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    Benzo[b ]pyrano[3,2- h ]acridin-7-one cinnamate compounds
    3.
    发明授权
    Benzo[b ]pyrano[3,2- h ]acridin-7-one cinnamate compounds 失效
    苯并[b]吡喃并[3,2-h]吖啶-7-酮肉桂酸酯化合物

    公开(公告)号：US07144891B2

    公开(公告)日：2006-12-05

    申请号：US11313386

    申请日：2005-12-21

    申请人： Michel Koch ,  François Tillequin ,  Sylvie Michel ,  John Hickman ,  Alain Pierre ,  Stéphane Leonce ,  Bruno Pfeiffer ,  Laurence Kraus-Berthier

    发明人： Michel Koch ,  François Tillequin ,  Sylvie Michel ,  John Hickman ,  Alain Pierre ,  Stéphane Leonce ,  Bruno Pfeiffer ,  Laurence Kraus-Berthier

    IPC分类号： A61K31/4741 ,  C07D491/02

    CPC分类号： C07D491/04

    摘要： A compound selected from those of formula (I): wherein: X and Y represent a group selected from hydrogen, halogen, alkoxy, nitro, cyano, alkyl, alkenyl, polyhaloalkyl and —NRaRb wherein Ra and Rb are as defined in the description, Z represents oxygen or NRc wherein Rc is as defined in the description, Ar represents aryl or heteroaryl, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, alkyl, —ORa and —NRaRb wherein Ra and Rb are as defined in the description, R3 and R4 represent hydrogen or alkyl, R5 represents hydrogen, ORc, NRcRd, W1—C(W2)—U—V, W1—C(W2)—W3-T1 or Z-CO—CH═CHAr wherein Rc, Rd, W1, W2, W3, U, V, T, Z and Ar are as defined in the description, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.

    摘要翻译： 选自式（I）的化合物：其中：X和Y表示选自氢，卤素，烷氧基，硝基，氰基，烷基，烯基，多卤代烷基和-NR a R 其中R a a和R b b如说明书中所定义，Z表示氧或NR C c，其中R - >如说明书中所定义，Ar表示芳基或杂芳基，R 1表示氢或烷基，R 2表示选自氢，烷基 其中R a a和R b都是 - ， - - - - - - - - >如说明书中所定义，R 3和R 4代表氢或烷基，R 5表示氢，或C 1-4烷基， R 1，R 2，R 2，R 2，R 2，R 2， （W 2）-W 3 -T 1或Z-CO-CH-CHAr其中R R 1，R 2，W 3，W 2，W 3，U 3， ，V，T，Z和Ar定义如下 在其描述中，其异构体及其与药学上可接受的酸或碱的加成盐，以及含有该物质的药物可用于治疗癌症。

    Benzo[b]pyrano[3,2-h]acridin-7-one cinnamate compounds
    4.
    发明申请
    Benzo[b]pyrano[3,2-h]acridin-7-one cinnamate compounds 失效
    苯并[b]吡喃并[3,2-h]吖啶-7-酮肉桂酸酯化合物

    公开(公告)号：US20060135545A1

    公开(公告)日：2006-06-22

    申请号：US11313386

    申请日：2005-12-21

    申请人： Michel Koch ,  Francois Tillequin ,  Sylvie Michel ,  John Hickman ,  Alain Pierre ,  Stephane Leonce ,  Bruno Pfeiffer ,  Laurence Kraus-Berthier

    发明人： Michel Koch ,  Francois Tillequin ,  Sylvie Michel ,  John Hickman ,  Alain Pierre ,  Stephane Leonce ,  Bruno Pfeiffer ,  Laurence Kraus-Berthier

    IPC分类号： A61K31/4741 ,  C07D491/02

    CPC分类号： C07D491/04

    摘要： A compound selected from those of formula (I): wherein: X and Y represent a group selected from hydrogen, halogen, alkoxy, nitro, cyano, alkyl, alkenyl, polyhaloalkyl and —NRaRb wherein Ra and Rb are as defined in the description, Z represents oxygen or NRc wherein Rc is as defined in the description, Ar represents aryl or heteroaryl, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, alkyl, —ORa and —NRaRb wherein Ra and Rb are as defined in the description, R3 and R4 represent hydrogen or alkyl, R5 represents hydrogen, ORc, NRcRd, W1—C(W2)—U—V, W1—C(W2)—W3-T1 or Z-CO—CH═CHAr wherein Rc, Rd, W1, W2, W3, U, V, T, Z and Ar are as defined in the description, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.

