公开(公告)号：US08175665B2

公开(公告)日：2012-05-08

申请号：US11716482

申请日：2007-03-09

申请人： Clark R. Baker, Jr. ,  Nicholas J. Durr ,  Murtaza Mogri ,  Carine Hoarau ,  Rafael Ostrowski ,  Martin P. Debreczeny

发明人： Clark R. Baker, Jr. ,  Nicholas J. Durr ,  Murtaza Mogri ,  Carine Hoarau ,  Rafael Ostrowski ,  Martin P. Debreczeny

IPC分类号： A61B5/1455

CPC分类号： A61B5/0059 ,  A61B5/4869 ,  A61B5/4878

摘要： Methods and systems for calculating body fluid metrics are provided. In accordance with an exemplary embodiment of the present technique, there is provided a method for calculating body fluid metrics by acquiring an absorbance spectrum of a subject's tissue over a range of near-infrared light, performing a multi-linear regression of the absorbance spectrum of the subject's tissue in relation to absorbance spectra of tissue constituents, and calculating body fluid metrics based on the results of the multi-linear regression. A system is provided having a sensor for emitting the light into the subject's tissue and detecting reflected, scattered, or transmitted light, a spectrometer for processing the detected light and generating the absorbance spectrum of the subject's tissue, memory for storing absorbance spectra of the tissue constituents and a multi-linear regression model, and a processor for performing the multi-linear regression and calculating the body fluid metrics.

摘要翻译： 提供了用于计算体液量度的方法和系统。 根据本技术的示例性实施例，提供了一种通过在近红外光范围内获取受试者组织的吸收光谱来计算体液量度的方法，执行吸收光谱的多线性回归 相关于组织成分的吸收光谱的受试者组织，以及基于多线性回归的结果计算体液量度。 提供一种具有用于将光发射到被检体的组织中并检测反射，散射或透射光的传感器的系统，用于处理检测到的光并产生受试者组织的吸收光谱的光谱仪，用于存储组织的吸收光谱的存储器 成分和多线性回归模型，以及用于执行多线性回归和计算体液量度的处理器。

公开(公告)号：US20080221412A1

公开(公告)日：2008-09-11

申请号：US11716482

申请日：2007-03-09

申请人： Clark R. Baker, ,  Nicholas J. Durr ,  Murtaza Mogri ,  Carine Hoarau ,  Rafael Ostrowski ,  Martin P. Debreczeny

发明人： Clark R. Baker, ,  Nicholas J. Durr ,  Murtaza Mogri ,  Carine Hoarau ,  Rafael Ostrowski ,  Martin P. Debreczeny

IPC分类号： A61B5/00

CPC分类号： A61B5/0059 ,  A61B5/4869 ,  A61B5/4878

摘要： Methods and systems for calculating body fluid metrics are provided. In accordance with an exemplary embodiment of the present technique, there is provided a method for calculating body fluid metrics by acquiring an absorbance spectrum of a subject's tissue over a range of near-infrared light, performing a multi-linear regression of the absorbance spectrum of the subject's tissue in relation to absorbance spectra of tissue constituents, and calculating body fluid metrics based on the results of the multi-linear regression. A system is provided having a sensor for emitting the light into the subject's tissue and detecting reflected, scattered, or transmitted light, a spectrometer for processing the detected light and generating the absorbance spectrum of the subject's tissue, memory for storing absorbance spectra of the tissue constituents and a multi-linear regression model, and a processor for performing the multi-linear regression and calculating the body fluid metrics.

