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公开(公告)号：US06890901B2
公开(公告)日：2005-05-10
申请号：US09269529
申请日：1997-09-29
CPC分类号： A61K9/127 , A61K9/0014 , A61K9/0019 , A61K38/13 , A61K47/36
摘要： Pharmaceutical compositions comprising a mixture of hyaluronic acid and liposomes. Preferably, the pharmaceutical compositions further include a pharmaceutically active substance such as cyclosporin A encapsulated in the liposomes. A method for preparing a pharmaceutical composition includes producing liposomes from phospholipids, preferably in the presence of a pharmaceutically active substance (most preferably cyclosporin A) to be encapsulated within the liposomes, and mixing the liposomes with hyaluronic acid. Pharmaceutical compositions of this invention are used, for example, to topically administer pharmaceutical agents effective to treat skin disorders by deposition of that agent in the dermis or sub-dermis while minimizing systemic circulation thereof. These compositions are also administered orally, parenterally and intrarectally.
摘要翻译： 包含透明质酸和脂质体的混合物的药物组合物。 优选地，药物组合物还包括药物活性物质，例如包封在脂质体中的环孢菌素A. 制备药物组合物的方法包括从磷脂制备脂质体，优选在待包被在脂质体内的药物活性物质（最优选环孢菌素A）存在下，并将脂质体与透明质酸混合。 本发明的药物组合物用于例如局部施用有效治疗皮肤病症的药剂，通过在真皮或次真皮中沉积该药物同时最小化其体循环。 这些组合物也口服，肠胃外和直肠内给药。
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公开(公告)号：US06875449B1
公开(公告)日：2005-04-05
申请号：US09646111
申请日：1999-03-24
IPC分类号： A61K9/00 , A61K9/12 , A61K9/14 , A61K9/16 , A61K9/72 , A61K31/135 , A61K31/137 , B01D9/02 , C07D451/06 , C07H3/04 , A61L9/04
CPC分类号： A61K9/0075 , C07D451/06 , C07H3/04
摘要： A process for the production of crystals with controlled surface smoothness, size, shape and degree of crystallinity, compositions comprising such crystals, and the use of certain crystals, especially lactose, lactose monohydrate, fluticasone propionate, salmeterol xinafoate, salbutamol sulphate or ipratropium bromide in pharmaceutical compositions.
摘要翻译： 用于生产具有受控表面光滑度，大小，形状和结晶度的晶体的方法，包含这种晶体的组合物，以及使用某些晶体，特别是乳糖，一水合乳糖，丙酸氟替卡松，硫酸沙美特罗或异丙托溴铵 药物组合物。
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公开(公告)号：US5975076A
公开(公告)日：1999-11-02
申请号：US666537
申请日：1996-10-10
申请人： Michael Yianneskis , Gary Peter Martin , Christopher Marriott , Kwok-On Suen , Ka-lok Carroll Lee , David Ganderton , Mukunda Timsina
发明人： Michael Yianneskis , Gary Peter Martin , Christopher Marriott , Kwok-On Suen , Ka-lok Carroll Lee , David Ganderton , Mukunda Timsina
CPC分类号： A61M15/0065 , A61M2202/064
摘要： A dry powder inhaler is provided which comprises a reservoir of medicament powder, a dispensing chamber for receiving a charge of powder to be dispensed having a floor upon which the powder charge lies prior to inhalation, an inlet passage having at its outlet end a nozzle protruding into the dispensing chamber directed toward the floor thereof and an inhalation passage exiting from the chamber through which the powder may be inhaled entrained in air drawn into the inhaler through the air inlet passage. The inhalation passage has an inlet at the dispensing chamber and an outlet through which the powder may be inhaled and comprises a first upstream portion having a roof and a floor both of which rise progressively with respect to a straight line drawn form the center of the inlet to the center of the outlet ad a second portion having a roof and a floor both of which fall progressively with respect to the line in the downstream direction.
摘要翻译： PCT No.PCT / GB94 / 02829 Sec。 371日期：1996年10月10日 102（e）日期1996年10月10日PCT 1994年12月30日PCT PCT。 公开号WO95 / 17917 日期1995年7月6日提供了一种干粉吸入器，其包括药物粉末储存器，用于接收待分配粉末的药物的分配室，其具有在吸入之前粉末装料位于其上的底板，具有在其上的入口通道 出口端部突出到分配室中的喷嘴朝向其底部，以及从腔室出来的吸入通道，粉末可以通过该吸入通道夹带在通过进气通道吸入吸入器的空气中。 吸入通道在分配室处具有入口和出口，粉末可以通过该入口吸入，并且包括第一上游部分，其具有屋顶和地板，两者都相对于从入口的中心拉出的直线逐渐升高 到出口的中心，并且具有屋顶和地板的第二部分都相对于下游方向上的线逐渐下降。
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公开(公告)号：US20130069498A1
公开(公告)日：2013-03-21
申请号：US13635780
申请日：2011-03-18
CPC分类号： G07F11/62 , A47B88/40 , A47B88/497 , A47B88/90 , A47B88/969 , A47B96/00 , A47G2029/146 , G07F17/0092
摘要： A storage system comprising: a cartridge, said cartridge including an upright having mounted to one side a plurality of guide blocks; a plurality of first drawer information means for providing information on at least one of position and movement of respective drawers; and a plurality of latch mechanisms, said system further comprising a plurality of drawers, each said drawer including: guide block engaging means extending in a depth direction of the drawer and mounting a first side of the drawer adjacent a respective guide block; second drawer information means disposed adjacent the first drawer information means; and at least one stop on the first side of the drawer for engaging with a said latch mechanism, wherein the latch mechanisms are electronically controllable, whereby access to the drawers can be controlled.
