公开(公告)号：US20070161556A1

公开(公告)日：2007-07-12

申请号：US11516396

申请日：2006-09-05

申请人： Christopher Savoie ,  Satoru Kuhara ,  Kosuke Tashira

发明人： Christopher Savoie ,  Satoru Kuhara ,  Kosuke Tashira

IPC分类号： A61K38/17 ,  A61K48/00 ,  C12Q1/68 ,  C12Q1/18 ,  C07H21/04 ,  C12N9/24

CPC分类号： C07K14/37 ,  C12Q1/18

摘要： The present invention provides therapeutic targets for antifungal treatment, especially CIK1.

摘要翻译： 本发明提供抗真菌治疗的治疗靶点，特别是CIK1。

公开(公告)号：US5961358A

公开(公告)日：1999-10-05

申请号：US39628

申请日：1998-03-16

申请人： Jeff Hardesty ,  Cedric Savineau ,  Christopher Savoie

发明人： Jeff Hardesty ,  Cedric Savineau ,  Christopher Savoie

IPC分类号： B63H23/30 ,  F16H7/08 ,  F16H9/06 ,  B63H20/14

CPC分类号： B63H23/30 ,  B63H2023/0216 ,  F16H2007/0874 ,  F16H9/06

摘要： A reversible stern drive system incorporates a continuous drive member looped about a first and second intermediate shaft and a propeller shaft to transmit rotational power from the intermediate shafts to the propeller shaft in either a first or second propeller rotational direction. Rotational direction of the propeller shaft is determined by selective coupling of either a first driven member to the first intermediate shaft by a first clutch or a second driven member to the second intermediate shaft by a second clutch. In a second embodiment of the invention, two separate continuous drive members are employed to drive two concentrically mounted propeller shafts. The first continuous drive member is looped about one of two sprockets on the first and second intermediate shafts and the first propeller shaft such that when one of the sprockets is coupled by a first clutch to the first intermediate shaft, the first propeller shaft rotates in a first propeller rotational direction. The second continuous drive member is looped about the other of the sprocket on the first and second intermediate shafts and the second propeller shaft such that when one of the sprockets is coupled to the second intermediate shaft by a second clutch, the second propeller shaft rotates in a second propeller rotational direction.

摘要翻译： 可逆的船尾驱动系统包括环绕第一和第二中间轴和传动轴的连续驱动构件，以将旋转动力从第一或第二螺旋桨旋转方向的中间轴传递到传动轴。 通过第一离合器或第二从动构件将第一从动构件与第一中间轴的第二离合器选择性地联接到第二中间轴来确定传动轴的转动方向。 在本发明的第二实施例中，采用两个独立的连续驱动构件来驱动两个同心安装的传动轴。 第一连续驱动构件围绕第一和第二中间轴和第一传动轴上的两个链轮中的一个环绕，使得当其中一个链轮通过第一离合器联接到第一中间轴时，第一传动轴以 第一螺旋桨旋转方向。 第二连续驱动构件环绕第一和第二中间轴和第二传动轴上的另一个链轮，使得当其中一个链轮通过第二离合器联接到第二中间轴时，第二传动轴转动 第二个螺旋桨旋转方向。

公开(公告)号：US20080220977A1

公开(公告)日：2008-09-11

申请号：US11546820

申请日：2006-10-11

申请人： Seiya Imoto ,  Satoru Miyano ,  Christopher Savoie ,  Cristin Print ,  David Stephen Charnock-Jones

发明人： Seiya Imoto ,  Satoru Miyano ,  Christopher Savoie ,  Cristin Print ,  David Stephen Charnock-Jones

IPC分类号： C40B20/00 ,  C40B60/14 ,  C40B50/02

CPC分类号： G16B5/00 ,  G16B25/00

摘要： Embodiments of this invention include application of new inferential methods to analysis of complex biological information, including gene networks. New methods include modifications of Bayesian inferential methods and application of those methods to determining cause and effect relationships between expressed genes, and in some embodiments, for determining upstream effectors of regulated genes. Additional modifications of Bayesian methods include use of time course data and use of gene disruption data to infer causal relationships between expressed genes. Other embodiments include the use of bootstrapping methods and determination of edge effects to more accurately provide network information between expressed genes. Information about gene networks can be stored in a memory device and can be transmitted to an output device, or can be transmitted to remote location.

摘要翻译： 本发明的实施例包括应用新的推理方法来分析复杂的生物信息，包括基因网络。 新方法包括贝叶斯推理方法的修改和这些方法的应用以确定表达基因之间的因果关系，并且在一些实施方案中用于确定受调节基因的上游受体。 贝叶斯方法的其他修改包括使用时间过程数据和使用基因破坏数据来推断表达基因之间的因果关系。 其他实施例包括使用自举方法和确定边缘效应以更准确地提供表达基因之间的网络信息。 关于基因网络的信息可以存储在存储设备中，并且可以被传输到输出设备，或者可以被发送到远程位置。

公开(公告)号：US20050015519A1

公开(公告)日：2005-01-20

申请号：US10892746

申请日：2004-07-16

申请人： Babak Hodjat ,  Christopher Savoie ,  Makoto Amamiya

发明人： Babak Hodjat ,  Christopher Savoie ,  Makoto Amamiya

IPC分类号： G06F15/16 ,  G06F3/00 ,  G06F9/46 ,  G06F13/00 ,  G06F17/00 ,  G06F17/20 ,  G06F17/30 ,  G06N5/04 ,  G09G5/00

CPC分类号： G06N5/043

摘要： Method and agent network architecture for processing a subject message, where each agent has a view of its own domain of responsibility. An initiator agent which receives a user-input request and does not itself have a relevant interpretation policy, queries its downchain agents whether the queried agent considers such message to be in its domain of responsibility. Each queried agent recursively determines whether it has an interpretation policy of its own that applies to the request, and if not, further queries its own further downchain neighboring agents. The further agents eventually respond to such further queries, thereby allowing the first-queried agents to respond to the initiator agent. The recursive invocation of this procedure ultimately determines one or more paths through the network from the initiator agent to one more more leaf agents. The request is then transmitted down the path(s), with each agent along the way taking any local action thereon and passing the message on to the next agent in the path. In the event of a contradiction, the network is often able to resolve many of such contradictions according to predetermined algorithms. If it cannot resolve a contradiction automatically, it learns new interpretation policies necessary to interpret the subject message properly. Such learning preferably includes interaction with the user (but only to the extent necessary), and preferably localizes the learning close to the correct leaf agent in the network.

摘要翻译： 用于处理主题消息的方法和代理网络架构，其中每个代理人具有自己的责任领域的视图。 接收用户输入请求并且本身不具有相关解释策略的发起方代理，向其下行代理查询查询代理是否将该消息视为其责任领域。 每个查询代理递归地确定它是否具有适用于请求的自己的解释策略，如果不是，则进一步查询其自己的进一步的下行相邻代理。 其他代理最终响应这样的进一步的查询，从而允许第一询问代理对发起者代理作出响应。 该过程的递归调用最终确定通过网络从启动器代理到一个或多个叶代理的一个或多个路径。 然后，该请求沿着路径传送，每个代理沿着路线采取任何本地动作，并将消息传递到路径中的下一个代理。 在出现矛盾的情况下，网络通常能够根据预定的算法解决许多这样的矛盾。 如果不能自动解决矛盾，它会学习解释主题信息所需的新的解释政策。 这种学习优选地包括与用户的交互（但仅在必要的程度上），并且优选地将接近于网络中正确的叶代理的学习定位。