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公开(公告)号：US07439244B2
公开(公告)日：2008-10-21
申请号：US10571405
申请日：2004-09-09
IPC分类号： A61K31/496 , A61K31/551 , C07D215/40
CPC分类号： C07D215/40
摘要： Disclosed are quinoline compounds of formula (I) having pharmacological activity, processes for their preparation, compositions containing them, and methods for the treatment of CNS and other disorders.
摘要翻译： 公开了具有药理活性的式（I）喹啉化合物，其制备方法，含有它们的组合物，以及CNS和其它病症的治疗方法。
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公开(公告)号：US07977337B2
公开(公告)日：2011-07-12
申请号：US12847039
申请日：2010-07-30
申请人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R Witty
发明人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R Witty
IPC分类号： A61K31/47 , A61K31/496
CPC分类号： C07D487/04 , C07D215/00 , C07D487/08
摘要： Disclosed are quinoline compounds having affinity for the 5-HT6 receptor and having the formula: where R1, R2, R3, R4, R5, n, m, p and A are defined herein, and salts thereof, compositions containing these compounds and salts and processes for making and using the same.
摘要翻译： 公开了对5-HT 6受体具有亲和性并具有下式的喹啉化合物：其中R1，R2，R3，R4，R5，n，m，p和A如本文所定义，及其盐，含有这些化合物和盐的组合物 制作和使用相同的过程。
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3.发明申请Quinoline Compounds Capable of Binding the Cb2 and/or the 5-Ht6 Receptor 审中-公开能够结合Cb2和/或5-Ht6受体的喹啉化合物公开(公告)号：US20090012056A1
公开(公告)日：2009-01-08
申请号：US12088502
申请日：2006-09-26
申请人： Mahmood Ahmed , Gerard Martin Paul Giblin , Christopher Norbert Johnson , David George Hubert Livermore , Neil Derek Miller , Stephen Frederick Moss , David R. Witty
发明人： Mahmood Ahmed , Gerard Martin Paul Giblin , Christopher Norbert Johnson , David George Hubert Livermore , Neil Derek Miller , Stephen Frederick Moss , David R. Witty
IPC分类号： A61K31/4709 , C07D401/10 , A61P25/24
CPC分类号： C07D491/10 , C07D215/36 , C07D401/06
摘要： The present invention relates to novel quinoline derivatives such as compounds of the formula (I) which possess antagonist potency for the 5-HT6 receptor and/or are capable of selectively modulating the cannabinoid 2 receptor: and the use of such compounds or pharmaceutical compositions thereof in the treatment of CNS disorders.
摘要翻译： 本发明涉及新颖的喹啉衍生物，例如具有5-HT 6受体的拮抗剂效能和/或能够选择性调节大麻素2受体的式（I）化合物，以及这些化合物或其药物组合物的用途 在治疗中枢神经系统疾病。
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公开(公告)号：US07452888B2
公开(公告)日：2008-11-18
申请号：US10509078
申请日：2003-03-25
申请人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C Jones , Gregor James Macdonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R Witty
发明人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C Jones , Gregor James Macdonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R Witty
IPC分类号： A61K31/496 , C07D215/40
CPC分类号： C07D487/04 , C07D215/00 , C07D487/08
摘要： Disclosed are novel quinoline compounds of formula (I), processes for their preparation, compositions containing them and their use in the treatment of CNS disorders.
摘要翻译： 公开了式（I）的新型喹啉化合物，其制备方法，含有它们的组合物及其在治疗CNS障碍中的用途。
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公开(公告)号：US20090036682A1
公开(公告)日：2009-02-05
申请号：US12205079
申请日：2008-09-05
申请人： Mahmood AHMED , Christopher Norbert Johnson , Martin C. Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R. Witty
发明人： Mahmood AHMED , Christopher Norbert Johnson , Martin C. Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R. Witty
IPC分类号： C07D401/10
CPC分类号： C07D487/04 , C07D215/00 , C07D487/08
摘要： The present invention relates to novel quinoline compounds having pharmacological activity, to processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders.