    摘要翻译： 选自式（I）的化合物：其中：X和Y表示选自氢，卤素，烷氧基，硝基，氰基，烷基，烯基，多卤代烷基和-NR a R 其中R a a和R b b如说明书中所定义，Z表示氧或NR C c，其中R - >如说明书中所定义，Ar表示芳基或杂芳基，R 1表示氢或烷基，R 2表示选自氢，烷基 其中R a a和R b都是 - ， - - - - - - - - >如说明书中所定义，R 3和R 4代表氢或烷基，R 5表示氢，或C 1-4烷基， R 1，R 2，R 2，R 2，R 2，R 2， （W 2）-W 3 -T 1或Z-CO-CH-CHAr其中R R 1，R 2，W 3，W 2，W 3，U 3， ，V，T，Z和Ar定义如下 在其描述中，其异构体及其与药学上可接受的酸或碱的加成盐，以及含有该物质的药物可用于治疗癌症。

    Carbamate and thiocarbamate podophyllotoxin derivatives, preparation method and pharmaceutical compositions containing them
    5.
    发明授权
    Carbamate and thiocarbamate podophyllotoxin derivatives, preparation method and pharmaceutical compositions containing them 失效
    氨基甲酸酯和硫代氨基甲酸酯鬼臼毒素衍生物，制备方法和含有它们的药物组合物

    公开(公告)号：US06878746B2

    公开(公告)日：2005-04-12

    申请号：US10312175

    申请日：2001-06-19

    申请人： Claude Monneret ,  Emmanuel Bertounesque ,  Philippe Meresse ,  Ghanem Atassi ,  Alain Pierre ,  John Hickman ,  Bruno Pfeiffer ,  Pierre Renard

    发明人： Claude Monneret ,  Emmanuel Bertounesque ,  Philippe Meresse ,  Ghanem Atassi ,  Alain Pierre ,  John Hickman ,  Bruno Pfeiffer ,  Pierre Renard

    IPC分类号： A61K31/36 ,  A61P35/00 ,  C07D493/04 ,  A61K31/365

    CPC分类号： C07D493/04 ,  Y02P20/55

    摘要： A compound selected from these of formula (I): wherein: R1 represents hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl or phosphono, R2 represents oxygen or sulphur, R3 represents hydrogen or alkyl, cycloalkyl or arylalkyl, X represents linear or branched (C1-C6)alkylene, R4 represents a group selected from amino optionally substituted by one or two groups, —N(R3)—X1—OR5 wherein R3, X1 and R5 are as defined in the description, —N(R3)—X1—NR6R7 wherein R3, X1, R6 and R7 are as defined in the description, hydroxy, alkoxy, aryloxy, —O—X1—OR5 wherein R5 and X1 are as defined in the description, and —O—X1—NR6R7 wherein R6, R7 and X1 are as defined in the description, its isomers, and also addition salts thereof with a pharmaceutically acceptable acid or base, and medical products containing the same which are useful in the treatment of cancer.

    摘要翻译： 选自这些式（I）的化合物：其中：R1表示氢，烷基，芳基，芳基烷基，杂芳基，杂芳基烷基，烷氧基羰基，芳氧基羰基，芳基烷氧基羰基，杂环烷氧基羰基，烷基磺酰基，芳基磺酰基，芳基烷基磺酰基或膦酰基，R2表示氧或硫，R3 表示氢或烷基，环烷基或芳基烷基，X表示直链或支链（C1-C6）亚烷基，R4表示选自任选被一个或两个基团取代的氨基的基团-N（R3）-X1-OR5，其中R3，X1和 R 5如说明书中所定义，-N（R3）-X1-NR6R7，其中R3，X1，R6和R7如说明书中所定义，羟基，烷氧基，芳氧基，-O-X1-OR5，其中R5和X1为 和-O-X 1 -NR 6 R 7，其中R 6，R 7和X 1如说明书中所定义，其异构体及其与药学上可接受的酸或碱的加成盐，以及含有它们的医药产品可用 在治疗癌症。

    Substituted benzo[e] [1,4] oxazino [3,2-g] isoindole compounds
    6.
    发明申请
    Substituted benzo[e] [1,4] oxazino [3,2-g] isoindole compounds 失效
    取代的苯并[e] [1,4]恶嗪并[3,2-g]异吲哚化合物

