-
公开(公告)号:US08974781B2
公开(公告)日:2015-03-10
申请号:US13079726
申请日:2011-04-04
申请人: Christopher Todd Bauer , Maureen Jeri Bourner , Melanie Boyle , Gerald Fries Casperson , David William Griggs , Richard David Head , William Dean Joy , Richard Allen Mazzarella , Ralph Raymond Minter , Mark Allen Moffat , Barrett Richard Thiele , Todd Lee Vanarsdale
发明人: Christopher Todd Bauer , Maureen Jeri Bourner , Melanie Boyle , Gerald Fries Casperson , David William Griggs , Richard David Head , William Dean Joy , Richard Allen Mazzarella , Ralph Raymond Minter , Mark Allen Moffat , Barrett Richard Thiele , Todd Lee Vanarsdale
IPC分类号: A61K39/395 , A61P35/02 , C07K16/18 , C07K16/28
CPC分类号: C07K16/28 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , Y02P20/582
摘要: The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to P-cadherin, and that function to inhibit P-cadherin. The invention also relates to heavy and light chain immunoglobulins derived from human P-cadherin antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human P-cadherin antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译: 本发明涉及结合P-钙粘蛋白的人抗体及其抗原结合部分的抗体,其功能是抑制P-钙粘蛋白。 本发明还涉及衍生自人P-钙粘蛋白抗体的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人P-钙粘蛋白抗体的方法,包含这些抗体的组合物和使用抗体和组合物的方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。
-
公开(公告)号:US20110182884A1
公开(公告)日:2011-07-28
申请号:US13079726
申请日:2011-04-04
申请人: Christopher Todd Bauer , Maureen Jeri Bourner , Melanie Boyle , Gerald Fries Casperson , David William Griggs , Richard David Head , William Dean Joy , Richard Allen Mazzarella , Ralph Raymond Minter , Mark Allen Moffat , Barrett Richard Thiele , Todd Lee Vanarsdale
发明人: Christopher Todd Bauer , Maureen Jeri Bourner , Melanie Boyle , Gerald Fries Casperson , David William Griggs , Richard David Head , William Dean Joy , Richard Allen Mazzarella , Ralph Raymond Minter , Mark Allen Moffat , Barrett Richard Thiele , Todd Lee Vanarsdale
IPC分类号: A61K39/395 , C07K16/18 , A61P35/00 , A61P35/02
CPC分类号: C07K16/28 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , Y02P20/582
摘要: The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to P-cadherin, and that function to inhibit P-cadherin. The invention also relates to heavy and light chain immunoglobulins derived from human P-cadherin antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human P-cadherin antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译: 本发明涉及结合P-钙粘蛋白的人抗体及其抗原结合部分的抗体,其功能是抑制P-钙粘蛋白。 本发明还涉及衍生自人P-钙粘蛋白抗体的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人P-钙粘蛋白抗体的方法,包含这些抗体的组合物和使用抗体和组合物的方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。
-
公开(公告)号:US07928214B2
公开(公告)日:2011-04-19
申请号:US12249843
申请日:2008-10-10
申请人: Christopher Todd Bauer , Maureen Jeri Bourner , Melanie Boyle , Gerald Fries Casperson , David William Griggs , Richard David Head , William Dean Joy , Richard Allen Mazzarella , Ralph Raymond Minter , Mark Allen Moffat , Barrett Richard Thiele , Todd Lee Vanarsdale
发明人: Christopher Todd Bauer , Maureen Jeri Bourner , Melanie Boyle , Gerald Fries Casperson , David William Griggs , Richard David Head , William Dean Joy , Richard Allen Mazzarella , Ralph Raymond Minter , Mark Allen Moffat , Barrett Richard Thiele , Todd Lee Vanarsdale
IPC分类号: C07H21/04
CPC分类号: C07K16/28 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , Y02P20/582
摘要: The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to P-cadherin, and that function to inhibit P-cadherin. The invention also relates to heavy and light chain immunoglobulins derived from human P-cadherin antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human P-cadherin antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译: 本发明涉及结合P-钙粘蛋白的人抗体及其抗原结合部分的抗体,其功能是抑制P-钙粘蛋白。 本发明还涉及衍生自人P-钙粘蛋白抗体的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人P-钙粘蛋白抗体的方法,包含这些抗体的组合物和使用抗体和组合物的方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。
-
公开(公告)号:US07452537B2
公开(公告)日:2008-11-18
申请号:US11410610
申请日:2006-04-25