摘要翻译： 一种存储系统，包括：盒，所述盒包括立柱，其一侧安装有多个引导块; 多个第一抽屉信息装置，用于提供关于各个抽屉的位置和移动中的至少一个的信息; 以及多个闩锁机构，所述系统还包括多个抽屉，每个所述抽屉包括：引导块接合装置，其在所述抽屉的深度方向上延伸并且将所述抽屉的第一侧邻近相应的导向块安装; 第二抽屉信息装置邻近第一抽屉信息装置设置; 以及在抽屉的第一侧上的至少一个止挡件，用于与所述闩锁机构接合，其中所述闩锁机构是电子可控的，从而可以控制对抽屉的接近。
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公开(公告)号：US20080087026A1
公开(公告)日：2008-04-17
申请号：US11667287
申请日：2005-10-26
IPC分类号： F25C1/18
摘要： A method for partially freezing an aqueous mixture comprising simultaneously or in either order the steps of: placing said aqueous mixture in contact with at least part of a freezing surface; cooling the freezing surface to below the freezing point of the aqueous mixture; so that ice forms at the freezing surface; and oscillating the freezing surface relative to the aqueous mixture in a direction that is not perpendicular to at least part of the freezing surface; characterised in that the oscillation is linear with a frequency of between 20 and 200 Hz.
摘要翻译： 一种部分冷冻含水混合物的方法，包括同时或以任何顺序的步骤：将所述含水混合物与冷冻表面的至少一部分接触; 将冷冻表面冷却至低于含水混合物的凝固点; 使冰在冰面上形成; 并且使所述冷冻表面相对于所述含水混合物在不垂直于所述冷冻表面的至少一部分的方向上摆动; 其特征在于振荡是线性的，频率在20和200Hz之间。
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公开(公告)号：US4985462A
公开(公告)日：1991-01-15
申请号：US435479
申请日：1989-12-04
IPC分类号： A61K31/16 , A61K31/205 , A61P1/04 , A61P27/02 , A61P29/00 , C07C235/82
CPC分类号： A61K31/205
摘要： Compounds of the general formula ##STR1## wherein n is from 1 to 6 and each of R.sup.1 and R.sup.2 represents an alkyl group of 1 to 4 carbon atoms and their acid addition salts are useful for thickening mucus, especially gastro-intestinal mucus as an anti-ulceration treatment or cervical mucus in contraception.
摘要翻译： PCT No.PCT / GB88 / 00408 Sec。 371日期1989年12月4日第 102（e）日期1989年12月4日PCT提交1988年5月24日PCT公布。 出版物WO88 / 09786 日本公报1988年12月15日。通式
的化合物，其中n为1至6，R1和R2各自为1至4个碳原子的烷基，其酸加成盐可用于增稠粘液，特别是 胃肠粘液作为抗溃疡治疗或宫颈粘液避孕。 -
公开(公告)号：US09492012B2
公开(公告)日：2016-11-15
申请号：US13635780
申请日：2011-03-18
CPC分类号： G07F11/62 , A47B88/40 , A47B88/497 , A47B88/90 , A47B88/969 , A47B96/00 , A47G2029/146 , G07F17/0092
摘要： A storage system comprising: a cartridge, said cartridge including an upright having mounted to one side a plurality of guide blocks; a plurality of first drawer information means for providing information on at least one of position and movement of respective drawers; and a plurality of latch mechanisms, said system further comprising a plurality of drawers, each said drawer including: guide block engaging means extending in a depth direction of the drawer and mounting a first side of the drawer adjacent a respective guide block; second drawer information means disposed adjacent the first drawer information means; and at least one stop on the first side of the drawer for engaging with a said latch mechanism, wherein the latch mechanisms are electronically controllable, whereby access to the drawers can be controlled.
摘要翻译： 一种存储系统，包括：盒，所述盒包括立柱，其一侧安装有多个引导块; 多个第一抽屉信息装置，用于提供关于各个抽屉的位置和移动中的至少一个的信息; 以及多个闩锁机构，所述系统还包括多个抽屉，每个所述抽屉包括：引导块接合装置，其在所述抽屉的深度方向上延伸并且将所述抽屉的第一侧邻近相应的导向块安装; 第二抽屉信息装置邻近第一抽屉信息装置设置; 以及在抽屉的第一侧上的至少一个止挡件，用于与所述闩锁机构接合，其中所述闩锁机构是电子可控的，从而可以控制对抽屉的接近。
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