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1.发明申请Esters of L-carnitine or alkanoyl L-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds 失效用作阳离子脂质用于细胞内递送药理活性化合物的左旋肉碱或烷酰基L-肉碱的酯公开(公告)号：US20070190128A1
公开(公告)日：2007-08-16
申请号：US11727526
申请日：2007-03-27
IPC分类号： A61K9/127
CPC分类号： C07C229/22 , A61K8/14 , A61K8/44 , A61K9/0019 , A61K9/127 , A61K9/1272 , A61K9/1277 , A61K9/19 , A61K31/225 , A61K48/00 , A61Q19/00
摘要： Esters of L-carnitine and alkanoyl L-carnitines are described which can be used as cationic lipids for the intracellular delivery of pharmacologically active compounds. New esters of L-carnitine and alkanoyl L-carnitines of formula (I) are also disclosed wherein the R groups are as defined in the description.
摘要翻译： 描述了左旋肉碱和烷酰基L-肉碱的酯，其可用作阳离子脂质用于药理学活性化合物的细胞内递送。 还公开了式（I）的L-肉碱和烷酰基L-肉毒碱的新酯，其中R基团如说明书中所定义。
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2.发明申请Esters of L-carnitine of alkanoyl L-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds 失效用作阳离子脂质的烷酰基L-肉碱的左旋肉碱的酯用于细胞内递送药理学活性化合物公开(公告)号：US20050079209A1
公开(公告)日：2005-04-14
申请号：US10624645
申请日：2003-07-23
IPC分类号： C07C229/00 , A61K8/00 , A61K8/11 , A61K8/14 , A61K8/30 , A61K8/37 , A61K8/44 , A61K9/127 , A61K31/225 , A61K31/337 , A61K31/4745 , A61K39/00 , A61K45/00 , A61K47/18 , A61K47/24 , A61K47/44 , A61K48/00 , A61P35/00 , A61Q19/00 , C07C229/02 , C07C229/22
CPC分类号： C07C229/22 , A61K8/14 , A61K8/44 , A61K9/0019 , A61K9/127 , A61K9/1272 , A61K9/1277 , A61K9/19 , A61K31/225 , A61K48/00 , A61Q19/00
摘要： Esters of L-carnitine and alkanoyl L-carnitines are described which can be used as cationic lipids for the intracellular delivery of pharmacologically active compounds. New esters of L-carnitine and alkanoyl L-carnitines of formula (I) are also disclosed wherein the R groups are as defined in the description.
摘要翻译： 描述了左旋肉碱和烷酰基L-肉碱的酯，其可用作阳离子脂质用于药理学活性化合物的细胞内递送。 还公开了式（I）的L-肉碱和烷酰基L-肉毒碱的新酯，其中R基团如说明书中所定义。
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公开(公告)号：US07854939B2
公开(公告)日：2010-12-21
申请号：US11938001
申请日：2007-11-09
申请人： Antonio Longo , Mose Santaniello , Paola Risi
发明人： Antonio Longo , Mose Santaniello , Paola Risi
摘要： A gel, for cosmetic use, composed of a mixture of a polymer which forms a gel, a surfactant, and propionyl L-carnitine glycinate hydrochloride, useful for treating disturbances of the skin such as cellulite and wrinkles is described.
