公开(公告)号：US20220010316A1

公开(公告)日：2022-01-13

申请号：US17490215

申请日：2021-09-30

Applicant: Codexis, Inc.

Inventor： Scott J. Novick ,  Nikki Dellas ,  Vesna Mitchell ,  Da Duan ,  Jovana Nazor ,  Oscar Alvizo ,  Auric Anthony Sowell-Kantz ,  Jeffrey C. Moore ,  Mark A. Huffman ,  Agustina Rodriguez-Granillo ,  Deeptak Verma ,  Nicholas M. Marshall ,  Jay H. Russell ,  Keith A. Canada

IPC: C12N15/63

Abstract: The present invention provides engineered purine nucleoside phosphorylase (PNP) enzymes, polypeptides having PNP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PNP enzymes are also provided. The present invention further provides compositions comprising the PNP enzymes and methods of using the engineered PNP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.

公开(公告)号：US20250027094A1

公开(公告)日：2025-01-23

申请号：US18906502

申请日：2024-10-04

Applicant: Codexis, Inc.

Inventor： Scott J. Novick ,  Nikki Dellas ,  Vesna Mitchell ,  Da Duan ,  Jovana Nazor ,  Oscar Alvizo ,  Auric Anthony Sowell-Kantz ,  Jeffrey C. Moore ,  Mark A. Huffman ,  Agustina Rodriguez-Granillo ,  Deeptak Verma ,  Nicholas M. Marshall ,  Jay H. Russell ,  Keith A. Canada

IPC: C12N15/63

Abstract: The present invention provides engineered purine nucleoside phosphorylase (PNP) enzymes, polypeptides having PNP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PNP enzymes are also provided. The present invention further provides compositions comprising the PNP enzymes and methods of using the engineered PNP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.

公开(公告)号：US12110493B2

公开(公告)日：2024-10-08

申请号：US17490215

申请日：2021-09-30

Applicant: Codexis, Inc.

Inventor： Scott J. Novick ,  Nikki Dellas ,  Vesna Mitchell ,  Da Duan ,  Jovana Nazor ,  Oscar Alvizo ,  Auric Anthony Sowell-Kantz ,  Jeffrey C. Moore ,  Mark A. Huffman ,  Agustina Rodriguez-Granillo ,  Deeptak Verma ,  Nicholas M. Marshall ,  Jay H. Russell ,  Keith A. Canada

IPC: C12N15/63

CPC classification number: C12N15/63 ,  C12Y204/02001

Abstract: The present invention provides engineered purine nucleoside phosphorylase (PNP) enzymes, polypeptides having PNP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PNP enzymes are also provided. The present invention further provides compositions comprising the PNP enzymes and methods of using the engineered PNP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.