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    Benzo[b ]pyrano[3,2- h ]acridin-7-one cinnamate compounds
    1.
    发明授权
    Benzo[b ]pyrano[3,2- h ]acridin-7-one cinnamate compounds 失效
    苯并[b]吡喃并[3,2-h]吖啶-7-酮肉桂酸酯化合物

    公开(公告)号：US07144891B2

    公开(公告)日：2006-12-05

    申请号：US11313386

    申请日：2005-12-21

    申请人： Michel Koch ,  François Tillequin ,  Sylvie Michel ,  John Hickman ,  Alain Pierre ,  Stéphane Leonce ,  Bruno Pfeiffer ,  Laurence Kraus-Berthier

    发明人： Michel Koch ,  François Tillequin ,  Sylvie Michel ,  John Hickman ,  Alain Pierre ,  Stéphane Leonce ,  Bruno Pfeiffer ,  Laurence Kraus-Berthier

    IPC分类号： A61K31/4741 ,  C07D491/02

    CPC分类号： C07D491/04

    摘要： A compound selected from those of formula (I): wherein: X and Y represent a group selected from hydrogen, halogen, alkoxy, nitro, cyano, alkyl, alkenyl, polyhaloalkyl and —NRaRb wherein Ra and Rb are as defined in the description, Z represents oxygen or NRc wherein Rc is as defined in the description, Ar represents aryl or heteroaryl, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, alkyl, —ORa and —NRaRb wherein Ra and Rb are as defined in the description, R3 and R4 represent hydrogen or alkyl, R5 represents hydrogen, ORc, NRcRd, W1—C(W2)—U—V, W1—C(W2)—W3-T1 or Z-CO—CH═CHAr wherein Rc, Rd, W1, W2, W3, U, V, T, Z and Ar are as defined in the description, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.

    摘要翻译： 选自式（I）的化合物：其中：X和Y表示选自氢，卤素，烷氧基，硝基，氰基，烷基，烯基，多卤代烷基和-NR a R 其中R a a和R b b如说明书中所定义，Z表示氧或NR C c，其中R - >如说明书中所定义，Ar表示芳基或杂芳基，R 1表示氢或烷基，R 2表示选自氢，烷基 其中R a a和R b都是 - ， - - - - - - - - >如说明书中所定义，R 3和R 4代表氢或烷基，R 5表示氢，或C 1-4烷基， R 1，R 2，R 2，R 2，R 2，R 2， （W 2）-W 3 -T 1或Z-CO-CH-CHAr其中R R 1，R 2，W 3，W 2，W 3，U 3， ，V，T，Z和Ar定义如下 在其描述中，其异构体及其与药学上可接受的酸或碱的加成盐，以及含有该物质的药物可用于治疗癌症。

    Benzo[b]chromeno-naphthyridin-7-one and pyrano[2′,3′:7,8]quino[2,3-b]quinoxalin-7-one compounds
    2.
    发明授权
    Benzo[b]chromeno-naphthyridin-7-one and pyrano[2′,3′:7,8]quino[2,3-b]quinoxalin-7-one compounds 失效
    苯并[b]色烯 - 萘啶-7-酮和吡喃并[2'，3'：7,8]喹啉并[2,3-b]喹喔啉-7-酮化合物

    公开(公告)号：US07741325B2

    公开(公告)日：2010-06-22

    申请号：US11047259

    申请日：2005-01-31

    申请人： Michel Koch ,  François Tillequin ,  Sylvie Michel ,  John Hickman ,  Alain Pierre ,  Stéphane Leonce ,  Bruno Pfeiffer ,  Pierre Renard

    发明人： Michel Koch ,  François Tillequin ,  Sylvie Michel ,  John Hickman ,  Alain Pierre ,  Stéphane Leonce ,  Bruno Pfeiffer ,  Pierre Renard

    IPC分类号： A01N43/58 ,  A01N43/60 ,  A01N43/42 ,  A61K31/50 ,  A61K31/495 ,  A61K31/44 ,  C07D241/36 ,  C07D471/00 ,  C07D491/00 ,  C07D498/00 ,  C07D513/00 ,  C07D515/00

    CPC分类号： C07D491/14

    摘要： A compound selected from those of formula (I): wherein: B1, B2 represent carbon or nitrogen, X, Y, X1 and Y1 represent a group selected from hydrogen, halogen, hydroxy, alkoxy, nitro, cyano, trihaloalkyl and NRaRb wherein Ra and Rb are as defined in the description, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, alkyl, —OR″a, —NR′aR′b, —O-Ta-OR″a, —NR″a-Ta-NR′aR′b, NR″a—C(O)-TaH, —O—C(O)-TaH, —O-Ta-NRa′Rb′, —NR″a-Ta-OR″a, —NR″a-Ta-CO2R″a and —NR″a—C(O)-Ta-NR′aR′b wherein R′a, R′b, R″a and Ta are as defined in the description, R3, R4 represent hydrogen or alkyl, A represents a group of formula —CH(R5)—CH(R6)—, —CH═C(R7)—, —C(R7)═CH—, —C(O)—CH(R8)— or —CH(R8)—C(O)— wherein R5, R6, R7 and R8 are as defined in the description, its isomers, N-oxides, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.

