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1.发明申请Esters of L-carnitine or alkanoyl L-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds 失效用作阳离子脂质用于细胞内递送药理活性化合物的左旋肉碱或烷酰基L-肉碱的酯公开(公告)号：US20070190128A1
公开(公告)日：2007-08-16
申请号：US11727526
申请日：2007-03-27
IPC分类号： A61K9/127
CPC分类号： C07C229/22 , A61K8/14 , A61K8/44 , A61K9/0019 , A61K9/127 , A61K9/1272 , A61K9/1277 , A61K9/19 , A61K31/225 , A61K48/00 , A61Q19/00
摘要： Esters of L-carnitine and alkanoyl L-carnitines are described which can be used as cationic lipids for the intracellular delivery of pharmacologically active compounds. New esters of L-carnitine and alkanoyl L-carnitines of formula (I) are also disclosed wherein the R groups are as defined in the description.
摘要翻译： 描述了左旋肉碱和烷酰基L-肉碱的酯，其可用作阳离子脂质用于药理学活性化合物的细胞内递送。 还公开了式（I）的L-肉碱和烷酰基L-肉毒碱的新酯，其中R基团如说明书中所定义。
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2.发明申请Esters of L-carnitine of alkanoyl L-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds 失效用作阳离子脂质的烷酰基L-肉碱的左旋肉碱的酯用于细胞内递送药理学活性化合物公开(公告)号：US20050079209A1
公开(公告)日：2005-04-14
申请号：US10624645
申请日：2003-07-23
IPC分类号： C07C229/00 , A61K8/00 , A61K8/11 , A61K8/14 , A61K8/30 , A61K8/37 , A61K8/44 , A61K9/127 , A61K31/225 , A61K31/337 , A61K31/4745 , A61K39/00 , A61K45/00 , A61K47/18 , A61K47/24 , A61K47/44 , A61K48/00 , A61P35/00 , A61Q19/00 , C07C229/02 , C07C229/22
CPC分类号： C07C229/22 , A61K8/14 , A61K8/44 , A61K9/0019 , A61K9/127 , A61K9/1272 , A61K9/1277 , A61K9/19 , A61K31/225 , A61K48/00 , A61Q19/00
摘要： Esters of L-carnitine and alkanoyl L-carnitines are described which can be used as cationic lipids for the intracellular delivery of pharmacologically active compounds. New esters of L-carnitine and alkanoyl L-carnitines of formula (I) are also disclosed wherein the R groups are as defined in the description.
摘要翻译： 描述了左旋肉碱和烷酰基L-肉碱的酯，其可用作阳离子脂质用于药理学活性化合物的细胞内递送。 还公开了式（I）的L-肉碱和烷酰基L-肉毒碱的新酯，其中R基团如说明书中所定义。
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公开(公告)号：US06797281B1
公开(公告)日：2004-09-28
申请号：US09958328
申请日：2001-10-09
申请人： Claudio Pisano , Maria Ornella Tinti , Mosé Santaniello , Luciana Critelli , Giovanni Salvatori
发明人： Claudio Pisano , Maria Ornella Tinti , Mosé Santaniello , Luciana Critelli , Giovanni Salvatori
IPC分类号： A61K9127
CPC分类号： C07C229/22 , A61K8/14 , A61K8/44 , A61K9/0019 , A61K9/127 , A61K9/1272 , A61K9/1277 , A61K9/19 , A61K31/225 , A61K48/00 , A61Q19/00
摘要： Esters of L-carnitine and alkanoyl L-carnitines are described which can be used as cationic lipids for the intracellular delivery of pharmacologically active compounds. New esters of L-carnitine and alkanoyl L-carnitines of formula (I) are also disclosed wherein the R groups are as defined in the description.
摘要翻译： 描述了左旋肉碱和烷酰基L-肉碱的酯，其可用作阳离子脂质用于药理学活性化合物的细胞内递送。 还公开了式（I）的L-肉碱和烷酰基L-肉毒碱的新酯，其中R基团如说明书中所定义。
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4.发明授权Esters of L-carnitine or alkanoyl L-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds 失效用作阳离子脂质用于细胞内递送药理活性化合物的左旋肉碱或烷酰基L-肉碱的酯公开(公告)号：US07585519B2
公开(公告)日：2009-09-08
申请号：US11727526
申请日：2007-03-27
申请人： Claudio Pisano , Maria Ornella Tinti , Mosé Santaniello , Luciana Critelli , Giovanni Salvatori
发明人： Claudio Pisano , Maria Ornella Tinti , Mosé Santaniello , Luciana Critelli , Giovanni Salvatori
IPC分类号： A61K9/127
CPC分类号： C07C229/22 , A61K8/14 , A61K8/44 , A61K9/0019 , A61K9/127 , A61K9/1272 , A61K9/1277 , A61K9/19 , A61K31/225 , A61K48/00 , A61Q19/00
摘要： Esters of L-carnitine and alkanoyl L-carnitines are described which can be used as cationic lipids for the intracellular delivery of pharmacologically active compounds. New esters of L-carnitine and alkanoyl L-carnitines of formula (I) are also disclosed wherein the R groups are as defined in the description.
