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公开(公告)号：US20240287474A1
公开(公告)日：2024-08-29
申请号：US18657101
申请日：2024-05-07
Applicant: Codexis, Inc.
Inventor： Christopher Micklitsch , Oscar Alvizo , Jovana Nazor , Harvinder Chagger Maniar , Mikayla Jianghongxia Krawczyk , Margie Tabuga Borra-Garske , Nandhitha Subramanian , Anna Fryszkowska , Nicholas M. Marshall , Agustina Rodriguez-Granillo , Deeptak Verma , Dewan Andrews
CPC classification number: C12N9/0006 , C12N15/52 , C12N9/001 , C12P21/02 , C12Y101/03009
Abstract: The present invention provides engineered galactose oxidase (GOase) enzymes, polypeptides having GOase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing GOase enzymes are also provided. The present invention further provides compositions comprising the GOase enzymes and methods of using the engineered GOase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.
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公开(公告)号：US12012618B2
公开(公告)日：2024-06-18
申请号：US17931003
申请日：2022-09-09
Applicant: Codexis, Inc.
Inventor： Christopher Michael Micklitsch , Oscar Alvizo , Jovana Nazor , Harvinder Chagger Maniar , Mikayla Jianghongxia Krawczyk , Margie Tabuga Borra-Garske , Nandhitha Subramanian , Anna Fryszkowska , Nicholas M. Marshall , Agustina Rodriguez-Granillo , Deeptak Verma , Dewan Andrews
CPC classification number: C12N9/0006 , C12N15/52 , C12N9/001 , C12P21/02 , C12Y101/03009
Abstract: The present invention provides engineered galactose oxidase (GOase) enzymes, polypeptides having GOase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing GOase enzymes are also provided. The present invention further provides compositions comprising the GOase enzymes and methods of using the engineered GOase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.
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公开(公告)号：US20230183663A1
公开(公告)日：2023-06-15
申请号：US18046451
申请日：2022-10-13
Applicant: Codexis, Inc.
Inventor： Charlene Ching , Stephanie Marie Forget , Anders Matthew Knight , Mikayla Jianghongxia Krawczyk , Niusha Mahmoodi , Melissa Ann Mayo , Mathew G. Miller , Jonathan Vroom
CPC classification number: C12N9/1264 , C12Y207/07031 , C12N15/63
Abstract: The present invention provides engineered terminal deoxynucleotidyl transferase (TdT) polypeptides useful in template-independent polynucleotide synthesis using a nucleoside triphosphate-3′-O-removable blocking group (NTP-3′-O-RBG), as well as compositions, methods of utilizing these engineered polypeptides, and polynucleotides encoding the engineered terminal deoxynucleotidyl transferases.
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公开(公告)号：US20230026007A1
公开(公告)日：2023-01-26
申请号：US17931003
申请日：2022-09-09
Applicant: Codexis, Inc.
Inventor： Christopher Michael Micklitsch , Oscar Alvizo , Jovana Nazor , Harvinder Chagger Maniar , Mikayla Jianghongxia Krawczyk , Margie Tabuga Borra-Garske , Nandhitha Subramanian , Anna Fryszkowska , Nicholas M. Marshall , Agustina Rodriguez-Granillo , Deeptak Verma , Dewan Andrews
Abstract: The present invention provides engineered galactose oxidase (GOase) enzymes, polypeptides having GOase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing GOase enzymes are also provided. The present invention further provides compositions comprising the GOase enzymes and methods of using the engineered GOase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.
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公开(公告)号：US20220251523A1
公开(公告)日：2022-08-11
申请号：US17617527
申请日：2020-06-30
Applicant: Codexis, Inc.
Inventor： Jonathan Vroom , Alberto Ortega Guerra , Jovana Nazor , Mikayla Jianghongxia Krawczyk
Abstract: The present invention provides engineered acetate kinase (AcK) enzymes, polypeptides having AcK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing AcK enzymes are also provided. The present invention further provides compositions comprising the AcK enzymes and methods of using the engineered AcK enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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Patent Agency Ranking
公开(公告)号：US20240309353A1
公开(公告)日：2024-09-19
申请号：US18420040
申请日：2024-01-23
Applicant: Codexis, Inc.