摘要翻译： 提供了用于计算体液量度的方法和系统。 根据本技术的示例性实施例，提供了一种通过在近红外光范围内获取受试者组织的吸收光谱来计算体液量度的方法，执行吸收光谱的多线性回归 相关于组织成分的吸收光谱的受试者组织，以及基于多线性回归的结果计算体液量度。 提供一种具有用于将光发射到被检体的组织中并检测反射，散射或透射光的传感器的系统，用于处理检测到的光并产生受试者组织的吸收光谱的光谱仪，用于存储组织的吸收光谱的存储器 成分和多线性回归模型，以及用于执行多线性回归和计算体液量度的处理器。

公开(公告)号：US08346327B2

公开(公告)日：2013-01-01

申请号：US11716264

申请日：2007-03-09

申请人： Shannon E. Campbell ,  Martin P. Debreczeny ,  Carine Hoarau

发明人： Shannon E. Campbell ,  Martin P. Debreczeny ,  Carine Hoarau

IPC分类号： A61B5/1455

CPC分类号： A61B5/1495 ,  A61B5/0059 ,  A61B5/14551 ,  A61B5/14552 ,  A61B5/443 ,  G01N21/474

摘要： A method is provided for determining the location of the sensor. The method comprises determining a physiological parameter based on detected light and determining the location of the sensor based on the physiological parameter. In addition, a method is provided for operating a sensor that includes calibrating a sensor based on a patient-specific physiological parameter, in which the patient-specific physiological parameter is skin color, age, gender, pooled blood, venous blood pulsation, or abnormal tissue.

摘要翻译： 提供了一种用于确定传感器位置的方法。 该方法包括基于检测到的光来确定生理参数，并基于生理参数确定传感器的位置。 此外，提供了一种用于操作传感器的方法，该传感器包括基于患者特异性生理参数来校准传感器，其中患者特异性生理参数是皮肤颜色，年龄，性别，汇集的血液，静脉血液脉动或异常 组织。

公开(公告)号：US20080221410A1

公开(公告)日：2008-09-11

申请号：US11716264

申请日：2007-03-09

申请人： Shannon E. Campbell ,  Martin P. Debreczeny ,  Carine Hoarau

发明人： Shannon E. Campbell ,  Martin P. Debreczeny ,  Carine Hoarau

IPC分类号： A61B5/00

CPC分类号： A61B5/1495 ,  A61B5/0059 ,  A61B5/14551 ,  A61B5/14552 ,  A61B5/443 ,  G01N21/474

摘要： A method is provided for determining the location of the sensor. The method comprises determining a physiological parameter based on detected light and determining the location of the sensor based on the physiological parameter. In addition, a method is provided for operating a sensor that includes calibrating a sensor based on a patient-specific physiological parameter, in which the patient-specific physiological parameter is skin color, age, gender, pooled blood, venous blood pulsation, or abnormal tissue.

摘要翻译： 提供了一种用于确定传感器位置的方法。 该方法包括基于检测到的光来确定生理参数，并基于生理参数确定传感器的位置。 此外，提供了一种用于操作传感器的方法，该传感器包括基于患者特异性生理参数来校准传感器，其中患者特异性生理参数是皮肤颜色，年龄，性别，汇集的血液，静脉血液脉动或异常 组织。

公开(公告)号：US07869850B2

公开(公告)日：2011-01-11

申请号：US11241375

申请日：2005-09-29

申请人： Carine Hoarau ,  Clark R. Baker, Jr. ,  Edward Karst

发明人： Carine Hoarau ,  Clark R. Baker, Jr. ,  Edward Karst

IPC分类号： A61B5/1455

CPC分类号： A61B5/6886 ,  A61B5/14552 ,  A61B5/6826 ,  A61B5/6838 ,  A61B5/6844 ,  Y10T29/49826

摘要： A sensor for pulse oximetry or other applications utilizing spectrophotometry may be adapted to reduce motion artifacts by fixing the optical distance between an emitter and detector. A flexible sensor is provided with a stiffening member to hold the emitter and detector of the sensor in a relatively fixed position when applied to a patient. Further, an annular or partially annular sensor is adapted to hold an emitter and detector of the sensor in a relatively fixed position when applied to a patient. A clip-style sensor is provided with a spacer that controls the distance between the emitter and detector.