    摘要翻译： 选自式（I）的化合物：其中：B1，B2表示碳或氮，X，Y，X1和Y1表示选自氢，卤素，羟基，烷氧基，硝基，氰基，三卤代烷基和NRaRb的基团，其中Ra 和R b如说明书中所定义，R 1表示氢或烷基，R 2表示选自氢，烷基，-OR“a，-NR'aR'b，-O-Ta-OR”a，-NR“a -Ta-NR'aR'b，NR“a-C（O）-TaH，-O-C（O）-TaH，-O-Ta-NRa'Rb'，-NR”a-Ta-OR“a ，-NR“a-Ta-CO 2 R”a和-NR“a-C（O）-Ta-NR'aR'b其中R'a，R'b，R”a和Ta如说明书中所定义， R 3，R 4表示氢或烷基，A表示式-CH（R 5）-CH（R 6） - ， - CH = C（R 7） - ， - C（R 7） CH（R 8） - 或-CH（R 8）-C（O） - ，其中R 5，R 6，R 7和R 8如说明书中所定义，其异构体，N-氧化物及其加成盐与药学上可接受的酸或碱 ，以及含有该药物的药物 它们可用于治疗癌症。

    Benzo[b]pyrano[3,2-h]acridin-7-one cinnamate compounds
    4.
    发明申请
    Benzo[b]pyrano[3,2-h]acridin-7-one cinnamate compounds 失效
    苯并[b]吡喃并[3,2-h]吖啶-7-酮肉桂酸酯化合物

    公开(公告)号：US20060135545A1

    公开(公告)日：2006-06-22

    申请号：US11313386

    申请日：2005-12-21

    申请人： Michel Koch ,  Francois Tillequin ,  Sylvie Michel ,  John Hickman ,  Alain Pierre ,  Stephane Leonce ,  Bruno Pfeiffer ,  Laurence Kraus-Berthier

    发明人： Michel Koch ,  Francois Tillequin ,  Sylvie Michel ,  John Hickman ,  Alain Pierre ,  Stephane Leonce ,  Bruno Pfeiffer ,  Laurence Kraus-Berthier

    IPC分类号： A61K31/4741 ,  C07D491/02

    CPC分类号： C07D491/04

    摘要： A compound selected from those of formula (I): wherein: X and Y represent a group selected from hydrogen, halogen, alkoxy, nitro, cyano, alkyl, alkenyl, polyhaloalkyl and —NRaRb wherein Ra and Rb are as defined in the description, Z represents oxygen or NRc wherein Rc is as defined in the description, Ar represents aryl or heteroaryl, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, alkyl, —ORa and —NRaRb wherein Ra and Rb are as defined in the description, R3 and R4 represent hydrogen or alkyl, R5 represents hydrogen, ORc, NRcRd, W1—C(W2)—U—V, W1—C(W2)—W3-T1 or Z-CO—CH═CHAr wherein Rc, Rd, W1, W2, W3, U, V, T, Z and Ar are as defined in the description, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.

    摘要翻译： 选自式（I）的化合物：其中：X和Y表示选自氢，卤素，烷氧基，硝基，氰基，烷基，烯基，多卤代烷基和-NR a R 其中R a a和R b b如说明书中所定义，Z表示氧或NR C c，其中R - >如说明书中所定义，Ar表示芳基或杂芳基，R 1表示氢或烷基，R 2表示选自氢，烷基 其中R a a和R b都是 - ， - - - - - - - - >如说明书中所定义，R 3和R 4代表氢或烷基，R 5表示氢，或C 1-4烷基， R 1，R 2，R 2，R 2，R 2，R 2， （W 2）-W 3 -T 1或Z-CO-CH-CHAr其中R R 1，R 2，W 3，W 2，W 3，U 3， ，V，T，Z和Ar定义如下 在其描述中，其异构体及其与药学上可接受的酸或碱的加成盐，以及含有该物质的药物可用于治疗癌症。

    Benzo[b]pyrano[3,2-h]acridin-7-one compounds
    5.
    发明授权
    Benzo[b]pyrano[3,2-h]acridin-7-one compounds 失效
    苯并[b]吡喃并[3,2-h]吖啶-7-酮化合物

    公开(公告)号：US06642248B2

    公开(公告)日：2003-11-04

    申请号：US10205566

    申请日：2002-07-25

    申请人： Michel Koch ,  François Tillequin ,  Sylvie Michel ,  Elisabeth Seguin ,  Abdelhakim El Omri ,  John Hickman ,  Alain Pierre ,  Bruno Pfeiffer ,  Pierre Renard

