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29 条记录 (耗时 0.017 秒)

    Identification of immunoglobulin (lg) disorders using fourier transform infrared spectroscopy
    1.
    发明授权
    Identification of immunoglobulin (lg) disorders using fourier transform infrared spectroscopy 有权
    使用傅里叶变换红外光谱鉴定免疫球蛋白（Ig）病症

    公开(公告)号：US08421019B2

    公开(公告)日：2013-04-16

    申请号：US12175022

    申请日：2008-07-17

    申请人： Christopher B. Riley ,  J. Trenton McClure ,  R. Anthony Shaw

    发明人： Christopher B. Riley ,  J. Trenton McClure ,  R. Anthony Shaw

    IPC分类号： G01J5/02

    CPC分类号： G01N21/35 ,  G01N21/3577 ,  G01N2021/3595

    摘要： A method and a corresponding system for obtaining a serum mid-infrared spectroscopic profile using Fourier-transform infrared spectroscopy (FTIR) are described. The method comprises acquiring FTIR spectra for dried sera and preprocessing the FTIR spectra of sera by differentiation and smoothing to enhance weak spectral features and to remove baseline variations. The preprocessed FTIR spectra are normalized to a common intensity range, the normalization being performed in a spectral sub-region defined by strongest infrared (IR) absorption for a protein to obtain the serum spectroscopic profile. The serum spectroscopic profiles provide a basis to diagnose immunoglobulin disorders or to quantify serum immunoglobulin levels.

    摘要翻译： 描述了使用傅立叶变换红外光谱（FTIR）获得血清中红外光谱分布的方法和相应的系统。 该方法包括获取干血清的FTIR光谱，并通过分化和平滑预处理血清的FTIR光谱以增强弱光谱特征并消除基线变化。 将预处理的FTIR光谱归一化为常见的强度范围，归一化在由蛋白质的最强红外（IR）吸收限定的光谱亚区域中进行，以获得血清光谱图。 血清光谱图为诊断免疫球蛋白病症或定量血清免疫球蛋白水平提供依据。

    Mesh sponge with pocket
    2.
    发明申请
    Mesh sponge with pocket 审中-公开
    口袋海绵

    公开(公告)号：US20070269259A9

    公开(公告)日：2007-11-22

    申请号：US11483112

    申请日：2006-07-07

    申请人： Anthony Shaw

    发明人： Anthony Shaw

    IPC分类号： A47K7/02

    CPC分类号： A47K7/03 ,  A47K7/02

    摘要： A mesh sponge is formed as a batting of multiple layers of a tubular mesh material defining a pocket. The pocket may house a cleaning aid article, for example, a bar of soap or a structural form. Liquid soap may be used in conjunction with the mesh sponge and structural form, which provides a solid feel to the user. The pocket in the mesh sponge may house a bladder that is filled with liquid soap. The bladder may be porous or contain one or more valved openings to facilitate the excretion or dispensing of the liquid soap upon squeezing of the bladder by a user.

    摘要翻译： 形成网状海绵作为限定袋的多层管状网状材料的棉条。 口袋可以容纳清洁助剂物品，例如一条肥皂或结构形式。 液体皂可以与网状海绵和结构形式结合使用，这为使用者提供了坚实的感觉。 网状海绵中的口袋可容纳充满液体肥皂的膀胱。 膀胱可以是多孔的或包含一个或多个阀门开口，以便于在用户挤压膀胱时排出或分配液体肥皂。

    Steering control mechanism for kick scooter
    4.
    发明授权
    Steering control mechanism for kick scooter 失效
    脚踏车的转向控制机构

    公开(公告)号：US06398238B1

    公开(公告)日：2002-06-04

    申请号：US09865556

    申请日：2001-05-29

    申请人： Anthony Shaw

    发明人： Anthony Shaw

    IPC分类号： A63C1700

    CPC分类号： B62K3/002

    摘要： A steering control mechanism formed of a base, two steering bars, an intermediate block, and two links, and installed in a kick scooter to function as two parallel four-bar linkages for controlling the steering direction of the front wheels of the kick scooter.

