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1.发明授权公开(公告)号：US11780908B2
公开(公告)日：2023-10-10
申请号：US17066092
申请日：2020-10-08
CPC分类号： C07K16/1081 , A61P31/12 , A61K2039/505 , C07K2317/52 , C07K2317/56 , C07K2317/734 , C07K2317/92 , C07K2317/94 , Y02A50/30
摘要： The disclosure provides anti-DENV antibodies and methods of making and using the same. Nucleic acids encoding anti-DENV antibodies and host cells comprising the nucleic acids are also provided. The anti-DENV antibodies have uses that include treating DENV infection. The disclosure also provided polypeptides containing a variant Fc region and methods of making the same. Nucleic acids encoding polypeptides and host cells comprising the nucleic acids are also provided. The polypeptides have uses that include treating a viral infection. Also claimed is a polypeptide comprising a Fc variant comprising at least one amino acid alteration in a parent Fc region, wherein the variant Fc region has a substantially decreased FcYR-binding activity and does not have a substantially decreased C1 q-binding activity when compared to the parent Fc region.
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2.发明授权公开(公告)号：US10604561B2
公开(公告)日：2020-03-31
申请号：US16333736
申请日：2017-09-15
IPC分类号： A61K39/00 , A61K39/12 , A61K39/295 , C07K14/005 , C07K16/10 , A61P31/12
摘要： The disclosure provides anti-DENV antibodies and methods of making and using the same. Nucleic acids encoding anti-DENV antibodies and host cells comprising the nucleic acids are also provided. The anti-DENV antibodies have uses that include treating DENV infection. The disclosure also provided polypeptides containing a variant Fc region and methods of making the same. Nucleic acids encoding polypeptides and host cells comprising the nucleic acids are also provided. The polypeptides have uses that include treating a viral infection. Also claimed is a polypeptide comprising a Fc variant comprising at least one amino acid alteration in a parent Fc region, wherein the variant Fc region has a substantially decreased FcYR-binding activity and does not have a substantially decreased C1 q-binding activity when compared to the parent Fc region.
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公开(公告)号：US10316078B2
公开(公告)日：2019-06-11
申请号：US15558937
申请日：2016-03-17
发明人： Cheng-I Wang , Katja Fink , Paul Macary , Roland Zuest , Meihui Xu
IPC分类号： C07K16/10 , G01N33/569 , A61P31/12 , A61K39/00
摘要： Disclosed are isolated antibodies, or antigen binding fragments thereof, that bind to dengue virus epitopes, as well as kits containing them, compositions containing them, and passive vaccines comprising them, in one embodiment, the antibody or antigen binding fragment thereof is capable of binding to a whole dengue virus particle better than binding to a dengue virus surface glycoprotein. Also disclosed are methods of using the antibodies or antigen binding fragments thereof, nucleic acids encoding them, vectors expressing the nucleic acids, host producing them, and methods of manufacturing them.
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