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1.发明申请Transgenic animals for analyzing CYP3A4 cytochrome P450 gene regulation 有权用于分析CYP3A4细胞色素P450基因调控的转基因动物公开(公告)号：US20090288181A1
公开(公告)日：2009-11-19
申请号：US12463246
申请日：2009-05-08
Applicant: Christopher LIDDLE , Bryan James Goodwin , Graham Robertson
Inventor： Christopher LIDDLE , Bryan James Goodwin , Graham Robertson
IPC: A01K67/033 , A01N1/00 , C12Q1/68
CPC classification number: C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/10 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , A61K49/0008 , C12N9/0077
Abstract: The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located between the initiation of transcription site of the gene and a position located 13,000 nucleotides upstream from the site. The invention also relates to the use of these animals for determining the effect of a compound, particularly, but not exclusively, a xenobiotic or steroid, on the regulation of expression of the CYP3A4 gene in a human.
Abstract translation: 本发明涉及产生非人转基因动物，其包含用于产生可检测量的报告分子的报道构建体，所述报道分子可操作地连接于来自位于基因转录位点的起始点之间的人CYP3A4基因的转录调节核酸分子，和 位于位于该位点上游13,000个核苷酸的位置。 本发明还涉及这些动物用于测定化合物，特别是但不排除地，异生物或类固醇对人类CYP3A4基因表达调节的影响的用途。
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2.发明授权Transgenic animals for analyzing CYP3A4 cytochrome P450 gene regulation 失效用于分析CYP3A4细胞色素P450基因调控的转基因动物公开(公告)号：US08629318B2
公开(公告)日：2014-01-14
申请号：US12855383
申请日：2010-08-12
Applicant: Christopher Liddle , Bryan James Goodwin , Graham Robertson
Inventor： Christopher Liddle , Bryan James Goodwin , Graham Robertson
IPC: A01K67/027 , G01N33/00 , C12N5/00
CPC classification number: C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/10 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , A61K49/0008 , C12N9/0077
Abstract: The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located between the initiation of transcription site of the gene and a position located 13,000 nucleotides upstream from the site. The invention also relates to the use of these animals for determining the effect of a compound, particularly, but not exclusively, a xenobiotic or steroid, on the regulation of expression of the CYP3A4 gene in a human.
Abstract translation: 本发明涉及产生非人转基因动物，其包含用于产生可检测量的报告分子的报道构建体，所述报道分子可操作地连接于来自位于基因转录位点的起始点之间的人CYP3A4基因的转录调节核酸分子，和 位于位于该位点上游13,000个核苷酸的位置。 本发明还涉及这些动物用于测定化合物，特别是但不排除地，异生物或类固醇对人类CYP3A4基因表达调节的影响的用途。
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公开(公告)号：US07638614B2
公开(公告)日：2009-12-29
申请号：US11324921
申请日：2006-01-04
Applicant: Christopher Liddle , Bryan James Goodwin
Inventor： Christopher Liddle , Bryan James Goodwin
CPC classification number: C12Q1/6897 , A01K2267/0393
Abstract: An isolated nucleic acid molecule comprising a nucleotide sequence encoding a transcriptional enhancer of cytochrome P450 (P450) CYP3A4 production or expression, and uses of the nucleic acid molecule for screening compounds for xenobiotic induction of CYP3A4 expression in cells and animals.
Abstract translation: 包含编码细胞色素P450（P450）CYP3A4产生或表达的转录增强子的核苷酸序列的分离的核酸分子，以及核酸分子用于筛选细胞和动物中CYP3A4表达的异种生物诱导化合物的用途。
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4.发明授权Transgenic animals for analyzing CYP3A4 cytochrome P450 gene regulation 有权用于分析CYP3A4细胞色素P450基因调控的转基因动物公开(公告)号：US08088968B2
公开(公告)日：2012-01-03
申请号：US12463246
申请日：2009-05-08
Applicant: Christopher Liddle , Bryan James Goodwin , Graham Robertson
Inventor： Christopher Liddle , Bryan James Goodwin , Graham Robertson
IPC: G01N33/00 , A01K67/00 , A01K67/027 , C12N5/00 , C12N15/11
CPC classification number: C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/10 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , A61K49/0008 , C12N9/0077
Abstract: The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located between the initiation of transcription site of the gene and a position located 13,000 nucleotides upstream from the site. The invention also relates to the use of these animals for determining the effect of a compound, particularly, but not exclusively, a xenobiotic or steroid, on the regulation of expression of the CYP3A4 gene in a human.
Abstract translation: 本发明涉及产生非人转基因动物，其包含用于产生可检测量的报告分子的报道构建体，所述报道分子可操作地连接于来自位于基因转录位点的起始点之间的人CYP3A4基因的转录调节核酸分子，和 位于位于该位点上游13,000个核苷酸的位置。 本发明还涉及这些动物用于测定化合物，特别是但不排除地，异生物或类固醇对人类CYP3A4基因表达调节的影响的用途。
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公开(公告)号：US20100146652A1
公开(公告)日：2010-06-10
申请号：US12629186
申请日：2009-12-02
Applicant: Christopher LIDDLE , Bryan James Goodwin
Inventor： Christopher LIDDLE , Bryan James Goodwin
CPC classification number: C12Q1/6897 , A01K2267/0393
Abstract: An isolated nucleic acid molecule comprising a nucleotide sequence encoding a transcriptional enhancer of cytochrome P450 (P450) CYP3A4 production or expression, and uses of the nucleic acid molecule for screening compounds for xenobiotic induction of CYP3A4 expression in cells and animals.