摘要翻译： 描述了左旋肉碱和烷酰基L-肉碱的酯，其可用作阳离子脂质用于药理学活性化合物的细胞内递送。 还公开了式（I）的L-肉碱和烷酰基L-肉毒碱的新酯，其中R基团如说明书中所定义。
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5.发明授权Esters of L-carnitine of alkanoyl L-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds 失效用作阳离子脂质的烷酰基L-肉碱的左旋肉碱的酯用于细胞内递送药理学活性化合物公开(公告)号：US07629003B2
公开(公告)日：2009-12-08
申请号：US10624645
申请日：2003-07-23
申请人： Claudio Pisano , Maria Ornella Tinti , Mosé Santaniello , Luciana Critelli , Giovanni Salvatori
发明人： Claudio Pisano , Maria Ornella Tinti , Mosé Santaniello , Luciana Critelli , Giovanni Salvatori
IPC分类号： A61K9/127
CPC分类号： C07C229/22 , A61K8/14 , A61K8/44 , A61K9/0019 , A61K9/127 , A61K9/1272 , A61K9/1277 , A61K9/19 , A61K31/225 , A61K48/00 , A61Q19/00
摘要： Esters of L-carnitine and alkanoyl L-carnitines are described which can be used as cationic lipids for the intracellular delivery of pharmacologically active compounds. New esters of L-carnitine and alkanoyl L-carnitines of formula (I) are also disclosed wherein the R groups are as defined in the description.
摘要翻译： 描述了左旋肉碱和烷酰基L-肉碱的酯，其可用作阳离子脂质用于药理学活性化合物的细胞内递送。 还公开了式（I）的L-肉碱和烷酰基L-肉毒碱的新酯，其中R基团如说明书中所定义。
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公开(公告)号：US07683032B2
公开(公告)日：2010-03-23
申请号：US11575346
申请日：2005-09-28
摘要： Deglycosylated long pentraxin PTX3 and desialidated long pentraxin PTX3 are disclosed, as well as processes for their preparation, pharmacological compositions containing them, and their use for the preparation of a medicament for the treatment of diseases in which the use of the long pentraxin PTX is indicated, particularly infectious and inflammatory diseases and female fertility disorders. These proteins are endowed with therapeutic activity superior to that of glycosylated pentraxin.
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7.发明授权公开(公告)号：US08778389B2
公开(公告)日：2014-07-15
申请号：US11579805
申请日：2005-04-28
IPC分类号： A61K9/127
CPC分类号： A61K38/1709 , A61K31/7048 , A61K2300/00
摘要： The combination of pentraxin PTX3 with antifungal agents is described for the treatment of fungal infections and particularly for infections caused by Aspergillus fumigatus. Thanks to the synergistic effect of the two drugs, the combination allows the administration of suboptimal doses of antifungal agent.
摘要翻译： 描述了pentraxin PTX3与抗真菌剂的组合用于治疗真菌感染，特别是用于烟曲霉引起的感染。 由于两种药物的协同效应，组合允许给予次优剂量的抗真菌剂。
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公开(公告)号：US07833981B2
公开(公告)日：2010-11-16
申请号：US12710559
申请日：2010-02-23
摘要： Deglycosylated long pentraxin PTX3 and desialidated long pentraxin PTX3 are disclosed, as well as processes for their preparation, pharmacological compositions containing them, and their use for the preparation of a medicament for the treatment of diseases in which the use of the long pentraxin PTX is indicated, particularly infectious and inflammatory diseases and female fertility disorders. These proteins are endowed with therapeutic activity superior to that of glycosylated pentraxin.
摘要翻译： 公开了脱糖基化的长五倍体PTX3和去离子的长五聚蛋白PTX3，以及其制备方法，含有它们的药理学组合物及其用于制备用于治疗其中使用长五倍素PTX的疾病的药物的用途 ，特别是感染性和炎性疾病和女性生殖障碍。 这些蛋白质具有优于糖基化五肽的治疗活性。
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公开(公告)号：US20100209442A1
公开(公告)日：2010-08-19
申请号：US12710559
申请日：2010-02-23
IPC分类号： A61K39/00 , A61K38/17 , C07K14/435 , A61P31/04 , A61P29/00 , A61P35/00 , A61P19/04 , A61P15/08 , A61P19/02 , A61P3/10 , A61P5/14 , A61P7/06 , A61P7/00 , A61P21/04 , A61P1/16 , A61P9/10 , A61P1/04 , A61P17/00 , A61P31/12
摘要： Deglycosylated long pentraxin PTX3 and desialidated long pentraxin PTX3 are disclosed, as well as processes for their preparation, pharmacological compositions containing them, and their use for the preparation of a medicament for the treatment of diseases in which the use of the long pentraxin PTX is indicated, particularly infectious and inflammatory diseases and female fertility disorders. These proteins are endowed with therapeutic activity superior to that of glycosylated pentraxin.
摘要翻译： 公开了脱糖基化的长五倍体PTX3和去离子的长五聚蛋白PTX3，以及其制备方法，含有它们的药理学组合物及其用于制备用于治疗其中使用长五倍素PTX的疾病的药物的用途 ，特别是感染性和炎性疾病和女性生殖障碍。 这些蛋白质具有优于糖基化五肽的治疗活性。
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10.发明申请公开(公告)号：US20080026997A1
公开(公告)日：2008-01-31
申请号：US11579805
申请日：2005-04-28
CPC分类号： A61K38/1709 , A61K31/7048 , A61K2300/00
摘要： The combination of pentraxin PTX3 with antifungal agents is described for the treatment of fungal infections and particularly for infections caused by Aspergillus fumigatus. Thanks to the synergistic effect of the two drugs, the combination allows the administration of suboptimal doses of antifungal agent.
摘要翻译： 描述了pentraxin PTX3与抗真菌剂的组合用于治疗真菌感染，特别是用于烟曲霉引起的感染。 由于两种药物的协同效应，组合允许给予次优剂量的抗真菌剂。
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