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    Opioid salts and formulations exhibiting anti-abuse and anti-dose dumping properties
    4.
    发明授权
    Opioid salts and formulations exhibiting anti-abuse and anti-dose dumping properties 有权
    具有抗滥用和抗剂量倾倒性能的阿片类盐和制剂

    公开(公告)号：US08921386B1

    公开(公告)日：2014-12-30

    申请号：US13484964

    申请日：2012-05-31

    申请人： Clifford Riley King ,  Stephen G. D'Ambrosio ,  David W. Bristol ,  Michael L. English

    发明人： Clifford Riley King ,  Stephen G. D'Ambrosio ,  David W. Bristol ,  Michael L. English

    IPC分类号： A61K31/44 ,  C07D489/00

    CPC分类号： C07D489/04 ,  A61K31/485

    摘要： A drug substance with a pharmaceutically acceptable organic acid addition salt of an opioid wherein said organic acid is selected from Structure A: wherein R1-R4 are independently selected from H, alkyl or substituted alkyl of 1-6 carbons, adjacent groups may be taken together to form a cyclic alkyl, cyclic alkyl-aryl, or cyclic aryl moiety; R5 is selected from H, or an alkali earth cation; R6 and R7 are independently selected from H, alkyl of 1-6 carbons, an alkali earth cation, and aryl of 6 to 12 carbons, in a number sufficient to complete the valence bonding of X, and wherein X is selected from nitrogen, oxygen or sulfur; and wherein the drug substance has a morphology selected from amorphous and crystalline.

    摘要翻译： 具有阿片样物质的药学上可接受的有机酸加成盐的药物，其中所述有机酸选自结构A：其中R 1 -R 4独立地选自H，烷基或取代的1-6个碳原子的烷基，相邻基团可以一起 形成环状烷基，环状烷基 - 芳基或环状芳基部分; R5选自H或碱土金属阳离子; R6和R7独立地选自H，烷基的1-6个碳原子，碱土金属阳离子和6至12个碳的芳基，其数量足以完成X的价键，其中X选自氮，氧 或硫磺; 并且其中所述药物具有选自无定形和结晶的形态。

    Opioid salts and formulations exhibiting anti-abuse and anti-dumping properties
    6.
    发明授权
    Opioid salts and formulations exhibiting anti-abuse and anti-dumping properties 有权
    具有抗滥用和反倾销特性的阿片类盐和制剂

    公开(公告)号：US08748416B1

    公开(公告)日：2014-06-10

    申请号：US13331298

    申请日：2011-12-20

    申请人： Clifford Riley King ,  Stephen G. D'Ambrosio ,  David W. Bristol ,  Michael L. English

    发明人： Clifford Riley King ,  Stephen G. D'Ambrosio ,  David W. Bristol ,  Michael L. English

    IPC分类号： A01N43/00 ,  A61K31/33 ,  A01N37/10 ,  A61K31/19

    CPC分类号： C07D489/04 ,  A61K31/485

    摘要： A drug substance with a pharmaceutically acceptable organic acid addition salt of an opioid wherein said organic acid is selected from Structure A: wherein R1-R4 are independently selected from H, alkyl or substituted alkyl of 1-6 carbons, adjacent groups may be taken together to form a cyclic alkyl, cyclic alkyl-aryl, or cyclic aryl moiety; R5 is selected from H, or an alkali earth cation; R6 and R7 are independently selected from H, alkyl of 1-6 carbons, an alkali earth cation, and aryl of 6 to 12 carbons, in a number sufficient to complete the valence bonding of X, and wherein X is selected from nitrogen, oxygen or sulfur; and wherein the drug substance has a morphology selected from amorphous and crystalline.

    摘要翻译： 具有阿片样物质的药学上可接受的有机酸加成盐的药物，其中所述有机酸选自结构A：其中R 1 -R 4独立地选自H，烷基或取代的1-6个碳原子的烷基，相邻基团可以一起 形成环状烷基，环状烷基 - 芳基或环状芳基部分; R5选自H或碱土金属阳离子; R6和R7独立地选自H，烷基的1-6个碳原子，碱土金属阳离子和6至12个碳的芳基，其数量足以完成X的价键，其中X选自氮，氧 或硫磺; 并且其中所述药物具有选自无定形和结晶的形态。