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公开(公告)号：US20120141464A1
公开(公告)日：2012-06-07
申请号：US11692008
申请日：2007-03-27
申请人： Emma Suzanne Cohen , Ralph Raymond Minter , Paula Rosamund Harrison , Matthew Alexander Sleeman , Andrew Donald Nash , Louis Jerry Fabri
发明人： Emma Suzanne Cohen , Ralph Raymond Minter , Paula Rosamund Harrison , Matthew Alexander Sleeman , Andrew Donald Nash , Louis Jerry Fabri
IPC分类号： A61K39/395 , A61P29/00 , A61P11/00 , A61P25/00 , A61P11/06 , A61P9/10 , A61P35/02 , C07K16/18 , A61P19/02
CPC分类号： C07K16/2866 , A61K38/00 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76
摘要： Binding members are provided for alpha chain of receptor for granulocyte macrophage colony stimulating factor (GM-CSFRα), especially antibody molecules. Use of the binding members in treating inflammatory and autoimmune diseases, e.g. rheumatoid leukaemia and atherosclerosis is also provided.
摘要翻译： 为粒细胞巨噬细胞集落刺激因子（GM-CSFRα），特别是抗体分子的α链受体提供结合成员。 使用结合成员治疗炎性和自身免疫疾病，例如， 还提供类风湿性白血病和动脉粥样硬化。
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公开(公告)号：US20090118487A1
公开(公告)日：2009-05-07
申请号：US12249843
申请日：2008-10-10
申请人： CHRISTOPHER TODD BAUER , MAUREEN JERI BOURNER , MELANIE BOYLE , GERALD FRIES CASPERSON , DAVID WILLIAM GRIGGS , RICHARD DAVID HEAD , WILLIAM DEAN JOY , RICHARD ALLEN MAZZARELLA , RALPH RAYMOND MINTER , MARK ALLEN MOFFAT , BARRETT RICHARD THIELE , TODD LEE VANARSDALE
发明人： CHRISTOPHER TODD BAUER , MAUREEN JERI BOURNER , MELANIE BOYLE , GERALD FRIES CASPERSON , DAVID WILLIAM GRIGGS , RICHARD DAVID HEAD , WILLIAM DEAN JOY , RICHARD ALLEN MAZZARELLA , RALPH RAYMOND MINTER , MARK ALLEN MOFFAT , BARRETT RICHARD THIELE , TODD LEE VANARSDALE
IPC分类号： C07H21/04
CPC分类号： C07K16/28 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , Y02P20/582
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to P-cadherin, and that function to inhibit P-cadherin. The invention also relates to heavy and light chain immunoglobulins derived from human P-cadherin antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human P-cadherin antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译： 本发明涉及结合P-钙粘蛋白的人抗体及其抗原结合部分的抗体，其功能是抑制P-钙粘蛋白。 本发明还涉及衍生自人P-钙粘蛋白抗体的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人P-钙粘蛋白抗体的方法，包含这些抗体的组合物和使用抗体和组合物的方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。
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公开(公告)号：US09315575B2
公开(公告)日：2016-04-19
申请号：US12941677
申请日：2010-11-08
IPC分类号： A61K39/395 , C07K16/24 , A61K39/00
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S514/826 , Y10S514/883
摘要： Specific binding members, in particular human anti-IL-13 antibody molecules and especially those which neutralise IL-13 activity. Methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, including asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma.
摘要翻译： 特异性结合成员，特别是人抗IL-13抗体分子，特别是中和IL-13活性的那些。 用于诊断或治疗IL-13相关疾病（包括哮喘，特应性皮炎，过敏性鼻炎，纤维化，炎性肠病和霍奇金淋巴瘤）的抗IL-13抗体分子的方法。
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公开(公告)号：US20110182884A1
公开(公告)日：2011-07-28
申请号：US13079726
申请日：2011-04-04
申请人： Christopher Todd Bauer , Maureen Jeri Bourner , Melanie Boyle , Gerald Fries Casperson , David William Griggs , Richard David Head , William Dean Joy , Richard Allen Mazzarella , Ralph Raymond Minter , Mark Allen Moffat , Barrett Richard Thiele , Todd Lee Vanarsdale
发明人： Christopher Todd Bauer , Maureen Jeri Bourner , Melanie Boyle , Gerald Fries Casperson , David William Griggs , Richard David Head , William Dean Joy , Richard Allen Mazzarella , Ralph Raymond Minter , Mark Allen Moffat , Barrett Richard Thiele , Todd Lee Vanarsdale
IPC分类号： A61K39/395 , C07K16/18 , A61P35/00 , A61P35/02
CPC分类号： C07K16/28 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , Y02P20/582
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to P-cadherin, and that function to inhibit P-cadherin. The invention also relates to heavy and light chain immunoglobulins derived from human P-cadherin antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human P-cadherin antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译： 本发明涉及结合P-钙粘蛋白的人抗体及其抗原结合部分的抗体，其功能是抑制P-钙粘蛋白。 本发明还涉及衍生自人P-钙粘蛋白抗体的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人P-钙粘蛋白抗体的方法，包含这些抗体的组合物和使用抗体和组合物的方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。
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公开(公告)号：US07928214B2
公开(公告)日：2011-04-19
申请号：US12249843
申请日：2008-10-10
申请人： Christopher Todd Bauer , Maureen Jeri Bourner , Melanie Boyle , Gerald Fries Casperson , David William Griggs , Richard David Head , William Dean Joy , Richard Allen Mazzarella , Ralph Raymond Minter , Mark Allen Moffat , Barrett Richard Thiele , Todd Lee Vanarsdale
发明人： Christopher Todd Bauer , Maureen Jeri Bourner , Melanie Boyle , Gerald Fries Casperson , David William Griggs , Richard David Head , William Dean Joy , Richard Allen Mazzarella , Ralph Raymond Minter , Mark Allen Moffat , Barrett Richard Thiele , Todd Lee Vanarsdale
IPC分类号： C07H21/04
CPC分类号： C07K16/28 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , Y02P20/582
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to P-cadherin, and that function to inhibit P-cadherin. The invention also relates to heavy and light chain immunoglobulins derived from human P-cadherin antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human P-cadherin antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译： 本发明涉及结合P-钙粘蛋白的人抗体及其抗原结合部分的抗体，其功能是抑制P-钙粘蛋白。 本发明还涉及衍生自人P-钙粘蛋白抗体的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人P-钙粘蛋白抗体的方法，包含这些抗体的组合物和使用抗体和组合物的方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。
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公开(公告)号：US07829090B2
公开(公告)日：2010-11-09
申请号：US10564647
申请日：2004-07-15
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S514/826 , Y10S514/883
摘要： Specific binding members, in particular human anti-IL-13 antibody molecules and especially those which neutralise IL-13 activity. Methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, including asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma.