摘要翻译： 用于脉搏血氧饱和度测定的传感器或利用分光光度法的其它应用可适用于通过固定发射器和检测器之间的光学距离来减少运动伪影。 柔性传感器设置有加强构件，以在应用于患者时将传感器的发射器和检测器保持在相对固定的位置。 此外，环形或部分环形的传感器适于在施加到患者时将传感器的发射器和检测器保持在相对固定的位置。 夹式传感器设置有间隔器，该间隔件控制发射器和检测器之间的距离。

公开(公告)号：US07650177B2

公开(公告)日：2010-01-19

申请号：US11496869

申请日：2006-08-01

申请人： Carine Hoarau ,  Clark R. Baker, Jr. ,  Edward Karst

发明人： Carine Hoarau ,  Clark R. Baker, Jr. ,  Edward Karst

IPC分类号： A61B5/1455

CPC分类号： A61B5/6886 ,  A61B5/14552 ,  A61B5/6826 ,  A61B5/6838 ,  A61B5/6844 ,  Y10T29/49826

摘要： A sensor for pulse oximetry or other applications utilizing spectrophotometry may be adapted to reduce motion artifacts by fixing the optical distance between an emitter and detector. A flexible sensor is provided with a stiffening member to hold the emitter and detector of the sensor in a relatively fixed position when applied to a patient. Further, an annular or partially annular sensor is adapted to hold an emitter and detector of the sensor in a relatively fixed position when applied to a patient. A clip-style sensor is provided with a spacer that controls the distance between the emitter and detector.

摘要翻译： 用于脉搏血氧饱和度测定的传感器或利用分光光度法的其它应用可适用于通过固定发射器和检测器之间的光学距离来减少运动伪影。 柔性传感器设置有加强构件，以在应用于患者时将传感器的发射器和检测器保持在相对固定的位置。 此外，环形或部分环形的传感器适于在施加到患者时将传感器的发射器和检测器保持在相对固定的位置。 夹式传感器设置有间隔器，该间隔件控制发射器和检测器之间的距离。

公开(公告)号：US08965473B2

公开(公告)日：2015-02-24

申请号：US13267681

申请日：2011-10-06

申请人： Carine Hoarau ,  Clark R. Baker, Jr. ,  Edward Karst

发明人： Carine Hoarau ,  Clark R. Baker, Jr. ,  Edward Karst

IPC分类号： A61B5/1455 ,  A61B5/00

CPC分类号： A61B5/6886 ,  A61B5/14552 ,  A61B5/6826 ,  A61B5/6838 ,  A61B5/6844 ,  Y10T29/49826

摘要： A sensor for pulse oximetry or other applications utilizing spectrophotometry may be adapted to reduce motion artifacts by fixing the optical distance between an emitter and detector. A flexible sensor is provided with a stiffening member to hold the emitter and detector of the sensor in a relatively fixed position when applied to a patient. Further, an annular or partially annular sensor is adapted to hold an emitter and detector of the sensor in a relatively fixed position when applied to a patient. A clip-style sensor is provided with a spacer that controls the distance between the emitter and detector.

摘要翻译： 用于脉搏血氧饱和度测定的传感器或利用分光光度法的其它应用可适用于通过固定发射器和检测器之间的光学距离来减少运动伪影。 柔性传感器设置有加强构件，以在应用于患者时将传感器的发射器和检测器保持在相对固定的位置。 此外，环形或部分环形的传感器适于在施加到患者时将传感器的发射器和检测器保持在相对固定的位置。 夹式传感器设置有间隔器，该间隔件控制发射器和检测器之间的距离。

公开(公告)号：US08175670B2

公开(公告)日：2012-05-08

申请号：US11521960

申请日：2006-09-15

申请人： Clark R. Baker, Jr. ,  Edward Karst ,  Carine Hoarau

发明人： Clark R. Baker, Jr. ,  Edward Karst ,  Carine Hoarau

IPC分类号： A61B5/1455 ,  A61B5/02

CPC分类号： A61B5/7207 ,  A61B5/02416 ,  A61B5/14551

摘要： A method and system for measuring a physiological parameter, comprising collecting a first absorbance at a first wavelength, chosen to be primarily absorbed by water; collecting a second absorbance at a second wavelength, chosen to be primarily absorbed by hemoglobin; and combining the first signal and the second signal to generate a combined plethysmograph signal which is proportionate lower in noise caused by motion-related interference.