摘要翻译： 描述了用于化妆品使用的凝胶，其由形成凝胶的聚合物，表面活性剂和丙酸L-肉碱甘氨酸盐酸盐盐酸盐的混合物组成，其用于治疗皮肤的干扰，如脂肪团和皱纹。
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4.发明授权Alkanoyl L-carnitine amides with aminoacids and pharmaceutical compositions containing same for promoting regeneration of the nervous tissue, inhibiting neuronal degeneration, enhancing the process of learning and memory and for the treatment of coma 失效含有氨基酸的烷酰基L-肉碱酰胺和含有其的药物组合物，用于促进神经组织的再生，抑制神经元变性，增强学习和记忆的过程以及治疗昏迷
公开(公告)号：US5270472A
公开(公告)日：1993-12-14
申请号：US883388
申请日：1992-05-15
IPC分类号： C07C229/26 , C07C237/12 , C07C237/22 , C07C275/16 , C07C279/14 , C07C67/02
CPC分类号： C07C279/14 , C07C237/12 , C07C237/22 , C07C275/16
摘要： Amides of alkanoyl L-carnitines of general formula (1). ##STR1## wherein R is a straight or branched alkanoyl group having from 2 to 8 carbon atoms selected from acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, hexanoyl, 1-methylbutyryl, t-butylacetyl, 2-ethylbutyryl, 3-methylvaleryl, 4-methylvaleryl, 2-ethylhexanoyl and 2-propylpentanoyl;R' is the monovalent residue of a naturally occurring aminoacid selected from: ##STR2## X.sup.- is the anion of a pharmacologically acceptable acid are active in regenerating the nervous tissue, inhibiting neuronal degeneration, enhancing the processes of learning and memory and for the treatment of coma.Orally or parenterally administrable compositions in unit dosage form comprise between about 50 and about 500 mg of an amide of formula (1).
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5.发明授权Esters of acyl carnitines with long-chain aliphatic alcohols and pharmaceutical compositions containing same having antimycotic activity 失效具有长链脂肪醇的酰基肉碱的酯和含有它们的具有抗真菌活性的药物组合物
公开(公告)号：US5519056A
公开(公告)日：1996-05-21
申请号：US250108
申请日：1994-05-26
IPC分类号： A61K31/22 , A61P31/04 , A61P31/10 , C07C229/22 , A61K31/225
CPC分类号： C07C229/22
摘要： Esters of acyl L-carnitines of general formula (I) ##STR1## wherein R is a straight or branched acyl group having 2 to 16 carbon atoms, in particular isobutyryl and isovaleryl;n is an integer comprised between 7 and 15, particularly 10; and,X.sup.- is the anion of a pharmacologically acceptable acid are endowed with potent antimycotic activity particularly against yeast like fungi, such as Candida albicans, the aetiologic agent of candidiasis and against filamentous fungi, such as Aspergillus fumigatus, the aetiologic agent of aspergillosis.Orally or parenterally administrable or topically applicable pharmaceutical compositions comprise an ester of formula (I) as active ingredient.
摘要翻译： （I）的酰基L-肉碱的酯其中R是具有2至16个碳原子的直链或支链酰基，特别是异丁酰基和异戊酰基; n是7和15之间的整数，特别是10; X-是药理学上可接受的酸的阴离子，特别是对酵母样真菌如白色假丝酵母，念珠菌病的病原体和丝状真菌如烟曲霉，曲霉病的病原体具有有效的抗真菌活性。 口服或肠胃外给药或局部适用的药物组合物包含式（I）的酯作为活性成分。
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6.发明授权Esters of acyl carnitines with long-chain aliphatic alcohols and pharmaceutical compositions containing same having antibacterial activity 失效具有长链脂肪醇的酰基肉碱的酯和含有其的具有抗菌活性的药物组合物
公开(公告)号：US5498632A
公开(公告)日：1996-03-12
申请号：US250107
申请日：1994-05-26
IPC分类号： A61K31/22 , A61P31/04 , C07C229/22 , A61K31/225
CPC分类号： C07C229/22
摘要： Esters of acyl L-carnitines of general formula (I) ##STR1## wherein R is a straight or branched acyl group having 2 to 16 carbon atoms, in particular isobutyryl and isovaleryl;n is an integer comprised between 7 and 15, particularly 10; and,X- is the anion of a pharmacologically acceptable acid are endowed with potent antibacterial activity.Pharmaceutical compositions comprising an ester of formula (I) can be utilized in human therapy and in the veterinary field.
