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公开(公告)号：US20120220994A1
公开(公告)日：2012-08-30
申请号：US13423205
申请日：2012-03-17
IPC分类号： A61B18/18
CPC分类号： A61B18/1477 , A61B2018/143 , A61B2018/1432
摘要： A medical device for delivering RF energy to a target tissue region includes an elongate delivery cannula having a lumen in communication with a distal opening. A deployment member is positioned and longitudinally movable in the lumen. An array of electrode elements are secured to a distal end of the deployment member, the deployment member being movable from a delivery position, in which the electrode elements are positioned within the lumen, to a deployed position, in which the electrode elements extend distally out of the cannula distal opening. A sealing member formed from a bio-compatible material sufficiently rigid to penetrate solid body tissue partially extends from, and substantially seals, the distal cannula opening when the deployment member is in the delivery position.
摘要翻译： 用于将RF能量递送到目标组织区域的医疗装置包括具有与远端开口连通的内腔的细长输送套管。 展开构件在内腔中定位和纵向移动。 电极元件的阵列固定到展开构件的远端，展开构件可从电子元件位于内腔内的输送位置移动到展开位置，电极元件向远侧延伸 的套管远端开口。 当展开构件处于输送位置时，由足够刚性以穿透实体组织的生物相容性材料形成的密封构件部分延伸并且基本上密封远侧插管开口。
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公开(公告)号：US08216235B2
公开(公告)日：2012-07-10
申请号：US11944257
申请日：2007-11-21
IPC分类号： A61B18/14
CPC分类号： A61B18/1477 , A61B2018/00065 , A61B2018/1472 , A61B2018/1475
摘要： An apparatus for delivering electrical energy includes a tubular member having a pair of opposing members extendable from the distal end of the tubular member, the opposing members being directable towards one another for engaging tissue between inner surfaces of the opposing members, the opposing members having one or more electrodes for delivering electrical energy to tissue engaged between the opposing members. One or more hollow needles extend from an inner surface of at least one opposing member, the hollow needles configured to deliver conductive fluid from a lumen into tissue penetrated by the needles.
摘要翻译： 一种用于传递电能的装置包括管状构件，该管状构件具有从管状构件的远端延伸的一对相对构件，相对构件可相对于彼此指向，用于在相对构件的内表面之间接合组织，相对构件具有一个 或更多的电极，用于将电能传递到在相对构件之间接合的组织。 一个或多个中空针从至少一个相对构件的内表面延伸，所述中空针被配置成将导管流体从内腔输送到被针穿透的组织中。
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公开(公告)号：US08632538B2
公开(公告)日：2014-01-21
申请号：US13423205
申请日：2012-03-17
IPC分类号： A61B18/18
CPC分类号： A61B18/1477 , A61B2018/143 , A61B2018/1432
摘要： A medical device for delivering RF energy to a target tissue region includes an elongate delivery cannula having a lumen in communication with a distal opening. A deployment member is positioned and longitudinally movable in the lumen. An array of electrode elements are secured to a distal end of the deployment member, the deployment member being movable from a delivery position, in which the electrode elements are positioned within the lumen, to a deployed position, in which the electrode elements extend distally out of the cannula distal opening. A sealing member formed from a bio-compatible material sufficiently rigid to penetrate solid body tissue partially extends from, and substantially seals, the distal cannula opening when the deployment member is in the delivery position.
摘要翻译： 用于将RF能量递送到目标组织区域的医疗装置包括具有与远端开口连通的内腔的细长输送套管。 展开构件在内腔中定位和纵向移动。 电极元件的阵列固定到展开构件的远端，展开构件可从电子元件位于内腔内的输送位置移动到展开位置，电极元件向远侧延伸 的套管远端开口。 当展开构件处于输送位置时，由足够刚性以穿透实体组织的生物相容性材料形成的密封构件部分延伸并且基本上密封远侧插管开口。
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公开(公告)号：US08142427B2
公开(公告)日：2012-03-27
申请号：US10831244
申请日：2004-04-23
IPC分类号： A61B18/18
CPC分类号： A61B18/1477 , A61B2018/143 , A61B2018/1432
摘要： An invasive medical device for delivery radio frequency energy to a target tissue region includes an elongate delivery cannula having a lumen in communication with a distal opening. A deployment member is positioned and longitudinally movable in the lumen. An array of electrode elements are secured to a distal end of the deployment member, the deployment member being movable from a delivery position, in which the electrode elements are positioned within the lumen, to a deployed position, in which the electrode elements extend distally out of the cannula distal opening. A sealing member formed from a biocompatible material sufficiently rigid to penetrate solid body tissue partially extends from, and substantially seals, the distal cannula opening when the deployment member is in the delivery position. By way of examples, the sealing member may be carried on a distal end of the deployment member, or on a separately movable deployment member, or frictionally fit in the cannula distal opening.
