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公开(公告)号：US20080108098A1
公开(公告)日：2008-05-08
申请号：US11867504
申请日：2007-10-04
IPC分类号： C12Q1/48
CPC分类号： C12N9/1205 , C12Q1/485 , G01N33/5041 , G01N2500/02
摘要： The present invention provides compositions and methods for modulating cell proliferation, survival, morphology, and migration. Nucleic acids encoding proteins, and proteins so encoded which are capable of modulating proliferation, survival, morphology, and migration in mammalian cells are provided. Compositions and methods for the treatment of disorders related to cell proliferation, survival, morphology and migration are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions are methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating proliferation, survival, morphology, and migration in mammalian cells.
摘要翻译： 本发明提供调节细胞增殖，存活，形态和迁移的组合物和方法。 提供了编码蛋白质的核酸和如此编码的能够调节哺乳动物细胞中增殖，存活，形态和迁移的蛋白质。 还提供了用于治疗与细胞增殖，存活，形态和迁移相关的病症的组合物和方法。 还提供了预防和预防这种疾病的方法。 还提供组合物是用于诊断和预测这些疾病的方法。 进一步提供了用于鉴定能够调节哺乳动物细胞中增殖，存活，形态和迁移的生物活性剂的测定。
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公开(公告)号：US07265214B2
公开(公告)日：2007-09-04
申请号：US10029115
申请日：2001-10-19
CPC分类号： C12N9/1205 , C12Q1/485 , G01N33/5041 , G01N2500/02
摘要： The present invention provides compositions and methods for modulating cell proliferation, survival, morphology, and migration. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating proliferation, survival, morphology and migration in mammalian cells are provided. Compositions and methods for the treatment of disorders related to cell proliferation, survival, morphology and migration are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating proliferation, survival, morphology and migration in mammalian cells.
摘要翻译： 本发明提供调节细胞增殖，存活，形态和迁移的组合物和方法。 提供了编码能够调节哺乳动物细胞中增殖，存活，形态和迁移的蛋白质和蛋白质的核酸。 还提供了用于治疗与细胞增殖，存活，形态和迁移相关的病症的组合物和方法。 还提供了预防和预防这种疾病的方法。 还提供了用于诊断和预测这些疾病的组合物和方法。 还提供了用于鉴定能够调节哺乳动物细胞中增殖，存活，形态和迁移的生物活性剂的测定。
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公开(公告)号：US07300780B2
公开(公告)日：2007-11-27
申请号：US10493164
申请日：2002-10-21
CPC分类号： C12N9/1205 , C12Q1/485 , G01N33/5041 , G01N2500/02
摘要： The present invention provides compositions and methods for modulating cell proliferation, survival, morphology, and migration. Nucleic adds encoding proteins and proteins so encoded which are capable of modulating proliferation, survival, morphology and migration in mammalian cells are provided. Compositions and methods for the treatment of disorders related to cell proliferation, survival, morphology and migration are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating proliferation, survival, morphology and migration in mammalian cells.
摘要翻译： 本发明提供调节细胞增殖，存活，形态和迁移的组合物和方法。 核酸添加编码蛋白质和如此编码的蛋白质，其能够调节哺乳动物细胞中的增殖，存活，形态和迁移。 还提供了用于治疗与细胞增殖，存活，形态和迁移相关的病症的组合物和方法。 还提供了预防和预防这种疾病的方法。 还提供了用于诊断和预测这些疾病的组合物和方法。 还提供了用于鉴定能够调节哺乳动物细胞中增殖，存活，形态和迁移的生物活性剂的测定。
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4.发明申请公开(公告)号：US20050019771A1
公开(公告)日：2005-01-27
申请号：US10493164
申请日：2002-10-21
CPC分类号： C12N9/1205 , C12Q1/485 , G01N33/5041 , G01N2500/02
摘要： The present invention provides compositions and methods for modulating cell proliferation, survival, morphology, and migration. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating proliferation, survival, morphology and migration in mammalian cells are provided. Compositions and methods for the treatment of disorders related to cell proliferation, survival, morphology and migration are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating proliferation, survival, morphology and migration in mammalian cells.