摘要翻译： 本发明涉及具有药理学活性的新喹啉化合物，其制备方法，含有它们的组合物及其在治疗CNS和其它疾病中的用途。
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6.发明授权Piperazinyl-quinoline derivatives useful for the treatment of CNS disorders 失效可用于治疗CNS病症的哌嗪基 - 喹啉衍生物公开(公告)号：US07439243B2
公开(公告)日：2008-10-21
申请号：US10572671
申请日：2004-09-23
IPC分类号： A61K31/496 , A61K31/551 , C07D215/40
CPC分类号： C07D215/40
摘要： Disclosed are quinoline compounds of formula (I) having pharmacological activity, processes for their preparation, compositions containing them, and methods for the treatment of CNS and other disorders.
摘要翻译： 公开了具有药理活性的式（I）喹啉化合物，其制备方法，含有它们的组合物，以及CNS和其它病症的治疗方法。
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公开(公告)号：US20110237792A1
公开(公告)日：2011-09-29
申请号：US13152356
申请日：2011-06-03
申请人： Mahmood AHMED , Christopher Norbert Johnson , Martin C. Johnes , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R. Witty
发明人： Mahmood AHMED , Christopher Norbert Johnson , Martin C. Johnes , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R. Witty
IPC分类号： C07D403/10 , C07D401/10 , C07D487/04
CPC分类号： C07D487/04 , C07D215/00 , C07D487/08
摘要： Disclosed are quinoline compounds having affinity for the 5-HT6 receptor and having the formula: where R1, R2, R3, R4, R5, n, m, p and A are defined herein, and salts thereof, compositions containing these compounds and salts and processes for making and using the same.
摘要翻译： 公开了对5-HT 6受体具有亲和性并具有下式的喹啉化合物：其中R1，R2，R3，R4，R5，n，m，p和A如本文所定义，及其盐，含有这些化合物和盐的组合物 制作和使用相同的过程。
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公开(公告)号：US20100305107A1
公开(公告)日：2010-12-02
申请号：US12847039
申请日：2010-07-30
申请人： Mahmood AHMED , Christopher Norbert Johnson , Martin C. Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R. Witty
发明人： Mahmood AHMED , Christopher Norbert Johnson , Martin C. Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R. Witty
IPC分类号： A61K31/4709 , A61K31/496 , A61K31/551 , A61K31/4985 , A61P25/00 , A61P25/06 , A61P25/16 , A61P25/24 , A61P25/30
CPC分类号： C07D487/04 , C07D215/00 , C07D487/08
摘要： Disclosed are quinoline compounds having affinity for the 5-HT6 receptor and having the formula: where R1, R2, R3, R4, R5, n, m, p and A are defined herein, and salts thereof, compositions containing these compounds and salts and processes for making and using the same.
摘要翻译： 公开了对5-HT 6受体具有亲和性并具有下式的喹啉化合物：其中R1，R2，R3，R4，R5，n，m，p和A如本文所定义，及其盐，含有这些化合物和盐的组合物 制作和使用相同的过程。
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公开(公告)号：US07799774B2
公开(公告)日：2010-09-21
申请号：US12541456
申请日：2009-08-14
申请人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R Witty
发明人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R Witty
IPC分类号： A61K31/496 , A61K31/47 , C07D215/40 , C07D471/04 , C07D487/08
CPC分类号： C07D487/04 , C07D215/00 , C07D487/08
摘要： Disclosed are quinoline compounds having affinity for the 5-HT6 receptor and having the formula: where R1, R2, R3, R4, R5, n, m, p and A are defined herein, and salts thereof, compositions containing these compounds and salts and processes for making and using the same.
摘要翻译： 公开了对5-HT 6受体具有亲和性并具有下式的喹啉化合物：其中R1，R2，R3，R4，R5，n，m，p和A如本文所定义，及其盐，含有这些化合物和盐的组合物 制作和使用相同的过程。
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公开(公告)号：US08236947B2
公开(公告)日：2012-08-07
申请号：US13152356
申请日：2011-06-03
申请人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R Witty
发明人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R Witty
IPC分类号： A61K31/496 , A61K31/551 , C07D401/04 , C07D487/08
CPC分类号： C07D487/04 , C07D215/00 , C07D487/08
摘要： Disclosed are quinoline compounds having affinity for the 5-HT6 receptor and having the formula: where R1, R2, R3, R4, R5, n, m, p and A are defined herein, and salts thereof, compositions containing these compounds and salts and processes for making and using the same.
摘要翻译： 公开了对5-HT 6受体具有亲和性并具有下式的喹啉化合物：其中R1，R2，R3，R4，R5，n，m，p和A如本文所定义，及其盐，含有这些化合物和盐的组合物 制作和使用相同的过程。
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