/387 ,  A61M2205/35 ,  A61M2205/3561 ,  A61M2205/505 ,  A61M2205/84 ,  G06F19/00 ,  G06F19/325 ,  G06F19/3418 ,  G06Q50/22 ,  G16H10/60 ,  G16H15/00 ,  G16H40/63

摘要： A blood component collection system with manipulation and optimization capabilities. In one embodiment, process parameters are derived from an input/configured predetermined blood component yield and which is based upon the maximization of at least one process parameter. Thereafter, the blood component collection procedure is performed with these derived process control parameters. In another embodiment, process parameters are derived from an input total procedure time from a maximized value for at least one of the other process control parameters so as to maximize blood component yield in this fixed time. Thereafter, the blood component collection procedure is performed with these derived parameters.

摘要翻译： 具有操作和优化功能的血液成分收集系统。 在一个实施例中，过程参数是根据输入/配置的预定血液成分产量导出的，并且其基于至少一个过程参数的最大化。 此后，使用这些导出的过程控制参数来执行血液成分收集过程。 在另一个实施例中，从至少一个其它过程控制参数的最大值的输入总程序时间导出过程参数，以便在该固定时间内使血液成分产量最大化。 此后，用这些导出的参数进行血液成分收集过程。

公开(公告)号：US07951059B2

公开(公告)日：2011-05-31

申请号：US12233185

申请日：2008-09-18

申请人： William Sweat

发明人： William Sweat

IPC分类号： B04B15/00

CPC分类号： G01N15/042 ,  G01N15/05 ,  G01N2015/045

摘要： A density centrifuge blood processing system with automatic two-dimensional optical control of fluid separation by observing fluid characteristics in observation regions. The location of the regions is determined by monitoring an optical reference. Points representing edges of an optical reference are measured and lines are computed through the points. An error measurement is calculated for each line. If the error is too large, the image is abandoned. One of the lines is selected as a referent line. A new line is calculated orthogonal to the referent line. The error function is again computed for the dependant line. If the error exceeds a selected maximum, the frame is discarded. A transformation function translates data points from an (r, s) domain derived from measurements of the edges into an (x, y) domain used to identify pixels in the observation areas.

公开(公告)号：US20100065507A1

公开(公告)日：2010-03-18

申请号：US12233185

申请日：2008-09-18

申请人： William Sweat

发明人： William Sweat

IPC分类号： B01D35/14

CPC分类号： G01N15/042 ,  G01N15/05 ,  G01N2015/045

摘要： A density centrifuge blood processing system with automatic two-dimensional optical control of fluid separation by observing fluid characteristics in observation regions. The location of the regions is determined by monitoring an optical reference. Points representing edges of an optical reference are measured and lines are computed through the points. An error measurement is calculated for each line. If the error is too large, the image is abandoned. One of the lines is selected as a referent line. A new line is calculated orthogonal to the referent line. The error function is again computed for the dependant line. If the error exceeds a selected maximum, the frame is discarded. A transformation function translates data points from an (r, s) domain derived from measurements of the edges into an (x, y) domain used to identify pixels in the observation areas.

摘要翻译： 密度离心机血液处理系统，通过观察观察区域的流体特性，自动进行二维光学控制流体分离。 通过监视光学参考来确定区域的位置。 测量表示光学基准的边缘的点，并通过点计算线条。 计算每行的误差测量。 如果错误太大，图像被放弃。 选择其中一行作为指示行。 计算与指示线正交的新线。 对依赖线再次计算误差函数。 如果错误超过选定的最大值，则丢弃该帧。 变换函数将来自（r，s）域的数据点从边缘的测量转换成用于识别观察区域中的像素的（x，y）域。

公开(公告)号：US08062202B2

公开(公告)日：2011-11-22

申请号：US12899791

申请日：2010-10-07

申请人： William Sweat

发明人： William Sweat

IPC分类号： B04B13/00

CPC分类号： G01N15/042 ,  G01N15/05 ,  G01N2015/0073 ,  G01N2015/045

摘要： A density centrifuge blood processing system comprising a separation chamber rotating about a central rotation axis, the separation chamber being coupled to an elutriation chamber, a first detector for the separation chamber to detect light from an observation region, a computational apparatus distinguishing at least two regions in the observation region and distinguishing incipient spill over of cellular components out of the elutriation chamber as a function of light intensity received from the at least two regions in the separation chamber, and a controller regulating speed of at least one pump or of the separation chamber in response to signals from the computational apparatus to avoid spill over.