摘要翻译： 用于将射频能量传送到目标组织区域的侵入性医疗装置包括具有与远端开口连通的内腔的细长输送套管。 展开构件在内腔中定位和纵向移动。 电极元件的阵列固定到展开构件的远端，展开构件可从电子元件位于内腔内的输送位置移动到展开位置，电极元件向远侧延伸 的套管远端开口。 当展开构件处于输送位置时，由足够刚性以穿透实体组织的生物相容性材料形成的密封构件部分延伸并且基本上密封远端插管开口。 作为示例，密封构件可以承载在展开构件的远端上，或者在可单独移动的展开构件上承载，或摩擦地配合在套管远侧开口中。
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公开(公告)号：US20080108950A1
公开(公告)日：2008-05-08
申请号：US11834186
申请日：2007-08-06
IPC分类号： A61M5/00
CPC分类号： A61B17/064 , A61B2017/0649 , A61M5/3287 , A61M5/329 , A61M25/0084 , A61M39/0208 , A61M39/0247 , A61M2005/3289 , A61M2039/0081
摘要： Described is a method and a device for inserting a helical member into a living body. The device may include a handle having an actuator lever rotatably coupled thereto. The device may also include a helical member which has a tissue piercing distal tip. The helical member is coupled to the handle via a linkage operating so that, as the actuator lever is rotated in a first direction relative to the handle, the helical member is rotated and moved distally to screw into tissue along a substantially helical path.
摘要翻译： 描述了一种用于将螺旋构件插入生物体的方法和装置。 该装置可以包括具有可旋转地联接到其上的致动器杆的手柄。 该装置还可以包括螺旋构件，该螺旋构件具有组织穿刺的远端。 螺旋构件通过联接操作联接到手柄，使得当致动器杆相对于把手沿第一方向旋转时，螺旋构件被旋转并向远侧移动以沿着基本上螺旋的路径螺旋进入组织。
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公开(公告)号：US20050240174A1
公开(公告)日：2005-10-27
申请号：US10831244
申请日：2004-04-23
CPC分类号： A61B18/1477 , A61B2018/143 , A61B2018/1432
摘要： An invasive medical device for delivery radio frequency energy to a target tissue region includes an elongate delivery cannula having a lumen in communication with a distal opening. A deployment member is positioned and longitudinally movable in the lumen. An array of electrode elements are secured to a distal end of the deployment member, the deployment member being movable from a delivery position, in which the electrode elements are positioned within the lumen, to a deployed position, in which the electrode elements extend distally out of the cannula distal opening. A sealing member formed from a biocompatible material sufficiently rigid to penetrate solid body tissue partially extends from, and substantially seals, the distal cannula opening when the deployment member is in the delivery position. By way of examples, the sealing member may be carried on a distal end of the deployment member, or on a separately movable deployment member, or frictionally fit in the cannula distal opening.
摘要翻译： 用于将射频能量传送到目标组织区域的侵入性医疗装置包括具有与远端开口连通的内腔的细长输送套管。 展开构件在内腔中定位和纵向移动。 电极元件的阵列固定到展开构件的远端，展开构件可从电子元件位于内腔内的输送位置移动到展开位置，电极元件向远侧延伸 的套管远端开口。 当展开构件处于输送位置时，由足够刚性以穿透实体组织的生物相容性材料形成的密封构件部分延伸并且基本上密封远端插管开口。 作为示例，密封构件可以承载在展开构件的远端上，或者在可单独移动的展开构件上承载，或摩擦地配合在套管远侧开口中。
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公开(公告)号：US20080071266A1
公开(公告)日：2008-03-20
申请号：US11944257
申请日：2007-11-21
IPC分类号： A61B18/14
CPC分类号： A61B18/1477 , A61B2018/00065 , A61B2018/1472 , A61B2018/1475
摘要： An apparatus for delivering electrical energy includes a cannula and one or more needles extendable from and retractable into a lumen of the cannula. A distal portion of each needle is extendable from the lumen and terminates in a tissue-piercing distal tip. Each distal portion is formed from an electrically conductive and porous material, thereby providing a porous electrode through which electrolytic fluid may flow for delivering electrical energy to tissue surrounding the distal portion. The cannula is introduced into a tissue structure of a patient, the one or more needles are advanced from the cannula, saline is introduced from the porous material to surrounding tissue, and electrical energy from an RF generator is delivered to ablate tissue within the tissue structure.