Abstract translation: 包含编码细胞色素P450（P450）CYP3A4产生或表达的转录增强子的核苷酸序列的分离的核酸分子，以及核酸分子用于筛选细胞和动物中CYP3A4表达的异种生物诱导化合物的用途。
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Patent Agency Ranking
公开(公告)号：US06984489B1
公开(公告)日：2006-01-10
申请号：US09700991
申请日：1999-05-20
Applicant: Christopher Liddle , Bryan James Goodwin
Inventor： Christopher Liddle , Bryan James Goodwin
CPC classification number: C12Q1/6897 , A01K2267/0393
Abstract: An isolated nucleic acid molecule comprising a nucleotide sequence encoding a transcriptional enhancer of cytochrome P450 (P450) CYP3A4 production or expression is disclosed, as are uses of the nucleic acid molecule for screening compounds for xenobiotic induction of CYP3A4 expression in cells and animals.
Abstract translation: 公开了包含编码细胞色素P450（P450）CYP3A4产生或表达的转录增强子的核苷酸序列的分离的核酸分子，核酸分子用于筛选细胞和动物中CYP3A4表达的异种生物诱导化合物的用途。
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公开(公告)号：US09029336B2
公开(公告)日：2015-05-12
申请号：US12629186
申请日：2009-12-02
Applicant: Christopher Liddle , Bryan James Goodwin
Inventor： Christopher Liddle , Bryan James Goodwin
CPC classification number: C12Q1/6897 , A01K2267/0393
Abstract: An isolated nucleic acid molecule comprising a nucleotide sequence encoding a transcriptional enhancer of cytochrome P450 (P450) CYP3A4 production or expression, and uses of the nucleic acid molecule for screening compounds for xenobiotic induction of CYP3A4 expression in cells and animals.
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8.发明申请Transgenic Animals for Analyzing CYP3A4 Cytochrome P450 Gene Regulation 失效用于分析CYP3A4细胞色素P450基因调控的转基因动物公开(公告)号：US20120171690A1
公开(公告)日：2012-07-05
申请号：US12855383
申请日：2010-08-12
Applicant: Christopher Liddle , Bryan James Goodwin , Graham Robertson
Inventor： Christopher Liddle , Bryan James Goodwin , Graham Robertson
IPC: C12Q1/68 , C12N5/10 , G01N21/17 , A01K67/027
CPC classification number: C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/10 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , A61K49/0008 , C12N9/0077
Abstract: The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located between the initiation of transcription site of the gene and a position located 13,000 nucleotides upstream from the site. The invention also relates to the use of these animals for determining the effect of a compound, particularly, but not exclusively, a xenobiotic or steroid, on the regulation of expression of the CYP3A4 gene in a human.
Abstract translation: 本发明涉及产生非人转基因动物，其包含用于产生可检测量的报告分子的报道构建体，所述报道分子可操作地连接于来自位于基因转录位点的起始点之间的人CYP3A4基因的转录调节核酸分子，和 位于位于该位点上游13,000个核苷酸的位置。 本发明还涉及这些动物用于测定化合物，特别是但不排除地，异生物或类固醇对人类CYP3A4基因表达调节的影响的用途。
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公开(公告)号：US20090307785A1
公开(公告)日：2009-12-10
申请号：US12430672
申请日：2009-04-27
Applicant: Christopher Liddle , Bryan James Goodwin , Graham Robertson
Inventor： Christopher Liddle , Bryan James Goodwin , Graham Robertson
IPC: A01K67/027 , C12N5/06
CPC classification number: C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/10 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , A61K49/0008 , C12N9/0077
Abstract: The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located between the initiation of transcription site of the gene and a position located 13,000 nucleotides upstream from the site. The invention also relates to the use of these animals for determining the effect of a compound, particularly, but not exclusively, a xenobiotic or steroid, on the regulation of expression of the CYP3A4 gene in a human.
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公开(公告)号：US07531712B2
公开(公告)日：2009-05-12
申请号：US10415607
申请日：2001-11-01
Applicant: Christopher Liddle , Bryan James Goodwin , Graham Robertson
Inventor： Christopher Liddle , Bryan James Goodwin , Graham Robertson
CPC classification number: C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/10 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , A61K49/0008 , C12N9/0077
Abstract: The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located between the initiation of transcription site of the gene and a position located 13,000 nucleotides upstream from the site. The invention also relates to the use of these animals for determining the effect of a compound, particularly, but not exclusively, a xenobiotic or steriod, on the regulation of expression of the CYP3A4 gene in a human.
Abstract translation: 本发明涉及产生非人转基因动物，其包含用于产生可检测量的报告分子的报道构建体，所述报道分子可操作地连接于来自位于基因转录位点的起始点之间的人CYP3A4基因的转录调节核酸分子，和 位于位于该位点上游13,000个核苷酸的位置。 本发明还涉及这些动物用于确定化合物，特别是但不排除地，异生物或抑制剂对人类CYP3A4基因表达调节的影响的用途。
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