摘要翻译： （I）的酰基L-肉碱的酯其中R是具有2至16个碳原子的直链或支链酰基，特别是异丁酰基和异戊酰基; n是7和15之间的整数，特别是10; 而X-是药理学上可接受的酸的阴离子具有很强的抗菌活性。 包含式（I）的酯的药物组合物可用于人类治疗和兽医领域。
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公开(公告)号：US08389014B2
公开(公告)日：2013-03-05
申请号：US12517445
申请日：2007-11-28
CPC分类号： A61K9/0048 , A61K9/06 , A61K9/19 , A61K31/205 , A61K31/7036 , A61K45/06 , A61K47/12 , A61K47/26 , A61K47/32 , A61K2300/00
摘要： The present invention relates to a solid powder composed of a mixture of a natural or a synthetic polymer which forms a gel, a buffer, such as an hydroxyacid or a dicarboxyacid, a saccharide, one or more drugs useful for the treatment of diseases of the eyes and optionally one or more excipients and/or regulators of the osmotic pressure ophthalmologically acceptable.
摘要翻译： 本发明涉及由形成凝胶的天然或合成聚合物，羟基酸或二羧酸缓冲液，糖类，一种或多种用于治疗疾病的药物的混合物组成的固体粉末 眼睛和任选的一种或多种在眼科学上可接受的渗透压的赋形剂和/或调节剂。
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公开(公告)号：US5498633A
公开(公告)日：1996-03-12
申请号：US408394
申请日：1995-03-22
IPC分类号： A61K31/22 , A61P31/04 , C07C229/22 , A61K31/225
CPC分类号： C07C229/22
摘要： Esters of acyl L-carnitines of general formula (I) ##STR1## wherein R is a straight or branched acyl group having 2 to 16 carbon atoms, in particular isobutyryl and isovaleryl;n is an integer comprised between 7 and 15, particularly 10; and,X- is the anion of a pharmacologically acceptable acid are endowed with potent antibacterial activity. Pharmaceutical compositions comprising an ester of formula (I) can be utilized in human therapy and in the veterinary field.
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9.发明授权Solid compositions suitable for oral administration comprising L-carnitine or alkanoyl-L-carnitine magnesium fumarate 失效适用于口服给药的固体组合物，其包含左旋肉碱或链烷酰-L-肉碱富马酸镁
公开(公告)号：US6051608A
公开(公告)日：2000-04-18
申请号：US402649
申请日：1998-10-08
IPC分类号： A23L1/30 , A23K1/16 , A23L1/305 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/48 , A61K31/205 , A61P21/02 , A61P21/04 , C07C57/15 , C07C229/22 , C07C229/00
CPC分类号： C07C229/22 , A23K20/105 , A23L33/175 , C07C57/15
摘要： Stable and non-hygroscopic salts consisting of L-carnitine or alkanoyl-L-carnitine magnesium fumarate are disclosed which are suitable for preparing solid compositions useful as dietary/nutritional supplements for human use and as fodder supplement for veterinary purposes.
摘要翻译： PCT No.PCT / IT98 / 00079 Sec。 371 1999年10月8日第 102（e）1999年10月8日PCT PCT 1998年4月8日PCT公布。 公开号WO98 / 49134 日期1998年11月5日公开了由L-肉碱或链烷酰-L-肉碱镁富马酸盐组成的稳定和非吸湿盐，其适用于制备用作人类膳食/营养补充剂的固体组合物，以及用于兽医用途的饲料补充剂。
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公开(公告)号：US5856569A
公开(公告)日：1999-01-05
申请号：US941722
申请日：1997-10-01
IPC分类号： A61K31/20 , B01J31/22 , C07B61/00 , C07C51/02 , C07C51/09 , C07C51/41 , C07C53/126 , C07C67/343 , C07C69/02 , C07C53/128
CPC分类号： C07C51/412 , C07C51/02 , C07C67/343
摘要： A process for making valproic acid from an alkyl alkanoylacetate is disclosed. The alkyl alkanoylacetate is reacted with an n-propyl halide in a biphasic system in the presence of a base and a phase transfer catalyst. The product mixture is acidified to convert the resulting valproate salt into valproic acid.
摘要翻译： 公开了一种从烷基链烷酰乙酸烷基酯制备丙戊酸的方法。 在碱和相转移催化剂的存在下，烷基乙酰基乙酸烷基酯与正丙基卤化物在双相体系中反应。 将产物混合物酸化以将得到的丙戊酸盐转化成丙戊酸。
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