摘要翻译： 一种用于测量生理参数的方法和系统，包括收集被选择为主要被水吸收的第一波长的第一吸光度; 收集第二波长的第二吸光度，其被选择为主要由血红蛋白吸收; 以及组合第一信号和第二信号以产生由运动相关干扰引起的噪声相对较低的组合体积描记器信号。

公开(公告)号：US20120035443A1

公开(公告)日：2012-02-09

申请号：US13267681

申请日：2011-10-06

申请人： Carine Hoarau ,  Clark R. Baker, JR. ,  Edward Karst

发明人： Carine Hoarau ,  Clark R. Baker, JR. ,  Edward Karst

IPC分类号： A61B5/1455 ,  B23P11/00

CPC分类号： A61B5/6886 ,  A61B5/14552 ,  A61B5/6826 ,  A61B5/6838 ,  A61B5/6844 ,  Y10T29/49826

摘要： A sensor for pulse oximetry or other applications utilizing spectrophotometry may be adapted to reduce motion artifacts by fixing the optical distance between an emitter and detector. A flexible sensor is provided with a stiffening member to hold the emitter and detector of the sensor in a relatively fixed position when applied to a patient. Further, an annular or partially annular sensor is adapted to hold an emitter and detector of the sensor in a relatively fixed position when applied to a patient. A clip-style sensor is provided with a spacer that controls the distance between the emitter and detector.

摘要翻译： 用于脉搏血氧饱和度测定的传感器或利用分光光度法的其它应用可适用于通过固定发射器和检测器之间的光学距离来减少运动伪影。 柔性传感器设置有加强构件，以在应用于患者时将传感器的发射器和检测器保持在相对固定的位置。 此外，环形或部分环形的传感器适于在施加到患者时将传感器的发射器和检测器保持在相对固定的位置。 夹式传感器设置有间隔器，该间隔件控制发射器和检测器之间的距离。

公开(公告)号：US07657292B2

公开(公告)日：2010-02-02

申请号：US11283506

申请日：2005-11-18

申请人： Clark R. Baker, Jr. ,  Joseph Schmitt ,  Shannon Campbell ,  Nick Durr ,  Carine Hoarau ,  Rafeal Ostrowski ,  Martin Debreczeny

发明人： Clark R. Baker, Jr. ,  Joseph Schmitt ,  Shannon Campbell ,  Nick Durr ,  Carine Hoarau ,  Rafeal Ostrowski ,  Martin Debreczeny

IPC分类号： A61B5/145

CPC分类号： G01N21/359 ,  A61B5/0059 ,  A61B5/0537 ,  A61B5/4869 ,  G01N21/274

摘要： The present disclosure provides systems, devices, and/or methods for assessing body fluid-related metrics and/or changes therein. The disclosure further provides systems, devices, and/or methods for correlating body fluid-related metrics in a particular tissue with the corresponding whole-body metric. The disclosure also provides, systems, devices, and/or methods for assessment of such metrics to facilitate diagnosis and/or therapeutic interventions related to maintaining and/or restoring body fluid balance.

摘要翻译： 本公开提供了用于评估体液相关度量和/或其中变化的系统，装置和/或方法。 本公开还提供用于将特定组织中的体液相关度量与相应的全身度量相关联的系统，装置和/或方法。 本公开还提供了用于评估这些度量的系统，装置和/或方法，以促进与维持和/或恢复体液平衡相关的诊断和/或治疗干预。