Inventor： Jacob Hansen Artz , Rachelle Copeland , Jason Fell , Anders Matthew Knight , Mikayla Jianghongxia Krawczyk , Mathew G. Miller , Jovana Nazor , Amani Shoubber , Jonathan Vroom
IPC: C12N9/00
CPC classification number: C12N9/93 , C12Y605/01001
Abstract: The present disclosure relates to engineered DNA ligase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered DNA ligase polypeptides. The present disclosure also provides methods of using the engineered DNA ligase polypeptides or compositions thereof in diagnostics and as a molecular biological tool.
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公开(公告)号：US20240209406A1
公开(公告)日：2024-06-27
申请号：US18486140
申请日：2023-10-12
Applicant: Codexis, Inc.
Inventor： David Entwistle , Stephanie Marie Forget , Anders Matthew Knight , Mikayla Jianghongxia Krawczyk , Marissa Greene MacAvoy , Simon Ng , Nicholas Porter , Philip Provencher , Amani Shoubber , Leann Quertinmont Teadt , Jonathan Vroom , David Watts , Leland Ken Wong
CPC classification number: C12P19/34 , C12N9/1205 , C12N9/1217 , C12N9/1223 , C12N9/1229 , C12Y207/0102 , C12Y207/02001 , C12Y207/03002 , C12Y207/04001 , C12Y207/04003 , C12Y207/04006
Abstract: The present disclosure provides enzymatic methods for the production of 3′-phosphate-nucleoside-5′-triphosphate (NQP). The present disclosure further provides enzymatic methods for the production of nucleotide-5′-triphosphates.
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公开(公告)号：US20240002817A1
公开(公告)日：2024-01-04
申请号：US18247054
申请日：2021-09-29
Applicant: Codexis, Inc.
Inventor： Jovana Nazor , Mikayla Jianghongxia Krawczyk , Zara Maxine Seibel , Nandhitha Subramanian , Joshua Kolev
CPC classification number: C12N9/1205 , C12Y207/01033 , C12N15/63
Abstract: The present invention provides engineered pantothenate kinase (PanK) enzymes, polypeptides having PanK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PanK enzymes are also provided. The present invention further provides compositions comprising the PanK enzymes and methods of using the engineered PanK enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US11466259B2
公开(公告)日：2022-10-11
申请号：US16460376
申请日：2019-07-02
Applicant: Codexis, Inc.
Inventor： Christopher Michael Micklitsch , Oscar Alvizo , Jovana Nazor , Harvinder Chagger Maniar , Mikayla Jianghongxia Krawczyk , Margie Tabuga Borra-Garske , Nandhitha Subramanian , Anna Fryszkowska , Nicholas M. Marshall , Agustina Rodriguez-Granillo , Deeptak Verma , Dewan Andrews
Abstract: The present invention provides engineered galactose oxidase (GOase) enzymes, polypeptides having GOase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing GOase enzymes are also provided. The present invention further provides compositions comprising the GOase enzymes and methods of using the engineered GOase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.
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公开(公告)号：US20200010869A1
公开(公告)日：2020-01-09
申请号：US16460376
申请日：2019-07-02
Applicant: Codexis, Inc.
Inventor： Christopher Michael Micklitsch , Oscar Alvizo , Jovana Nazor , Harvinder Chagger Maniar , Mikayla Jianghongxia Krawczyk , Margie Tabuga Borra-Garske , Nandhitha Subramanian , Anna Fryszkowska , Nicholas M. Marshall , Agustina Rodriguez-Granillo , Deeptak Verma , Dewan Andrews
Abstract: The present invention provides engineered galactose oxidase (GOase) enzymes, polypeptides having GOase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing GOase enzymes are also provided. The present invention further provides compositions comprising the GOase enzymes and methods of using the engineered GOase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.
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