    公开(公告)号：US20060003997A1

    公开(公告)日：2006-01-05

    申请号：US10531648

    申请日：2003-10-17

    申请人： Gerard Coudert ,  Franck Lepifre ,  Daniel-Henri Caignard ,  Pierre Renard ,  John Hickman ,  Alain Pierre ,  Laurence Kraus-Berthier

    发明人： Gerard Coudert ,  Franck Lepifre ,  Daniel-Henri Caignard ,  Pierre Renard ,  John Hickman ,  Alain Pierre ,  Laurence Kraus-Berthier

    IPC分类号： A61K31/5383 ,  C07D491/14

    CPC分类号： C07D497/04 ,  C07D497/14

    摘要： A compound selected from those of formula (I): wherein: W1, with the carbon atoms to which it is bonded, represents phenyl or pyridyl, Z represents a group selected from hydrogen, halogen, linear or branched (C1-C6)alkyl, aryl, aryl-(C1-C6)alkyl, aryloxy, aryl-(C1-C6)alkoxy, hydroxy and linear or branched (C1-C6)alkoxy, R1 is as defined in the description, R2 represents hydrogen or —CH2CH2O—R8, R3 and R4 each represents hydrogen, linear or branched (C1-C6)alkyl, aryl or aryl-(C1-C6)alkyl, n represents an integer of from 1 to 6 inclusive, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.

    摘要翻译： 选自式（I）的化合物的化合物：其中：W 1与其键合的碳原子代表苯基或吡啶基，Z表示选自氢，卤素，直链或 支链（C 1 -C 6 -C 6）烷基，芳基，芳基 - （C 1 -C 6 -C 6）烷基 ，芳氧基，芳基 - （C 1 -C 6 -C 6）烷氧基，羟基和直链或支链（C 1 -C 6 - R 1和R 2如在说明书中所定义，R 2表示氢或-CH 2 CH 2， R 3，R 3和R 4各自表示直链或支链（C 1 -C 4）烷基的氢， C 6 -C 6烷基，芳基或芳基 - （C 1 -C 6）烷基，n表示1〜6的整数， 其异构体及其与药学上可接受的酸或碱的加成盐，以及含有该物质的药物，可用于治疗癌症。

    Substituted benzo[e][1,4]oxazino[3,2-g]isoindole compounds
    8.
    发明授权
    Substituted benzo[e][1,4]oxazino[3,2-g]isoindole compounds 失效
    取代的苯并[e] [1,4]恶嗪并[3,2-g]异吲哚化合物

    公开(公告)号：US07312213B2

    公开(公告)日：2007-12-25

    申请号：US10531648

    申请日：2003-10-17

    申请人： Gérard Coudert ,  Franck Lepifre ,  Daniel-Henri Caignard ,  Pierre Renard ,  John Hickman ,  Alain Pierre ,  Laurence Kraus-Berthier

    发明人： Gérard Coudert ,  Franck Lepifre ,  Daniel-Henri Caignard ,  Pierre Renard ,  John Hickman ,  Alain Pierre ,  Laurence Kraus-Berthier

    IPC分类号： C07D498/04 ,  A61K31/5383

    CPC分类号： C07D497/04 ,  C07D497/14

    摘要： A compound selected from those of formula (I): wherein: W1, with the carbon atoms to which it is bonded, represents phenyl or pyridyl, Z represents a group selected from hydrogen, halogen, linear or branched (C1-C6)alkyl, aryl, aryl-(C1-C6)alkyl, aryloxy, aryl-(C1-C6)alkoxy, hydroxy and linear or branched (C1-C6)alkoxy, R1 is as defined in the description, R2 represents hydrogen or —CH2CH2O—R8, R3 and R4 each represents hydrogen, linear or branched (C1-C6)alkyl, aryl or aryl-(C1-C6)alkyl, n represents an integer of from 1 to 6 inclusive, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.