摘要翻译： 用于递送电能的装置包括套管和一个或多个可从套管的内腔中伸出并可收缩的针。 每个针的远端部分可从内腔延伸并终止于组织刺穿的远端。 每个远端部分由导电和多孔材料形成，从而提供多孔电极，电解液可通过该多孔电极流动，用于将电能传递到围绕远端部分的组织。 将套管引入患者的组织结构中，一个或多个针从套管前进，盐水从多孔材料引入周围组织，并且来自RF发生器的电能被输送以烧蚀组织结构内的组织 。
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公开(公告)号：US06685703B2
公开(公告)日：2004-02-03
申请号：US10036068
申请日：2001-10-19
IPC分类号： A61B1818
CPC分类号： A61B18/14 , A61B2018/00178 , A61B2018/00988
摘要： An adapter to couple a dissimilar, normally incompatible radiotherapeutic probe and radio frequency generator includes an adapter body having a proximal connector to be coupled to the generator, a distal connector to be coupled to the dissimilar, normally incompatible radiotherapeutic probe, and one or more electrical elements to emulate one or more operating parameters of a compatible, native radiotherapeutic probe to interface the generator with the dissimilar, normally incompatible radiotherapeutic probe.
摘要翻译： 用于耦合不同的通常不兼容的放射治疗探针和射频发生器的适配器包括具有要耦合到发生器的近端连接器的适配器主体，要耦合到不同的通常不相容的放射治疗探针的远端连接器，以及一个或多个电气 元件以模拟相容的天然放射治疗探针的一个或多个操作参数，以将发生器与不同的通常不相容的放射治疗探针相接触。
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公开(公告)号：US20050080410A1
公开(公告)日：2005-04-14
申请号：US10685744
申请日：2003-10-14
IPC分类号： A61B18/14
CPC分类号： A61B18/1477 , A61B2018/00065 , A61B2018/1472 , A61B2018/1475
摘要： An apparatus for delivering electrical energy includes a cannula and one or more needles extendable from and retractable into a lumen of the cannula. A distal portion of each needle is extendable from the lumen and terminates in a tissue-piercing distal tip. Each distal portion is formed from an electrically conductive and porous material, thereby providing a porous electrode through which electrolytic fluid may flow for delivering electrical energy to tissue surrounding the distal portion. The cannula is introduced into a tissue structure of a patient, the one or more needles are advanced from the cannula, saline is introduced from the porous material to surrounding tissue, and electrical energy from an RF generator is delivered to ablate tissue within the tissue structure.
摘要翻译： 用于递送电能的装置包括套管和一个或多个可从套管的内腔中伸出并可收缩的针。 每个针的远端部分可从内腔延伸并终止于组织刺穿的远端。 每个远端部分由导电和多孔材料形成，从而提供多孔电极，电解液可通过该多孔电极流动，用于将电能传递到围绕远端部分的组织。 将套管引入患者的组织结构中，一个或多个针从套管前进，盐水从多孔材料引入周围组织，并且来自RF发生器的电能被输送以烧蚀组织结构内的组织 。
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公开(公告)号：US20080293925A1
公开(公告)日：2008-11-27
申请号：US11913514
申请日：2006-05-09
IPC分类号： C07K1/00 , C07D251/48
CPC分类号： B01J20/289 , B01J20/286 , B01J20/3212 , B01J20/3219 , B01J20/3242 , B01J20/3244 , B01J20/3251 , B01J20/3253 , B01J20/3255 , B01J2220/54 , B01J2220/58 , C07D251/48 , C07D251/50 , C12Q1/56 , G01N33/86
摘要： For the separation, removal, isolation, purification, characterisation, identification or quantification of plasminogen or a protein that is a plasminogen analogue, an affinity adsorbent is used that is a compound of formula (II) wherein one X is N and the other is N, C—Cl or C—CN; A is a support matrix, optionally linked to the triazine ring by a spacer; Z is O, S or N—R and R is H, C1-6 alkyl, C1-6 hydroxyalkyl, benzyl or &bgr;-phenylethyl; B is an optionally substituted hydrocarbon linkage containing from 1 to 10 carbon atoms; D is H, OH or a primary amino, secondary amino, tertiary amino, quaternary ammonium, imidazole, guanidino or amidino group; or B-D is —CHCOOH—(CH2)3-4—NH2; and q is 2 to 6.
摘要翻译： 对于纤溶酶原或纤溶酶原类似物的蛋白质的分离，去除，分离，纯化，表征，鉴定或定量，使用亲和吸附剂，其为一个X为N且另一个为N的式（II）化合物 ，C-Cl或C-CN; A是支持基质，任选地通过间隔基与三嗪环连接; Z是O，S或N-R，R是H，C 1-6烷基，C 1-6羟基烷基，苄基或β-苯基乙基; B是含有1至10个碳原子的任选取代的烃键; D是H，OH或伯氨基，仲氨基，叔氨基，季铵，咪唑，胍基或脒基; 或B-D为-CHCOOH-（CH2）3-4-NH2; q为2〜6。
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