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    NOVEL GERMINAL KINASE PROTEINS, COMPOSITIONS AND METHODS OF USE
    1.
    发明申请
    NOVEL GERMINAL KINASE PROTEINS, COMPOSITIONS AND METHODS OF USE 审中-公开
    新型端粒激酶蛋白，组合物和使用方法

    公开(公告)号：US20080108098A1

    公开(公告)日：2008-05-08

    申请号：US11867504

    申请日：2007-10-04

    申请人： Cindy Leo ,  Ying Luo ,  Xiang Xu ,  Simon Yu

    发明人： Cindy Leo ,  Ying Luo ,  Xiang Xu ,  Simon Yu

    IPC分类号： C12Q1/48

    CPC分类号： C12N9/1205 ,  C12Q1/485 ,  G01N33/5041 ,  G01N2500/02

    摘要： The present invention provides compositions and methods for modulating cell proliferation, survival, morphology, and migration. Nucleic acids encoding proteins, and proteins so encoded which are capable of modulating proliferation, survival, morphology, and migration in mammalian cells are provided. Compositions and methods for the treatment of disorders related to cell proliferation, survival, morphology and migration are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions are methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating proliferation, survival, morphology, and migration in mammalian cells.

    摘要翻译： 本发明提供调节细胞增殖，存活，形态和迁移的组合物和方法。 提供了编码蛋白质的核酸和如此编码的能够调节哺乳动物细胞中增殖，存活，形态和迁移的蛋白质。 还提供了用于治疗与细胞增殖，存活，形态和迁移相关的病症的组合物和方法。 还提供了预防和预防这种疾病的方法。 还提供组合物是用于诊断和预测这些疾病的方法。 进一步提供了用于鉴定能够调节哺乳动物细胞中增殖，存活，形态和迁移的生物活性剂的测定。

    Germinal center kinase proteins, compositions and methods of use
    2.
    发明授权
    Germinal center kinase proteins, compositions and methods of use 失效
    生发中心激酶蛋白，组成和使用方法

    公开(公告)号：US07265214B2

    公开(公告)日：2007-09-04

    申请号：US10029115

    申请日：2001-10-19

    申请人： Ying Luo ,  Simon Yu ,  Xiang Xu ,  Cindy Leo

    发明人： Ying Luo ,  Simon Yu ,  Xiang Xu ,  Cindy Leo

    IPC分类号： C07H21/04 ,  C12Q1/68 ,  C12N5/02

    CPC分类号： C12N9/1205 ,  C12Q1/485 ,  G01N33/5041 ,  G01N2500/02

    摘要： The present invention provides compositions and methods for modulating cell proliferation, survival, morphology, and migration. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating proliferation, survival, morphology and migration in mammalian cells are provided. Compositions and methods for the treatment of disorders related to cell proliferation, survival, morphology and migration are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating proliferation, survival, morphology and migration in mammalian cells.

    摘要翻译： 本发明提供调节细胞增殖，存活，形态和迁移的组合物和方法。 提供了编码能够调节哺乳动物细胞中增殖，存活，形态和迁移的蛋白质和蛋白质的核酸。 还提供了用于治疗与细胞增殖，存活，形态和迁移相关的病症的组合物和方法。 还提供了预防和预防这种疾病的方法。 还提供了用于诊断和预测这些疾病的组合物和方法。 还提供了用于鉴定能够调节哺乳动物细胞中增殖，存活，形态和迁移的生物活性剂的测定。

    Germinal center kinase proteins, compositions, and methods of use
    3.
    发明授权
    Germinal center kinase proteins, compositions, and methods of use 有权
    生发中心激酶蛋白，组合物和使用方法

    公开(公告)号：US07300780B2

    公开(公告)日：2007-11-27

    申请号：US10493164

    申请日：2002-10-21

    申请人： Cindy Leo ,  Ying Luo ,  Xiang Xu ,  Simon Yu

    发明人： Cindy Leo ,  Ying Luo ,  Xiang Xu ,  Simon Yu

    IPC分类号： C12N9/12 ,  C07K1/00

    CPC分类号： C12N9/1205 ,  C12Q1/485 ,  G01N33/5041 ,  G01N2500/02

    摘要： The present invention provides compositions and methods for modulating cell proliferation, survival, morphology, and migration. Nucleic adds encoding proteins and proteins so encoded which are capable of modulating proliferation, survival, morphology and migration in mammalian cells are provided. Compositions and methods for the treatment of disorders related to cell proliferation, survival, morphology and migration are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating proliferation, survival, morphology and migration in mammalian cells.

