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公开(公告)号：US20090098191A1
公开(公告)日：2009-04-16
申请号：US11975126
申请日：2007-10-16
CPC分类号： A61K9/7053 , A61K9/7061 , A61K31/56
摘要： Stabilized transdermal acid sensitive drug formulations and their associated methods of production and use are described. The formulations containing acid sensitive drugs can also an acrylic adhesive, and a pharmaceutically acceptable base. The formulations can further contain other adhesives, permeation enhancers, and other stabilizing compounds such as free radical inhibitors.
摘要翻译： 描述了稳定的透皮酸敏感药物制剂及其相关的生产和使用方法。 含酸敏感药物的制剂也可以是丙烯酸粘合剂和药学上可接受的碱。 制剂还可以含有其它粘合剂，渗透促进剂和其它稳定化合物如自由基抑制剂。
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2.发明授权
公开(公告)号：US5416198A
公开(公告)日：1995-05-16
申请号：US013967
申请日：1993-02-05
CPC分类号： C07K17/00 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3227 , B01J20/3272 , C08G69/10
摘要： A polycationic system for the removal of polyanions from a fluid medium is formed by, first, activating a biocompatible hydroxylated support with an organic sulfonyl chloride, such as p-toluene-sulfonyl chloride, in the presence of a dialkylamino pyridine activation catalyst, such as 4-dimethylamino-pyridine (DMAP). The activated support is then reacted with a polymer having a polyamide backbone with pendent alkyl amine groups, such as poly-L-lysine (PLL), to form C--N bonds between an activated carbon from the hydroxylated polymer and an amine group from the polymeric polyamide. Finally, any unreacted activated sites on the hydroxylated polymer are capped or removed with an effective amount of capping agent such as a mercapto (--SH), hydroxy (--OH) or amino (--NH.sub.2) containing compound which reacts with the unreacted activated sites. The pendent alkyl amines on the polyamide backbone exist, at the appropriate pH, as polycations. The polyanion, such as heparin, is removed from fluids, such as blood plasma and whole blood, by bringing these fluids in contact with the polycationic system. The polyanion is bound to the polycation system by ionic attraction. The polyanion can then be released from the polycation system by treatment with a basic solution, thereby allowing the system to be reused.
摘要翻译： 通过首先在二烷基氨基吡啶活化催化剂存在下，用有机磺酰氯如对甲苯磺酰氯活化与生物相容的羟基化载体，形成用于从流体介质中除去聚阴离子的聚阳离子体系， 4-二甲基氨基 - 吡啶（DMAP）。 然后将活化的载体与具有聚酰胺主链的聚合物主链与悬浮的烷基胺基例如聚-L-赖氨酸（PLL）反应，以在羟基化聚合物的活性炭和来自聚合物聚酰胺的胺基之间形成CN键 。 最后，用羟基化聚合物上的任何未反应的活化部位用有效量的封端剂如巯基（-SH），羟基（-OH）或含氨基（-NH 2）的化合物进行封端或除去，该化合物与未反应的活化部位反应 。 聚酰胺主链上的侧链烷基胺在适当的pH下作为聚阳离子存在。 通过使这些流体与聚阳离子系统接触，聚阴离子如肝素从流体（例如血浆和全血）中除去。 聚阴离子通过离子吸附结合聚阳离子体系。 然后可以通过用碱性溶液处理从聚阳离子体系释放聚阴离子，从而允许系统重复使用。
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公开(公告)号：US5403549A
公开(公告)日：1995-04-04
申请号：US148829
申请日：1993-11-04
IPC分类号： A61L2/16 , A01N35/02 , A01N41/02 , A01N41/04 , A01N43/24 , A01N59/02 , A61L2/18 , C07D321/00
CPC分类号： C07D321/00 , A01N43/24 , A01N59/02
摘要： A method and a composition for disinfecting matter or materials such as medical instruments, operating rooms, examining tables, walls, windows, floors, solutions, porous substances and the like contaminated with bacteria, bacterial spores, fungi, or viruses is disclosed. The composition consists of a mixture of a peroxymonosulfate and a carbonyl-containing compound and reaction products thereof and is preferably dioxirane formed by in situ oxidation of a ketone or aldehyde by the peroxymonosulfate in aqueous solution. Carbonyl-containing compounds that have been tested include acetone, 2-pentanone, 4-hydroxy-4-methyl-2-pentanone, and camphorsulfonic acid. The method includes providing a solution containing the dioxirane reaction mixture and contacting the matter or materials with it at room temperature for a time sufficient to disinfect and sterilize the matter or materials.
摘要翻译： 公开了一种用于消毒被细菌，细菌孢子，真菌或病毒污染的医疗器械，手术室，检查台，墙壁，窗户，地板，溶液，多孔物质等物质或材料的方法和组合物。 该组合物由过氧化硫酸盐和含羰基化合物的混合物及其反应产物组成，并且优选通过在水溶液中过氧化硫酸盐原位氧化酮或醛形成的二环氧环。 已经测试的含羰基化合物包括丙酮，2-戊酮，4-羟基-4-甲基-2-戊酮和樟脑磺酸。 该方法包括提供含有二环氧乙烷反应混合物的溶液，并在室温下将物质或物质与其接触一段足以消毒和消毒物质或物质的时间。
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