申请人: Christopher Todd Bauer , Maureen Jeri Bourner , Melanie Boyle , Gerald Fries Casperson , David William Griggs , Richard David Head , William Dean Joy , Richard Allen Mazzarella , Ralph Raymond Minter , Mark Allen Moffat , Barrett Richard Thiele , Todd Lee Vanarsdale
发明人: Christopher Todd Bauer , Maureen Jeri Bourner , Melanie Boyle , Gerald Fries Casperson , David William Griggs , Richard David Head , William Dean Joy , Richard Allen Mazzarella , Ralph Raymond Minter , Mark Allen Moffat , Barrett Richard Thiele , Todd Lee Vanarsdale
CPC分类号: C07K16/28 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , Y02P20/582
摘要: The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to P-cadherin, and that function to inhibit P-cadherin. The invention also relates to heavy and light chain immunoglobulins derived from human P-cadherin antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human P-cadherin antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译: 本发明涉及结合P-钙粘蛋白的人抗体及其抗原结合部分的抗体,其功能是抑制P-钙粘蛋白。 本发明还涉及衍生自人P-钙粘蛋白抗体的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人P-钙粘蛋白抗体的方法,包含这些抗体的组合物和使用抗体和组合物的方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。
-
公开(公告)号:US20060240001A1
公开(公告)日:2006-10-26
申请号:US11410610
申请日:2006-04-25
申请人: Christopher Bauer , Maureen Bourner , Melanie Boyle , Gerald Casperson , David Griggs , Richard Head , William Joy , Richard Mazzarella , Ralph Minter , Mark Moffat , Barrett Thiele , Todd Vanarsdale
发明人: Christopher Bauer , Maureen Bourner , Melanie Boyle , Gerald Casperson , David Griggs , Richard Head , William Joy , Richard Mazzarella , Ralph Minter , Mark Moffat , Barrett Thiele , Todd Vanarsdale
IPC分类号: A61K39/395 , C07K16/30
CPC分类号: C07K16/28 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , Y02P20/582
摘要: The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to P-cadherin, and that function to inhibit P-cadherin. The invention also relates to heavy and light chain immunoglobulins derived from human P-cadherin antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human P-cadherin antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
-
公开(公告)号:US08779108B2
公开(公告)日:2014-07-15
申请号:US13511538
申请日:2010-11-24
申请人: Christophe Queva , Michelle Morrow , Scott Hammond , Marat Alimzhanov , John Babcook , Ian Nevin Foltz , Jaspal Singh Kang , Laura Sekirov , Melanie Boyle , Matthieu Chodorge , Ross A. Stewart , Kathleen Ann Mulgrew
发明人: Christophe Queva , Michelle Morrow , Scott Hammond , Marat Alimzhanov , John Babcook , Ian Nevin Foltz , Jaspal Singh Kang , Laura Sekirov , Melanie Boyle , Matthieu Chodorge , Ross A. Stewart , Kathleen Ann Mulgrew
CPC分类号: C07K16/2827 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/70 , C07K2317/76 , C07K2317/92
摘要: Human monoclonal antibodies directed against B7-H1 and uses of these antibodies in diagnostics and for the treatment of diseases associated with the activity and/or expression of B7-H1 are disclosed. Additionally, hybridomas or other cell lines expressing such antibodies are disclosed.
摘要翻译: 公开了针对B7-H1的人单克隆抗体以及这些抗体在诊断中的用途以及用于治疗与B7-H1的活性和/或表达相关的疾病的疾病。 此外,公开了表达这种抗体的杂交瘤或其它细胞系。
-
公开(公告)号:US20130034559A1
公开(公告)日:2013-02-07
申请号:US13511538
申请日:2010-11-24
申请人: Christophe Queva , Michelle Morrow , Scott Hammond , Marat Alimzhanov , John Babcook , Ian Nevin Foltz , Jaspal Singh Kang , Laura Sekirov , Melanie Boyle , Matthieu Chodorge , Ross A. Stewart , Kathleen Ann Mulgrew
发明人: Christophe Queva , Michelle Morrow , Scott Hammond , Marat Alimzhanov , John Babcook , Ian Nevin Foltz , Jaspal Singh Kang , Laura Sekirov , Melanie Boyle , Matthieu Chodorge , Ross A. Stewart , Kathleen Ann Mulgrew
IPC分类号: A61K39/395 , A61P35/00 , C07K16/30 , C12N15/13 , C12N5/10
CPC分类号: C07K16/2827 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/70 , C07K2317/76 , C07K2317/92
摘要: Human monoclonal antibodies directed against B7-H1 and uses of these antibodies in diagnostics and for the treatment of diseases associated with the activity and/or expression of B7-H1 are disclosed. Additionally, hybridomas or other cell lines expressing such antibodies are disclosed
摘要翻译: 公开了针对B7-H1的人单克隆抗体以及这些抗体在诊断中的用途以及用于治疗与B7-H1的活性和/或表达相关的疾病的疾病。 此外,公开了表达这种抗体的杂交瘤或其它细胞系
-
-
-
-
-
-