摘要翻译： 特异性结合成员，特别是人抗IL-13抗体分子，特别是中和IL-13活性的那些。 用于诊断或治疗IL-13相关疾病（包括哮喘，特应性皮炎，过敏性鼻炎，纤维化，炎性肠病和霍奇金淋巴瘤）的抗IL-13抗体分子的方法。
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公开(公告)号：US20090123478A1
公开(公告)日：2009-05-14
申请号：US11821880
申请日：2007-06-25
IPC分类号： A61K39/395 , C07K16/00 , C07H21/00 , C12N5/00 , C12P21/00 , G01N33/53 , A61P11/06 , A61P17/00 , A61P35/00
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S514/826 , Y10S514/883
摘要： Specific binding members, in particular human anti-IL-13 antibody molecules and especially those which neutralise IL-13 activity. Methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, including asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma.
摘要翻译： 特异性结合成员，特别是人抗IL-13抗体分子，特别是中和IL-13活性的那些。 用于诊断或治疗IL-13相关疾病（包括哮喘，特应性皮炎，过敏性鼻炎，纤维化，炎性肠病和霍奇金淋巴瘤）的抗IL-13抗体分子的方法。
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公开(公告)号：US07452537B2
公开(公告)日：2008-11-18
申请号：US11410610
申请日：2006-04-25
申请人： Christopher Todd Bauer , Maureen Jeri Bourner , Melanie Boyle , Gerald Fries Casperson , David William Griggs , Richard David Head , William Dean Joy , Richard Allen Mazzarella , Ralph Raymond Minter , Mark Allen Moffat , Barrett Richard Thiele , Todd Lee Vanarsdale
发明人： Christopher Todd Bauer , Maureen Jeri Bourner , Melanie Boyle , Gerald Fries Casperson , David William Griggs , Richard David Head , William Dean Joy , Richard Allen Mazzarella , Ralph Raymond Minter , Mark Allen Moffat , Barrett Richard Thiele , Todd Lee Vanarsdale
CPC分类号： C07K16/28 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , Y02P20/582
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to P-cadherin, and that function to inhibit P-cadherin. The invention also relates to heavy and light chain immunoglobulins derived from human P-cadherin antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human P-cadherin antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译： 本发明涉及结合P-钙粘蛋白的人抗体及其抗原结合部分的抗体，其功能是抑制P-钙粘蛋白。 本发明还涉及衍生自人P-钙粘蛋白抗体的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人P-钙粘蛋白抗体的方法，包含这些抗体的组合物和使用抗体和组合物的方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。
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公开(公告)号：US20080171365A1
公开(公告)日：2008-07-17
申请号：US11813507
申请日：2006-01-09
申请人： Ralph Raymond Minter , Steven Godfrey Lane , Roberto George Edward Holgate , Maria Anastasia Theresa Groves
发明人： Ralph Raymond Minter , Steven Godfrey Lane , Roberto George Edward Holgate , Maria Anastasia Theresa Groves
CPC分类号： C12N15/102
摘要： The present invention relates to a method of mutagenesis for introducing mutations into a molecule and, in particular, to methods that may be applied to populations of molecules for the generation or screening of libraries involving the mutation of multiple molecules.
摘要翻译： 本发明涉及将突变引入分子的诱变方法，特别涉及可用于生成或筛选涉及多个分子突变的文库的分子群的方法。
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公开(公告)号：US08518645B2
公开(公告)日：2013-08-27
申请号：US11813507
申请日：2006-01-09
申请人： Ralph Raymond Minter , Steven Godfrey Lane , Robert George Edward Holgate , Maria Anastasia Theresa Groves
发明人： Ralph Raymond Minter , Steven Godfrey Lane , Robert George Edward Holgate , Maria Anastasia Theresa Groves
CPC分类号： C12N15/102
摘要： The present invention relates to a method of mutagenesis for introducing mutations into a molecule and, in particular, to methods that may be applied to populations of molecules for the generation or screening of libraries involving the mutation of multiple molecules.
摘要翻译： 本发明涉及将突变引入分子的诱变方法，特别涉及可用于生成或筛选涉及多个分子突变的文库的分子群的方法。
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