    摘要翻译： 一种由基座，两个转向杆，中间块和两个连杆组成的转向控制机构，并安装在脚踏踏板车中，用作两个平行的四杆连杆，用于控制脚踏踏板车前轮的转向方向。

    Method and test for blood serum component analysis
    6.
    发明授权
    Method and test for blood serum component analysis 有权
    血清成分分析方法和试验

    公开(公告)号：US08124415B2

    公开(公告)日：2012-02-28

    申请号：US12000334

    申请日：2007-12-11

    申请人： Kan-Zhi Liu ,  Anthony Shaw

    发明人： Kan-Zhi Liu ,  Anthony Shaw

    IPC分类号： G01N33/92 ,  G01N31/00

    CPC分类号： G01N33/92 ,  G01N21/35 ,  G01N2333/775

    摘要： The discovery that apolipoprotein B exhibits spectral features in the mid IR spectrum that make it identifiable within blood serum leads to the invented use of a statistical correlation between a concentration of apolipoprotein-B (apoB) in a sample of blood serum and infrared spectral features of the blood serum sample to produce a test for apoB. A method for providing such a test, and tests produced by the method are taught.

    摘要翻译： 发现载脂蛋白B在中红外光谱中显示光谱特征，使其在血清中可识别，导致本发明使用血清样品中载脂蛋白B（apoB）的浓度与红细胞光谱特征之间的统计学相关性 血清样品产生apoB检测。 提供了一种用于提供这种测试的方法，以及通过该方法产生的测试。

    Microfluidic preconditioning of (bio)fluids for reagent-free infrared clinical analysis and diagnostics
    7.
    发明授权
    Microfluidic preconditioning of (bio)fluids for reagent-free infrared clinical analysis and diagnostics 有权
    （生物）流体的微流体预处理，用于无试剂红外临床分析和诊断

    公开(公告)号：US07754490B2

    公开(公告)日：2010-07-13

    申请号：US11568937

    申请日：2005-05-05

    申请人： Colin Mansfield ,  Anthony Shaw

    发明人： Colin Mansfield ,  Anthony Shaw

    IPC分类号： G01N21/35 ,  G01N21/17 ,  G01N21/00

    CPC分类号： G01N21/35 ,  G01N21/03 ,  G01N2001/4016 ,  G01N2001/4072

    摘要： A number of reagent-free infrared spectroscopic diagnostic and analytical methods have been established previously, making use of dry biofluid films. For example, this approach has successfully measured high concentration analytes of serum and urine. However, a number of low concentration diagnostically relevant analytes presently elude detection by infrared spectroscopy. This is due in part to their relatively low concentration and in part to spectral interference by other strongly absorbing constituents. The applicability of the technique would be broadened substantially if it were possible to separate and concentrate, lower concentration analytes, e.g. serum creatinine and urine proteins, from the obscuring presence of relatively high concentration compounds. The invention disclosed achieves this is through microfluidic sample preconditioning based upon laminar fluid diffusion interfaces. Preferential separation of certain low concentration serum and urine analytes of clinical interest that presently lie just below the threshold of detection by infrared spectroscopy is provided.

    摘要翻译： 以前已经建立了许多无试剂的红外光谱诊断和分析方法，利用干生物流体膜。 例如，这种方法已成功测量血清和尿液的高浓度分析物。 然而，许多低浓度诊断相关分析物目前排除通过红外光谱检测。 这部分归因于它们的相对低的浓度，部分是由于其它强吸收组分的光谱干扰。 如果可以分离和浓缩，降低浓度的分析物，例如，可以将该技术的适用性显着扩大。 血清肌酐和尿蛋白，来自相对高浓度化合物的模糊存在。 所公开的发明通过基于层流扩散界面的微流体样品预处理来实现。 提供目前正在低于通过红外光谱法检测阈值的临床兴趣的某些低浓度血清和尿液分析物的优先分离。

    Method and test for blood serum component analysis
    8.
    发明申请
    Method and test for blood serum component analysis 有权
    血清成分分析方法和试验

    公开(公告)号：US20080153171A1

    公开(公告)日：2008-06-26

    申请号：US12000334

    申请日：2007-12-11

    申请人： Kan-Zhi Liu ,  Anthony Shaw

    发明人： Kan-Zhi Liu ,  Anthony Shaw

    IPC分类号： G01N33/92 ,  G01N31/00

    CPC分类号： G01N33/92 ,  G01N21/35 ,  G01N2333/775

    摘要： The discovery that apolipoprotein B exhibits spectral features in the mid IR spectrum that make it identifiable within blood serum leads to the invented use of a statistical correlation between a concentration of apolipoprotein-B (apoB) in a sample of blood serum and infrared spectral features of the blood serum sample to produce a test for apoB. A method for providing such a test, and tests produced by the method are taught.

    摘要翻译： 发现载脂蛋白B在中红外光谱中显示光谱特征，使其在血清中可识别，导致本发明使用血清样品中载脂蛋白B（apoB）的浓度与红细胞光谱特征之间的统计学相关性 血清样品产生apoB检测。 提供了一种用于提供这种测试的方法，以及通过该方法产生的测试。