摘要翻译： 本发明提供调节细胞增殖，存活，形态和迁移的组合物和方法。 提供了编码能够调节哺乳动物细胞中增殖，存活，形态和迁移的蛋白质和蛋白质的核酸。 还提供了用于治疗与细胞增殖，存活，形态和迁移相关的病症的组合物和方法。 还提供了预防和预防这种疾病的方法。 还提供了用于诊断和预测这些疾病的组合物和方法。 还提供了用于鉴定能够调节哺乳动物细胞中增殖，存活，形态和迁移的生物活性剂的测定。
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5.发明授权公开(公告)号：US07423118B1
公开(公告)日：2008-09-09
申请号：US09715725
申请日：2000-11-16
申请人： Ying Luo , Xiang Xu , Cindy Leo , Betty Huang , Mary Shen
发明人： Ying Luo , Xiang Xu , Cindy Leo , Betty Huang , Mary Shen
IPC分类号： C07K14/00
CPC分类号： C07K14/4747 , A61K38/00
摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
摘要翻译： 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。
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6.发明授权公开(公告)号：US07420045B1
公开(公告)日：2008-09-02
申请号：US10130555
申请日：2000-11-17
申请人： Ying Luo , Xiang Xu , Cindy Leo , Betty Huang , Mary Shen
发明人： Ying Luo , Xiang Xu , Cindy Leo , Betty Huang , Mary Shen
CPC分类号： C07K14/4747 , A61K38/00
摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also, provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
摘要翻译： 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 此外，本文提供的是包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及用于产生本发明多肽的方法 本发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。
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7.发明授权公开(公告)号：US06737232B1
公开(公告)日：2004-05-18
申请号：US09442013
申请日：1999-11-17
申请人： Ying Luo , Xiang Xu , Cindy Leo , Betty Huang , Mary Shen
发明人： Ying Luo , Xiang Xu , Cindy Leo , Betty Huang , Mary Shen
IPC分类号： C12Q100
CPC分类号： C07K14/4747 , A61K38/00
摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
摘要翻译： 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。
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8.发明申请Cell cycle proteins associated with rad9, compositions and methods of use 有权与rad9相关的细胞周期蛋白，组合物和使用方法公开(公告)号：US20070238134A9
公开(公告)日：2007-10-11
申请号：US10220375
申请日：2001-03-02
CPC分类号： C07K14/4738 , C12N9/16 , C12Y301/03016 , G01N33/5011 , G01N33/6872 , G01N2333/4739 , G01N2333/8114
摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
摘要翻译： 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。
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9.发明授权Methods of identifying an agent capable of interfering with Rad9 dephosphorylation 有权鉴定能够干扰Rad9去磷酸化的试剂的方法公开(公告)号：US07384761B2
公开(公告)日：2008-06-10
申请号：US10220375
申请日：2001-03-02
CPC分类号： C07K14/4738 , C12N9/16 , C12Y301/03016 , G01N33/5011 , G01N33/6872 , G01N2333/4739 , G01N2333/8114
摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
摘要翻译： 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了与异源多肽序列融合的本发明的载体和宿主细胞多肽，与本发明的多肽结合的抗体和用于产生本发明的多肽的方法。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。
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10.发明授权公开(公告)号：US06887675B1
公开(公告)日：2005-05-03
申请号：US09843159
申请日：2001-04-25
申请人： Ying Luo , Eva Chan , Xiang Xu , Betty Huang , Valeria Ossovskaya
发明人： Ying Luo , Eva Chan , Xiang Xu , Betty Huang , Valeria Ossovskaya
CPC分类号： C12N9/1077 , A61K38/00 , C12N2310/111
摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
摘要翻译： 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导细胞周期生物活性的新组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。
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