摘要翻译： 一种密度离心机血液处理系统，包括围绕中心旋转轴线旋转的分离室，所述分离室联接到淘洗室，所述分离室的第一检测器用于检测来自观察区域的光，计算装置，区分至少两个区域 在所述观察区域中，根据从所述分离室中的所述至少两个区域接收的光强度的函数，将所述淘洗室中的细胞成分的初期溢出区分开，并且控制器调节至少一个泵或所述分离室 响应于来自计算设备的信号以避免溢出。

公开(公告)号：US09173990B2

公开(公告)日：2015-11-03

申请号：US13569673

申请日：2012-08-08

申请人： John R. Lindner ,  William Sweat

发明人： John R. Lindner ,  William Sweat

IPC分类号： A61M37/00 ,  A61M1/38 ,  A61M1/36

CPC分类号： A61M1/3696 ,  A61M1/3672 ,  A61M1/3693 ,  A61M1/3695 ,  A61M1/38 ,  B04B15/00

摘要： A method is provided in a centrifugal blood processing system for adding replacement fluid without a dedicated peristaltic pump to blood components being returned to the donor. A disposable blood processing set for use in the method comprises a hermetically sealed set of blood bags, connecting tubes, needles or connectors, and supporting structures with a replacement fluid line coupled directly to a return reservoir without contact with an intervening pump.

摘要翻译： 在离心血液处理系统中提供一种方法，用于将没有专用蠕动泵的替换流体添加到返回给供体的血液成分中。 用于该方法的一次性血液处理装置包括气密密封的一组血袋，连接管，针或连接器，以及支撑结构，其具有直接连接到返回容器而不与中间泵接触的替换流体管线。

公开(公告)号：US08070663B2

公开(公告)日：2011-12-06

申请号：US13092639

申请日：2011-04-22

申请人： William Sweat

发明人： William Sweat

IPC分类号： B04B15/00

CPC分类号： G01N15/042 ,  G01N15/05 ,  G01N2015/045

摘要： A density centrifuge blood processing system with automatic two-dimensional optical control of fluid separation by observing fluid characteristics in observation regions. The location of the regions is determined by monitoring an optical reference. Points representing edges of an optical reference are measured and lines are computed through the points. An error measurement is calculated for each line. If the error is too large, the image is abandoned. One of the lines is selected as a referent line. A new line is calculated orthogonal to the referent line. The error function is again computed for the dependant line. If the error exceeds a selected maximum, the frame is discarded. A transformation function translates data points from an (r, s) domain derived from measurements of the edges into an (x, y) domain used to identify pixels in the observation areas.

摘要翻译： 密度离心机血液处理系统，通过观察观察区域的流体特性，自动进行二维光学控制流体分离。 通过监视光学参考来确定区域的位置。 测量表示光学基准的边缘的点，并通过点计算线条。 计算每行的误差测量。 如果错误太大，图像被放弃。 选择其中一行作为指示行。 计算与指示线正交的新线。 对依赖线再次计算误差函数。 如果错误超过选定的最大值，则丢弃该帧。 变换函数将来自（r，s）域的数据点从边缘的测量转换成用于识别观察区域中的像素的（x，y）域。

公开(公告)号：US07828709B2

公开(公告)日：2010-11-09

申请号：US12241846

申请日：2008-09-30

申请人： William Sweat

发明人： William Sweat

IPC分类号： B01D21/26

CPC分类号： G01N15/042 ,  G01N15/05 ,  G01N2015/0073 ,  G01N2015/045

摘要： A density centrifuge blood processing system comprising a separation chamber rotating about a central rotation axis, the separation chamber being coupled to an elutriation chamber, a first detector for the separation chamber to detect light from an observation region, a computational apparatus distinguishing at least two regions in the observation region and distinguishing incipient spill over of cellular components out of the elutriation chamber as a function of light intensity received from the at least two regions in the separation chamber, and a controller regulating speed of at least one pump or of the separation chamber in response to signals from the computational apparatus to avoid spill over.

摘要翻译： 一种密度离心机血液处理系统，包括围绕中心旋转轴线旋转的分离室，所述分离室联接到淘洗室，所述分离室的第一检测器用于检测来自观察区域的光，计算装置，区分至少两个区域 在所述观察区域中，根据从所述分离室中的所述至少两个区域接收的光强度的函数，将所述淘洗室中的细胞成分的初期溢出区分开，并且控制器调节至少一个泵或所述分离室 响应于来自计算设备的信号以避免溢出。