    摘要翻译： 选自式（I）的化合物的化合物：其中：W 1与其键合的碳原子代表苯基或吡啶基，Z表示选自氢，卤素，直链或 支链（C 1 -C 6 -C 6）烷基，芳基，芳基 - （C 1 -C 6 -C 6）烷基 ，芳氧基，芳基 - （C 1 -C 6 -C 6）烷氧基，羟基和直链或支链（C 1 -C 6 - R 1和R 2如在说明书中所定义，R 2表示氢或-CH 2 CH 2， R 3，R 3和R 4各自表示直链或支链（C 1 -C 4）烷基的氢， C 6 -C 6烷基，芳基或芳基 - （C 1 -C 6）烷基，n表示1〜6的整数， 其异构体及其与药学上可接受的酸或碱的加成盐，以及含有该物质的药物，可用于治疗癌症。

    9-(3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro-[3′,4′:6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one compounds
    9.
    发明授权
    9-(3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro-[3′,4′:6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one compounds 失效
    9-（3,5-二甲氧基苯基）-5,8,8a，9-四氢呋喃（3'，4'：6,7）萘并（2,3-d）（1,3）二氧杂环戊烯-6（5aH） 一种化合物

    公开(公告)号：US06281198B1

    公开(公告)日：2001-08-28

    申请号：US09697248

    申请日：2000-10-26

    申请人： Claude Monneret ,  Emmanuel Bertounesque ,  Philippe Meresse ,  Ghanem Atassi ,  Alain Pierre ,  Bruno Pfeiffer ,  Pierre Renard

    发明人： Claude Monneret ,  Emmanuel Bertounesque ,  Philippe Meresse ,  Ghanem Atassi ,  Alain Pierre ,  Bruno Pfeiffer ,  Pierre Renard

    IPC分类号： A61K31365

    CPC分类号： C07D493/04 ,  Y02P20/55

    摘要： Compound of formula (I): wherein: R represents: a group of formula (i):  wherein X, Y and W are as defined in the description, or a group of formula (ii): —A—G  (ii) wherein: A represents a single bond or an optionally substituted alkylene chain, G represents a group selected from hydrogen, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, —OR2, —O—T1—NR3R4, —O—T1—NR2—T′1—NR3R4, —NR3R4, —NR2—T1—NR3R4, —NR2—T1—OR5, —NR2—T1—CO2R6, —NR2—T1—C(O)R6, —C(O)—NR3R4, —C(O)—NR2—T2, —O—C(O)T2, —O—C(S)—T2, —NR2—C(O)—T2, —NR2—C(S)—T2, —O—C(O)—O—T2, —O—C(O)—NR2—T2, —O—C(S)—O—T2, —O—C(S)—NR2—T2, —NR2—C(O)—O—T2, —NR2—C(O)—NR—T2, —NR2—C(S)—O—T2, —NR2—C(S)—NR6—T2 and —NR2—SO2—T3,  wherein R2, R3, R4, R5, R6, T1, T′1, T2 and T3 are as defined in the description, R1 represents a group selected from hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, heterocycloalkylcarbonyl, alkylsulphonyl, arylsulphonyl, arylalkylsulphonyl, phosphono, aryloxycarbonyl, alkoxycarbonyl and arylalkoxycarbonyl, its isomers, and also addition salts thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful in the treatment of cancer.

    摘要翻译： 式（I）的化合物：其中：R表示：式（ⅰ）的基团：其中X，Y和W如说明书中所定义，或式（ⅱ）的基团：其中：A表示单键或 任选取代的亚烷基链，G表示选自氢，环烷基，杂环烷基，芳基，杂芳基，-OR2，-O-T1-NR3R4，-O-T1-NR2-T'1-NR3R4，-NR3R4，-NR2 -T 1 -NR 3 R 4，-NR 2 -T 1 -OR 5，-NR 2 -T 1 -CO 2 R 6，-NR 2 -T 1 -C（O）R 6，-C（O）-NR 3 R 4，-C（O）-NR 2 -T 2，-OC （O）T 2，-OC（S）-T 2，-NR 2 -C（O）-T 2，-NR 2 -C（S）-T 2，-OC（O）-O-T 2，-OC（O） -T 2，-OC（S）-O-T2，-OC（S）-NR2-T2，-NR2-C（O）-O-T2，-NR2-C（O）-NR-T2， C（S）-O-T2，-NR2-C（S）-NR6-T2和-NR2-SO2-T3，其中R2，R3，R4，R5，R6，T1，T'1，T2和T3为 R 1表示选自氢，烷基，芳基，芳基烷基，杂芳基，杂芳基烷基，烷基羰基，芳基羰基，芳基烷基羰基，杂环烷基羰基，烷基磺酰基，芳基磺酰基，芳基烷基磺酰基，膦酰基，芳氧基羰基，烷氧基羰基和 芳基烷氧基羰基，其异构体，以及其与药学上可接受的酸或碱的加成盐。含有该化合物的药物可用于治疗癌症。