公开(公告)号：US20060135531A1

公开(公告)日：2006-06-22

申请号：US11016967

申请日：2004-12-21

申请人： Clas Sonesson ,  Bengt Andersson ,  Ingela Svan ,  Anders Lilja ,  Liselott Ronnqvist ,  Jenny Carlberg ,  Susanna Waters ,  Nicholas Waters ,  Joakim Tedroff

发明人： Clas Sonesson ,  Bengt Andersson ,  Ingela Svan ,  Anders Lilja ,  Liselott Ronnqvist ,  Jenny Carlberg ,  Susanna Waters ,  Nicholas Waters ,  Joakim Tedroff

IPC分类号： A61K31/496 ,  A61K31/495 ,  A61K31/452 ,  C07D405/02 ,  C07D211/18 ,  A61K31/445

CPC分类号： C07D295/073 ,  C07D211/18 ,  C07D211/20 ,  C07D211/22 ,  C07D211/24 ,  C07D211/32 ,  C07D211/34 ,  C07D211/70 ,  C07D295/096 ,  C07D295/112 ,  C07D295/155 ,  C07D405/06

摘要： A 3-substituted 4-(phenyl-N-alkyl)-piperazine compound of the following formula: wherein R1 is selected from the group consisting of OSO2CF3, OSO2CH3, SO2R3, COCF3, COCH3 and COCH2CH3, wherein R3 is as defined hereafter; R2 is selected from the group consisting of C1-C4 alkyls, allyl, CH2CH2CH2F, CH2CF3, 3,3,3-trifluoropropyl and 4,4,4-trifluorobutyl; R3 is selected from the group consisting of C1-C3 alkyls, CF3, and N(CH3)2; with the proviso that when R1 is SO2R3 and R3 is a C1-C3 alkyl, then R2 is not CH2CH2OCH3; or a pharmaceutically acceptable salt thereof are provided. Also, pharmaceutical compositions comprising the above compound and methods wherein the above compound is used for the treatment of various disorders are provided.

摘要翻译： 下式的3-取代的4-（苯基-N-烷基） - 哌嗪化合物：其中R 1选自OSO 2 CF _{或其药学上可接受的盐。 此外，提供了包含上述化合物的药物组合物和其中使用上述化合物治疗各种疾病的方法。}