    摘要翻译： 本发明提供调节细胞增殖，存活，形态和迁移的组合物和方法。 核酸添加编码蛋白质和如此编码的蛋白质，其能够调节哺乳动物细胞中的增殖，存活，形态和迁移。 还提供了用于治疗与细胞增殖，存活，形态和迁移相关的病症的组合物和方法。 还提供了预防和预防这种疾病的方法。 还提供了用于诊断和预测这些疾病的组合物和方法。 还提供了用于鉴定能够调节哺乳动物细胞中增殖，存活，形态和迁移的生物活性剂的测定。

    Novel germinal center kinase proteins, compositions, and methods of use
    4.
    发明申请
    Novel germinal center kinase proteins, compositions, and methods of use 有权
    新型生发中心激酶蛋白，组合物和使用方法

    公开(公告)号：US20050019771A1

    公开(公告)日：2005-01-27

    申请号：US10493164

    申请日：2002-10-21

    申请人： Cindy Leo ,  Ying Luo ,  Xiang Xu ,  Simon Yu

    发明人： Cindy Leo ,  Ying Luo ,  Xiang Xu ,  Simon Yu

    IPC分类号： C07H21/04 ,  C12N9/12 ,  C12Q1/48 ,  C12Q1/68 ,  G01N33/50

    CPC分类号： C12N9/1205 ,  C12Q1/485 ,  G01N33/5041 ,  G01N2500/02

    摘要： The present invention provides compositions and methods for modulating cell proliferation, survival, morphology, and migration. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating proliferation, survival, morphology and migration in mammalian cells are provided. Compositions and methods for the treatment of disorders related to cell proliferation, survival, morphology and migration are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating proliferation, survival, morphology and migration in mammalian cells.

    摘要翻译： 本发明提供调节细胞增殖，存活，形态和迁移的组合物和方法。 提供了编码能够调节哺乳动物细胞中增殖，存活，形态和迁移的蛋白质和蛋白质的核酸。 还提供了用于治疗与细胞增殖，存活，形态和迁移相关的病症的组合物和方法。 还提供了预防和预防这种疾病的方法。 还提供了用于诊断和预测这些疾病的组合物和方法。 还提供了用于鉴定能够调节哺乳动物细胞中增殖，存活，形态和迁移的生物活性剂的测定。

    Inflatable item with a valve attached thereto
    7.
    发明申请
    Inflatable item with a valve attached thereto 失效
    带有阀门的充气物品

    公开(公告)号：US20080047072A1

    公开(公告)日：2008-02-28

    申请号：US11507133

    申请日：2006-08-22

    申请人： Hsien-Wen Chang ,  Simon Yu

    发明人： Hsien-Wen Chang ,  Simon Yu

    IPC分类号： A47C27/08

    CPC分类号： A47C27/081 ,  A47C27/084

    摘要： An inflatable item includes a hollow body and a valve is connected to the hollow body. The valve is a bladder which has an inlet from which air is introduced in the bladder, and an outlet through which the air is introduced into the hollow body. A tubular insertion is engaged with the inlet and has a passage defined therethrough. A bouncing member is mounted to the tubular insertion so that the user compresses the bladder to push the air in the bladder into the hollow body and the bouncing member bounces the bladder back to original status. The hollow body can be inflated by repeatedly compressing the bladder. A cap removably seals the inlet after the inflatable item is inflated.

    摘要翻译： 充气物品包括中空体，阀连接到中空体。 阀是具有入口的气囊，空气从气体引入到气囊中，以及出口，空气通过该出口引入中空体。 管状插入件与入口接合并具有通过其限定的通道。 弹性构件安装到管状插入件上，使得使用者压缩膀胱以将膀胱中的空气推入中空体并且弹跳构件使膀胱反弹回到原始状态。 中空体可以通过反复压缩膀胱而膨胀。 在充气物品充气之后，帽可移除地密封入口。