    发明人： Michel Koch ,  François Tillequin ,  Sylvie Michel ,  Elisabeth Seguin ,  Abdelhakim El Omri ,  John Hickman ,  Alain Pierre ,  Bruno Pfeiffer ,  Pierre Renard

    IPC分类号： A61K314741

    CPC分类号： C07D491/04

    摘要： A compound selected from those of formula (I): wherein: X and Y represent group selected from hydrogen, halogen, mercapto, cyano, nitro, alkyl, trihaloalkyl, trihaloalkylcarbonylamino, —ORa, —NRaRb, —NRa—C(O)—T1, —O—C(O)—T1, —O—T2-NRaRb, —O—T2-ORa, —NRa—T2-NRaRb, —NRa—T2-ORa and —NRa—T2-CO2Ra wherein Ra, Rb, T1, T2 are as defined in the description, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, —ORa, —NRaRb, —NRa—C(O)—T1, —O—C(O)—T1, —O—T2-NRaRb, —O—T2-ORa, —NRa—T2-NRaRb, —NRa—T2-ORa and —NRa—T2-CO2Ra wherein Ra, Rb, T1 and T2 are as defined hereinbefore, R3 and R4 represent hydrogen or alkyl, W represents a group of formula —CH(R5)—CH(R6)—, —CH═C(R7)—, —C(R7)═CH— or —C(O)—CH(R8)— wherein R5, R6, R7 and R8 are as defined in the description, their isomers and N-oxides, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.

    摘要翻译： 选自式（I）的化合物：其中：X和Y表示选自氢，卤素，巯基，氰基，硝基，烷基，三卤代烷基，三卤代烷基羰基氨基，-OR a，-NR a R b，-NR a -C（O） - T1，-OC（O）-T1，-O-T2-NRaRb，-O-T2-ORa，-NRa-T2-NRaRb，-NRa-T2-ORa和-NRa-T2-CO2Ra，其中Ra，Rb，T1 ，T 2如说明书中所定义，R 1表示氢或烷基，R 2表示选自氢，-OR a，-NR a R b，-NR a -C（O）-T1，-OC（O）-T1，-O- R2-NRaRb，-O-T2-ORa，-NRa-T2-NRaRb，-NRa-T2-ORa和-NRa-T2-CO2Ra，其中Ra，Rb，T1和T2如上所定义，R3和R4代表氢或 烷基，W表示式-CH（R 5）-CH（R 6） - ， - CH = C（R 7） - ， - C（R 7）= CH-或-C（O）-CH（R 8） R5，R6，R7和R8如说明书中所定义，它们的异构体和N-氧化物及其与药学上可接受的酸或碱的加成盐，以及含有它们的药物，可用于治疗癌症。

    Benzo[b]pyrano[3,2-h]acridin-7-one compounds
    7.
    发明授权
    Benzo[b]pyrano[3,2-h]acridin-7-one compounds 失效

    公开(公告)号：US07056929B2

    公开(公告)日：2006-06-06

    申请号：US10627463

    申请日：2003-07-26

    申请人： Michel Koch ,  Francois Tillequin ,  Sylvie Michel ,  Elisabeth Seguin ,  Abdelhakim El Omri ,  John Hickman ,  Alain Pierre ,  Bruno Pfeiffer ,  Pierre Renard

    发明人： Michel Koch ,  Francois Tillequin ,  Sylvie Michel ,  Elisabeth Seguin ,  Abdelhakim El Omri ,  John Hickman ,  Alain Pierre ,  Bruno Pfeiffer ,  Pierre Renard

    IPC分类号： A61K31/44

    CPC分类号： C07D491/04

    摘要： A method for treating a living body afflicted with a cancer selected from lung and ovarian carcinoma, comprising the step of administering to the living animal body an amount of a compound selected from those of formula (I): wherein: X and Y represent group selected from hydrogen, halogen, mercapto, cyano, nitro, alkyl, trihaloalkyl, trihaloalkylcarbonylamino, —ORa, —NRaRb, —NRa—C(O)-T1, —O—C(O)-T1, —O-T2-NRaRb, —O-T2-ORa, —NRa-T2-NRaRb, —NRa-T2-ORa and —NRa-T2-CO2Ra wherein Ra, Rb, T1, T2 are as defined in the description, or X and Y together form a methylenedioxy or ethylenedioxy, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, —ORa, —NRaRb, —NRa—C(O)-T1, —O—C(O)-T1, —O-T2-NRaRb, —O-T2-ORa, —NRa-T2-NRaRb, —NRa-T2-ORa and —NRa-T2-CO2Ra wherein Ra, Rb, T1 and T2 are as defined hereinbefore, R3 and R4 represent hydrogen or alkyl, W represents a group of formula —CH(R5)—CH(R6)—, —CH═C(R7)—, —C(R7)═CH— or —C(O)—CH(R8)— wherein R5, R6, R7 and R8 are as defined in the description, their isomers and N-oxides, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same are useful in the treatment of cancer.