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    Methods of Enhancing Delivery of Drugs Using Ultrasonic Waves and Systems for Performing The Same
    2.
    发明申请
    Methods of Enhancing Delivery of Drugs Using Ultrasonic Waves and Systems for Performing The Same 有权
    使用超声波和系统进行药物递送的方法

    公开(公告)号：US20120271167A1

    公开(公告)日：2012-10-25

    申请号：US13409634

    申请日：2012-03-01

    申请人： Christy K. Holland ,  Kathryn E. Hitchcock ,  Kevin Haworth ,  Nikolas Ivancevich ,  T. Douglas Mast

    发明人： Christy K. Holland ,  Kathryn E. Hitchcock ,  Kevin Haworth ,  Nikolas Ivancevich ,  T. Douglas Mast

    IPC分类号： A61B8/08 ,  A61N7/00

    CPC分类号： A61M37/0092 ,  A61B8/0833 ,  A61B8/481

    摘要： Methods and systems for inducing and passively detecting stable cavitation and/or inertial cavitation for targeted drug delivery across a biological membrane are disclosed. Such methods include administering vesicles having a nucleating agent and a therapeutic drug to a vascular system of a patient, and providing an active interval of ultrasonic exposure substantially throughout a targeted treatment zone. The ultrasonic exposure is produced by a source transducer at a specified fundamental frequency, amplitude, duty cycle, and duration. The methods also include detecting a scattered ultrasonic wave, where the scattered ultrasonic wave is received by a detection transducer. Detection of the scattered ultrasonic wave is indicative of stable and/or inertial cavitation. The ultrasonic exposure is provided intermittently in the active intervals separated by rest periods, and substantially less ultrasonic exposure is provided during the rest period than during the active interval.

    摘要翻译： 公开了用于诱导和被动检测稳定气蚀和/或惯性空化以用于横跨生物膜的靶向药物递送的方法和系统。 这样的方法包括将具有成核剂和治疗药物的囊泡给予患者的血管系统，并且基本上在整个靶向治疗区域提供超声暴露的活性间隔。 超声波曝光由源传感器以指定的基频，幅度，占空比和持续时间产生。 该方法还包括检测散射超声波，其中散射的超声波被检测传感器接收。 散射超声波的检测表明稳定和/或惯性空化。 超声波曝光以间隔隔开的活动间隔间歇地提供，并且在休止期间比在活动间隔期间提供显着更少的超声波曝光。