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公开(公告)号：US20170086963A1
公开(公告)日：2017-03-30
申请号：US15274229
申请日：2016-09-23
发明人： Yu-Chong Tai , Dongyang Kang , Hirotake Komatsu , Henry K. Lin , Yoko Mullen
IPC分类号： A61F2/02
CPC分类号： A61F2/022 , A61F2240/004 , C12M21/00
摘要： An implantable medical device, a method of manufacturing, and a method of use are described. The implantable medical device includes an absorption bag connected by a cannula to a discharge bag. The implantable medical device also includes a reservoir external to the discharge bag and attached to a surface of the discharge bag. At least a portion of the absorption bag and at least a portion of a bottom surface of the reservoir are permeable to a predefined class of small molecules, such as molecular oxygen. The reservoir can retain live cells that rely on the small molecules for survival and growth. Based on concentration of the small molecules, the small molecules permeate into the absorption bag and are transported to the discharge bag for permeation into the reservoir, thereby providing a supply of the small molecules to the live cells.
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公开(公告)号：US20230166004A1
公开(公告)日：2023-06-01
申请号：US18070334
申请日：2022-11-28
发明人： Yu-Chong Tai , Kuang-Ming Shang , Hirotake Komatsu
CPC分类号： A61L27/3804 , C12N5/0068 , A61L27/56 , A61L27/54 , C12N2533/30 , C12N2535/10
摘要： A two-dimensional lattice or mesh scaffold for therapeutic cell implants is disclosed as well as methods for manufacture and use. The lattice is constructed of crisscrossing capillaries of hydrophobic parylene, such as parylene AF4, that may be coated with a hydrophilic polymer, such as parylene C, for cell adhesion. At each intersection of the crisscross, the intersecting capillaries are internally connected so as to allow oxygen to flow freely within. The walls of the capillaries are thin enough to be permeable to oxygen, on the scale of a micron thick, so that oxygen can flow through the lattice and permeate through the capillary walls. For some implants, cells are sandwiched between two or more lattices, the cells being slightly held apart from aggregation with each other by the lattice holes. The implants may then be surgically implanted within a subject.
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公开(公告)号：US20210283308A1
公开(公告)日：2021-09-16
申请号：US17199844
申请日：2021-03-12
摘要： An oxygen transporter device configured to transport O2 from an ambient air location into or toward a subcutaneous site. The device includes an absorption component, a cannula, and a discharge component configured to be implanted in a subcutaneous location while the absorption component is not subcutaneous. The cannula can extend through or across the skin of a patient. The discharge component can includes one or more multi-layered, flexible mesh sheets, which are coupled to cells.
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公开(公告)号：US10092387B2
公开(公告)日：2018-10-09
申请号：US15274229
申请日：2016-09-23
发明人： Yu-Chong Tai , Dongyang Kang , Hirotake Komatsu , Henry K. Lin , Yoko Mullen
摘要： An implantable medical device, a method of manufacturing, and a method of use are described. The implantable medical device includes an absorption bag connected by a cannula to a discharge bag. The implantable medical device also includes a reservoir external to the discharge bag and attached to a surface of the discharge bag. At least a portion of the absorption bag and at least a portion of a bottom surface of the reservoir are permeable to a predefined class of small molecules, such as molecular oxygen. The reservoir can retain live cells that rely on the small molecules for survival and growth. Based on concentration of the small molecules, the small molecules permeate into the absorption bag and are transported to the discharge bag for permeation into the reservoir, thereby providing a supply of the small molecules to the live cells.
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